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Volumn 4, Issue 2, 2012, Pages 182-197

Dual targeting strategies with bispecific antibodies

Author keywords

Allergic diseases; Bispecific antibodies; Cancer therapy; Dual retargeting; Dual targeting; Inflammatory diseases

Indexed keywords

ALPHA2B INTERFERON; BISPECIFIC ANTIBODY; INTERLEUKIN 2; LIPOSOME; NANOPARTICLE; TOXIN; TUMOR NECROSIS FACTOR;

EID: 84858257263     PISSN: 19420862     EISSN: 19420870     Source Type: Journal    
DOI: 10.4161/mabs.4.2.19000     Document Type: Review
Times cited : (373)

References (151)
  • 1
    • 78651387929 scopus 로고    scopus 로고
    • Antibody-based therapeutics to watch in 2011
    • PMID:21051951
    • Reichert JM. Antibody-based therapeutics to watch in 2011. MAbs 2011; 3:76-99; PMID:21051951; http://dx.doi.org/10.4161/mabs.3.1.13895.
    • (2011) MAbs , vol.3 , pp. 76-99
    • Reichert, J.M.1
  • 2
    • 77957361348 scopus 로고    scopus 로고
    • Development trends for human monoclonal antibody therapeutics
    • PMID:20811384
    • Nelson AL, Dhimolea E, Reichert JM. Development trends for human monoclonal antibody therapeutics. Nat Rev Drug Discov 2010; 9:767-74; PMID:20811384; http://dx.doi.org/10.1038/nrd3229.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 767-774
    • Nelson, A.L.1    Dhimolea, E.2    Reichert, J.M.3
  • 3
    • 33747616656 scopus 로고    scopus 로고
    • Engineering of therapeutic antibodies to minimize immunogenicity and optimize function
    • PMID:16904789
    • Presta LG. Engineering of therapeutic antibodies to minimize immunogenicity and optimize function. Adv Drug Deliv Rev 2006; 58:640-56; PMID:16904789; http://dx.doi.org/10.1016/j.addr.2006.01.026.
    • (2006) Adv Drug Deliv Rev , vol.58 , pp. 640-656
    • Presta, L.G.1
  • 4
    • 48549105161 scopus 로고    scopus 로고
    • Molecular engineering and design of therapeutic antibodies
    • PMID:18656541
    • Presta LG. Molecular engineering and design of therapeutic antibodies. Curr Opin Immunol 2008; 20:460-70; PMID:18656541; http://dx.doi.org/10.1016/j. coi.2008.06.012.
    • (2008) Curr Opin Immunol , vol.20 , pp. 460-470
    • Presta, L.G.1
  • 5
    • 80052812106 scopus 로고    scopus 로고
    • Recombinant proteins in rheumatology - Recent advances
    • PMID:21473939
    • Rothe A, Rubbert A. Recombinant proteins in rheumatology - recent advances. N Biotechnol 2011; 28:502-10; PMID:21473939; http://dx.doi.org/10. 1016/j.nbt.2011.03.019.
    • (2011) N Biotechnol , vol.28 , pp. 502-510
    • Rothe, A.1    Rubbert, A.2
  • 7
    • 70349148288 scopus 로고    scopus 로고
    • Crosstalk between epidermal growth factor receptor- and insulin-like growth factor-1 receptor signaling: Implications for cancer therapy
    • PMID:19754359
    • van der Veeken J, Oliveira S, Schiffelers RM, Storm G, van Bergen En Henegouwen PM, Roovers RC. Crosstalk between epidermal growth factor receptor- and insulin-like growth factor-1 receptor signaling: implications for cancer therapy. Curr Cancer Drug Targets 2009; 9:748-60; PMID:19754359; http://dx.doi.org/10.2174/156800909789271495.
    • (2009) Curr Cancer Drug Targets , vol.9 , pp. 748-760
    • Van Der Veeken, J.1    Oliveira, S.2    Schiffelers, R.M.3    Storm, G.4    Van Bergen En Henegouwen, P.M.5    Roovers, R.C.6
  • 8
    • 27944467499 scopus 로고    scopus 로고
    • Resistance to epidermal growth factor receptor-targeted therapy
    • PMID:16172017
    • Morgillo F, Lee HY. Resistance to epidermal growth factor receptor-targeted therapy. Drug Resist Updat 2005; 8:298-310; PMID:16172017; http://dx.doi.org/10.1016/j.drup.2005.08.004.
    • (2005) Drug Resist Updat , vol.8 , pp. 298-310
    • Morgillo, F.1    Lee, H.Y.2
  • 9
    • 79955675632 scopus 로고    scopus 로고
    • A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity
    • PMID:21393993
    • Dong J, Sereno A, Aivazian D, Langley E, Miller BR, Snyder WB, et al. A stable IgG-like bispecific antibody targeting the epidermal growth factor receptor and the type I insulin-like growth factor receptor demonstrates superior anti-tumor activity. MAbs 2011; 3:273-88; PMID:21393993; http://dx.doi.org/10.4161/mabs.3.3.15188.
    • (2011) MAbs , vol.3 , pp. 273-288
    • Dong, J.1    Sereno, A.2    Aivazian, D.3    Langley, E.4    Miller, B.R.5    Snyder, W.B.6
  • 10
    • 79960089263 scopus 로고    scopus 로고
    • Emerging antibody combinations in oncology
    • PMID:21697653
    • Demarest SJ, Hariharan K, Dong J. Emerging antibody combinations in oncology. MAbs 2011; 3:338-51; PMID:21697653; http://dx.doi.org/10.4161/mabs.3. 4.16615.
    • (2011) MAbs , vol.3 , pp. 338-351
    • Demarest, S.J.1    Hariharan, K.2    Dong, J.3
  • 11
    • 33745192259 scopus 로고    scopus 로고
    • Recombinant polyclonal antibodies: The next generation of antibody therapeutics?
    • PMID:16793535
    • Haurum JS. Recombinant polyclonal antibodies: the next generation of antibody therapeutics? Drug Discov Today 2006; 11:655-60; PMID:16793535; http://dx.doi.org/10.1016/j.drudis.2006.05.009.
    • (2006) Drug Discov Today , vol.11 , pp. 655-660
    • Haurum, J.S.1
  • 12
    • 81255210858 scopus 로고    scopus 로고
    • Rational identification of an optimal antibody mixture for targeting the epidermal growth factor receptor
    • In press; PMID:22123060
    • Koefoed K, Steinaa L, Søderberg JN, Kjær I, Jacobsen HJ, Meijer PJ, et al. Rational identification of an optimal antibody mixture for targeting the epidermal growth factor receptor. MAbs 2011; 3; In press; PMID:22123060.
    • (2011) MAbs , vol.3
    • Koefoed, K.1    Steinaa, L.2    Søderberg, J.N.3    Kjær, I.4    Jacobsen, H.J.5    Meijer, P.J.6
  • 13
    • 76549085643 scopus 로고    scopus 로고
    • Sym004: A novel synergistic anti-epidermal growth factor receptor antibody mixture with superior anticancer efficacy
    • PMID:20068188
    • Pedersen MW, Jacobsen HJ, Koefoed K, Hey A, Pyke C, Haurum JS, et al. Sym004: a novel synergistic anti-epidermal growth factor receptor antibody mixture with superior anticancer efficacy. Cancer Res 2010; 70:588-97; PMID:20068188; http://dx.doi.org/10.1158/0008-5472.CAN-09-1417.
    • (2010) Cancer Res , vol.70 , pp. 588-597
    • Pedersen, M.W.1    Jacobsen, H.J.2    Koefoed, K.3    Hey, A.4    Pyke, C.5    Haurum, J.S.6
  • 14
    • 80052843636 scopus 로고    scopus 로고
    • Preclinical pharmacokinetics and safety of Sym004: A synergistic antibody mixture directed against epidermal growth factor receptor
    • PMID:21825041
    • Skartved NJ, Jacobsen HJ, Pedersen MW, Jensen PF, Sen JW, Jørgensen TK, et al. Preclinical pharmacokinetics and safety of Sym004: a synergistic antibody mixture directed against epidermal growth factor receptor. Clin Cancer Res 2011; 17:5962-72; PMID:21825041; http://dx.doi.org/10.1158/ 1078-0432.CCR-11-1209.
    • (2011) Clin Cancer Res , vol.17 , pp. 5962-5972
    • Skartved, N.J.1    Jacobsen, H.J.2    Pedersen, M.W.3    Jensen, P.F.4    Sen, J.W.5    Jørgensen, T.K.6
  • 15
    • 77951529848 scopus 로고    scopus 로고
    • Therapeutic antibodies for autoimmunity and inflammation
    • PMID:20414204
    • Chan AC, Carter PJ. Therapeutic antibodies for autoimmunity and inflammation. Nat Rev Immunol 2010; 10:301-16; PMID:20414204; http://dx.doi.org/10.1038/nri2761.
    • (2010) Nat Rev Immunol , vol.10 , pp. 301-316
    • Chan, A.C.1    Carter, P.J.2
  • 16
    • 77749239974 scopus 로고    scopus 로고
    • Bispecific antibodies for cancer immunotherapy: Current perspectives
    • PMID:20199124
    • Müller D, Kontermann RE. Bispecific antibodies for cancer immunotherapy: Current perspectives. BioDrugs 2010; 24:89-98; PMID:20199124; http://dx.doi.org/10.2165/11530960-000000000-00000.
    • (2010) BioDrugs , vol.24 , pp. 89-98
    • Müller, D.1    Kontermann, R.E.2
  • 18
    • 77956344338 scopus 로고    scopus 로고
    • Development and approval of the trifunctional antibody catumaxomab (anti-EpCAM x anti-CD3) as a targeted cancer immunotherapy
    • PMID:20347527
    • Seimetz D, Lindhofer H, Bokemeyer C. Development and approval of the trifunctional antibody catumaxomab (anti-EpCAM x anti-CD3) as a targeted cancer immunotherapy. Cancer Treat Rev 2010; 36:458-67; PMID:20347527; http://dx.doi.org/10.1016/j.ctrv.2010.03.001.
    • (2010) Cancer Treat Rev , vol.36 , pp. 458-467
    • Seimetz, D.1    Lindhofer, H.2    Bokemeyer, C.3
  • 19
    • 4644258744 scopus 로고    scopus 로고
    • Chemical production of bispecific antibodies
    • PMID:15197303
    • Graziano RF, Guptill P. Chemical production of bispecific antibodies. Methods Mol Biol 2004; 283:71-85; PMID:15197303.
    • (2004) Methods Mol Biol , vol.283 , pp. 71-85
    • Graziano, R.F.1    Guptill, P.2
  • 21
    • 0031059402 scopus 로고    scopus 로고
    • Design and production of novel tetravalent bispecific antibodies
    • PMID:9035142
    • Coloma MJ, Morrison SL. Design and production of novel tetravalent bispecific antibodies. Nat Biotechnol 1997; 15:159-63; PMID:9035142; http://dx.doi.org/10.1038/nbt0297-159.
    • (1997) Nat Biotechnol , vol.15 , pp. 159-163
    • Coloma, M.J.1    Morrison, S.L.2
  • 23
    • 79953016709 scopus 로고    scopus 로고
    • Stable IgG-like bispecific antibodies directed toward the type I insulin-like growth factor receptor demonstrate enhanced ligand blockade and anti-tumor activity
    • PMID:21123183
    • Dong J, Sereno A, Snyder WB, Miller BR, Tamraz S, Doern A, et al. Stable IgG-like bispecific antibodies directed toward the type I insulin-like growth factor receptor demonstrate enhanced ligand blockade and anti-tumor activity. J Biol Chem 2011; 286:4703-17; PMID:21123183; http://dx.doi.org/10.1074/jbc.M110. 184317.
    • (2011) J Biol Chem , vol.286 , pp. 4703-4717
    • Dong, J.1    Sereno, A.2    Snyder, W.B.3    Miller, B.R.4    Tamraz, S.5    Doern, A.6
  • 24
    • 79955548494 scopus 로고    scopus 로고
    • Development of tetravalent, bispecific CCR5 antibodies with antiviral activity against CCR5 monoclonal antibody-resistant HIV-1 strains
    • PMID:21300827
    • Schanzer J, Jekle A, Nezu J, Lochner A, Croasdale R, Dioszegi M, et al. Development of tetravalent, bispecific CCR5 antibodies with antiviral activity against CCR5 monoclonal antibody-resistant HIV-1 strains. Antimicrob Agents Chemother 2011; 55:2369-78; PMID:21300827; http://dx.doi.org/10.1128/AAC.00215- 10.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 2369-2378
    • Schanzer, J.1    Jekle, A.2    Nezu, J.3    Lochner, A.4    Croasdale, R.5    Dioszegi, M.6
  • 25
    • 35948977323 scopus 로고    scopus 로고
    • Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin
    • PMID:17934452
    • Wu C, Ying H, Grinnell C, Bryant S, Miller R, Clabbers A, et al. Simultaneous targeting of multiple disease mediators by a dual-variable-domain immunoglobulin. Nat Biotechnol 2007; 25:1290-7; PMID:17934452; http://dx.doi.org/10.1038/nbt1345.
    • (2007) Nat Biotechnol , vol.25 , pp. 1290-1297
    • Wu, C.1    Ying, H.2    Grinnell, C.3    Bryant, S.4    Miller, R.5    Clabbers, A.6
  • 26
    • 62849095162 scopus 로고    scopus 로고
    • Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site
    • PMID:19299620
    • Bostrom J, Yu SF, Kan D, Appleton BA, Lee CV, Billeci K, et al. Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site. Science 2009; 323:1610-4; PMID:19299620; http://dx.doi.org/10. 1126/science.1165480.
    • (2009) Science , vol.323 , pp. 1610-1614
    • Bostrom, J.1    Yu, S.F.2    Kan, D.3    Appleton, B.A.4    Lee, C.V.5    Billeci, K.6
  • 27
    • 77954638589 scopus 로고    scopus 로고
    • Introducing antigen-binding sites in structural loops of immunoglobulin constant domains: Fc fragments with engineered HER2/neu-binding sites and antibody properties
    • PMID:20150180
    • Wozniak-Knopp G, Bartl S, Bauer A, Mostageer M, Woisetschläger M, Antes B, et al. Introducing antigen-binding sites in structural loops of immunoglobulin constant domains: Fc fragments with engineered HER2/neu-binding sites and antibody properties. Protein Eng Des Sel 2010; 23:289-97; PMID:20150180; http://dx.doi.org/10.1093/protein/gzq005.
    • (2010) Protein Eng des Sel , vol.23 , pp. 289-297
    • Wozniak-Knopp, G.1    Bartl, S.2    Bauer, A.3    Mostageer, M.4    Woisetschläger, M.5    Antes, B.6
  • 28
    • 0029946383 scopus 로고    scopus 로고
    • 'Knobs-into-holes' engineering of antibody CH3 domains for heavy chain heterodimerization
    • PMID:8844834
    • Ridgway JB, Presta LG, Carter P. 'Knobs-into-holes' engineering of antibody CH3 domains for heavy chain heterodimerization. Protein Eng 1996; 9:617-21; PMID:8844834; http://dx.doi.org/10.1093/protein/9.7.617.
    • (1996) Protein Eng , vol.9 , pp. 617-621
    • Ridgway, J.B.1    Presta, L.G.2    Carter, P.3
  • 30
    • 79960592856 scopus 로고    scopus 로고
    • Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies
    • PMID:21690412
    • Schaefer W, Regula JT, Bähner M, Schanzer J, Croasdale R, Dürr H, et al. Immunoglobulin domain crossover as a generic approach for the production of bispecific IgG antibodies. Proc Natl Acad Sci USA 2011; 108:11187-92; PMID:21690412; http://dx.doi.org/10.1073/pnas.1019002108.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 11187-11192
    • Schaefer, W.1    Regula, J.T.2    Bähner, M.3    Schanzer, J.4    Croasdale, R.5    Dürr, H.6
  • 31
    • 77953485268 scopus 로고    scopus 로고
    • Enhancing antibody Fc heterodimer formation through electrostatic steering effects: Applications to bispecific molecules and monovalent IgG
    • PMID:20400508
    • Gunasekaran K, Pentony M, Shen M, Garrett L, Forte C, Woodward A, et al. Enhancing antibody Fc heterodimer formation through electrostatic steering effects: applications to bispecific molecules and monovalent IgG. J Biol Chem 2010; 285:19637-46; PMID:20400508; http://dx.doi.org/10.1074/jbc.M110.117382.
    • (2010) J Biol Chem , vol.285 , pp. 19637-19646
    • Gunasekaran, K.1    Pentony, M.2    Shen, M.3    Garrett, L.4    Forte, C.5    Woodward, A.6
  • 32
    • 77954628740 scopus 로고    scopus 로고
    • SEEDbodies: Fusion proteins based on strand-exchange engineered domain (SEED) CH3 heterodimers in an Fc analogue platform for asymmetric binders or immunofusions and bispecific antibodies
    • PMID:20299542
    • Davis JH, Aperlo C, Li Y, Kurosawa E, Lan Y, Lo KM, et al. SEEDbodies: fusion proteins based on strand-exchange engineered domain (SEED) CH3 heterodimers in an Fc analogue platform for asymmetric binders or immunofusions and bispecific antibodies. Protein Eng Des Sel 2010; 23:195-202; PMID:20299542; http://dx.doi.org/10.1093/protein/gzp094.
    • (2010) Protein Eng des Sel , vol.23 , pp. 195-202
    • Davis, J.H.1    Aperlo, C.2    Li, Y.3    Kurosawa, E.4    Lan, Y.5    Lo, K.M.6
  • 33
    • 81255210896 scopus 로고    scopus 로고
    • A novel bispecific antibody format enables simultaneous bivalent and monovalent co-engagement of distinct target antigens
    • In press; PMID:22123055
    • Moore GL, Bautista C, Pong E, Nguyen DHT, Jacinto J, Eivazi A, et al. A novel bispecific antibody format enables simultaneous bivalent and monovalent co-engagement of distinct target antigens. MAbs 2011; 3; In press; PMID:22123055.
    • (2011) MAbs , vol.3
    • Moore, G.L.1    Bautista, C.2    Pong, E.3    Nguyen, D.H.T.4    Jacinto, J.5    Eivazi, A.6
  • 34
    • 77950787098 scopus 로고    scopus 로고
    • Alternative antibody formats
    • PMID:20373261
    • Kontermann RE. Alternative antibody formats. Curr Opin Mol Ther 2010; 12:176-83; PMID:20373261.
    • (2010) Curr Opin Mol Ther , vol.12 , pp. 176-183
    • Kontermann, R.E.1
  • 35
    • 85026147994 scopus 로고    scopus 로고
    • A novel CD19-directed recombinant bispecific antibody derivative with enhanced immune effector functions for human leukemic cells
    • PMID:18833000
    • Kellner C, Bruenke J, Stieglmaier J, Schwemmlein M, Schwenkert M, Singer H, et al. A novel CD19-directed recombinant bispecific antibody derivative with enhanced immune effector functions for human leukemic cells. J Immunother 2008; 31:871-84; PMID:18833000; http://dx.doi.org/10.1097/CJI.0b013e318186c8b4.
    • (2008) J Immunother , vol.31 , pp. 871-884
    • Kellner, C.1    Bruenke, J.2    Stieglmaier, J.3    Schwemmlein, M.4    Schwenkert, M.5    Singer, H.6
  • 36
    • 0027197493 scopus 로고
    • "Diabodies": Small bivalent and bispecific antibody fragments
    • PMID:8341653
    • Holliger P, Prospero T, Winter G. "Diabodies": small bivalent and bispecific antibody fragments. Proc Natl Acad Sci USA 1993; 90:6444-8; PMID:8341653; http://dx.doi.org/10.1073/pnas.90.14.6444.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 6444-6448
    • Holliger, P.1    Prospero, T.2    Winter, G.3
  • 37
    • 0031441221 scopus 로고    scopus 로고
    • Improved tumour targeting by disulphide stabilized diabodies expressed in Pichia pastoris
    • PMID:9488147
    • FitzGerald K, Holliger P, Winter G. Improved tumour targeting by disulphide stabilized diabodies expressed in Pichia pastoris. Protein Eng 1997; 10:1221-5; PMID:9488147; http://dx.doi.org/10.1093/protein/10.10.1221.
    • (1997) Protein Eng , vol.10 , pp. 1221-1225
    • FitzGerald, K.1    Holliger, P.2    Winter, G.3
  • 38
    • 77954757304 scopus 로고    scopus 로고
    • Effector cell recruitment with novel Fv-based dual-affinity re-targeting protein leads to potent tumor cytolysis and in vivo B-cell depletion
    • PMID:20382161
    • Johnson S, Burke S, Huang L, Gorlatov S, Li H, Wang W, et al. Effector cell recruitment with novel Fv-based dual-affinity re-targeting protein leads to potent tumor cytolysis and in vivo B-cell depletion. J Mol Biol 2010; 399:436-49; PMID:20382161; http://dx.doi.org/10.1016/j.jmb.2010.04.001.
    • (2010) J Mol Biol , vol.399 , pp. 436-449
    • Johnson, S.1    Burke, S.2    Huang, L.3    Gorlatov, S.4    Li, H.5    Wang, W.6
  • 39
    • 0032844812 scopus 로고    scopus 로고
    • Enzyme recruitment and tumor cell killing in vitro by a secreted bispecific single-chain diabody
    • Brüsselbach S, Korn T, Völkel T, Müller R, Kontermann RE. Enzyme recruitment and tumor cell killing in vitro by a secreted bispecific single-chain diabody. Tumor Targeting 1999; 4:115-23.
    • (1999) Tumor Targeting , vol.4 , pp. 115-123
    • Brüsselbach, S.1    Korn, T.2    Völkel, T.3    Müller, R.4    Kontermann, R.E.5
  • 40
    • 0033569478 scopus 로고    scopus 로고
    • Bispecific tandem diabody for tumor therapy with improved antigen binding and pharmacokinetics
    • PMID:10512714
    • Kipriyanov SM, Moldenhauer G, Schuhmacher J, Cochlovius B, Von der Lieth CW, Matys ER, et al. Bispecific tandem diabody for tumor therapy with improved antigen binding and pharmacokinetics. J Mol Biol 1999; 293:41-56; PMID:10512714; http://dx.doi.org/10.1006/jmbi.1999.3156.
    • (1999) J Mol Biol , vol.293 , pp. 41-56
    • Kipriyanov, S.M.1    Moldenhauer, G.2    Schuhmacher, J.3    Cochlovius, B.4    Von Der Lieth, C.W.5    Matys, E.R.6
  • 41
    • 0035043050 scopus 로고    scopus 로고
    • A new model for intermediate molecular weight recombinant bispecific and trispecific antibodies by efficient heterodimerization of single chain variable domains through fusion to a Fab-chain
    • PMID:11337278
    • Schoonjans R, Willems A, Schoonooghe S, Leoen J, Grooten J, Mertens N. A new model for intermediate molecular weight recombinant bispecific and trispecific antibodies by efficient heterodimerization of single chain variable domains through fusion to a Fab-chain. Biomol Eng 2001; 17:193-202; PMID:11337278; http://dx.doi.org/10.1016/S1389-0344(01)00066-1.
    • (2001) Biomol Eng , vol.17 , pp. 193-202
    • Schoonjans, R.1    Willems, A.2    Schoonooghe, S.3    Leoen, J.4    Grooten, J.5    Mertens, N.6
  • 42
    • 37649020163 scopus 로고    scopus 로고
    • Multifunctional antibodies by the Dock-and-Lock method for improved cancer imaging and therapy by pretargeting
    • PMID:18077530
    • Goldenberg DM, Rossi EA, Sharkey RM, McBride WJ, Chang CH. Multifunctional antibodies by the Dock-and-Lock method for improved cancer imaging and therapy by pretargeting. J Nucl Med 2008; 49:158-63; PMID:18077530; http://dx.doi.org/10.2967/jnumed.107.046185.
    • (2008) J Nucl Med , vol.49 , pp. 158-163
    • Goldenberg, D.M.1    Rossi, E.A.2    Sharkey, R.M.3    McBride, W.J.4    Chang, C.H.5
  • 43
    • 67649843650 scopus 로고    scopus 로고
    • Strategies to extend plasma half-lives of recombinant antibodies
    • PMID:19489651
    • Kontermann RE. Strategies to extend plasma half-lives of recombinant antibodies. BioDrugs 2009; 23:93-109; PMID:19489651; http://dx.doi.org/10.2165/ 00063030-00923020-00003.
    • (2009) BioDrugs , vol.23 , pp. 93-109
    • Kontermann, R.E.1
  • 44
    • 82755197856 scopus 로고    scopus 로고
    • Strategies for extended serum half-life of protein therapeutics
    • Epub ahead of print; PMID: 21862310
    • Kontermann RE. Strategies for extended serum half-life of protein therapeutics. Curr Opin Biotechnol 2011; Epub ahead of print; PMID: 21862310.
    • (2011) Curr Opin Biotechnol
    • Kontermann, R.E.1
  • 45
    • 44449127592 scopus 로고    scopus 로고
    • The epidermal growth factor receptor family: Biology driving targeted therapeutics
    • PMID:18259690
    • Wieduwilt MJ, Moasser MM. The epidermal growth factor receptor family: biology driving targeted therapeutics. Cell Mol Life Sci 2008; 65:1566-84; PMID:18259690; http://dx.doi.org/10.1007/s00018-008-7440-8.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 1566-1584
    • Wieduwilt, M.J.1    Moasser, M.M.2
  • 46
    • 35148837581 scopus 로고    scopus 로고
    • Mechanisms of disease: Signaling of the insulin-like growth factor 1 receptor pathway - Therapeutic perspectives in cancer
    • PMID:17898809
    • Tao Y, Pinzi V, Bourhis J, Deutsch E. Mechanisms of disease: signaling of the insulin-like growth factor 1 receptor pathway - therapeutic perspectives in cancer. Nat Clin Pract Oncol 2007; 4:591-602; PMID:17898809; http://dx.doi.org/10.1038/ncponc0934.
    • (2007) Nat Clin Pract Oncol , vol.4 , pp. 591-602
    • Tao, Y.1    Pinzi, V.2    Bourhis, J.3    Deutsch, E.4
  • 47
    • 65549158055 scopus 로고    scopus 로고
    • High coexpression of both insulin-like growth factor receptor-1 (IGFR-1) and epidermal growth factor receptor (EGFR) is associated with shorter disease-free survival in resected non-small-cell lung cancer patients
    • PMID:19153117
    • Ludovini V, Bellezza G, Pistola L, Bianconi F, Di Carlo L, Sidoni A, et al. High coexpression of both insulin-like growth factor receptor-1 (IGFR-1) and epidermal growth factor receptor (EGFR) is associated with shorter disease-free survival in resected non-small-cell lung cancer patients. Ann Oncol 2009; 20:842-9; PMID:19153117; http://dx.doi.org/10.1093/annonc/mdn727.
    • (2009) Ann Oncol , vol.20 , pp. 842-849
    • Ludovini, V.1    Bellezza, G.2    Pistola, L.3    Bianconi, F.4    Di Carlo, L.5    Sidoni, A.6
  • 48
    • 33646871998 scopus 로고    scopus 로고
    • Potential crosstalk between insulin- like growth factor receptor type 1 and epidermal growth factor receptor in progression and metastasis of pancreatic cancer
    • PMID:16575403
    • Ueda S, Hatsuse K, Tsuda H, Ogata S, Kawarabayashi N, Takigawa T, et al. Potential crosstalk between insulin- like growth factor receptor type 1 and epidermal growth factor receptor in progression and metastasis of pancreatic cancer. Mod Pathol 2006; 19:788-96; PMID:16575403.
    • (2006) Mod Pathol , vol.19 , pp. 788-796
    • Ueda, S.1    Hatsuse, K.2    Tsuda, H.3    Ogata, S.4    Kawarabayashi, N.5    Takigawa, T.6
  • 49
    • 9144256621 scopus 로고    scopus 로고
    • Simultaneous blockade of both the epidermal growth factor receptor and the insulin-like growth factor receptor signaling pathways in cancer cells with a fully human recombinant bispecific antibody
    • PMID:14576153
    • Lu D, Zhang H, Ludwig D, Persaud A, Jimenez X, Burtrum D, et al. Simultaneous blockade of both the epidermal growth factor receptor and the insulin-like growth factor receptor signaling pathways in cancer cells with a fully human recombinant bispecific antibody. J Biol Chem 2004; 279:2856-65; PMID:14576153; http://dx.doi.org/10.1074/jbc.M310132200.
    • (2004) J Biol Chem , vol.279 , pp. 2856-2865
    • Lu, D.1    Zhang, H.2    Ludwig, D.3    Persaud, A.4    Jimenez, X.5    Burtrum, D.6
  • 50
    • 2142662111 scopus 로고    scopus 로고
    • The effect of variable domain orientation and arrangement on the antigen-binding activity of a recombinant human bispecific diabody
    • PMID:15120630
    • Lu D, Jimenez X, Witte L, Zhu Z. The effect of variable domain orientation and arrangement on the antigen-binding activity of a recombinant human bispecific diabody. Biochem Biophys Res Commun 2004; 318:507-13; PMID:15120630; http://dx.doi.org/10.1016/j.bbrc.2004.04.060.
    • (2004) Biochem Biophys Res Commun , vol.318 , pp. 507-513
    • Lu, D.1    Jimenez, X.2    Witte, L.3    Zhu, Z.4
  • 51
    • 21244441508 scopus 로고    scopus 로고
    • A fully human recombinant IgG-like bispecific antibody to both the epidermal growth factor receptor and the insulin-like growth factor receptor for enhanced antitumor activity
    • PMID:15757893
    • Lu D, Zhang H, Koo H, Tonra J, Balderes P, Prewett M, et al. A fully human recombinant IgG-like bispecific antibody to both the epidermal growth factor receptor and the insulin-like growth factor receptor for enhanced antitumor activity. J Biol Chem 2005; 280:19665-72; PMID:15757893; http://dx.doi.org/10.1074/jbc.M500815200.
    • (2005) J Biol Chem , vol.280 , pp. 19665-19672
    • Lu, D.1    Zhang, H.2    Koo, H.3    Tonra, J.4    Balderes, P.5    Prewett, M.6
  • 52
    • 78651399650 scopus 로고    scopus 로고
    • A fibronectin scaffold approach to bispecific inhibitors of epidermal growth factor receptor and insulin-like growth factor-I receptor
    • PMID:21099371
    • Emanuel SL, Engle LJ, Chao G, Zhu RR, Cao C, Lin Z, et al. A fibronectin scaffold approach to bispecific inhibitors of epidermal growth factor receptor and insulin-like growth factor-I receptor. MAbs 2011; 3:38-48; PMID:21099371; http://dx.doi.org/10.4161/mabs.3.1.14168.
    • (2011) MAbs , vol.3 , pp. 38-48
    • Emanuel, S.L.1    Engle, L.J.2    Chao, G.3    Zhu, R.R.4    Cao, C.5    Lin, Z.6
  • 53
    • 84920103322 scopus 로고    scopus 로고
    • MM-111: A novel bispecific antibody targeting ErbB3 with potent anti-tumor activity in ErbB2 overexpressing malignancies
    • Nielsen U, Huhalov A, Harms B, Paragas V, Adams S, Gu J, et al. MM-111: a novel bispecific antibody targeting ErbB3 with potent anti-tumor activity in ErbB2 overexpressing malignancies. Cancer Res 2009; 69:4166.
    • (2009) Cancer Res , vol.69 , pp. 4166
    • Nielsen, U.1    Huhalov, A.2    Harms, B.3    Paragas, V.4    Adams, S.5    Gu, J.6
  • 54
    • 33845884563 scopus 로고    scopus 로고
    • Single variable domain antibody as a versatile building block for the construction of IgG-like bispecific antibodies
    • PMID:17126853
    • Shen J, Vil MD, Jimenez X, Zhang H, Iacolina M, Mangalampalli V, et al. Single variable domain antibody as a versatile building block for the construction of IgG-like bispecific antibodies. J Immunol Methods 2007; 318:65-74; PMID:17126853; http://dx.doi.org/10.1016/j.jim.2006.09.020.
    • (2007) J Immunol Methods , vol.318 , pp. 65-74
    • Shen, J.1    Vil, M.D.2    Jimenez, X.3    Zhang, H.4    Iacolina, M.5    Mangalampalli, V.6
  • 55
    • 0038544202 scopus 로고    scopus 로고
    • Platelet-derived growth factor signaling and human cancer
    • PMID:12542975
    • Yu J, Ustach C, Kim HRC. Platelet-derived growth factor signaling and human cancer. J Biochem Mol Biol 2003; 36:49-59; PMID:12542975; http://dx.doi.org/10.5483/BMBRep.2003.36.1.049.
    • (2003) J Biochem Mol Biol , vol.36 , pp. 49-59
    • Yu, J.1    Ustach, C.2    Kim, H.R.C.3
  • 56
    • 20444430119 scopus 로고    scopus 로고
    • Platelet-derived growth factor receptor (PDGFR): A target for anticancer therapeutics
    • PMID:15939344
    • Board R, Jayson GC. Platelet-derived growth factor receptor (PDGFR): a target for anticancer therapeutics. Drug Resist Updat 2005; 8:75-83; PMID:15939344; http://dx.doi.org/10.1016/j.drup.2005.03.004.
    • (2005) Drug Resist Updat , vol.8 , pp. 75-83
    • Board, R.1    Jayson, G.C.2
  • 57
    • 33744964246 scopus 로고    scopus 로고
    • Single variable domain-IgG fusion. A novel recombinant approach to Fc domain-containing bispecific antibodies
    • PMID:16481314
    • Shen J, Vil MD, Jimenez X, Iacolina M, Zhang H, Zhu Z. Single variable domain-IgG fusion. A novel recombinant approach to Fc domain-containing bispecific antibodies. J Biol Chem 2006; 281:10706-14; PMID:16481314; http://dx.doi.org/10.1074/jbc.M513415200.
    • (2006) J Biol Chem , vol.281 , pp. 10706-10714
    • Shen, J.1    Vil, M.D.2    Jimenez, X.3    Iacolina, M.4    Zhang, H.5    Zhu, Z.6
  • 58
    • 79957925832 scopus 로고    scopus 로고
    • Vascular endothelial growth factors and receptors: Anti-angiogenic therapy in the treatment of cancer
    • PMID:21565214
    • Tugues S, Koch S, Gualandi L, Li X, Claesson-Welsh L. Vascular endothelial growth factors and receptors: anti-angiogenic therapy in the treatment of cancer. Mol Aspects Med 2011; 32:88-111; PMID:21565214; http://dx.doi.org/10.1016/j.mam.2011.04.004.
    • (2011) Mol Aspects Med , vol.32 , pp. 88-111
    • Tugues, S.1    Koch, S.2    Gualandi, L.3    Li, X.4    Claesson-Welsh, L.5
  • 59
    • 15944419554 scopus 로고    scopus 로고
    • A recombinant, fully human, bispecific antibody neutralizes the biological activities mediated by both vascular endothelial growth factor receptors 2 and 3
    • PMID:15767551
    • Jimenez X, Lu D, Brennan L, Persaud K, Liu M, Miao H, et al. A recombinant, fully human, bispecific antibody neutralizes the biological activities mediated by both vascular endothelial growth factor receptors 2 and 3. Mol Cancer Ther 2005; 4:427-34; PMID:15767551.
    • (2005) Mol Cancer Ther , vol.4 , pp. 427-434
    • Jimenez, X.1    Lu, D.2    Brennan, L.3    Persaud, K.4    Liu, M.5    Miao, H.6
  • 60
    • 0142061073 scopus 로고    scopus 로고
    • Di-diabody: A novel tetravalent bispecific antibody molecule by design
    • PMID:12969563
    • Lu D, Jimenez X, Zhang H, Atkins A, Brennan L, Balderes P, et al. Di-diabody: a novel tetravalent bispecific antibody molecule by design. J Immunol Methods 2003; 279:219-32; PMID:12969563; http://dx.doi.org/10.1016/ S0022-1759(03)00251-5.
    • (2003) J Immunol Methods , vol.279 , pp. 219-232
    • Lu, D.1    Jimenez, X.2    Zhang, H.3    Atkins, A.4    Brennan, L.5    Balderes, P.6
  • 61
    • 55849128896 scopus 로고    scopus 로고
    • Durable complete responses from therapy with combined epratuzumab and rituximab: Final results from an international multicenter, phase 2 study in recurrent, indolent, non-Hodgkin lymphoma
    • PMID:18853418
    • Leonard JP, Schuster SJ, Emmanouilides C, Couture F, Teoh N, Wegener WA, et al. Durable complete responses from therapy with combined epratuzumab and rituximab: final results from an international multicenter, phase 2 study in recurrent, indolent, non-Hodgkin lymphoma. Cancer 2008; 113:2714-23; PMID:18853418; http://dx.doi.org/10.1002/cncr.23890.
    • (2008) Cancer , vol.113 , pp. 2714-2723
    • Leonard, J.P.1    Schuster, S.J.2    Emmanouilides, C.3    Couture, F.4    Teoh, N.5    Wegener, W.A.6
  • 62
    • 41349118741 scopus 로고    scopus 로고
    • Bispecific anti-CD20/22 antibodies inhibit B-cell lymphoma proliferation by a unique mechanism of action
    • PMID:18025153
    • Qu Z, Goldenberg DM, Cardillo TM, Shi V, Hansen HJ, Chang CH. Bispecific anti-CD20/22 antibodies inhibit B-cell lymphoma proliferation by a unique mechanism of action. Blood 2008; 111:2211-9; PMID:18025153; http://dx.doi.org/ 10.1182/blood-2007-08-110072.
    • (2008) Blood , vol.111 , pp. 2211-2219
    • Qu, Z.1    Goldenberg, D.M.2    Cardillo, T.M.3    Shi, V.4    Hansen, H.J.5    Chang, C.H.6
  • 63
    • 67650346177 scopus 로고    scopus 로고
    • Hexavalent bispecific antibodies represent a new class of anticancer therapeutics: 1. Properties of anti-CD20/CD22 antibodies in lymphoma
    • PMID:19372261
    • Rossi EA, Goldenberg DM, Cardillo TM, Stein R, Chang CH. Hexavalent bispecific antibodies represent a new class of anticancer therapeutics: 1. Properties of anti-CD20/CD22 antibodies in lymphoma. Blood 2009; 113:6161-71; PMID:19372261; http://dx.doi.org/10.1182/blood-2008-10-187138.
    • (2009) Blood , vol.113 , pp. 6161-6171
    • Rossi, E.A.1    Goldenberg, D.M.2    Cardillo, T.M.3    Stein, R.4    Chang, C.H.5
  • 64
    • 78049395507 scopus 로고    scopus 로고
    • Multiple signaling pathways induced by hexavalent, monospecific, anti-CD20 and hexavalent, bispecific, anti-CD20/CD22 humanized antibodies correlate with enhanced toxicity to B-cell lymphomas and leukemias
    • PMID:20628151
    • Gupta P, Goldenberg DM, Rossi EA, Chang CH. Multiple signaling pathways induced by hexavalent, monospecific, anti-CD20 and hexavalent, bispecific, anti-CD20/CD22 humanized antibodies correlate with enhanced toxicity to B-cell lymphomas and leukemias. Blood 2010; 116:3258-67; PMID:20628151; http://dx.doi.org/10.1182/blood-2010-03-276857.
    • (2010) Blood , vol.116 , pp. 3258-3267
    • Gupta, P.1    Goldenberg, D.M.2    Rossi, E.A.3    Chang, C.H.4
  • 65
    • 79959766443 scopus 로고    scopus 로고
    • The Bs20 x 22 anti-CD20-CD22 bispecific antibody has more lymphomacidal activity than do the parent antibodies alone
    • PMID:21347809
    • Tuscano JM, Ma Y, Martin SM, Kato J, O'Donnell RT. The Bs20 x 22 anti-CD20-CD22 bispecific antibody has more lymphomacidal activity than do the parent antibodies alone. Cancer Immunol Immunother 2011; 60:771-80; PMID:21347809; http://dx.doi.org/10.1007/s00262-011-0978-6.
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 771-780
    • Tuscano, J.M.1    Ma, Y.2    Martin, S.M.3    Kato, J.4    O'Donnell, R.T.5
  • 66
    • 49049086338 scopus 로고    scopus 로고
    • Ligand-based targeting of apoptosis in cancer: The potential of recombinant human apoptosis ligand 2/Tumor necrosis factor-related apoptosis-inducing ligand (rhApo2L/TRAIL)
    • PMID:18640940
    • Ashkenazi A, Holland P, Eckhardt SG. Ligand-based targeting of apoptosis in cancer: the potential of recombinant human apoptosis ligand 2/Tumor necrosis factor-related apoptosis-inducing ligand (rhApo2L/TRAIL). J Clin Oncol 2008; 26:3621-30; PMID:18640940; http://dx.doi.org/10.1200/JCO.2007.15.7198.
    • (2008) J Clin Oncol , vol.26 , pp. 3621-3630
    • Ashkenazi, A.1    Holland, P.2    Eckhardt, S.G.3
  • 67
    • 70449770418 scopus 로고    scopus 로고
    • Anti-tumor activity of stability-engineered IgG-like bispecific antibodies targeting TRAIL-R2 and LTbetaR
    • PMID:20061822
    • Michaelson JS, Demarest SJ, Miller B, Amatucci A, Snyder WB, Wu X, et al. Anti-tumor activity of stability-engineered IgG-like bispecific antibodies targeting TRAIL-R2 and LTbetaR. MAbs 2009; 1:128-41; PMID:20061822; http://dx.doi.org/10.4161/mabs.1.2.7631.
    • (2009) MAbs , vol.1 , pp. 128-141
    • Michaelson, J.S.1    Demarest, S.J.2    Miller, B.3    Amatucci, A.4    Snyder, W.B.5    Wu, X.6
  • 68
    • 27744501244 scopus 로고    scopus 로고
    • B cells as a therapeutic target in autoimmune diseases other than rheumatoid arthritis
    • Oxford PMID:15851522
    • Looney RJ. B cells as a therapeutic target in autoimmune diseases other than rheumatoid arthritis. Rheumatology (Oxford) 2005; 44:13-7; PMID:15851522; http://dx.doi.org/10.1093/rheumatology/keh618.
    • (2005) Rheumatology , vol.44 , pp. 13-17
    • Looney, R.J.1
  • 69
    • 33748639508 scopus 로고    scopus 로고
    • B cell depletion therapy in rheumatic disease
    • PMID:16980214
    • Edwards JCW, Cambridge G, Leandro MJ. B cell depletion therapy in rheumatic disease. Best Pract Res Clin Rheumatol 2006; 20:915-28; PMID:16980214; http://dx.doi.org/10.1016/j.berh.2006.05.010.
    • (2006) Best Pract Res Clin Rheumatol , vol.20 , pp. 915-928
    • Edwards, J.C.W.1    Cambridge, G.2    Leandro, M.J.3
  • 70
    • 77956158598 scopus 로고    scopus 로고
    • Targeting the B cell in rheumatoid arthritis
    • PMID:20732652
    • Cohen SB. Targeting the B cell in rheumatoid arthritis. Best Pract Res Clin Rheumatol 2010; 24:553-63; PMID:20732652; http://dx.doi.org/10.1016/j.berh. 2009.11.006.
    • (2010) Best Pract Res Clin Rheumatol , vol.24 , pp. 553-563
    • Cohen, S.B.1
  • 71
    • 77951610700 scopus 로고    scopus 로고
    • FcgammaRIIB in autoimmunity and infection: Evolutionary and therapeutic implications
    • PMID:20414206
    • Smith KG, Clatworthy MR. FcgammaRIIB in autoimmunity and infection: evolutionary and therapeutic implications. Nat Rev Immunol 2010; 10:328-43; PMID:20414206; http://dx.doi.org/10.1038/nri2762.
    • (2010) Nat Rev Immunol , vol.10 , pp. 328-343
    • Smith, K.G.1    Clatworthy, M.R.2
  • 72
    • 77954232707 scopus 로고    scopus 로고
    • Therapeutic control of B cell activation via recruitment of Fcγ receptor IIb (CD32B) inhibitory function with a novel bispecific antibody scaffold
    • Munch
    • Veri MC, Burke S, Huang L, Li H, Gorlatov S, Tuaillon N, et al. Therapeutic control of B cell activation via recruitment of Fcγ receptor IIb (CD32B) inhibitory function with a novel bispecific antibody scaffold. Arthritis Rheum (Munch) 2010; 62:1933-43.
    • (2010) Arthritis Rheum , vol.62 , pp. 1933-1943
    • Veri, M.C.1    Burke, S.2    Huang, L.3    Li, H.4    Gorlatov, S.5    Tuaillon, N.6
  • 73
    • 4344605211 scopus 로고    scopus 로고
    • Inhibition of allergen-specific IgE reactivity by a human Ig Fcgamma-Fcepsilon bifunctional fusion protein
    • PMID:15316510
    • Zhang K, Kepley CL, Terada T, Zhu D, Perez H, Saxon A. Inhibition of allergen-specific IgE reactivity by a human Ig Fcgamma-Fcepsilon bifunctional fusion protein. J Allergy Clin Immunol 2004; 114:321-7; PMID:15316510; http://dx.doi.org/10.1016/j.jaci.2004.03.058.
    • (2004) J Allergy Clin Immunol , vol.114 , pp. 321-327
    • Zhang, K.1    Kepley, C.L.2    Terada, T.3    Zhu, D.4    Perez, H.5    Saxon, A.6
  • 74
    • 77954225154 scopus 로고    scopus 로고
    • Development of a two-part strategy to identify a therapeutic human bispecific antibody that inhibits IgE receptor signaling
    • PMID:20444694
    • Jackman J, Chen Y, Huang A, Moffat B, Scheer JM, Leong SR, et al. Development of a two-part strategy to identify a therapeutic human bispecific antibody that inhibits IgE receptor signaling. J Biol Chem 2010; 285:20850-9; PMID:20444694; http://dx.doi.org/10.1074/jbc.M110.113910.
    • (2010) J Biol Chem , vol.285 , pp. 20850-20859
    • Jackman, J.1    Chen, Y.2    Huang, A.3    Moffat, B.4    Scheer, J.M.5    Leong, S.R.6
  • 75
    • 3042778582 scopus 로고    scopus 로고
    • A bispecific antibody against human IgE and human FcgammaRII that inhibits antigen-induced histamine release by human mast cells and basophils
    • PMID:15180766
    • Tam SW, Demissie S, Thomas D, Daëron M. A bispecific antibody against human IgE and human FcgammaRII that inhibits antigen-induced histamine release by human mast cells and basophils. Allergy 2004; 59:772-80; PMID:15180766; http://dx.doi.org/10.1111/j.1398-9995.2004.00332.x.
    • (2004) Allergy , vol.59 , pp. 772-780
    • Tam, S.W.1    Demissie, S.2    Thomas, D.3    Daëron, M.4
  • 76
    • 72049112028 scopus 로고    scopus 로고
    • Monoclonal antibody- based therapies for microbial diseases
    • PMID: 20006139
    • Saylor C, Dadachova E, Casadevall A. Monoclonal antibody- based therapies for microbial diseases. Vaccine 2009; 27:38-46; PMID: 20006139.
    • (2009) Vaccine , vol.27 , pp. 38-46
    • Saylor, C.1    Dadachova, E.2    Casadevall, A.3
  • 77
    • 4444342539 scopus 로고    scopus 로고
    • Passive antibody therapy for infectious diseases
    • PMID:15372080
    • Casadevall A, Dadachova E, Pirofski LA. Passive antibody therapy for infectious diseases. Nat Rev Microbiol 2004; 2:695-703; PMID:15372080; http://dx.doi.org/10.1038/nrmicro974.
    • (2004) Nat Rev Microbiol , vol.2 , pp. 695-703
    • Casadevall, A.1    Dadachova, E.2    Pirofski, L.A.3
  • 79
    • 33845641402 scopus 로고    scopus 로고
    • Human domain antibodies against virulence traits of Candida albicans inhibit fungus adherence to vaginal epithelium and protect against experimental vaginal candidiasis
    • PMID:17152019
    • De Bernardis F, Liu H, O'Mahony R, La Valle R, Bartollino S, Sandini S, et al. Human domain antibodies against virulence traits of Candida albicans inhibit fungus adherence to vaginal epithelium and protect against experimental vaginal candidiasis. J Infect Dis 2007; 195:149-57; PMID:17152019; http://dx.doi.org/10.1086/509891.
    • (2007) J Infect Dis , vol.195 , pp. 149-157
    • De Bernardis, F.1    Liu, H.2    O'Mahony, R.3    La Valle, R.4    Bartollino, S.5    Sandini, S.6
  • 80
    • 77956602095 scopus 로고    scopus 로고
    • Combination of two insulin-like growth factor-I receptor inhibitory antibodies targeting distinct epitopes leads to an enhanced antitumor response
    • PMID:20716637
    • Dong J, Demarest SJ, Sereno A, Tamraz S, Langley E, Doern A, et al. Combination of two insulin-like growth factor-I receptor inhibitory antibodies targeting distinct epitopes leads to an enhanced antitumor response. Mol Cancer Ther 2010; 9:2593-604; PMID:20716637; http://dx.doi.org/10.1158/1535-7163.MCT- 09-1018.
    • (2010) Mol Cancer Ther , vol.9 , pp. 2593-2604
    • Dong, J.1    Demarest, S.J.2    Sereno, A.3    Tamraz, S.4    Langley, E.5    Doern, A.6
  • 81
    • 70349784988 scopus 로고    scopus 로고
    • DARPins as bispecific receptor antagonists analyzed for immunoglobulin e receptor blockage
    • PMID:19683003
    • Eggel A, Baumann MJ, Amstutz P, Stadler BM, Vogel M. DARPins as bispecific receptor antagonists analyzed for immunoglobulin E receptor blockage. J Mol Biol 2009; 393:598-607; PMID:19683003; http://dx.doi.org/10.1016/j.jmb. 2009.08.014.
    • (2009) J Mol Biol , vol.393 , pp. 598-607
    • Eggel, A.1    Baumann, M.J.2    Amstutz, P.3    Stadler, B.M.4    Vogel, M.5
  • 82
    • 80052601580 scopus 로고    scopus 로고
    • Emerging therapies for severe asthma
    • PMID:21896202
    • Thomson NC, Chaudhuri R, Spears M. Emerging therapies for severe asthma. BMC Med 2011; 9:102; PMID:21896202; http://dx.doi.org/10.1186/1741-7015-9-102.
    • (2011) BMC Med , vol.9 , pp. 102
    • Thomson, N.C.1    Chaudhuri, R.2    Spears, M.3
  • 83
    • 33749321597 scopus 로고    scopus 로고
    • Management of asthma with anti-immunoglobulin E: A review of clinical trials of omalizumab
    • PMID:16949266
    • Nowak D. Management of asthma with anti-immunoglobulin E: a review of clinical trials of omalizumab. Respir Med 2006; 100:1907-17; PMID:16949266; http://dx.doi.org/10.1016/j.rmed.2005.10.004.
    • (2006) Respir Med , vol.100 , pp. 1907-1917
    • Nowak, D.1
  • 84
    • 80053625820 scopus 로고    scopus 로고
    • Heavy chain-only antibodies and tetravalent bispecific antibody neutralizing Staphylococcus aureus leukotoxins
    • PMID:21930905
    • Laventie BJ, Rademaker HJ, Saleh M, de Boer E, Janssens R, Bourcier T, et al. Heavy chain-only antibodies and tetravalent bispecific antibody neutralizing Staphylococcus aureus leukotoxins. Proc Natl Acad Sci USA 2011; 108:16404-9; PMID:21930905; http://dx.doi.org/10.1073/pnas.1102265108.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 16404-16409
    • Laventie, B.J.1    Rademaker, H.J.2    Saleh, M.3    De Boer, E.4    Janssens, R.5    Bourcier, T.6
  • 85
    • 77956631367 scopus 로고    scopus 로고
    • A bispecific nanobody to provide full protection against lethal scorpion envenoming
    • PMID:20410443
    • Hmila I, Saerens D, Ben Abderrazek R, Vincke C, Abidi N, Benlasfar Z, et al. A bispecific nanobody to provide full protection against lethal scorpion envenoming. FASEB J 2010; 24:3479-89; PMID:20410443; http://dx.doi.org/10.1096/ fj.09-148213.
    • (2010) FASEB J , vol.24 , pp. 3479-3489
    • Hmila, I.1    Saerens, D.2    Ben Abderrazek, R.3    Vincke, C.4    Abidi, N.5    Benlasfar, Z.6
  • 86
    • 33846846359 scopus 로고    scopus 로고
    • Toxicokinetic and toxicodynamic analyses of Androctonus australis hector venom in rats: Optimization of antivenom therapy
    • PMID:17198719
    • Hammoudi-Triki D, Lefort J, Rougeot C, Robbe-Vincent A, Bon C, Laraba-Djebari F, et al. Toxicokinetic and toxicodynamic analyses of Androctonus australis hector venom in rats: optimization of antivenom therapy. Toxicol Appl Pharmacol 2007; 218:205-14; PMID:17198719; http://dx.doi.org/10.1016/j.taap. 2006.11.003.
    • (2007) Toxicol Appl Pharmacol , vol.218 , pp. 205-214
    • Hammoudi-Triki, D.1    Lefort, J.2    Rougeot, C.3    Robbe-Vincent, A.4    Bon, C.5    Laraba-Djebari, F.6
  • 87
    • 0034648765 scopus 로고    scopus 로고
    • Angiogenesis in cancer and other diseases
    • PMID:11001068
    • Carmeliet P, Jain RK. Angiogenesis in cancer and other diseases. Nature 2000; 407:249-57; PMID:11001068; http://dx.doi.org/10.1038/35025220.
    • (2000) Nature , vol.407 , pp. 249-257
    • Carmeliet, P.1    Jain, R.K.2
  • 88
    • 4143136640 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Basic science and clinical progress
    • PMID:15294883
    • Ferrara N. Vascular endothelial growth factor: basic science and clinical progress. Endocr Rev 2004; 25:581-611; PMID:15294883; http://dx.doi.org/10. 1210/er.2003-0027.
    • (2004) Endocr Rev , vol.25 , pp. 581-611
    • Ferrara, N.1
  • 89
    • 78049233650 scopus 로고    scopus 로고
    • A bispecific antibody effectively inhibits tumor growth and metastasis by simultaneous blocking vascular endothelial growth factor A and osteopontin
    • PMID:20826049
    • Kou G, Shi J, Chen L, Zhang D, Hou S, Zhao L, et al. A bispecific antibody effectively inhibits tumor growth and metastasis by simultaneous blocking vascular endothelial growth factor A and osteopontin. Cancer Lett 2010; 299:130-6; PMID:20826049; http://dx.doi.org/10.1016/j.canlet.2010.08.011.
    • (2010) Cancer Lett , vol.299 , pp. 130-136
    • Kou, G.1    Shi, J.2    Chen, L.3    Zhang, D.4    Hou, S.5    Zhao, L.6
  • 90
    • 0038641840 scopus 로고    scopus 로고
    • Chemically programmed monoclonal antibodies for cancer therapy: Adaptor immunotherapy based on a covalent antibody catalyst
    • PMID:12702756
    • Rader C, Sinha SC, Popkov M, Lerner RA, Barbas CF, 3rd. Chemically programmed monoclonal antibodies for cancer therapy: adaptor immunotherapy based on a covalent antibody catalyst. Proc Natl Acad Sci USA 2003; 100:5396-400; PMID:12702756; http://dx.doi.org/10.1073/pnas.0931308100.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 5396-5400
    • Rader, C.1    Sinha, S.C.2    Popkov, M.3    Lerner, R.A.4    Barbas III, C.F.5
  • 91
    • 33846853779 scopus 로고    scopus 로고
    • Selective costimulation modulation using abatacept in patients with active rheumatoid arthritis while receiving etanercept: A randomised clinical trial
    • PMID:16935912
    • Weinblatt M, Schiff M, Goldman A, Kremer J, Luggen M, Li T, et al. Selective costimulation modulation using abatacept in patients with active rheumatoid arthritis while receiving etanercept: a randomised clinical trial. Ann Rheum Dis 2007; 66:228-34; PMID:16935912; http://dx.doi.org/10.1136/ard. 2006.055111.
    • (2007) Ann Rheum Dis , vol.66 , pp. 228-234
    • Weinblatt, M.1    Schiff, M.2    Goldman, A.3    Kremer, J.4    Luggen, M.5    Li, T.6
  • 92
    • 77951520735 scopus 로고    scopus 로고
    • Molecular construction and optimization of anti-human IL-1α/β dual variable domain immunoglobulin (DVD-Ig) molecules
    • PMID:20068402
    • Wu C, Ying H, Bose S, Miller R, Medina L, Santora L, et al. Molecular construction and optimization of anti-human IL-1α/β dual variable domain immunoglobulin (DVD-Ig) molecules. MAbs 2009; 1:339-47; PMID:20068402; http://dx.doi.org/10.4161/mabs.1.4.8755.
    • (2009) MAbs , vol.1 , pp. 339-347
    • Wu, C.1    Ying, H.2    Bose, S.3    Miller, R.4    Medina, L.5    Santora, L.6
  • 93
    • 76949084270 scopus 로고    scopus 로고
    • Engineering of stable bispecific antibodies targeting IL-17A and IL-23
    • PMID:20022918
    • Mabry R, Lewis KE, Moore M, McKernan PA, Bukowski TR, Bontadelli K, et al. Engineering of stable bispecific antibodies targeting IL-17A and IL-23. Protein Eng Des Sel 2010; 23:115-27; PMID:20022918; http://dx.doi.org/10.1093/ protein/gzp073.
    • (2010) Protein Eng des Sel , vol.23 , pp. 115-127
    • Mabry, R.1    Lewis, K.E.2    Moore, M.3    McKernan, P.A.4    Bukowski, T.R.5    Bontadelli, K.6
  • 94
    • 41549134361 scopus 로고    scopus 로고
    • Th17 cell differentiation: The long and winding road
    • PMID:18400187
    • McGeachy MJ, Cua DJ. Th17 cell differentiation: the long and winding road. Immunity 2008; 28:445-53; PMID:18400187; http://dx.doi.org/10.1016/j. immuni.2008.03.001.
    • (2008) Immunity , vol.28 , pp. 445-453
    • McGeachy, M.J.1    Cua, D.J.2
  • 95
    • 67649403299 scopus 로고    scopus 로고
    • The IL-12/IL-23 axis and its role in Th17 cell development, pathology and plasticity in arthritis
    • PMID:19431078
    • Cornelissen F, van Hamburg JP, Lubberts E. The IL-12/IL-23 axis and its role in Th17 cell development, pathology and plasticity in arthritis. Curr Opin Investig Drugs 2009; 10:452-62; PMID:19431078.
    • (2009) Curr Opin Investig Drugs , vol.10 , pp. 452-462
    • Cornelissen, F.1    Van Hamburg, J.P.2    Lubberts, E.3
  • 96
    • 57349164272 scopus 로고    scopus 로고
    • Specific blockade of VEGF and HER2 pathways results in greater growth inhibition of breast cancer xenografts that overexpress HER2
    • PMID:19029832
    • Le XF, Mao W, Lu C, Thornton A, Heymach JV, Sood AK, et al. Specific blockade of VEGF and HER2 pathways results in greater growth inhibition of breast cancer xenografts that overexpress HER2. Cell Cycle 2008; 7:3747-58; PMID:19029832; http://dx.doi.org/10.4161/cc.7.23.7212.
    • (2008) Cell Cycle , vol.7 , pp. 3747-3758
    • Le, X.F.1    Mao, W.2    Lu, C.3    Thornton, A.4    Heymach, J.V.5    Sood, A.K.6
  • 97
    • 0036604183 scopus 로고    scopus 로고
    • ErbB2 overexpression correlates with increased expression of vascular endothelial growth factors A, C and D in human breast carcinoma
    • PMID:12115372
    • Yang W, Klos K, Yang Y, Smith TL, Shi D, Yu D. ErbB2 overexpression correlates with increased expression of vascular endothelial growth factors A, C and D in human breast carcinoma. Cancer 2002; 94:2855-61; PMID:12115372; http://dx.doi.org/10.1002/cncr.10553.
    • (2002) Cancer , vol.94 , pp. 2855-2861
    • Yang, W.1    Klos, K.2    Yang, Y.3    Smith, T.L.4    Shi, D.5    Yu, D.6
  • 98
    • 1442290142 scopus 로고    scopus 로고
    • Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms
    • PMID:14657001
    • Erber R, Thurnher A, Katsen AD, Groth G, Kerger H, Hammes HP, et al. Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms. FASEB J 2004; 18:338-40; PMID:14657001.
    • (2004) FASEB J , vol.18 , pp. 338-340
    • Erber, R.1    Thurnher, A.2    Katsen, A.D.3    Groth, G.4    Kerger, H.5    Hammes, H.P.6
  • 99
    • 34247853560 scopus 로고    scopus 로고
    • An antibody directed against PDGF receptor beta enhances the antitumor and the anti-angiogenic activities of an anti-VEGF receptor 2 antibody
    • PMID:17462601
    • Shen J, Vil MD, Zhang H, Tonra JR, Rong LL, Damoci C, et al. An antibody directed against PDGF receptor beta enhances the antitumor and the anti-angiogenic activities of an anti-VEGF receptor 2 antibody. Biochem Biophys Res Commun 2007; 357:1142-7; PMID:17462601; http://dx.doi.org/10.1016/j.bbrc. 2007.04.075.
    • (2007) Biochem Biophys Res Commun , vol.357 , pp. 1142-1147
    • Shen, J.1    Vil, M.D.2    Zhang, H.3    Tonra, J.R.4    Rong, L.L.5    Damoci, C.6
  • 100
    • 77953369554 scopus 로고    scopus 로고
    • A dual-targeting PDGFRbeta/VEGF-A molecule assembled from stable antibody fragments demonstrates anti-angiogenic activity in vitro and in vivo
    • PMID:20065654
    • Mabry R, Gilbertson DG, Frank A, Vu T, Ardourel D, Ostrander C, et al. A dual-targeting PDGFRbeta/VEGF-A molecule assembled from stable antibody fragments demonstrates anti-angiogenic activity in vitro and in vivo. MAbs 2010; 2:20-34; PMID:20065654; http://dx.doi.org/10.4161/mabs.2.1.10498.
    • (2010) MAbs , vol.2 , pp. 20-34
    • Mabry, R.1    Gilbertson, D.G.2    Frank, A.3    Vu, T.4    Ardourel, D.5    Ostrander, C.6
  • 101
    • 25444502674 scopus 로고    scopus 로고
    • Retargeting T cells and immune effector cells with bispecific antibodies
    • PMID:16110617
    • Lum LG, Davol PA. Retargeting T cells and immune effector cells with bispecific antibodies. Cancer Chemother Biol Response Modif 2005; 22:273-91; PMID:16110617.
    • (2005) Cancer Chemother Biol Response Modif , vol.22 , pp. 273-291
    • Lum, L.G.1    Davol, P.A.2
  • 102
    • 34547855838 scopus 로고    scopus 로고
    • Recombinant bispecific antibodies for cellular cancer immunotherapy
    • PMID:17694444
    • Müller D, Kontermann RE. Recombinant bispecific antibodies for cellular cancer immunotherapy. Curr Opin Mol Ther 2007; 9:319-26; PMID:17694444.
    • (2007) Curr Opin Mol Ther , vol.9 , pp. 319-326
    • Müller, D.1    Kontermann, R.E.2
  • 103
    • 49649120397 scopus 로고    scopus 로고
    • Tumor regression in cancer patients by very low doses of a T cell-engaging antibody
    • PMID:18703743
    • Bargou R, Leo E, Zugmaier G, Klinger M, Goebeler M, Knop S, et al. Tumor regression in cancer patients by very low doses of a T cell-engaging antibody. Science 2008; 321:974-7; PMID:18703743; http://dx.doi.org/10.1126/science. 1158545.
    • (2008) Science , vol.321 , pp. 974-977
    • Bargou, R.1    Leo, E.2    Zugmaier, G.3    Klinger, M.4    Goebeler, M.5    Knop, S.6
  • 104
    • 79959312575 scopus 로고    scopus 로고
    • Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy- refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival
    • PMID:21576633
    • Topp MS, Kufer P, Gökbuget N, Goebeler M, Klinger M, Neumann S, et al. Targeted therapy with the T-cell-engaging antibody blinatumomab of chemotherapy- refractory minimal residual disease in B-lineage acute lymphoblastic leukemia patients results in high response rate and prolonged leukemia-free survival. J Clin Oncol 2011; 29:2493-8; PMID:21576633; http://dx.doi.org/10.1200/JCO.2010.32.7270.
    • (2011) J Clin Oncol , vol.29 , pp. 2493-2498
    • Topp, M.S.1    Kufer, P.2    Gökbuget, N.3    Goebeler, M.4    Klinger, M.5    Neumann, S.6
  • 105
    • 77955782190 scopus 로고    scopus 로고
    • A recombinant trispecific single- chain Fv derivative directed against CD123 and CD33 mediates effective elimination of acute myeloid leukaemia cells by dual targeting
    • PMID:20636437
    • Kügler M, Stein C, Kellner C, Mentz K, Saul D, Schwenkert M, et al. A recombinant trispecific single- chain Fv derivative directed against CD123 and CD33 mediates effective elimination of acute myeloid leukaemia cells by dual targeting. Br J Haematol 2010; 150:574-86; PMID:20636437; http://dx.doi.org/10. 1111/j.1365-2141.2010.08300.x.
    • (2010) Br J Haematol , vol.150 , pp. 574-586
    • Kügler, M.1    Stein, C.2    Kellner, C.3    Mentz, K.4    Saul, D.5    Schwenkert, M.6
  • 106
    • 78651404837 scopus 로고    scopus 로고
    • A single-chain triplebody with specificity for CD19 and CD33 mediates effective lysis of mixed lineage leukemia cells by dual targeting
    • PMID:21081841
    • Schubert I, Kellner C, Stein C, Kügler M, Schwenkert M, Saul D, et al. A single-chain triplebody with specificity for CD19 and CD33 mediates effective lysis of mixed lineage leukemia cells by dual targeting. MAbs 2011; 3:21-30; PMID:21081841; http://dx.doi.org/10.4161/mabs.3.1.14057.
    • (2011) MAbs , vol.3 , pp. 21-30
    • Schubert, I.1    Kellner, C.2    Stein, C.3    Kügler, M.4    Schwenkert, M.5    Saul, D.6
  • 107
    • 34047136785 scopus 로고    scopus 로고
    • Immunotoxin treatment of cancer
    • PMID:17059365
    • Pastan I, Hassan R, FitzGerald DJ, Kreitman RJ. Immunotoxin treatment of cancer. Annu Rev Med 2007; 58:221-37; PMID:17059365; http://dx.doi.org/10.1146/ annurev.med.58.070605.115320.
    • (2007) Annu Rev Med , vol.58 , pp. 221-237
    • Pastan, I.1    Hassan, R.2    FitzGerald, D.J.3    Kreitman, R.J.4
  • 108
    • 79958187876 scopus 로고    scopus 로고
    • Therapeutic potential of anticancer immunotoxins
    • PMID:21511052
    • Choudhary S, Mathew M, Verma RS. Therapeutic potential of anticancer immunotoxins. Drug Discov Today 2011; 16:495-503; PMID:21511052; http://dx.doi.org/10.1016/j.drudis.2011.04.003.
    • (2011) Drug Discov Today , vol.16 , pp. 495-503
    • Choudhary, S.1    Mathew, M.2    Verma, R.S.3
  • 109
    • 70350645181 scopus 로고    scopus 로고
    • Denileukin diftitox: A novel immunotoxin
    • PMID:19817678
    • Manoukian G, Hagemeister F. Denileukin diftitox: a novel immunotoxin. Expert Opin Biol Ther 2009; 9:1445-51; PMID:19817678; http://dx.doi.org/10.1517/ 14712590903348135.
    • (2009) Expert Opin Biol Ther , vol.9 , pp. 1445-1451
    • Manoukian, G.1    Hagemeister, F.2
  • 110
    • 79955007493 scopus 로고    scopus 로고
    • Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes
    • PMID:21436054
    • Onda M, Beers R, Xiang L, Lee B, Weldon JE, Kreitman RJ, et al. Recombinant immunotoxin against B-cell malignancies with no immunogenicity in mice by removal of B-cell epitopes. Proc Natl Acad Sci USA 2011; 108:5742-7; PMID:21436054; http://dx.doi.org/10.1073/pnas.1102746108.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 5742-5747
    • Onda, M.1    Beers, R.2    Xiang, L.3    Lee, B.4    Weldon, J.E.5    Kreitman, R.J.6
  • 111
    • 67549106629 scopus 로고    scopus 로고
    • Bispecific immunotoxins
    • PMID:19406472
    • Frankel AE, Woo JH. Bispecific immunotoxins. Leuk Res 2009; 33:1173-4; PMID:19406472; http://dx.doi.org/10.1016/j.leukres.2009.03.037.
    • (2009) Leuk Res , vol.33 , pp. 1173-1174
    • Frankel, A.E.1    Woo, J.H.2
  • 112
    • 0027482188 scopus 로고
    • Targeting of an activated T-cell subset using a bispecific antibody-toxin conjugate directed against CD4 and CD26
    • PMID:8104537
    • Duke-Cohan JS, Morimoto C, Schlossman SF. Targeting of an activated T-cell subset using a bispecific antibody-toxin conjugate directed against CD4 and CD26. Blood 1993; 82:2224-34; PMID:8104537.
    • (1993) Blood , vol.82 , pp. 2224-2234
    • Duke-Cohan, J.S.1    Morimoto, C.2    Schlossman, S.F.3
  • 113
    • 0027521171 scopus 로고
    • Depletion of the helper/inducer (memory) T cell subset using a bispecific antibody-toxin conjugate directed against CD4 and CD29
    • PMID:7504344
    • Duke-Cohan JS, Morimoto C, Schlossman SF. Depletion of the helper/inducer (memory) T cell subset using a bispecific antibody-toxin conjugate directed against CD4 and CD29. Transplantation 1993; 56:1188-96; PMID:7504344; http://dx.doi.org/10.1097/00007890-199311000-00027.
    • (1993) Transplantation , vol.56 , pp. 1188-1196
    • Duke-Cohan, J.S.1    Morimoto, C.2    Schlossman, S.F.3
  • 114
    • 18844444471 scopus 로고    scopus 로고
    • A bispecific recombinant immunotoxin, DT2219, targeting human CD19 and CD22 receptors in a mouse xenograft model of B-cell leukemia/lymphoma
    • PMID:15897589
    • Vallera DA, Todhunter DA, Kuroki DW, Shu Y, Sicheneder A, Chen H. A bispecific recombinant immunotoxin, DT2219, targeting human CD19 and CD22 receptors in a mouse xenograft model of B-cell leukemia/lymphoma. Clin Cancer Res 2005; 11:3879-88; PMID:15897589; http://dx.doi.org/10.1158/1078-0432.CCR-04- 2290.
    • (2005) Clin Cancer Res , vol.11 , pp. 3879-3888
    • Vallera, D.A.1    Todhunter, D.A.2    Kuroki, D.W.3    Shu, Y.4    Sicheneder, A.5    Chen, H.6
  • 115
    • 67549102111 scopus 로고    scopus 로고
    • Genetic alteration of a bispecific ligand-directed toxin targeting human CD19 and CD22 receptors resulting in improved efficacy against systemic B cell malignancy
    • PMID:19327829
    • Vallera DA, Chen H, Sicheneder AR, Panoskaltsis-Mortari A, Taras EP. Genetic alteration of a bispecific ligand-directed toxin targeting human CD19 and CD22 receptors resulting in improved efficacy against systemic B cell malignancy. Leuk Res 2009; 33:1233-42; PMID:19327829; http://dx.doi.org/10.1016/ j.leukres. 2009.02.006.
    • (2009) Leuk Res , vol.33 , pp. 1233-1242
    • Vallera, D.A.1    Chen, H.2    Sicheneder, A.R.3    Panoskaltsis-Mortari, A.4    Taras, E.P.5
  • 116
    • 77953435950 scopus 로고    scopus 로고
    • Bioengineering a unique deimmunized bispecific targeted toxin that simultaneously recognizes human CD22 and CD19 receptors in a mouse model of B-cell metastases
    • PMID:20530709
    • Vallera DA, Oh S, Chen H, Shu Y, Frankel AE. Bioengineering a unique deimmunized bispecific targeted toxin that simultaneously recognizes human CD22 and CD19 receptors in a mouse model of B-cell metastases. Mol Cancer Ther 2010; 9:1872-83; PMID:20530709; http://dx.doi.org/10.1158/1535-7163.MCT-10-0203.
    • (2010) Mol Cancer Ther , vol.9 , pp. 1872-1883
    • Vallera, D.A.1    Oh, S.2    Chen, H.3    Shu, Y.4    Frankel, A.E.5
  • 117
    • 34249820779 scopus 로고    scopus 로고
    • Increasing anticarcinoma activity of an anti-erbB2 recombinant immunotoxin by the addition of an anti-EpCAM sFv
    • PMID:17505009
    • Stish BJ, Chen H, Shu Y, Panoskaltsis-Mortari A, Vallera DA. Increasing anticarcinoma activity of an anti-erbB2 recombinant immunotoxin by the addition of an anti-EpCAM sFv. Clin Cancer Res 2007; 13:3058-67; PMID:17505009; http://dx.doi.org/10.1158/1078-0432.CCR-06-2454.
    • (2007) Clin Cancer Res , vol.13 , pp. 3058-3067
    • Stish, B.J.1    Chen, H.2    Shu, Y.3    Panoskaltsis-Mortari, A.4    Vallera, D.A.5
  • 118
    • 35948938040 scopus 로고    scopus 로고
    • A bispecific recombinant cytotoxin (DTEGF13) targeting human interleukin-13 and epidermal growth factor receptors in a mouse xenograft model of prostate cancer
    • PMID:17975161
    • Stish BJ, Chen H, Shu Y, Panoskaltsis-Mortari A, Vallera DA. A bispecific recombinant cytotoxin (DTEGF13) targeting human interleukin-13 and epidermal growth factor receptors in a mouse xenograft model of prostate cancer. Clin Cancer Res 2007; 13:6486-93; PMID:17975161; http://dx.doi.org/10.1158/1078-0432. CCR-07-0938.
    • (2007) Clin Cancer Res , vol.13 , pp. 6486-6493
    • Stish, B.J.1    Chen, H.2    Shu, Y.3    Panoskaltsis-Mortari, A.4    Vallera, D.A.5
  • 119
    • 38649092392 scopus 로고    scopus 로고
    • Anti-glioblastoma effect of a recombinant bispecific cytotoxin cotargeting human IL-13 and EGF receptors in a mouse xenograft model
    • PMID:18084721
    • Stish BJ, Oh S, Vallera DA. Anti-glioblastoma effect of a recombinant bispecific cytotoxin cotargeting human IL-13 and EGF receptors in a mouse xenograft model. J Neurooncol 2008; 87:51-61; PMID:18084721; http://dx.doi.org/10.1007/s11060-007-9499-8.
    • (2008) J Neurooncol , vol.87 , pp. 51-61
    • Stish, B.J.1    Oh, S.2    Vallera, D.A.3
  • 120
    • 42549106512 scopus 로고    scopus 로고
    • Genetically designing a more potent antipancreatic cancer agent by simultaneously co-targeting human IL13 and EGF receptors in a mouse xenograft model
    • PMID:18222985
    • Vallera DA, Stish BJ, Shu Y, Chen H, Saluja A, Buchsbaum DJ, et al. Genetically designing a more potent antipancreatic cancer agent by simultaneously co-targeting human IL13 and EGF receptors in a mouse xenograft model. Gut 2008; 57:634-41; PMID:18222985; http://dx.doi.org/10.1136/gut.2007. 137802.
    • (2008) Gut , vol.57 , pp. 634-641
    • Vallera, D.A.1    Stish, B.J.2    Shu, Y.3    Chen, H.4    Saluja, A.5    Buchsbaum, D.J.6
  • 121
    • 70450253409 scopus 로고    scopus 로고
    • Intracranial elimination of human glioblastoma brain tumors in nude rats using the bispecific ligand-directed toxin, DTEGF13 and convection enhanced delivery
    • PMID:19517064
    • Oh S, Ohlfest JR, Todhunter DA, Vallera VD, Hall WA, Chen H, et al. Intracranial elimination of human glioblastoma brain tumors in nude rats using the bispecific ligand-directed toxin, DTEGF13 and convection enhanced delivery. J Neurooncol 2009; 95:331-42; PMID:19517064; http://dx.doi.org/10.1007/s11060- 009-9932-2.
    • (2009) J Neurooncol , vol.95 , pp. 331-342
    • Oh, S.1    Ohlfest, J.R.2    Todhunter, D.A.3    Vallera, V.D.4    Hall, W.A.5    Chen, H.6
  • 122
    • 77953403241 scopus 로고    scopus 로고
    • A new drug delivery method of bispecific ligand-directed toxins, which reduces toxicity and promotes efficacy in a model of orthotopic pancreatic cancer
    • PMID:20182395
    • Oh S, Stish BJ, Vickers SM, Buchsbaum DJ, Saluja AK, Vallera DA. A new drug delivery method of bispecific ligand-directed toxins, which reduces toxicity and promotes efficacy in a model of orthotopic pancreatic cancer. Pancreas 2010; 39:913-22; PMID:20182395; http://dx.doi.org/10.1097/MPA. 0b013e3181cbd908.
    • (2010) Pancreas , vol.39 , pp. 913-922
    • Oh, S.1    Stish, B.J.2    Vickers, S.M.3    Buchsbaum, D.J.4    Saluja, A.K.5    Vallera, D.A.6
  • 123
    • 1842665126 scopus 로고    scopus 로고
    • A bispecific immunotoxin (DTAT13) targeting human IL-13 receptor (IL-13R) and urokinase-type plasminogen activator receptor (uPAR) in a mouse xenograft model
    • PMID:15047912
    • Todhunter DA, Hall WA, Rustamzadeh E, Shu Y, Doumbia SO, Vallera DA. A bispecific immunotoxin (DTAT13) targeting human IL-13 receptor (IL-13R) and urokinase-type plasminogen activator receptor (uPAR) in a mouse xenograft model. Protein Eng Des Sel 2004; 17:157-64; PMID:15047912; http://dx.doi.org/10.1093/ protein/gzh023.
    • (2004) Protein Eng des Sel , vol.17 , pp. 157-164
    • Todhunter, D.A.1    Hall, W.A.2    Rustamzadeh, E.3    Shu, Y.4    Doumbia, S.O.5    Vallera, D.A.6
  • 124
    • 33747187531 scopus 로고    scopus 로고
    • Efficacy of antiangiogenic targeted toxins against glioblastoma multiforme
    • PMID:16709029
    • Hall WA, Vallera DA. Efficacy of antiangiogenic targeted toxins against glioblastoma multiforme. Neurosurg Focus 2006; 20:23; PMID:16709029; http://dx.doi.org/10.3171/foc.2006.20.4.15.
    • (2006) Neurosurg Focus , vol.20 , pp. 23
    • Hall, W.A.1    Vallera, D.A.2
  • 125
    • 33748413376 scopus 로고    scopus 로고
    • Immunotoxin pharmacokinetics: A comparison of the anti-glioblastoma bi-specific fusion protein (DTAT13) to DTAT and DTIL13
    • PMID:16314943
    • Rustamzadeh E, Vallera DA, Todhunter DA, Low WC, Panoskaltsis-Mortari A, Hall WA. Immunotoxin pharmacokinetics: a comparison of the anti-glioblastoma bi-specific fusion protein (DTAT13) to DTAT and DTIL13. J Neurooncol 2006; 77:257-66; PMID:16314943; http://dx.doi.org/10.1007/s11060-005-9051-7.
    • (2006) J Neurooncol , vol.77 , pp. 257-266
    • Rustamzadeh, E.1    Vallera, D.A.2    Todhunter, D.A.3    Low, W.C.4    Panoskaltsis-Mortari, A.5    Hall, W.A.6
  • 126
    • 70349653790 scopus 로고    scopus 로고
    • A novel "reduced immunogenicity" bispecific targeted toxin simultaneously recognizing human EGF and IL-4 receptors in a mouse model of metastatic breast carcinoma
    • PMID:19789305
    • Oh S, Stish BH, Sachdev D, Chen H, Dudek AZ, Vallera DA. A novel "reduced immunogenicity" bispecific targeted toxin simultaneously recognizing human EGF and IL-4 receptors in a mouse model of metastatic breast carcinoma. Clin Cancer Res 2009; 15:6137-47; PMID:19789305; http://dx.doi.org/ 10.1158/1078-0432.CCR-09-0696.
    • (2009) Clin Cancer Res , vol.15 , pp. 6137-6147
    • Oh, S.1    Stish, B.H.2    Sachdev, D.3    Chen, H.4    Dudek, A.Z.5    Vallera, D.A.6
  • 127
    • 70349655268 scopus 로고    scopus 로고
    • Design and modification of EGF4KDEL 7Mut, a novel bispecific ligand-directed toxin, with decreased immunogenicity and potent anti-mesothelioma activity
    • PMID:19755995
    • Stish BJ, Oh S, Chen H, Dudek AZ, Kratzke RA, Vallera DA. Design and modification of EGF4KDEL 7Mut, a novel bispecific ligand-directed toxin, with decreased immunogenicity and potent anti-mesothelioma activity. Br J Cancer 2009; 101:1114-23; PMID:19755995; http://dx.doi.org/10.1038/sj.bjc.6605297.
    • (2009) Br J Cancer , vol.101 , pp. 1114-1123
    • Stish, B.J.1    Oh, S.2    Chen, H.3    Dudek, A.Z.4    Kratzke, R.A.5    Vallera, D.A.6
  • 128
    • 79959830232 scopus 로고    scopus 로고
    • A novel bispecific ligand-directed toxin designed to simultaneously target EGFR on human glioblastoma cells and uPAR on tumor neovasculature
    • PMID:20830604
    • Tsai AK, Oh S, Chen H, Shu Y, Ohlfest JR, Vallera DA. A novel bispecific ligand-directed toxin designed to simultaneously target EGFR on human glioblastoma cells and uPAR on tumor neovasculature. J Neurooncol 2011; 103:255-66; PMID:20830604; http://dx.doi.org/10.1007/s11060-010-0392-5.
    • (2011) J Neurooncol , vol.103 , pp. 255-266
    • Tsai, A.K.1    Oh, S.2    Chen, H.3    Shu, Y.4    Ohlfest, J.R.5    Vallera, D.A.6
  • 129
    • 67650744372 scopus 로고    scopus 로고
    • Immune therapy for cancer
    • PMID:19007331
    • Dougan M, Dranoff G. Immune therapy for cancer. Annu Rev Immunol 2009; 27:83-117; PMID:19007331; http://dx.doi.org/10.1146/annurev.immunol.021908. 132544.
    • (2009) Annu Rev Immunol , vol.27 , pp. 83-117
    • Dougan, M.1    Dranoff, G.2
  • 131
    • 79953318400 scopus 로고    scopus 로고
    • A phase 1 study of AS1409, a novel antibody-cytokine fusion protein, in patients with malignant melanoma or renal cell carcinoma
    • PMID:21447719
    • Rudman SM, Jameson MB, McKeage MJ, Savage P, Jodrell DI, Harries M, et al. A phase 1 study of AS1409, a novel antibody-cytokine fusion protein, in patients with malignant melanoma or renal cell carcinoma. Clin Cancer Res 2011; 17:1998-2005; PMID:21447719; http://dx.doi.org/10.1158/1078-0432.CCR-10-2490.
    • (2011) Clin Cancer Res , vol.17 , pp. 1998-2005
    • Rudman, S.M.1    Jameson, M.B.2    McKeage, M.J.3    Savage, P.4    Jodrell, D.I.5    Harries, M.6
  • 132
    • 77957366599 scopus 로고    scopus 로고
    • A bispecific antibody-IFNalpha2b immunocytokine targeting CD20 and HLA-DR is highly toxic to human lymphoma and multiple myeloma cells
    • PMID:20876805
    • Rossi EA, Rossi DL, Stein R, Goldenberg DM, Chang CH. A bispecific antibody-IFNalpha2b immunocytokine targeting CD20 and HLA-DR is highly toxic to human lymphoma and multiple myeloma cells. Cancer Res 2010; 70:7600-9; PMID:20876805; http://dx.doi.org/10.1158/0008-5472.CAN-10-2126.
    • (2010) Cancer Res , vol.70 , pp. 7600-7609
    • Rossi, E.A.1    Rossi, D.L.2    Stein, R.3    Goldenberg, D.M.4    Chang, C.H.5
  • 133
    • 40949127319 scopus 로고    scopus 로고
    • Therapeutic nanoparticles for drug delivery in cancer
    • PMID:18316549
    • Cho K, Wang X, Nie S, Chen ZG, Shin DM. Therapeutic nanoparticles for drug delivery in cancer. Clin Cancer Res 2008; 14:1310-6; PMID:18316549; http://dx.doi.org/10.1158/1078-0432.CCR-07-1441.
    • (2008) Clin Cancer Res , vol.14 , pp. 1310-1316
    • Cho, K.1    Wang, X.2    Nie, S.3    Chen, Z.G.4    Shin, D.M.5
  • 134
    • 70350292588 scopus 로고    scopus 로고
    • Liposomes and nanoparticles: Nanosized vehicles for drug delivery in cancer
    • PMID:19837467
    • Malam Y, Loizidou M, Seifalian AM. Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer. Trends Pharmacol Sci 2009; 30:592-9; PMID:19837467; http://dx.doi.org/10.1016/j.tips.2009.08.004.
    • (2009) Trends Pharmacol Sci , vol.30 , pp. 592-599
    • Malam, Y.1    Loizidou, M.2    Seifalian, A.M.3
  • 135
    • 39049171058 scopus 로고    scopus 로고
    • Liposomal nanomedicines
    • PMID:18095927
    • Fenske DB, Cullis PR. Liposomal nanomedicines. Expert Opin Drug Deliv 2008; 5:25-44; PMID:18095927; http://dx.doi.org/10.1517/17425247.5.1.25.
    • (2008) Expert Opin Drug Deliv , vol.5 , pp. 25-44
    • Fenske, D.B.1    Cullis, P.R.2
  • 136
    • 36849067019 scopus 로고    scopus 로고
    • Nanocarriers as an emerging platform for cancer therapy
    • PMID:18654426
    • Peer D, Karp JM, Hong S, Farokhzad OC, Margalit R, Langer R. Nanocarriers as an emerging platform for cancer therapy. Nat Nanotechnol 2007; 2:751-60; PMID:18654426; http://dx.doi.org/10.1038/nnano.2007.387.
    • (2007) Nat Nanotechnol , vol.2 , pp. 751-760
    • Peer, D.1    Karp, J.M.2    Hong, S.3    Farokhzad, O.C.4    Margalit, R.5    Langer, R.6
  • 137
    • 80955139792 scopus 로고    scopus 로고
    • Pegylated liposomal doxorubicin: Appraisal of its current role in the management of epithelial ovarian cancer
    • PMID:21792330
    • Markman M. Pegylated liposomal doxorubicin: appraisal of its current role in the management of epithelial ovarian cancer. Cancer Manag Res 2011; 3:219-25; PMID:21792330; http://dx.doi.org/10.2147/CMAR.S15558.
    • (2011) Cancer Manag Res , vol.3 , pp. 219-225
    • Markman, M.1
  • 138
    • 32544452539 scopus 로고    scopus 로고
    • Immunoliposomes for cancer therapy
    • PMID:16506524
    • Kontermann RE. Immunoliposomes for cancer therapy. Curr Opin Mol Ther 2006; 8:39-45; PMID:16506524.
    • (2006) Curr Opin Mol Ther , vol.8 , pp. 39-45
    • Kontermann, R.E.1
  • 139
    • 54049090061 scopus 로고    scopus 로고
    • Antibody-modified liposomes for cancer chemotherapy
    • PMID:18754750
    • Torchilin V. Antibody-modified liposomes for cancer chemotherapy. Expert Opin Drug Deliv 2008; 5:1003-25; PMID:18754750; http://dx.doi.org/10.1517/ 17425247.5.9.1003.
    • (2008) Expert Opin Drug Deliv , vol.5 , pp. 1003-1025
    • Torchilin, V.1
  • 140
    • 33746172167 scopus 로고    scopus 로고
    • Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models
    • PMID:16818648
    • Kirpotin DB, Drummond DC, Shao Y, Shalaby MR, Hong K, Nielsen UB, et al. Antibody targeting of long-circulating lipidic nanoparticles does not increase tumor localization but does increase internalization in animal models. Cancer Res 2006; 66:6732-40; PMID:16818648; http://dx.doi.org/10.1158/0008-5472.CAN-05- 4199.
    • (2006) Cancer Res , vol.66 , pp. 6732-6740
    • Kirpotin, D.B.1    Drummond, D.C.2    Shao, Y.3    Shalaby, M.R.4    Hong, K.5    Nielsen, U.B.6
  • 141
    • 11144300731 scopus 로고    scopus 로고
    • Future directions of liposome- and immunoliposome-based cancer therapeutics
    • PMID:15717745
    • Park JW, Benz CC, Martin FJ. Future directions of liposome- and immunoliposome-based cancer therapeutics. Semin Oncol 2004; 31:196-205; PMID:15717745; http://dx.doi.org/10.1053/j.seminoncol.2004.08.009.
    • (2004) Semin Oncol , vol.31 , pp. 196-205
    • Park, J.W.1    Benz, C.C.2    Martin, F.J.3
  • 142
    • 34250187101 scopus 로고    scopus 로고
    • pH-sensitive liposomes - Principle and application in cancer therapy
    • PMID:17430630
    • Karanth H, Murthy RS. pH-sensitive liposomes - principle and application in cancer therapy. J Pharm Pharmacol 2007; 59:469-83; PMID:17430630; http://dx.doi.org/10.1211/jpp.59.4.0001.
    • (2007) J Pharm Pharmacol , vol.59 , pp. 469-483
    • Karanth, H.1    Murthy, R.S.2
  • 143
    • 0042626531 scopus 로고    scopus 로고
    • Interaction of differently designed immunoliposomes with colon cancer cells and Kupffer cells. An in vitro comparison
    • PMID:12948023
    • Koning GA, Morselt HW, Gorter A, Allen TM, Zalipsky S, Scherphof GL, et al. Interaction of differently designed immunoliposomes with colon cancer cells and Kupffer cells. An in vitro comparison. Pharm Res 2003; 20:1249-57; PMID:12948023; http://dx.doi.org/10.1023/A:1025009300562.
    • (2003) Pharm Res , vol.20 , pp. 1249-1257
    • Koning, G.A.1    Morselt, H.W.2    Gorter, A.3    Allen, T.M.4    Zalipsky, S.5    Scherphof, G.L.6
  • 144
    • 13544268486 scopus 로고    scopus 로고
    • Preclinical manufacture of an anti-HER2 scFv-PEG-DSPE, liposome-inserting conjugate. 1. Gram-scale production and purification
    • PMID:15903260
    • Nellis DF, Ekstrom DL, Kirpotin DB, Zhu J, Andersson R, Broadt TL, et al. Preclinical manufacture of an anti-HER2 scFv-PEG-DSPE, liposome-inserting conjugate. 1. Gram-scale production and purification. Biotechnol Prog 2005; 21:205-20; PMID:15903260; http://dx.doi.org/10.1021/bp049840y.
    • (2005) Biotechnol Prog , vol.21 , pp. 205-220
    • Nellis, D.F.1    Ekstrom, D.L.2    Kirpotin, D.B.3    Zhu, J.4    Andersson, R.5    Broadt, T.L.6
  • 145
    • 19444362857 scopus 로고    scopus 로고
    • Liposomes targeted via two different antibodies: Assay, B-cell binding and cytotoxicity
    • 1711: PMID: 15904660
    • Mumbengegwi DL, Allen TM. Liposomes targeted via two different antibodies: assay, B-cell binding and cytotoxicity. Biochim Biophys Acta 2005; 1711:25-32; PMID: 15904660.
    • (2005) Biochim Biophys Acta , pp. 25-32
    • Mumbengegwi, D.L.1    Allen, T.M.2
  • 146
    • 33748165210 scopus 로고    scopus 로고
    • A dual-ligand approach for enhancing targeting selectivity of therapeutic nanocarriers
    • PMID:16904220
    • Saul JM, Annapragada AV, Bellamkonda RV. A dual-ligand approach for enhancing targeting selectivity of therapeutic nanocarriers. J Control Release 2006; 114:277-87; PMID:16904220; http://dx.doi.org/10.1016/j.jconrel.2006.05. 028.
    • (2006) J Control Release , vol.114 , pp. 277-287
    • Saul, J.M.1    Annapragada, A.V.2    Bellamkonda, R.V.3
  • 147
    • 70249134588 scopus 로고    scopus 로고
    • Dual targeting of a thermosensitive nanogel conjugated with transferrin and RGD-containing peptide for effective cell uptake and drug release
    • PMID:19636104
    • Quan CY, Chang C, Wei H, Chen CS, Xu XD, Cheng SX, et al. Dual targeting of a thermosensitive nanogel conjugated with transferrin and RGD-containing peptide for effective cell uptake and drug release. Nanotechnology 2009; 20:335101; PMID:19636104; http://dx.doi.org/10.1088/0957-4484/20/33/335101.
    • (2009) Nanotechnology , vol.20 , pp. 335101
    • Quan, C.Y.1    Chang, C.2    Wei, H.3    Chen, C.S.4    Xu, X.D.5    Cheng, S.X.6
  • 148
    • 77958576823 scopus 로고    scopus 로고
    • Enhanced antitumor effect of novel dual-targeted paclitaxel liposomes
    • PMID:20852356
    • Meng S, Su B, Li W, Ding Y, Tang L, Zhou W, et al. Enhanced antitumor effect of novel dual-targeted paclitaxel liposomes. Nanotechnology 2010; 21:415103; PMID:20852356; http://dx.doi.org/10.1088/0957-4484/21/41/415103.
    • (2010) Nanotechnology , vol.21 , pp. 415103
    • Meng, S.1    Su, B.2    Li, W.3    Ding, Y.4    Tang, L.5    Zhou, W.6
  • 149
    • 74849112431 scopus 로고    scopus 로고
    • Synergistic targeting of alphavbeta3 integrin and galectin-1 with heteromultivalent paramagnetic liposomes for combined MR imaging and treatment of angiogenesis
    • PMID:19968235
    • Kluza E, van der Schaft DWJ, Hautvast PAI, Mulder WJM, Mayo KH, Griffioen AW, et al. Synergistic targeting of alphavbeta3 integrin and galectin-1 with heteromultivalent paramagnetic liposomes for combined MR imaging and treatment of angiogenesis. Nano Lett 2010; 10:52-8; PMID:19968235; http://dx.doi.org/10. 1021/nl902659g.
    • (2010) Nano Lett , vol.10 , pp. 52-58
    • Kluza, E.1    Van Der Schaft, D.W.J.2    Hautvast, P.A.I.3    Mulder, W.J.M.4    Mayo, K.H.5    Griffioen, A.W.6
  • 150
    • 72949101190 scopus 로고    scopus 로고
    • A novel DDS strategy, "dual-targeting", and its application for antineovascular therapy
    • PMID:19616372
    • Murase Y, Asai T, Katanasaka Y, Sugiyama T, Shimizu K, Maeda N, et al. A novel DDS strategy, "dual-targeting", and its application for antineovascular therapy. Cancer Lett 2010; 287:165-71; PMID:19616372; http://dx.doi.org/10.1016/j.canlet.2009.06.008.
    • (2010) Cancer Lett , vol.287 , pp. 165-171
    • Murase, Y.1    Asai, T.2    Katanasaka, Y.3    Sugiyama, T.4    Shimizu, K.5    Maeda, N.6
  • 151
    • 70350561680 scopus 로고    scopus 로고
    • Engineering and characterization of a bispecific HER2 x EGFR-binding affibody molecule
    • PMID:19492986
    • Friedman M, Lindström S, Ekerljung L, Andersson-Svahn H, Carlsson J, Brismar H, et al. Engineering and characterization of a bispecific HER2 x EGFR-binding affibody molecule. Biotechnol Appl Biochem 2009; 54:121-31; PMID:19492986; http://dx.doi.org/10.1042/BA20090096.
    • (2009) Biotechnol Appl Biochem , vol.54 , pp. 121-131
    • Friedman, M.1    Lindström, S.2    Ekerljung, L.3    Andersson-Svahn, H.4    Carlsson, J.5    Brismar, H.6


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