Prediction of the human oral bioavailability by using in vitro and in silico drug related parameters in a physiologically based absorption model

International Journal of Pharmaceutics

Volumn 429, Issue 1-2, 2012, Pages 84-98

  Paixão, Paulo ^a,b   Gouveia, Luís F ^a   Morais, José A G ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b UNIVERSIDADE LUSÓFONA DE HUMANIDADES E TECNOLOGIAS   (Portugal)

Author keywords

Human absolute bioavailability; In silico in vivo correlation; In vitro in vivo correlation; Physiological based pharmacokinetic model of absorption

Indexed keywords

ALENDRONIC ACID; ALLOPURINOL; ALPRAZOLAM; AMIODARONE; AMITRIPTYLINE; AMLODIPINE; APREPITANT; BUSPIRONE; CALCITRIOL; CANDESARTAN; CEFIXIME; CHLORTALIDONE; CINACALCET; CLINDAMYCIN; CYCLOPHOSPHAMIDE; DAPSONE; DICLOXACILLIN; DIDANOSINE; DOFETILIDE; ENTACAPONE; ETHAMBUTOL; FINASTERIDE; FLECAINIDE; FLUMAZENIL; FLUOROURACIL; FLUPHENAZINE; GALANTAMINE; GLIBENCLAMIDE; GLIMEPIRIDE; UNINDEXED DRUG;

ARTICLE; CELL STRAIN CACO 2; CELL SUSPENSION; COMPUTER MODEL; COMPUTER PREDICTION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG EFFECT; DRUG PENETRATION; DRUG SOLUBILITY; HUMAN; HUMAN CELL; IN VITRO STUDY; LIVER CELL; PH; PRIORITY JOURNAL;

ADMINISTRATION, ORAL; BIOLOGICAL AVAILABILITY; CACO-2 CELLS; COMPUTER SIMULATION; DRUG DESIGN; GASTROINTESTINAL TRACT; HEPATOCYTES; HUMANS; HYDROGEN-ION CONCENTRATION; INTESTINAL ABSORPTION; MODELS, BIOLOGICAL; PERMEABILITY; PHARMACEUTICAL PREPARATIONS; SOLUBILITY;

EID: 84859561563     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2012.03.019     Document Type: Article

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