Minocycline corrects early, pre-plaque neuroinflammation and inhibits BACE-1 in a transgenic model of Alzheimer's disease-like amyloid pathology

Journal of Neuroinflammation

Volumn 9, Issue , 2012, Pages

  Ferretti, Maria T ^a   Allard, Simon ^a   Partridge, Vanessa ^a   Ducatenzeiler, Adriana ^a   Cuello, A Claudio ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Alzheimer; A oligomers; BACE; iNOS; Microglia; Minocycline; NFKb

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BETA SECRETASE 1; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; M 9511; MINOCYCLINE; PLACEBO; UNCLASSIFIED DRUG; ACTIN BINDING PROTEIN; AIF1 PROTEIN, MOUSE; AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN (1 42); AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA-PROTEIN (1-42); ASPARTIC PROTEINASE; BACE1 PROTEIN, MOUSE; CALCIUM BINDING PROTEIN; CTF 1 TRANSCRIPTION FACTOR; CTF-1 TRANSCRIPTION FACTOR; INTERLEUKIN 1BETA; NUCLEAR FACTOR I; PEPTIDE FRAGMENT; PTGS2 PROTEIN, MOUSE; SECRETASE;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INDUCTION; FEMALE; MALE; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; TRANSGENIC MOUSE; AMYLOID NEUROPATHY; ANALYSIS OF VARIANCE; ANIMAL; C57BL MOUSE; DISEASE MODEL; ENZYME LINKED IMMUNOSORBENT ASSAY; GENETICS; HUMAN; METABOLISM; MUTATION; NEUROGENIC INFLAMMATION; NEWBORN;

ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID NEUROPATHIES; AMYLOID PRECURSOR PROTEIN SECRETASES; ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, NEWBORN; ASPARTIC ACID ENDOPEPTIDASES; CALCIUM-BINDING PROTEINS; CYCLOOXYGENASE 2; DISEASE MODELS, ANIMAL; DOWN-REGULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; INTERLEUKIN-1BETA; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROFILAMENT PROTEINS; MINOCYCLINE; MUTATION; NEUROGENIC INFLAMMATION; NFI TRANSCRIPTION FACTORS; NITRIC OXIDE SYNTHASE TYPE II; PEPTIDE FRAGMENTS;

EID: 84859143780     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-9-62     Document Type: Article

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