Knock-in mice reveal nonsense-mediated mRNA decay in the brain

Genesis (United States)

Volumn 45, Issue 1, 2007, Pages 38-43

  Contet, Candice ^a   Dierich, Andrée ^b   Kieffer, Brigitte L ^a  

^a CNRS   (France)

^b INSTITUT CLINIQUE DE LA SOURIS   (France)

Author keywords

Brain; Knock in mice; Mu opioid receptor; Nonsense mediated mRNA decay; Premature termination codon

Indexed keywords

CYCLOHEXIMIDE; MESSENGER RNA; MU OPIATE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN DEVELOPMENT; CONTROLLED STUDY; GENE EXPRESSION; HOMOLOGOUS RECOMBINATION; IN VITRO STUDY; IN VIVO STUDY; MOR GENE; MUTANT; NONHUMAN; PRIORITY JOURNAL; RECEPTOR DOWN REGULATION; RECEPTOR GENE; RNA DEGRADATION; RNA PROCESSING; RNA SPLICING; RNA TRANSCRIPTION; STOP CODON; WILD TYPE;

MAMMALIA; MUS;

EID: 33846785287     PISSN: 1526954X     EISSN: 1526968X     Source Type: Journal    
DOI: 10.1002/dvg.20263     Document Type: Article

References (27)

1. Bailey CP, Connor M. 2005. Opioids: Cellular mechanisms of tolerance and physical dependence. Curr Opin Pharmacol 5:60-68.
2. Barondes SH, Cohen HD. 1968. Arousal and the conversion of "short-term" to "long-term" memory. Proc Natl Acad Sci USA 61:923-929.
3. Barton-Davis ER, Cordier L, Shoturma DI, Leland SE, Sweeney HL. 1999. Aminoglycoside antibiotics restore dystrophin function to skeletal muscles of mdx mice. J Clin Invest 104:375-381.
4. Bateman JF, Freddi S, Nattrass G, Savarirayan R. 2003. Tissue-specific RNA surveillance? Nonsense-mediated mRNA decay causes collagen X haploinsufficiency in Schmid metaphyseal chondrodysplasia cartilage. Hum Mol Genet 12:217-225.
5. Bühler M, Steiner S, Mohn F, Paillusson A, Mühlemann O. 2006. EJC-independent degradation of nonsense immunoglobulin-mu mRNA depends on 3′ UTR length. Nat Struct Mol Biol 13:462-464.
6. Carter MS, Doskow J, Morris P, Li S, Nhim RP, Sandstedt S, Wilkinson MF. 1995. A regulatory mechanism that detects premature nonsense codons in T-cell receptor transcripts in vivo is reversed by protein synthesis inhibitors in vitro. J Biol Chem 270:28995-29003.
7. Chen K, Holschneider DP, Wu W, Rebrin I, Shih JC. 2004. A spontaneous point mutation produces monoamine oxidase A/B knock-out mice with greatly elevated monoamines and anxiety-like behavior. J Biol Chem 279:39645-39652.
8. Cheng J, Belgrader P, Zhou X, Maquat LE. 1994. Introns are cis effectors of the nonsense-codon-mediated reduction in nuclear mRNA abun-dance. Mol Cell Biol 14:6317-6325.
9. Clancy JP, Bebok Z, Ruiz F, King C, Jones J, Walker L, Greer H, Hong J, Wing L, Macaluso M, Lyrene R, Sorscher EJ, Bedwell DM. 2001. Evidence that systemic gentamicin suppresses premature stop mutations in patients with cystic fibrosis. Am J Respir Crit Care Med 163:1683-1692.
10. Confaloni A, Crestini A, Albani D, Piscopo P, Campeggi LM, Terreni L, Tartaglia M, Forloni G. 2005. Rat nicastrin gene: cDNA isolation, mRNA variants and expression pattern analysis. Brain Res Mol Brain Res 136:12-22.
11. Conti E, Izaurralde E. 2005. Nonsense-mediated mRNA decay: Molecular insights and mechanistic variations across species. Curr Opin Cell Biol 17:316-325.
12. Culbertson MR, Leeds PF. 2003. Looking at mRNA decay pathways through the window of molecular evolution. Curr Opin Genet Dev 13:207-214.
13. Du M, Jones JR, Lanier J, Keeling KM, Lindsey JR, Tousson A, Bebok Z, Whitsett JA, Dey CR, Colledge WH, Evans MJ, Sorscher EJ, Bedwell DM. 2002. Aminoglycoside suppression of a premature stop mutation in a Cftr-/- mouse earning a human CFTR-G542X transgene. J Mol Med 80:595-604.
14. Frischmeyer PA, Dietz HC. 1999. Nonsense-mediated mRNA decay in health and disease. Hum Mol Genet 8:1893-1900.
15. Krawczak M, Ball EV, Fenton I, Stenson PD, Abeysinghe S, Thomas N, Cooper DN. 2000. Human gene mutation database-a biomedical information and research resource. Hum Mutat 15:45-51.
16. Maquat LE. 2005. Nonsense-mediated mRNA decay in mammals. J Cell Sci 118:1773-1776.
17. Mansour A, Fox CA, Thompson RC, Akil H, Watson SJ. 1994. Mu-opioid receptor mRNA expression in the rat CNS: Comparison to mu-receptor binding. Brain Res 643:245-265.
18. Matthes HW, Maldonado R, Simonin F, Valverde O, Slowe S, Kitchen I, Befort K, Dierich A, Le Meur M, Dolle P, Tzavara E, Hanoune J, Roques BP, Kieffer BL. 1996. Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene. Nature 383:819-823.
19. Mendell JT, Sharifi NA, Meyers JL, Martinez-Murillo F, Dietz HC. 2004. Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise. Nat Genet 36:1073-1078.
20. Nagy E, Maquat LE. 1998. A rule for termination-codon position within intron-containing genes: When nonsense affects RNA abundance. Trends Biochem Sci 23:198-199.
21. Paillusson A, Hirschi N, Vallan C, Azzalin CM, Muhlemann O. 2005. A GFP-based reporter system to monitor nonsense-mediated mRNA decay. Nucleic Acids Res 33:e54.
22. Ryan MM, Ouvrier R. 2005. Hereditary peripheral neuropathies of childhood. Curr Opin Neurol 18:105-110.
23. Sun X, Li X, Moriarty PM, Henics T, LaDuca JP, Maquat LE. 2001. Nonsense-mediated decay of mRNA for the selenoprotein phospholipid hydroperoxide glutathione peroxidase is detectable in cultured cells but masked or inhibited in rat tissues. Mol Biol Cell 12:1009-1017.
24. Waldhoer M, Bartlett SE, Whistler JL. 2004. Opioid receptors. Annu Rev Biochem 73:953-990.
25. Weischenfeldt J, Lykke-Andersen J, Porse B. 2005. Messenger RNA surveillance: Neutralizing natural nonsense. Curr Biol 15:R559-R562.
26. Wilschanski M, Yahav Y, Yaacov Y, Blau H, Bentur L, Rivlin J, Aviram M, Bdolah-Abram T, Bebok Z, Shushi L, Kerem B, Kerem E. 2003. Gentamicin-induced correction of CFTR function in patients with cystic fibrosis and CFTR stop mutations. N Engl J Med 349:1433-1441.
27. Zhang J, Sun X, Qian Y, Maquat LE. 1998. Intron function in the nonsense-mediated decay of β-globin mRNA: Indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm. RNA 4:801-815.