Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex

Current Biology

Volumn 11, Issue 21, 2001, Pages 1645-1655

  Krugmann, Sonja ^a   Jordens, Ingrid ^a   Gevaert, Kris ^b   Driessens, Mariëtte ^a   Vandekerckhove, Joel ^b   Hall, Alan ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMALIA; CRICETINAE; ENA; MENA;

EID: 0035975963     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(01)00506-1     Document Type: Article

References (43)

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2. The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
3. The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
4. Rho, Rac and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
5. The Ras-related protein Cdc42Hs and bradykinin promote formation of peripheral actin microspikes and filopodia in Swiss 3T3 fibroblasts
6. Rho GTPases and their effector proteins
7. A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases
8. Wiskott-Aldrich syndrome protein, a novel effector for the GTPase CDC42Hs, is implicated in actin polymerization
9. Autoinhibition and activation mechanism of the Wiscott-Aldrich syndrome protein
10. Structure of Pak1 in an autoinhibited conformation reveals a multistep activation switch
11. Flipping the switch: The structural basis for signaling through the CRIB motif
12. Scar1 and the related Wiscott-Aldrich syndrome protein, WASp, regulate the actin cytoskeleton through the Arp2/3 complex
13. Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate
14. Induction of filopodium formation by a WASP-related actin depolymerizing protein N-WASP
15. Inducible recruitment of Cdc42 or WASp to a cell surface receptor triggers actin polymerization and filopodium formation
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19. Characterization and cloning of a 58/53-kDa substrate of the insulin receptor tyrosine kinase
20. IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling
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22. Identification of BAIAP2 (BAI-associated protein2), a novel human homologue of hamster IRSp53, whose SH3 domain interacts with the cytoplasmic domain of BAI1
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25. Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics
26. Mena is required for neurolation and commissure formation
27. Recruitment of the Arp2/3 complex and Mena for the stimulation of actin polymerization in growth cones by nerve growth factor
28. The EVH2 domain of the vasodilator-stimulated phosphoprotein mediates tetramerization, F-actin binding and actin bundle formation
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35. The clutch hypothesis revisited: Ascribing the roles of actin-associated proteins in filopodial protrusions in the nerve growth cone
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37. PKA phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3-domains
38. Phosphorylation of Enabled by the Drosophila Abelson tyrosine kinase regulates the in vivo function and protein-protein interactions of Enabled
39. Yeast two hybrid system to detect protein-protein interactions with rho GTPases
40. Measurements of intrinsic nucleotide exchange and GTP hydrolysis rates
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