Elevation of glucosylceramide in multidrug-resistant cancer cells and accumulation in cytoplasmic droplets

International Journal of Cancer

Volumn 94, Issue 2, 2001, Pages 157-165

  Morjani, Hamid ^a   Aouali, Nasséra ^a   Belhoussine, Rajae ^a   Veldman, Robert Jan ^a   Levade, Thierry ^a   Manfait, Michel ^a,b  

^a CNRS   (France)

^b CHU RANGUEIL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE GLUCOSYLTRANSFERASE INHIBITOR; CYCLOSPORIN A; DOXORUBICIN; FAT DROPLET; GLUCOSYLCERAMIDE; LIPID; PALMITIC ACID; PHOSPHOLIPID; PROPRANOLOL DERIVATIVE; TAMOXIFEN; VINCRISTINE; ZIDOVUDINE;

ADVERSE DRUG REACTION; ARTICLE; CANCER; CANCER CELL CULTURE; CELL INCLUSION; CELLULAR DISTRIBUTION; CYTOTOXICITY; DRUG EFFECT; FLUORESCENCE MICROSCOPY; GOLGI COMPLEX; HUMAN; HUMAN CELL; LIPID STORAGE; MICROFLUOROMETRY; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; THIN LAYER CHROMATOGRAPHY;

CELL NUCLEUS; CYTOPLASM; DAUNORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; GLUCOSYLCERAMIDES; HUMANS; INOSITOL; MICROSCOPY, CONFOCAL; NEOPLASMS; TUMOR CELLS, CULTURED;

EID: 0035888295     PISSN: 00207136     EISSN: None     Source Type: Journal    
DOI: 10.1002/ijc.1449     Document Type: Article

References (46)

1. Biochemistry of multidrug resistance mediated by the multidrug transporter
2. Mechanism of multidrug resistance
3. Multidrug resistance (mdr1) gene expression in adult acute leukemias: Correlations with treatment outcome and in vitro drug sensitivity
4. Predictive value for treatment outcome in acute myeloid leukemia of cellular daunorubicin accumulation P-glycoprotein expression simultaneously determined by flow cytometry
5. Overexpression of a transporter gene in multidrug-resistant human lung cancer cell line
6. Major vault protein LRP-related multidrug resistance
7. A multidrug-resistance transporter from human MCF-7 breast cancer cells
8. Glutathione and related enzymes in multidrug-resistance
9. Anti-topoisomerase drug action and resistance
10. Increased phospholipase D activity in multidrug resistance breast cancer cells
11. Altered plasma membrane ultrastructure in multidrug-resistant cells
12. Role of membrane lipids in the interaction of daunomycin with plasma membranes from tumor cells implications in drug resistance phenomena
13. Proton nuclear magnetic resonance spectroscopy reveals cellular lipids involved in resistance to adriamycin taxol by the K562 leukemia cell line
14. Sphingolipid metabolism and cell growth regulation
15. Programmed cell death induced by ceramide
16. Accumulation of glucosylceramides in multidrug-resistant cancer cells
17. Agents that reverse multidrug-resistance, tamoxifen, verapamil and cyclosporin A, block glycosphingolipid metabolism by inhibiting ceramide glycosylation in human cancer cells
18. SDZ PSC 833 the drug resistance modulator activities cellular ceramide formation by a pathway independent of P-glycoprotein
19. Daunorubicin-induced apoptosis: Triggering of ceramide generation through sphingomyelin hydrolysis
20. Inhibition of cellular processing of surfactant protein C by drugs affecting pH gradients
21. Isolation of amplified overexpressed DNA sequences from adriamycin-resistant human breast cancer cells
22. Mechanism of multidrug-resistance in HL60 cells: Evidence that a surface membrane protein distinct from P-glycoprotein contributes to reduced cellular accumulation of drug
23. Lack of correlation between expression function of P-glycoprotein in acute myeloid leukemia cell lines
24. Effect of S9788, cyclosporin A and verapamil on intracellular distribution of THP-doxorubicin in multidrug-resistant K562 tumor cells, as studied by laser confocal microspectrofluorometry
25. Trafficking of glycosphingolipids in eucaryotic cells: Sorting and recycling of lipids
26. Characterization of pH gradient in human multidrug-resistant tumor cells by means of scanning microspectrofluorometry and dual emission ratio probes
27. Measurement of protein using bicinchoninic acid
28. A simple method for the isolation and purification of total lipids from animal tissues
29. Confocal spectral imaging analysis
30. Anthracycline subcellular distribution in human leukemic cells by microspectrofluorometry: Factors contributing to drug-induced cell death and reversal of multidrug resistance
31. Glucosylceramide is synthesized at the cytosolic surface of various Golgi subfractions
32. Acid sphingomyelinase-deficient human lymphoblasts and mice are defective in radiation-induced apoptosis
33. Tamoxifen retards glycosphingolipid metabolism in human cancer cells
34. 3′-azidothymidine (zidovudine) inhibits glycosylation and markedly alters glycosphingolipid synthesis in whole cells at clinically relevant concentrations
35. A mechanism for tamoxifen-mediated inhibition of acidification
36. Tamoxifen inhibits acidification in cells independent of the estrogen receptor
37. Elevation of intracellular glucosylceramide levels results in an increase in endoplasmic reticulum density in functional calcium stores in cultured neurons
38. Structure elucidation characterization of daunorubicin degradation products
39. Expression of glucosylceramide synthase, converting ceramide to glucosylceramide, confers adriamycin resistance in human breast cancer cells
40. Modulation of subcellular distribution of doxorubicin in multidrug-resistant P388/ADR mouse leukemia cells by the chemosensitizer {{2-isopropyl-1-{4-[3-N-methyl-N-(3,4-dimethoxy-β-phenethyl)amino] propyloxy}-benzene-sulfonyl}}indolizine
41. Accumulation of glucosylceramide and glucosylsphingosine (psychonine) in cerebrum and cerebralium in infantile and juvenile Gaucher disease
42. Neurodegenerative course in ceramidase deficiency (Farber disease) correlates with the residual lysosomal ceramide turnover in cultured living patients cells
43. rev cells
44. Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals
45. Restoration of TNF-α-induced ceramide generation and apoptosis in resistant human leukemic KG1a cells by the P-glycoprotein blocker PSC833
46. Lack of ceramide generation in TF-1 human myeloid leukemic cells resistant to ionizing radiation