Evaluation of the human prediction of clearance from hepatocyte and microsome intrinsic clearance for 52 drug compounds

Xenobiotica

Volumn 40, Issue 9, 2010, Pages 637-649

  Sohlenius Sternbeck, A K ^a   Afzelius, L ^a   Prusis, P ^a   Neelissen, J ^a   Hoogstraate, J ^a   Johansson, J ^a   Floby, E ^a   Bengtsson, A ^a   Gissberg, O ^a   Sternbeck, J ^b   Petersson, C ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b WSP Environmental   (Sweden)

Author keywords

In vitro; In vivo; Liver; Metabolism; Scaling; Well stirred model

Indexed keywords

AMITRIPTYLINE; ATENOLOL; BETAXOLOL; BUFURALOL; BUSPIRONE; CARVEDILOL; CHLORPHENIRAMINE; CHLORPROMAZINE; CIMETIDINE; CLOZAPINE; DESIPRAMINE; DEXAMETHASONE; DIAZEPAM; DICLOFENAC; DIFLUNISAL; DILTIAZEM; DIPHENHYDRAMINE; ETODOLAC; FENOPROFEN; FUROSEMIDE; GEMFIBROZIL; GLIPIZIDE; GRANISETRON; HYDROCORTISONE; IBUPROFEN; IMIPRAMINE; KETOPROFEN; LORAZEPAM; PARACETAMOL; UNINDEXED DRUG;

ANALYTICAL ERROR; ARTICLE; AVERAGE ABSOLUTE FOLD ERROR; BIOLOGICAL MODEL; CALCULATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG CLEARANCE; DRUG PROTEIN BINDING; EVALUATION; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; LIVER MICROSOME; MALE; PREDICTION; TECHNIQUE;

FEMALE; HEPATOCYTES; HUMANS; MALE; METABOLIC CLEARANCE RATE; MICROSOMES; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; REGRESSION ANALYSIS;

EID: 77955591482     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2010.500407     Document Type: Article

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