Inhibitors of the α-ketoglutarate dehydrogenase complex alter [1-13C]glucose and [U-13C]glutamate metabolism in cerebellar granule neurons

Journal of Neuroscience Research

Volumn 83, Issue 3, 2006, Pages 450-458

  Santos, Sónia Sá ^a,b   Gibson, Gary E ^c   Cooper, Arthur J L ^c   Denton, Travis T ^d   Thompson, Charles M ^d   Bunik, Victoria I ^e   Alves, Paula M ^a   Sonnewald, Ursula ^b,f  

^a INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^b NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

^d UNIVERSITY OF MONTANA   (United States)

^e MOSCOW STATE UNIVERSITY   (Russian Federation)

^f NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

Nuclear magnetic resonance spectroscopy; Transamination; Tricarboxylic acid cycle metabolism

Indexed keywords

2 OXOGLUTARIC ACID; 4 AMINOBUTYRIC ACID; ALANINE; ASPARTATE AMINOTRANSFERASE; ASPARTIC ACID; CARBON 13; ENZYME INHIBITOR; GLUCOSE; GLUTAMIC ACID; GLUTATHIONE; LEUCINE; OXOGLUTARATE DEHYDROGENASE; SUCCINYL PHOSPHATE CARBOXYETHYL ESTER; SUCCINYL PHOSPHATE PHOSPHONOETHYL ESTER; UNCLASSIFIED DRUG; VALINE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; BRAIN METABOLISM; CELL METABOLISM; CEREBELLUM; CITRIC ACID CYCLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; ENZYME MECHANISM; GLUCOSE METABOLISM; GRANULE CELL; ISOTOPE LABELING; MOUSE; NEUROLOGIC DISEASE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; REACTION ANALYSIS; TRANSAMINATION;

ANIMALS; ANIMALS, NEWBORN; CARBON ISOTOPES; CELLS, CULTURED; CEREBELLUM; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GLUCOSE; GLUTAMIC ACID; KETOGLUTARATE DEHYDROGENASE COMPLEX; MAGNETIC RESONANCE SPECTROSCOPY; MICE; MODELS, STATISTICAL; NEURAL INHIBITION; NEURONS;

EID: 31844435663     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.20749     Document Type: Article

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