Correlation between VEGF and HIF-1α expression in human oral squamous cell carcinoma

Experimental and Molecular Pathology

Volumn 76, Issue 2, 2004, Pages 143-152

  Mohamed, Khaled M ^a   Le, Anh ^b,c   Duong, Hai ^b   Wu, Yidi ^c   Zhang, Qunzhou ^c   Messadi, Diana V ^b,d  

^a SUEZ CANAL UNIVERSITY   (Egypt)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c CHARLES R DREW UNIVERSITY OF MEDICINE AND SCIENCE   (United States)

^d UCLA SCHOOL OF DENTISTRY   (United States)

Author keywords

HIF 1 ; Hypoxia; Normal oral keratinocytes; Oral cancer cell lines; VEGF

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MESSENGER RNA; VASCULOTROPIN;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CORNEA CELL; CORRELATION ANALYSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; HEAD AND NECK CARCINOMA; HUMAN; HUMAN CELL; HYPOXIA; MEASUREMENT; MOUTH CARCINOMA; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; SQUAMOUS CELL CARCINOMA; STATISTICAL SIGNIFICANCE; UPREGULATION; WESTERN BLOTTING;

ANOXIA; BLOTTING, NORTHERN; BLOTTING, WESTERN; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; KERATINOCYTES; MOUTH NEOPLASMS; RNA, MESSENGER; TRANSCRIPTION FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 1542268977     PISSN: 00144800     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yexmp.2003.10.005     Document Type: Article

References (41)

1. Aebersold D.M., Burri P., Beer K.T.et al. Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res. 61(7):2001;2911-2916.
2. Carmeliet P., Dor Y., Herbert J.-M.et al. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumor angiogenesis. Nature. 1998;485-488.
3. Chomczynski P., Saachi N. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:1987;156-159.
4. Costa A., Coradini D., Carrassi A., Erdas R., Sardella A., Daidone M.G. Levels of hypoxia-inducible factor-1alpha during breast carcinogenesis. J. Natl. Cancer Inst. 93(15):2001;1175-1177.
5. Dvorak H.F., Nagy J.A., Berse B.et al. Vascular permeability factor, fibrin and the pathogenesis of tumor stroma formation. Ann. N. Y. Acad. Sci. 667:1992;110-111.
6. Esser S., Wolburg K., Wolburg H., Breier G., Kurzchalia T., Tisau W. Vascular endothelium growth factor induces endothelial fenestrations in vitro. J. Cell Biol. 140:1998;947-959.
7. Ferrara N., Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr. Rev., Feb. 18(1):1997;4-25.
8. Folkman J. Tumor angiogenesis. Adv. Cancer Res. 43:1985;175-203.
9. Folkman J., Shing Y. Angiogenesis. J. Biol. Chem. 267:1992;10931-10934.
10. Freeman M.R., Schneck F.X., Gagnon M.L.et al. Peripheral blood T lymphocytes and lymphocytes infiltrating human cancers express vascular endothelial growth factor: a potential role of T cells in angiogenesis. Cancer Res. 55:1995;4140-4145.
11. Fukumura D., Xavier R., Sugiura T.et al. Tumor induction of VEGF promotor activity in stromal cells. Cell. 94:1998;715-725.
12. Gera N., Tazafra C., Stela G., Zoya P. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J. 13:1999;9-22.
13. Gerber H.-P., Condoreli F., Park J., Ferrara N. Differential transcriptional regulation of the two vascular endothelial growth factor receptor genes. J. Biol. Chem. 272(394):1997;23659-23667.
14. Gleich L.L., Biddinger P.W., Duperier F.D., Gluckman J.L. Tumor angiogenesis as a prognostic indicator in T2-T4 oral cavity squamous cell carcinoma: a clinical-pathologic correlation. Head Neck. 19:1997;276-280.
15. Hanahan D., Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell. 86:1996;353-364.
16. 2 homeostasis by hypoxia-inducible factor 1α Genes Dev. 1998;149-162.
17. Kang M., Bibb C., Baluda M.A., Rey O., Park N. In vitro replication and differentiation of normal human oral keratinocytes. Exp. Cell Res. 258:2000;288-297.
18. Kim K.J., Li B., Winer J.et al. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo. Nature. 362:1993;841-844.
19. Koong A.C., Denko N.C., Hudson K.M.et al. Candidate genes for the hypoxic tumor phenotype. Cancer Res. 60:2000;883-887.
20. Levy A.P., Levy N.S., Goldberg M.A. Post-transcriptional regulation of vascular endothelial factor by hypoxia. J. Biol. Chem. 271(5):1996;2746-2753.
21. Maeda T., Matsumura S., Hiranuma H.et al. Expression of vascular endothelial growth factor in human oral squamous cell carcinoma: its association with tumor progression and p53 gene status. J. Clin. Pathol. 51:1998;771-775.
22. Masashi A., Yoshiyuki S., Toshihiko A.et al. Vascular endothelial growth factor overproduced by tumor cells acts predominantly as a potent angiogenic factor contributing to malignant progression. Int. J. Exp. Pathol. 80:1999;271-281.
23. Maxwell P.H., Dachs G.U., Gleadle J.M.et al. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc. Natl. Acad. Sci. U. S. A. 94:1997;8104-8109.
24. Millauer B., Shwver L.K., Plate K.H., Risau W., Ullrich A. Glioblastoma growth inhibited in vivo by a dominant-negative Flk1 mutant. Nature. 367:1994;576-579.
25. Mineta H., Ogino T., Takebayashi S.et al. Prognostic value of vascular endothelial growth factor (VEGF) in head and neck squamous cell carcinoma. Br. J. Cancer. 83(6):2000;775-781.
26. Pagé E.L., Robitaille G.A., Pouysségur J., Richard D.E. Induction of hypoxia-inducible factor-1α by transcriptional and translational mechanisms. J. Biol. Chem. 277:2002;48403-48409.
27. Ravi D., Ramadas K., Mathew B.S., Nalinakumari K.R., Nair M.K., Pillai M.R. Angiogenesis during tumor progression in the oral cavity is related to reduced apoptosis and high tumor cell proliferation. Oral Oncol. 34:1998;543-548.
28. Ryan H.E., Lo J., Johnson R.S. HIF-1α is required for solid tumor formation and embryonic vascularization. EMBO J. 17:1998;3005-3015.
29. Salceda S., Caro J. Hypoxia inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions: its stabilization by hypoxia depends upon redox-induced changes. J. Biol. Chem. 272:1997;22642-22647.
30. Salven P., Heikkila P., Anttonen A., Kajanti M., Joensuu H. Vascular endothelial growth factor in squamous cell head and neck carcinoma: expression and prognostic significance. Mod. Path. 10:1997;1128-1133.
31. Schaeppi J.M., Wood J.M. Targeting vascular endothelial growth factor (VEGF) for anti-tumor therapy, by anti-VEGF neutralizing monoclonal antibodies or by VEGF receptor tyrosine-kinase inhibitors. Cancer Metastasis Rev. 18:1999;473-481.
32. Schweiki D., Itan A., Soffer D., Keshet E. Vascular endothelial growth factor may mediate hypoxia-initiated angiogenesis. Nature. 359:1992;843-845.
33. 2 homeostasis by hypoxia-inducible factor 1. Annu. Rev. Cell Dev. Biol. 15:1999;551-578.
34. Semenza G.L. Hypoxia-inducible factor 1: control of oxygen homeostasis in health and disease. Pediatr. Res. 49(5):2001;314-617.
35. Semenza G.L., Jiang B.-H., Leung S.W.et al. Hypoxia response elements in the aldolase enotase 1and lactate dehydrogenase Agene promoters contain essential binding sites for hypoxia-inducible factor 1. J. Biol. Chem. 271:1996;32529-32537.
36. Shemirani B., Crowe D.L. Hypoxic induction of HIF-α and VEGF expression in head and neck squamous cell carcinoma lines is mediated by stress activated protein kinases. Oral Oncol. 38:2002;251-257.
37. Sutter C.H., Laughner E., Semenza G.L. Hypoxia-inducible factor 1α protein expression is controlled by oxygen-regulated ubiquitination that is disrupted by deletions and missense mutations. Proc. Natl. Acad. Sci. U. S. A. 97:2000;4748-4753.
38. Torry R.J., Rongish B.J. Angiogenesis in the uterus: potential regulation and relation to tumor angiogenesis. Am. J. Reprod. Immunol. 27:1992;171-179.
39. Wang G.L., Semenza G.L. Purification and characterization of hypoxia-inducible factor 1. J. Biol. Chem. 270:1995;1230-1237.
40. 2 tension. Proc. Natl. Acad. Sci. 92:1995;5510-5514.
41. Zhong H., De Marzo A.M., Laughner E.et al. Over expression of hypoxia-inducible factor 1α in common human cancers and their metastasis. Cancer Res. 59:1999;5830-5835.