Enhancing antibody Fc heterodimer formation through electrostatic steering effects: Applications to bispecific molecules and monovalent IgG

Journal of Biological Chemistry

Volumn 285, Issue 25, 2010, Pages 19637-19646

  Gunasekaran, Kannan ^a   Pentony, Martin ^a   Shen, Min ^a   Garrett, Logan ^a   Forte, Carla ^a   Woodward, Anne ^a   Ng, Soo Bin ^a   Born, Teresa ^a   Retter, Marc ^a   Manchulenko, Kathy ^b   Sweet, Heather ^b   Foltz, Ian N ^b   Wittekind, Michael ^a   Yan, Wei ^a  

^a AMGEN INC   (United States)

^b Amgen British Columbia   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BIOMOLECULES; DIMERS; MOLECULES;

ATTRACTIVE INTERACTIONS; BINDING SPECIFICITIES; CHARGE INTERACTIONS; CLINICAL APPLICATION; HETERODIMER FORMATION; NATURALLY OCCURRING; SINGLE-CHAIN ANTIBODIES; THERAPEUTIC APPLICATION;

ANTIBODIES;

ASPARTIC ACID; GLUTAMINE; HETERODIMER; IMMUNOGLOBULIN FC FRAGMENT; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAIN; IMMUNOGLOBULIN LIGHT CHAIN; LYSINE; MONOCLONAL ANTIBODY;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIBODY PRODUCTION; ANTIBODY SPECIFICITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; CYTOTOXICITY; DRUG HALF LIFE; DRUG STRUCTURE; EMBRYO; FEMALE; GENE MUTATION; GLIOBLASTOMA; HUMAN; HUMAN CELL; MASS SPECTROMETRY; MOUSE; NONHUMAN; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN SYNTHESIS; STATIC ELECTRICITY; T LYMPHOCYTE; TUMOR VOLUME;

EID: 77953485268     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.117382     Document Type: Article

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