Engineering and characterization of a bispecific HER2 × EGFR-binding affibody molecule

Biotechnology and Applied Biochemistry

Volumn 54, Issue 2, 2009, Pages 121-131

  Friedman, Mikaela ^a   Lindström, Sara ^a   Ekerljung, Lina ^b   Andersson Svahn, Helene ^a   Carlsson, Jörgen ^b   Brismar, Hjalmar ^a   Gedda, Lars ^b   Frejd, Fredrik Y ^b,c   Ståhl, Stefan ^a  

^a ALBANOVA UNIVERSITY CENTER   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c Affibody AB   (Sweden)

Author keywords

Bispecific (bs) affibody molecule; Human epidermal growth factor receptor 3 (ErbB); Microwell array; Protein engineering; Tumour targeting

Indexed keywords

BISPECIFIC (BS) AFFIBODY MOLECULE; HUMAN EPIDERMAL-GROWTH-FACTOR RECEPTOR-3 (ERBB); MICROWELL ARRAY; PROTEIN ENGINEERING; TUMOUR TARGETING;

BIOCHEMICAL ENGINEERING; BIOSENSORS; CELL MEMBRANES; ENCODING (SYMBOLS); ESCHERICHIA COLI; GENE ENCODING; GENETIC ENGINEERING; MICROCHANNELS; TUMORS;

MOLECULES;

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2;

AFFIBODY MOLECULE; ARTICLE; BINDING AFFINITY; BIOSENSOR; CELL INTERACTION; CONTROLLED STUDY; FLOW CYTOMETRY; GENE CONSTRUCT; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN ENGINEERING; PROTEIN IMMOBILIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; RECEPTOR BINDING;

ANTIBODIES, BISPECIFIC; ANTIBODY SPECIFICITY; BIOSENSING TECHNIQUES; CELL COMMUNICATION; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN ENGINEERING; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; RECOMBINANT FUSION PROTEINS;

ESCHERICHIA COLI;

EID: 70350561680     PISSN: 08854513     EISSN: None     Source Type: Journal    
DOI: 10.1042/BA20090096     Document Type: Article

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