Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 14, 2012, Pages 5277-5282

  Kapp, Gregory T ^a,e   Liu, Sen ^a,f   Stein, Amelie ^a   Wong, Derek T ^b,c,d   Remeńyi, Attila ^d,g   Yeh, Brian J ^c,d   Fraser, James S ^d   Taunton, Jack ^d   Lim, Wendell A ^d   Kortemme, Tanja ^a  

^a San Francisco   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e Omniox Inc   (United States)

^f CHINA THREE GORGES UNIVERSITY   (China)

^g EÖTVÖS LORÁND UNIVERSITY   (Hungary)

Author keywords

Computational modeling and design; Signal transduction; Synthetic biology

Indexed keywords

GUANOSINE TRIPHOSPHATASE; GUANOSINE TRIPHOSPHATASE EXCHANGE FACTOR; INTERSECTIN; PROTEIN CDC42; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; ENZYME ANALYSIS; ENZYME BINDING; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; VALIDATION STUDY;

ANIMALS; CRYSTALLOGRAPHY; GTP PHOSPHOHYDROLASES; GUANINE NUCLEOTIDE EXCHANGE FACTORS; MICE; MODELS, MOLECULAR; NIH 3T3 CELLS; PROTEINS; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 84859467082     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1114487109     Document Type: Article

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