Stable IgG-like bispecific antibodies directed toward the type I insulin-like growth factor receptor demonstrate enhanced ligand blockade and anti-tumor activity

Journal of Biological Chemistry

Volumn 286, Issue 6, 2011, Pages 4703-4717

  Dong, Jianying ^a   Sereno, Arlene ^a   Snyder, William B ^a   Miller, Brian R ^a   Tamraz, Susan ^a   Doern, Adam ^a   Favis, Michael ^a   Wu, Xiufeng ^a   Tran, Hon ^a   Langley, Emma ^a   Joseph, Ingrid ^a   Boccia, Antonio ^a   Kelly, Rebecca ^a   Wortham, Kathleen ^a   Wang, Qin ^a   Berquist, Lisa ^a   Huang, Flora ^a   Gao, Sharon X ^a   Zhang, Ying ^a   Lugovskoy, Alexey ^a   Martin, Shelly ^a   Gouvis, Heather ^a   Berkowitz, Steven ^a   Chiang, Gisela ^a   Reff, Mitchell ^a   Glaser, Scott M ^a   Hariharan, Kandasamy ^a   Demarest, Stephen J ^a   more..

^a BIOGEN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-TUMOR ACTIVITIES; BIOPHYSICAL PROPERTIES; CLINICAL EVALUATION; IN-VIVO; INHIBITORY MECHANISM; INSULIN-LIKE GROWTH FACTOR RECEPTORS; LIGAND CONCENTRATION; MOLECULAR TARGETS; MONOCLONAL ANTIBODIES (MABS); NUDE MICE; PHARMACOKINETIC PROFILES; THERMAL STABILITY; TUMOR CELL LINES; TUMOR CELLS; TUMOR GROWTH;

ANTIGENS; CELL CULTURE; INSULIN; LIGANDS; MONOCLONAL ANTIBODIES; PEPTIDES;

TUMORS;

MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY BIIB4; MONOCLONAL ANTIBODY BIIB5; PLACEBO; RITUXIMAB; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY; SINGLE CHAIN FRAGMENT VARIABLE ANTIBODY BIIB4; SOMATOMEDIN C RECEPTOR; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; BISPECIFIC ANTIBODY; IMMUNOGLOBULIN G; LIGAND;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY PRODUCTION; ANTIGEN BINDING; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER IMMUNOTHERAPY; CELL CYCLE PROGRESSION; CELL GROWTH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG INDICATION; DRUG STRUCTURE; DRUG TARGETING; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN STABILITY; RECEPTOR DOWN REGULATION; THERMOSTABILITY; TUMOR; TUMOR CELL; TUMOR XENOGRAFT; ANIMAL; DRUG ANTAGONISM; DRUG SCREENING; DRUG STABILITY; EXPERIMENTAL NEOPLASM; IMMUNOLOGY; METHODOLOGY; NUDE MOUSE; TUMOR CELL LINE;

MUS MUSCULUS;

ANIMALS; ANTIBODIES, BISPECIFIC; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG STABILITY; HUMANS; IMMUNOGLOBULIN G; LIGANDS; MICE; MICE, NUDE; NEOPLASMS, EXPERIMENTAL; PROTEIN STABILITY; RECEPTOR, IGF TYPE 1; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 79953016709     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.184317     Document Type: Article

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