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Volumn 581, Issue 23, 2007, Pages 4473-4478

The oxindole/imidazole derivative C16 reduces in vivo brain PKR activation

Author keywords

mTOR; Neuroprotection; Newborn rat; Oxindole imidazole; PKR

Indexed keywords

C16 PROTEIN; IMIDAZOLE DERIVATIVE; INITIATION FACTOR 2ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; OXINDOLE; PROTEIN KINASE R; S6 KINASE; UNCLASSIFIED DRUG;

EID: 34548434297     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2007.08.022     Document Type: Article
Times cited : (66)

References (26)
  • 1
    • 0033230617 scopus 로고    scopus 로고
    • PKR; a sentinel kinase for cellular stress
    • Williams B.R. PKR; a sentinel kinase for cellular stress. Oncogene 18 (1999) 6112-6120
    • (1999) Oncogene , vol.18 , pp. 6112-6120
    • Williams, B.R.1
  • 3
    • 0033604521 scopus 로고    scopus 로고
    • Ribosomal S6 kinase signaling and the control of translation
    • Dufner A., and Thomas G. Ribosomal S6 kinase signaling and the control of translation. Exp. Cell Res. 253 (1999) 100-109
    • (1999) Exp. Cell Res. , vol.253 , pp. 100-109
    • Dufner, A.1    Thomas, G.2
  • 4
    • 2342545519 scopus 로고    scopus 로고
    • Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
    • Fingar D.C., and Blenis J. Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 23 (2004) 3151-3171
    • (2004) Oncogene , vol.23 , pp. 3151-3171
    • Fingar, D.C.1    Blenis, J.2
  • 6
    • 33749431713 scopus 로고    scopus 로고
    • The mTOR pathway in the control of protein synthesis
    • Wang X., and Proud C.G. The mTOR pathway in the control of protein synthesis. Physiology 21 (2006) 362-369
    • (2006) Physiology , vol.21 , pp. 362-369
    • Wang, X.1    Proud, C.G.2
  • 7
    • 0348010382 scopus 로고    scopus 로고
    • Upstream signaling pathways leading to the activation of double-stranded RNA-dependent serine/threonine protein kinase in beta-amyloid peptide neurotoxicity
    • Suen K.C., Yu M.S., So K.F., Chang R.C., and Hugon J. Upstream signaling pathways leading to the activation of double-stranded RNA-dependent serine/threonine protein kinase in beta-amyloid peptide neurotoxicity. J. Biol. Chem. 278 (2003) 49819-49827
    • (2003) J. Biol. Chem. , vol.278 , pp. 49819-49827
    • Suen, K.C.1    Yu, M.S.2    So, K.F.3    Chang, R.C.4    Hugon, J.5
  • 8
    • 0041833464 scopus 로고    scopus 로고
    • Activation of the cell stress kinase PKR in Alzheimer's disease and human amyloid precursor protein transgenic mice
    • Peel A.L., and Bredesen D.E. Activation of the cell stress kinase PKR in Alzheimer's disease and human amyloid precursor protein transgenic mice. Neurobiol. Dis. 14 (2003) 52-62
    • (2003) Neurobiol. Dis. , vol.14 , pp. 52-62
    • Peel, A.L.1    Bredesen, D.E.2
  • 9
    • 0037147666 scopus 로고    scopus 로고
    • Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease
    • Chang R.C., Wong A.K., Ng H.K., and Hugon J. Phosphorylation of eukaryotic initiation factor-2alpha (eIF2alpha) is associated with neuronal degeneration in Alzheimer's disease. Neuroreport 13 (2002) 2429-2432
    • (2002) Neuroreport , vol.13 , pp. 2429-2432
    • Chang, R.C.1    Wong, A.K.2    Ng, H.K.3    Hugon, J.4
  • 10
    • 9644303217 scopus 로고    scopus 로고
    • Double-strand RNA dependent protein kinase (PKR) is involved in the extrastriatal degeneration in Parkinson's disease and Huntington's disease
    • Bando Y., Onuki R., Katayama T., Manabe T., Kudo T., Taira K., and Tohyama M. Double-strand RNA dependent protein kinase (PKR) is involved in the extrastriatal degeneration in Parkinson's disease and Huntington's disease. Neurochem. Int. 46 (2005) 11-18
    • (2005) Neurochem. Int. , vol.46 , pp. 11-18
    • Bando, Y.1    Onuki, R.2    Katayama, T.3    Manabe, T.4    Kudo, T.5    Taira, K.6    Tohyama, M.7
  • 12
    • 0027787072 scopus 로고
    • 2-Aminopurine inhibits the double-stranded RNA-dependent protein kinase both in vitro and in vivo
    • Hu Y., and Conway T.W. 2-Aminopurine inhibits the double-stranded RNA-dependent protein kinase both in vitro and in vivo. J. Interferon Res. 13 (1993) 323-328
    • (1993) J. Interferon Res. , vol.13 , pp. 323-328
    • Hu, Y.1    Conway, T.W.2
  • 13
    • 0033567282 scopus 로고    scopus 로고
    • Modulation of murine phenobarbital-inducible CYP2A5, CYP2B10 and CYP1A enzymes by inhibitors of protein kinases and phosphatases
    • Posti K., Leinonen S., Tetri S., Kottari S., Viitala P., Pelkonen O., and Raunio H. Modulation of murine phenobarbital-inducible CYP2A5, CYP2B10 and CYP1A enzymes by inhibitors of protein kinases and phosphatases. Eur. J. Biochem. 264 (1999) 19-26
    • (1999) Eur. J. Biochem. , vol.264 , pp. 19-26
    • Posti, K.1    Leinonen, S.2    Tetri, S.3    Kottari, S.4    Viitala, P.5    Pelkonen, O.6    Raunio, H.7
  • 14
    • 0033783417 scopus 로고    scopus 로고
    • A cell-permeable peptide inhibits activation of PKR and enhances cell proliferation
    • Nekhai S., Bottaro D.P., Woldehawariat G., Spellerberg A., and Petryshyn R. A cell-permeable peptide inhibits activation of PKR and enhances cell proliferation. Peptides 21 (2000) 1449-1456
    • (2000) Peptides , vol.21 , pp. 1449-1456
    • Nekhai, S.1    Bottaro, D.P.2    Woldehawariat, G.3    Spellerberg, A.4    Petryshyn, R.5
  • 15
  • 16
    • 33750458339 scopus 로고    scopus 로고
    • Inhibitor of double stranded RNA-dependent protein kinase protects against cell damage induced by ER stress
    • Shimazawa M., and Hara H. Inhibitor of double stranded RNA-dependent protein kinase protects against cell damage induced by ER stress. Neurosci. Lett. 409 (2006) 192-195
    • (2006) Neurosci. Lett. , vol.409 , pp. 192-195
    • Shimazawa, M.1    Hara, H.2
  • 17
    • 21344459656 scopus 로고    scopus 로고
    • mTOR/p70S6k signalling alteration by Abeta exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer's disease
    • Lafay-Chebassier C., Paccalin M., Page G., Barc-Pain S., Perault-Pochat M.C., Gil R., Pradier L., and Hugon J. mTOR/p70S6k signalling alteration by Abeta exposure as well as in APP-PS1 transgenic models and in patients with Alzheimer's disease. J. Neurochem. 94 (2005) 215-225
    • (2005) J. Neurochem. , vol.94 , pp. 215-225
    • Lafay-Chebassier, C.1    Paccalin, M.2    Page, G.3    Barc-Pain, S.4    Perault-Pochat, M.C.5    Gil, R.6    Pradier, L.7    Hugon, J.8
  • 19
    • 0036892618 scopus 로고    scopus 로고
    • Involvement of double-stranded RNA-dependent protein kinase and phosphorylation of eukaryotic initiation factor-2alpha in neuronal degeneration
    • Chang R.C., Suen K.C., Ma C.H., Elyaman W., Ng H.K., and Hugon J. Involvement of double-stranded RNA-dependent protein kinase and phosphorylation of eukaryotic initiation factor-2alpha in neuronal degeneration. J. Neurochem. 83 (2002) 1215-1225
    • (2002) J. Neurochem. , vol.83 , pp. 1215-1225
    • Chang, R.C.1    Suen, K.C.2    Ma, C.H.3    Elyaman, W.4    Ng, H.K.5    Hugon, J.6
  • 20
    • 0025696092 scopus 로고
    • Naturally occurring cell death in the cerebral cortex of the rat and removal of dead cells by transitory phagocytes
    • Ferrer I., Bernet E., Soriano E., del Rio T., and Fonseca M. Naturally occurring cell death in the cerebral cortex of the rat and removal of dead cells by transitory phagocytes. Neuroscience 39 (1990) 451-458
    • (1990) Neuroscience , vol.39 , pp. 451-458
    • Ferrer, I.1    Bernet, E.2    Soriano, E.3    del Rio, T.4    Fonseca, M.5
  • 21
    • 0032557829 scopus 로고    scopus 로고
    • Programmed cell death is a universal feature of embryonic and postnatal neuroproliferative regions throughout the central nervous system
    • Blaschke A.J., Weiner J.A., and Chun J. Programmed cell death is a universal feature of embryonic and postnatal neuroproliferative regions throughout the central nervous system. J. Comp. Neurol. 396 (1998) 39-50
    • (1998) J. Comp. Neurol. , vol.396 , pp. 39-50
    • Blaschke, A.J.1    Weiner, J.A.2    Chun, J.3
  • 22
    • 0242573129 scopus 로고    scopus 로고
    • Development of the blood brain barrier
    • Engelhardt B. Development of the blood brain barrier. Cell Tissue Res. 314 (2003) 119-129
    • (2003) Cell Tissue Res. , vol.314 , pp. 119-129
    • Engelhardt, B.1
  • 23
    • 0026701570 scopus 로고
    • Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase
    • Koromilas A.E., Roy S., Barber G.N., Katze M.G., and Sonenberg N. Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase. Science 257 (1992) 1685-1689
    • (1992) Science , vol.257 , pp. 1685-1689
    • Koromilas, A.E.1    Roy, S.2    Barber, G.N.3    Katze, M.G.4    Sonenberg, N.5
  • 24
    • 0027396813 scopus 로고
    • Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase
    • Meurs E.F., Galabru J., Barber G.N., Katze M.G., and Hovanessian A.G. Tumor suppressor function of the interferon-induced double-stranded RNA-activated protein kinase. Proc. Natl. Acad. Sci. USA 90 (1993) 232-236
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 232-236
    • Meurs, E.F.1    Galabru, J.2    Barber, G.N.3    Katze, M.G.4    Hovanessian, A.G.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.