-
1
-
-
0034612175
-
Inflammation and Alzheimer's disease
-
Akiyama H, Barger S, Barnum S, Bradt B, Bauer J, Cole G, Cooper N, Eikelenboom P, Emmerling M, Fiebich B, et al. 2000. Inflammation and Alzheimer's disease. Neurobiol Aging 21:383-421.
-
(2000)
Neurobiol Aging
, vol.21
, pp. 383-421
-
-
Akiyama, H.1
Barger, S.2
Barnum, S.3
Bradt, B.4
Bauer, J.5
Cole, G.6
Cooper, N.7
Eikelenboom, P.8
Emmerling, M.9
Fiebich, B.10
-
2
-
-
0028924248
-
Generation of amyloid β-protein from its precursor is sequence specific
-
Citron M, Teplow DB, Selkoe DJ. 1995. Generation of amyloid β-protein from its precursor is sequence specific. Neuron 14:661-670.
-
(1995)
Neuron
, vol.14
, pp. 661-670
-
-
Citron, M.1
Teplow, D.B.2
Selkoe, D.J.3
-
3
-
-
0030669036
-
The pathogenesis of senile plaques
-
Dickson DW. 1997. The pathogenesis of senile plaques. J Neuropathol Exp Neurol 56:321-339.
-
(1997)
J Neuropathol Exp Neurol
, vol.56
, pp. 321-339
-
-
Dickson, D.W.1
-
4
-
-
3042755065
-
Deleterious effects of minocycline in animal models of Parkinson's disease and Huntington's disease
-
Diguet E, Fernagut PO, Wei X, Du Y, Rouland R, Gross C, Bezard E, Tison F. 2004. Deleterious effects of minocycline in animal models of Parkinson's disease and Huntington's disease. Eur J Neurosci 19:3266-3276.
-
(2004)
Eur J Neurosci
, vol.19
, pp. 3266-3276
-
-
Diguet, E.1
Fernagut, P.O.2
Wei, X.3
Du, Y.4
Rouland, R.5
Gross, C.6
Bezard, E.7
Tison, F.8
-
5
-
-
0035807904
-
Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease
-
USA
-
Du Y, Ma Z, Lin S, Dodel RC, Gao F, Bales KR, Triarhou LC, Chernet E, Perry KW, Nelson DL, et al. 2001. Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease. Proc Natl Acad Sci USA 98:14669-14674.
-
(2001)
Proc Natl Acad Sci
, vol.98
, pp. 14669-14674
-
-
Du, Y.1
Ma, Z.2
Lin, S.3
Dodel, R.C.4
Gao, F.5
Bales, K.R.6
Triarhou, L.C.7
Chernet, E.8
Perry, K.W.9
Nelson, D.L.10
-
6
-
-
85047691727
-
NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo
-
Eriksen J, Sagi S, Smith T, Weggen S, Das P, McLendon D, Ozols V, Jessing K, Zavitz K, Koo E, et al. 2003. NSAIDs and enantiomers of flurbiprofen target gamma-secretase and lower Abeta 42 in vivo. J Clin Invest 112:440-449.
-
(2003)
J Clin Invest
, vol.112
, pp. 440-449
-
-
Eriksen, J.1
Sagi, S.2
Smith, T.3
Weggen, S.4
Das, P.5
McLendon, D.6
Ozols, V.7
Jessing, K.8
Zavitz, K.9
Koo, E.10
-
7
-
-
32344450850
-
Inhibitory effect of minocycline on amyloid beta fibril formation and human microglial activation
-
Familian A, Boshuizen RS, Eikelenboom P, Veerhuis R. 2006. Inhibitory effect of minocycline on amyloid beta fibril formation and human microglial activation. Glia 53:233-240.
-
(2006)
Glia
, vol.53
, pp. 233-240
-
-
Familian, A.1
Boshuizen, R.S.2
Eikelenboom, P.3
Veerhuis, R.4
-
8
-
-
1642290835
-
Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein
-
Farris W, Mansourian S, Leissring MA, Eckman EA, Bertram L, Eckman CB, Tanzi RE, Selkoe DJ. 2004. Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein. Am J Pathol 164:1425-1434.
-
(2004)
Am J Pathol
, vol.164
, pp. 1425-1434
-
-
Farris, W.1
Mansourian, S.2
Leissring, M.A.3
Eckman, E.A.4
Bertram, L.5
Eckman, C.B.6
Tanzi, R.E.7
Selkoe, D.J.8
-
9
-
-
7244226629
-
Non-steroidal anti-inflammatory drugs (NSAIDs) in Alzheimer's disease: Old and new mechanisms of action
-
Gasparini L, Ongini E, Wenk G. 2004. Non-steroidal anti-inflammatory drugs (NSAIDs) in Alzheimer's disease: old and new mechanisms of action. J Neurochem 91:521-536.
-
(2004)
J Neurochem
, vol.91
, pp. 521-536
-
-
Gasparini, L.1
Ongini, E.2
Wenk, G.3
-
10
-
-
2442715084
-
Placebo-controlled phase I/II studies of minocycline in amyotrophic lateral sclerosis
-
Gordon PH, Moore DH, Gelinas DF, Qualls C, Meister ME, Werner J, Mendoza M, Mass J, Kushner G, Miller RG. 2004. Placebo-controlled phase I/II studies of minocycline in amyotrophic lateral sclerosis. Neurology 62:1845-1847.
-
(2004)
Neurology
, vol.62
, pp. 1845-1847
-
-
Gordon, P.H.1
Moore, D.H.2
Gelinas, D.F.3
Qualls, C.4
Meister, M.E.5
Werner, J.6
Mendoza, M.7
Mass, J.8
Kushner, G.9
Miller, R.G.10
-
11
-
-
23244453399
-
Antioxidant properties of minocycline: Neuroprotection in an oxidative stress assay and direct radical-scavenging activity
-
Kraus RL, Pasieczny R, Lariosa-Willingham K, Turner MS, Jiang A, Trauger JW. 2005. Antioxidant properties of minocycline: neuroprotection in an oxidative stress assay and direct radical-scavenging activity. J Neurochem 94:819-827.
-
(2005)
J Neurochem
, vol.94
, pp. 819-827
-
-
Kraus, R.L.1
Pasieczny, R.2
Lariosa-Willingham, K.3
Turner, M.S.4
Jiang, A.5
Trauger, J.W.6
-
12
-
-
3242737470
-
Challenging the amyloid cascade hypothesis: Senile plaques and amyloid-beta as protective adaptations to Alzheimer disease
-
Lee HG, Casadesus G, Zhu X, Takeda A, Perry G, Smith MA. 2004. Challenging the amyloid cascade hypothesis: senile plaques and amyloid-beta as protective adaptations to Alzheimer disease. Ann NY Acad Sci 1019:1-4.
-
(2004)
Ann NY Acad Sci
, vol.1019
, pp. 1-4
-
-
Lee, H.G.1
Casadesus, G.2
Zhu, X.3
Takeda, A.4
Perry, G.5
Smith, M.A.6
-
13
-
-
10344230955
-
Minocycline-mediated inhibition of microglia activation impairs oligodendrocyte progenitor cell responses and remyelination in a non-immune model of demyelination
-
Li WW, Setzu A, Zhao C, Franklin RJ. 2005. Minocycline-mediated inhibition of microglia activation impairs oligodendrocyte progenitor cell responses and remyelination in a non-immune model of demyelination. J Neuroimmunol 158:58-66.
-
(2005)
J Neuroimmunol
, vol.158
, pp. 58-66
-
-
Li, W.W.1
Setzu, A.2
Zhao, C.3
Franklin, R.J.4
-
14
-
-
11144354138
-
Minocycline reduces gadolinium-enhancing magnetic resonance imaging lesions in multiple sclerosis
-
Metz LM, Zhang Y, Yeung M, Patry DG, Bell RB, Stoian CA, Yong VW, Patten SB, Duquette P, Antel JP, et al. 2004. Minocycline reduces gadolinium-enhancing magnetic resonance imaging lesions in multiple sclerosis. Ann Neurol 55:756.
-
(2004)
Ann Neurol
, vol.55
, pp. 756
-
-
Metz, L.M.1
Zhang, Y.2
Yeung, M.3
Patry, D.G.4
Bell, R.B.5
Stoian, C.A.6
Yong, V.W.7
Patten, S.B.8
Duquette, P.9
Antel, J.P.10
-
15
-
-
0034213718
-
High-level neuronal expression of Aβ1-42 in wild-type human amyloid protein precursor transgenic mice: Synaptotoxicity without plaque formation
-
Mucke L, Masliah E, Yu G-Q, Mallory M, Rockenstein EM, Tatsuno G, Hu K, Kholodenko D, Johnson-Wood K, McConlogue L. 2000. High-level neuronal expression of Aβ1-42 in wild-type human amyloid protein precursor transgenic mice: synaptotoxicity without plaque formation. J Neurosci 20:4050-4058.
-
(2000)
J Neurosci
, vol.20
, pp. 4050-4058
-
-
Mucke, L.1
Masliah, E.2
Yu, G.-Q.3
Mallory, M.4
Rockenstein, E.M.5
Tatsuno, G.6
Hu, K.7
Kholodenko, D.8
Johnson-Wood, K.9
McConlogue, L.10
-
16
-
-
0042924399
-
Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits
-
USA
-
Palop JJ, Jones B, Kekonius L, Chin J, Yu GQ, Raber J, Masliah E, Mucke L. 2003. Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits. Proc Natl Acad Sci USA 100:9572-9577.
-
(2003)
Proc Natl Acad Sci
, vol.100
, pp. 9572-9577
-
-
Palop, J.J.1
Jones, B.2
Kekonius, L.3
Chin, J.4
Yu, G.Q.5
Raber, J.6
Masliah, E.7
Mucke, L.8
-
17
-
-
13244288122
-
Pro-NGF isolated from the human brain affected by Alzheimer's disease induces neuronal apoptosis mediated by p75NTR
-
Pedraza CE, Podlesniy P, Vidal N, Arevalo JC, Lee R, Hempstead B, Ferrer I, Iglesias M, Espinet C. 2005. Pro-NGF isolated from the human brain affected by Alzheimer's disease induces neuronal apoptosis mediated by p75NTR. Am J Pathol 166:533-543.
-
(2005)
Am J Pathol
, vol.166
, pp. 533-543
-
-
Pedraza, C.E.1
Podlesniy, P.2
Vidal, N.3
Arevalo, J.C.4
Lee, R.5
Hempstead, B.6
Ferrer, I.7
Iglesias, M.8
Espinet, C.9
-
18
-
-
0036849021
-
Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide
-
Rogers J, Strohmeyer R, Kovelowski C, Li R. 2002. Microglia and inflammatory mechanisms in the clearance of amyloid beta peptide. Glia 40:260-269.
-
(2002)
Glia
, vol.40
, pp. 260-269
-
-
Rogers, J.1
Strohmeyer, R.2
Kovelowski, C.3
Li, R.4
-
19
-
-
6044273035
-
Minocycline inhibits neuronal death and glial activation induced by beta-amyloid peptide in rat hippocampus
-
Ryu JK, Franciosi S, Sattayaprasert P, Kim SU, McLarnon JG. 2004. Minocycline inhibits neuronal death and glial activation induced by beta-amyloid peptide in rat hippocampus. Glia 48:85-90.
-
(2004)
Glia
, vol.48
, pp. 85-90
-
-
Ryu, J.K.1
Franciosi, S.2
Sattayaprasert, P.3
Kim, S.U.4
McLarnon, J.G.5
-
20
-
-
0344013138
-
High-yield isolation of murine microglia by mild trypsinization
-
Saura J, Tusell JM, Serratosa J. 2003. High-yield isolation of murine microglia by mild trypsinization. Glia 44:183-189.
-
(2003)
Glia
, vol.44
, pp. 183-189
-
-
Saura, J.1
Tusell, J.M.2
Serratosa, J.3
-
21
-
-
3042742470
-
Species-specific immune response to immunization with human versus rodent a beta peptide
-
Seabrook TJ, Bloom JK, Iglesias M, Spooner ET, Walsh DM, Lemere CA. 2004. Species-specific immune response to immunization with human versus rodent A beta peptide. Neurobiol Aging 25:1141-1151.
-
(2004)
Neurobiol Aging
, vol.25
, pp. 1141-1151
-
-
Seabrook, T.J.1
Bloom, J.K.2
Iglesias, M.3
Spooner, E.T.4
Walsh, D.M.5
Lemere, C.A.6
-
22
-
-
0035066332
-
Alzheimer's disease: Genes, proteins, and therapy
-
Selkoe D. 2001. Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 81:741-766.
-
(2001)
Physiol Rev
, vol.81
, pp. 741-766
-
-
Selkoe, D.1
-
23
-
-
0036847816
-
Microglia as neuroprotective, immunocompetent cells of the CNS
-
Streit W. 2002. Microglia as neuroprotective, immunocompetent cells of the CNS. Glia 40:133-139.
-
(2002)
Glia
, vol.40
, pp. 133-139
-
-
Streit, W.1
-
24
-
-
1442314722
-
Early vitamin E supplementation in young but not aged mice reduces Abeta levels and amyloid deposition in a transgenic model of Alzheimer's disease
-
Sung S, Yao Y, Uryu K, Yang H, Lee VM, Trojanowski JQ, Pratico D. 2004. Early vitamin E supplementation in young but not aged mice reduces Abeta levels and amyloid deposition in a transgenic model of Alzheimer's disease. Faseb J 18:323-325.
-
(2004)
Faseb J
, vol.18
, pp. 323-325
-
-
Sung, S.1
Yao, Y.2
Uryu, K.3
Yang, H.4
Lee, V.M.5
Trojanowski, J.Q.6
Pratico, D.7
-
25
-
-
0842322759
-
Production and release of neuroprotective tumor necrosis factor by P2X7 receptor-activated microglia
-
Suzuki T, Hide I, Ido K, Kohsaka S, Inoue K, Nakata Y. 2004. Production and release of neuroprotective tumor necrosis factor by P2X7 receptor-activated microglia. J Neurosci 24:1-7.
-
(2004)
J Neurosci
, vol.24
, pp. 1-7
-
-
Suzuki, T.1
Hide, I.2
Ido, K.3
Kohsaka, S.4
Inoue, K.5
Nakata, Y.6
-
26
-
-
0035871840
-
Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia
-
Tikka T, Fiebich BL, Goldsteins G, Keinanen R, Koistinaho J. 2001. Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia. J Neurosci 21:2580-2588.
-
(2001)
J Neurosci
, vol.21
, pp. 2580-2588
-
-
Tikka, T.1
Fiebich, B.L.2
Goldsteins, G.3
Keinanen, R.4
Koistinaho, J.5
-
27
-
-
0035876916
-
Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia
-
Tikka T, Koistinaho J. 2001. Minocycline provides neuroprotection against N-methyl-D-aspartate neurotoxicity by inhibiting microglia. J Immunol 166:7527-7533.
-
(2001)
J Immunol
, vol.166
, pp. 7527-7533
-
-
Tikka, T.1
Koistinaho, J.2
-
28
-
-
2542427690
-
Oligomers on the brain: The emerging role of soluble protein aggregates in neurodegeneration
-
Walsh DM, Selkoe DJ. 2004. Oligomers on the brain: the emerging role of soluble protein aggregates in neurodegeneration. Protein Pept Lett 11:213-228.
-
(2004)
Protein Pept Lett
, vol.11
, pp. 213-228
-
-
Walsh, D.M.1
Selkoe, D.J.2
-
29
-
-
3042839092
-
Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition
-
Wilcock DM, Rojiani A, Rosenthal A, Levkowitz G, Subbarao S, Alamed J, Wilson D, Wilson N, Freeman MJ, Gordon MN, et al. 2004. Passive amyloid immunotherapy clears amyloid and transiently activates microglia in a transgenic mouse model of amyloid deposition. J Neurosci 24:6144-6151.
-
(2004)
J Neurosci
, vol.24
, pp. 6144-6151
-
-
Wilcock, D.M.1
Rojiani, A.2
Rosenthal, A.3
Levkowitz, G.4
Subbarao, S.5
Alamed, J.6
Wilson, D.7
Wilson, N.8
Freeman, M.J.9
Gordon, M.N.10
-
30
-
-
0032442475
-
Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia
-
USA
-
Yrjanheikki J, Keinanen R, Pellikka M, Hokfelt T, Koistinaho J. 1998. Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia. Proc Natl Acad Sci USA 95:15769-15774.
-
(1998)
Proc Natl Acad Sci
, vol.95
, pp. 15769-15774
-
-
Yrjanheikki, J.1
Keinanen, R.2
Pellikka, M.3
Hokfelt, T.4
Koistinaho, J.5
-
31
-
-
0037007645
-
Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice
-
Zhu S, Stavrovskaya IG, Drozda M, Kim BY, Ona V, Li M, Sarang S, Liu AS, Hartley DM, Wu du C, et al. 2002. Minocycline inhibits cytochrome c release and delays progression of amyotrophic lateral sclerosis in mice. Nature 417:74-78.
-
(2002)
Nature
, vol.417
, pp. 74-78
-
-
Zhu, S.1
Stavrovskaya, I.G.2
Drozda, M.3
Kim, B.Y.4
Ona, V.5
Li, M.6
Sarang, S.7
Liu, A.S.8
Hartley, D.M.9
Wu Du, C.10
|