Reprogramming control of an allosteric signaling switch through modular recombination

Science

Volumn 301, Issue 5641, 2003, Pages 1904-1908

  Dueber, John E ^a,b   Yeh, Brian J ^a,b   Chak, Kayam ^b   Lim, Wendell A ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY;

REPROGRAMMING CONTROL;

PROTEINS;

ACTIN; NEURAL WISKOTT ALDRICH SYNDROME PROTEIN; PROTEIN; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

EUKARYOTE; PROTEIN;

ACTIN POLYMERIZATION; ALLOSTERISM; ANIMAL CELL; ARTICLE; BINDING SITE; CHANNEL GATING; CONTROLLED STUDY; EUKARYOTE; EVOLUTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ENGINEERING; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

ACTINS; ALLOSTERIC REGULATION; AMINO ACID MOTIFS; ANIMALS; CDC42 GTP-BINDING PROTEIN; COMBINATORIAL CHEMISTRY TECHNIQUES; EVOLUTION, MOLECULAR; LIGANDS; MALE; NERVE TISSUE PROTEINS; OOCYTES; PEPTIDE LIBRARY; PROTEIN ENGINEERING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT FUSION PROTEINS; RECOMBINATION, GENETIC; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; WISKOTT-ALDRICH SYNDROME PROTEIN, NEURONAL; XENOPUS;

ANIMALIA; EUKARYOTA;

EID: 0141757323     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1085945     Document Type: Article

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19. We thank R. Bhattacharyya, H. Bourne, C. Co, S. Collins, E. Cunningham, H. Madhani, D. Mullins, E. O'Shea, K. Shokat, J. Weissman, K. Prehoda, and members of the Lim Laboratory for comments and discussion; and J. Taunton for Xenopus oocyte extract. Supported by grants from the Sandler Foundation, NSF Bio-Qubic Program, the Packard Foundation, and the NIH (W.A.L.).