메뉴 건너뛰기




Volumn 279, Issue 1-2, 2003, Pages 219-232

Di-diabody: A novel tetravalent bispecific antibody molecule by design

Author keywords

Angiogenesis; Antibody engineering; CH 3 domain; Diabody; Endothelial cells; KDR Flt 1; Tetravalent bispecific antibody; VEGF VEGFR

Indexed keywords

BISPECIFIC ANTIBODY; TYROSINE KINASE RECEPTOR; VASCULOTROPIN;

EID: 0142061073     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-1759(03)00251-5     Document Type: Article
Times cited : (44)

References (45)
  • 1
    • 0344654890 scopus 로고    scopus 로고
    • Novel tetravalent and bispecific IgG-like antibody molecules combining single-chain diabodies with the immunoglobulin gamma1 Fc or CH3 region
    • Alt M., Muller R., Kontermann R.E. Novel tetravalent and bispecific IgG-like antibody molecules combining single-chain diabodies with the immunoglobulin gamma1 Fc or CH3 region. FEBS Lett. 454:1999;90-94.
    • (1999) FEBS Lett. , vol.454 , pp. 90-94
    • Alt, M.1    Muller, R.2    Kontermann, R.E.3
  • 2
    • 0032212020 scopus 로고    scopus 로고
    • Bispecific antibodies as novel bioconjugates
    • Cao Y., Suresh M.R. Bispecific antibodies as novel bioconjugates. Bioconjug. Chem. 9:1998;635-644.
    • (1998) Bioconjug. Chem. , vol.9 , pp. 635-644
    • Cao, Y.1    Suresh, M.R.2
  • 3
    • 0035251453 scopus 로고    scopus 로고
    • Bispecific human IgG by design
    • Carter P. Bispecific human IgG by design. J. Immunol. Methods. 248:2001;7-15.
    • (2001) J. Immunol. Methods , vol.248 , pp. 7-15
    • Carter, P.1
  • 4
    • 0028786757 scopus 로고
    • Toward the production of bispecific antibody fragments for clinical applications
    • Carter P., Ridgway J., Zhu Z. Toward the production of bispecific antibody fragments for clinical applications. J. Hematotherapy. 4:1995;463-470.
    • (1995) J. Hematotherapy , vol.4 , pp. 463-470
    • Carter, P.1    Ridgway, J.2    Zhu, Z.3
  • 5
    • 0031059402 scopus 로고    scopus 로고
    • Design and production of novel tetravalent bispecific antibodies
    • Coloma M.J., Morrison S.L. Design and production of novel tetravalent bispecific antibodies. Nat. Biotechnol. 15:1997;159-163.
    • (1997) Nat. Biotechnol. , vol.15 , pp. 159-163
    • Coloma, M.J.1    Morrison, S.L.2
  • 6
    • 0030009282 scopus 로고    scopus 로고
    • Leucine zipper dimerized bivalent and bispecific scFv antibodies from a semi-synthetic antibody phage display library
    • De Kruif J., Logtenberg T. Leucine zipper dimerized bivalent and bispecific scFv antibodies from a semi-synthetic antibody phage display library. J. Biol. Chem. 271:1996;7630-7634.
    • (1996) J. Biol. Chem. , vol.271 , pp. 7630-7634
    • De Kruif, J.1    Logtenberg, T.2
  • 7
    • 0028889940 scopus 로고
    • Bifunctional and multimeric complexes of streptavidin fused to single chain antibodies (scFv)
    • Dubel S., Breitling F., Kontermann R., Schmidt T., Skerra A., Little M. Bifunctional and multimeric complexes of streptavidin fused to single chain antibodies (scFv). J. Immunol. Methods. 178:1995;201-209.
    • (1995) J. Immunol. Methods , vol.178 , pp. 201-209
    • Dubel, S.1    Breitling, F.2    Kontermann, R.3    Schmidt, T.4    Skerra, A.5    Little, M.6
  • 8
    • 0032890051 scopus 로고    scopus 로고
    • Vascular endothelial growth factor: Molecular and biological aspects
    • Ferrara N. Vascular endothelial growth factor: molecular and biological aspects. Curr. Top. Microbiol. Immunol. 237:1999;1-30.
    • (1999) Curr. Top. Microbiol. Immunol. , vol.237 , pp. 1-30
    • Ferrara, N.1
  • 9
    • 4444243454 scopus 로고    scopus 로고
    • Determination of molecular masses of proteins in solution: Implementation of HPLC size exclusion chromatography and laser light scattering
    • Folta-Stogniew E., Williams K.R. Determination of molecular masses of proteins in solution: implementation of HPLC size exclusion chromatography and laser light scattering. J. Biomol. Technol. 10:1999;51-63.
    • (1999) J. Biomol. Technol. , vol.10 , pp. 51-63
    • Folta-Stogniew, E.1    Williams, K.R.2
  • 12
    • 0029890636 scopus 로고    scopus 로고
    • Minibody: A novel engineered anti-carcinoembryonic antigen antibody fragment (single-chain Fv-CH3) which exhibits rapid, high-level targeting of xenografts
    • Hu S., Shively L., Raubitschek A., Sherman M., Williams L.E., Wong J.Y., Shively J.E., Wu A.M. Minibody: a novel engineered anti-carcinoembryonic antigen antibody fragment (single-chain Fv-CH3) which exhibits rapid, high-level targeting of xenografts. Cancer Res. 56:1996;3055-3061.
    • (1996) Cancer Res. , vol.56 , pp. 3055-3061
    • Hu, S.1    Shively, L.2    Raubitschek, A.3    Sherman, M.4    Williams, L.E.5    Wong, J.Y.6    Shively, J.E.7    Wu, A.M.8
  • 13
    • 0029877588 scopus 로고    scopus 로고
    • Affinity enhancement of a recombinant antibody: Formation of complexes with multiple valency by a single-chain Fv fragment-core streptavidin fusion
    • Kipriyanov S.M., Little M., Kropshofer H., Breitling F., Gotter S., Dubel S. Affinity enhancement of a recombinant antibody: formation of complexes with multiple valency by a single-chain Fv fragment-core streptavidin fusion. Protein Eng. 9:1996;203-211.
    • (1996) Protein Eng. , vol.9 , pp. 203-211
    • Kipriyanov, S.M.1    Little, M.2    Kropshofer, H.3    Breitling, F.4    Gotter, S.5    Dubel, S.6
  • 14
    • 0030265393 scopus 로고    scopus 로고
    • Vascular endothelial growth factor and its receptors
    • Klagsbrum M., D'Amore P.A. Vascular endothelial growth factor and its receptors. Cytokine Growth Factor Rev. 7:1996;259-270.
    • (1996) Cytokine Growth Factor Rev. , vol.7 , pp. 259-270
    • Klagsbrum, M.1    D'Amore, P.A.2
  • 15
    • 0026567963 scopus 로고
    • Formation of a bispecific antibody by the use of leucine zippers
    • Kostelny S.A., Cole M.S., Tso J.Y. Formation of a bispecific antibody by the use of leucine zippers. J. Immunol. 148:1992;1547-1553.
    • (1992) J. Immunol. , vol.148 , pp. 1547-1553
    • Kostelny, S.A.1    Cole, M.S.2    Tso, J.Y.3
  • 16
    • 0032737901 scopus 로고    scopus 로고
    • Acquired antagonistic activity of a bispecific diabody directed against two different epitopes on vascular endothelial growth factor receptor 2
    • Lu D., Kotanides H., Jimenez J., Zhou Q., Persaud K., Bohlen P., Witte L., Zhu Z. Acquired antagonistic activity of a bispecific diabody directed against two different epitopes on vascular endothelial growth factor receptor 2. J. Immunol. Methods. 230:1999;159-171.
    • (1999) J. Immunol. Methods , vol.230 , pp. 159-171
    • Lu, D.1    Kotanides, H.2    Jimenez, J.3    Zhou, Q.4    Persaud, K.5    Bohlen, P.6    Witte, L.7    Zhu, Z.8
  • 17
    • 0034640422 scopus 로고    scopus 로고
    • Identification of residues in the extracellular region of KDR important for interaction with vascular endothelial growth factor and neutralizing anti-KDR antibodies
    • Lu D., Kussie P., Pytowski B., Persaud K., Bohlen P., Witte L., Zhu Z. Identification of residues in the extracellular region of KDR important for interaction with vascular endothelial growth factor and neutralizing anti-KDR antibodies. J. Biol. Chem. 275:2000;14321-14330.
    • (2000) J. Biol. Chem. , vol.275 , pp. 14321-14330
    • Lu, D.1    Kussie, P.2    Pytowski, B.3    Persaud, K.4    Bohlen, P.5    Witte, L.6    Zhu, Z.7
  • 18
    • 0035476882 scopus 로고    scopus 로고
    • Complete inhibition of vascular endothelial growth factor (VEGF) activities with a bifunctional diabody directed against both VEGF receptors, fms-like tyrosine kinase receptor and kinase insert domain-containing receptor
    • Lu D., Jimenez J., Zhang H., Wu Y., Bohlen P., Witte L., Zhu Z. Complete inhibition of vascular endothelial growth factor (VEGF) activities with a bifunctional diabody directed against both VEGF receptors, fms-like tyrosine kinase receptor and kinase insert domain-containing receptor. Cancer Res. 61:2001;7002-7008.
    • (2001) Cancer Res. , vol.61 , pp. 7002-7008
    • Lu, D.1    Jimenez, J.2    Zhang, H.3    Wu, Y.4    Bohlen, P.5    Witte, L.6    Zhu, Z.7
  • 19
    • 0037106007 scopus 로고    scopus 로고
    • Fab-scFv fusion protein: An efficient approach to production of bispecific antibody fragments
    • Lu D., Jimenez J., Zhang H., Bohlen P., Witte L., Zhu Z. Fab-scFv fusion protein: an efficient approach to production of bispecific antibody fragments. J. Immunol. Methods. 267:2002;213-226.
    • (2002) J. Immunol. Methods , vol.267 , pp. 213-226
    • Lu, D.1    Jimenez, J.2    Zhang, H.3    Bohlen, P.4    Witte, L.5    Zhu, Z.6
  • 21
    • 0029148633 scopus 로고
    • A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity
    • Mack M., Riethmuller G., Kufer P. A small bispecific antibody construct expressed as a functional single-chain molecule with high tumor cell cytotoxicity. Proc. Natl. Acad. Sci. U. S. A. 92:1995;7021-7025.
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 7021-7025
    • Mack, M.1    Riethmuller, G.2    Kufer, P.3
  • 22
    • 0028140247 scopus 로고
    • Construction, expression, and activity of a bivalent bispecific single-chain antibody
    • Mallender W.D., Voss E.W. Jr. Construction, expression, and activity of a bivalent bispecific single-chain antibody. J. Biol. Chem. 269:1994;199-206.
    • (1994) J. Biol. Chem. , vol.269 , pp. 199-206
    • Mallender, W.D.1    Voss E.W., Jr.2
  • 24
    • 0038867807 scopus 로고    scopus 로고
    • A dimeric bispecific miniantibody combines two specificities with avidity
    • Müller K., Arndt K.M., Plückthun A. A dimeric bispecific miniantibody combines two specificities with avidity. FEBS Lett. 432:1998;45-49.
    • (1998) FEBS Lett. , vol.432 , pp. 45-49
    • Müller, K.1    Arndt, K.M.2    Plückthun, A.3
  • 25
    • 0032579437 scopus 로고    scopus 로고
    • The first constant domain [C(H)1 and C(L)] of an antibody used as heterodimerization domain for bispecific miniantibodies
    • Müller K., Arndt K.M., Strittmatter W., Plückthun A. The first constant domain [C(H)1 and C(L)] of an antibody used as heterodimerization domain for bispecific miniantibodies. FEBS Lett. 422:1998;259-264.
    • (1998) FEBS Lett. , vol.422 , pp. 259-264
    • Müller, K.1    Arndt, K.M.2    Strittmatter, W.3    Plückthun, A.4
  • 26
    • 0026528230 scopus 로고
    • Miniantibodies: Use of amphipathic helices to produce functional, flexibly linked dimeric Fv fragments with high avidity in Escherichia coli
    • Pack P., Plückthun A. Miniantibodies: use of amphipathic helices to produce functional, flexibly linked dimeric Fv fragments with high avidity in Escherichia coli. Biochemistry. 31:1992;1579-1584.
    • (1992) Biochemistry , vol.31 , pp. 1579-1584
    • Pack, P.1    Plückthun, A.2
  • 27
    • 0027442660 scopus 로고
    • Improved bivalent minantibodies, with identical avidity as whole antibodies, produced by high cell density fermentation of Escherichia coli
    • Pack P., Kujau M., Schroeckh V., Knupfer U., Wenderoth R., Riesenberg D., Plückthun A. Improved bivalent minantibodies, with identical avidity as whole antibodies, produced by high cell density fermentation of Escherichia coli. Bio/technology. 11:1993;1271-1277.
    • (1993) Bio/technology , vol.11 , pp. 1271-1277
    • Pack, P.1    Kujau, M.2    Schroeckh, V.3    Knupfer, U.4    Wenderoth, R.5    Riesenberg, D.6    Plückthun, A.7
  • 28
    • 0030738617 scopus 로고    scopus 로고
    • New protein engineering approaches to multivalent and bispecific antibody fragments
    • Plückthun A., Pack P. New protein engineering approaches to multivalent and bispecific antibody fragments. Immunotechology. 3:1997;83-105.
    • (1997) Immunotechology , vol.3 , pp. 83-105
    • Plückthun, A.1    Pack, P.2
  • 31
    • 0034671764 scopus 로고    scopus 로고
    • Fab chains as an efficient heterodimerization scaffold for the production of recombinant bispecific and trispecific antibody derivatives
    • Schoonjans R., Willems A., Schoonooghe S., Fiers W., Grooten J., Mertens N. Fab chains as an efficient heterodimerization scaffold for the production of recombinant bispecific and trispecific antibody derivatives. J. Immunol. 165:2000;7050-7057.
    • (2000) J. Immunol. , vol.165 , pp. 7050-7057
    • Schoonjans, R.1    Willems, A.2    Schoonooghe, S.3    Fiers, W.4    Grooten, J.5    Mertens, N.6
  • 33
    • 0022555989 scopus 로고
    • Bispecific monoclonal antibodies from hybrid hybridomas
    • Suresh M.R., Cuello A.C., Milstein C. Bispecific monoclonal antibodies from hybrid hybridomas. Methods Enzymol. 121:1986;210-228.
    • (1986) Methods Enzymol. , vol.121 , pp. 210-228
    • Suresh, M.R.1    Cuello, A.C.2    Milstein, C.3
  • 36
    • 0030783183 scopus 로고    scopus 로고
    • Redirected cellular cytotoxicity employing bispecific antibodies and other multifunctional binding proteins
    • Weiner L.M., Alpaugh R.K., von Mehren M. Redirected cellular cytotoxicity employing bispecific antibodies and other multifunctional binding proteins. Cancer Immunol. Immunother. 45:1997;190-192.
    • (1997) Cancer Immunol. Immunother. , vol.45 , pp. 190-192
    • Weiner, L.M.1    Alpaugh, R.K.2    Von Mehren, M.3
  • 37
    • 0028074723 scopus 로고
    • Multivalent Fvs: Characterization of single-chain Fv oligomers and preparation of a bispecific Fv
    • Whitlow M., Filpula D., Rollence M.L., Feng S.L., Wood J.F. Multivalent Fvs: characterization of single-chain Fv oligomers and preparation of a bispecific Fv. Protein Eng. 7:1994;1017-1026.
    • (1994) Protein Eng. , vol.7 , pp. 1017-1026
    • Whitlow, M.1    Filpula, D.2    Rollence, M.L.3    Feng, S.L.4    Wood, J.F.5
  • 39
    • 0028099697 scopus 로고
    • Tumor localization and therapeutic potential of an antitumor-anti-CD3 heteroconjugate antibody in human renal cell carcinoma xenograft models
    • Zhu Z., Ghose T., Lee S.H.S., Fernandez L.A., Kerr L.A., Donohue J.H., McKean D.J. Tumor localization and therapeutic potential of an antitumor-anti-CD3 heteroconjugate antibody in human renal cell carcinoma xenograft models. Cancer Lett. 86:1994;127-134.
    • (1994) Cancer Lett. , vol.86 , pp. 127-134
    • Zhu, Z.1    Ghose, T.2    Lee, S.H.S.3    Fernandez, L.A.4    Kerr, L.A.5    Donohue, J.H.6    McKean, D.J.7
  • 42
    • 0030909820 scopus 로고    scopus 로고
    • Remodeling domain interfaces to enhance heterodimer formation
    • Zhu Z., Presta L.G., Zapata G., Carter P. Remodeling domain interfaces to enhance heterodimer formation. Protein Sci. 6:1997;781-788.
    • (1997) Protein Sci. , vol.6 , pp. 781-788
    • Zhu, Z.1    Presta, L.G.2    Zapata, G.3    Carter, P.4
  • 43
    • 0032145315 scopus 로고    scopus 로고
    • Inhibition of vascular endothelial growth factor-induced receptor activation with anti-kinase insert domain-containing receptor single chain antibodies from a phage display library
    • Zhu Z., Rockwell P., Lu D., Kotanides H., Pytowski B., Hicklin D.J., Bohlen P., Witte L. Inhibition of vascular endothelial growth factor-induced receptor activation with anti-kinase insert domain-containing receptor single chain antibodies from a phage display library. Cancer Res. 58:1998;3209-3214.
    • (1998) Cancer Res. , vol.58 , pp. 3209-3214
    • Zhu, Z.1    Rockwell, P.2    Lu, D.3    Kotanides, H.4    Pytowski, B.5    Hicklin, D.J.6    Bohlen, P.7    Witte, L.8
  • 44
    • 0036279804 scopus 로고    scopus 로고
    • Clinical development of angiogenesis inhibitors to vascular endothelial growth factor and its receptors as cancer therapeutics
    • Zhu Z., Bohlen P., Witte L. Clinical development of angiogenesis inhibitors to vascular endothelial growth factor and its receptors as cancer therapeutics. Curr. Cancer Drug Targets. 2:2002;135-156.
    • (2002) Curr. Cancer Drug Targets , vol.2 , pp. 135-156
    • Zhu, Z.1    Bohlen, P.2    Witte, L.3
  • 45
    • 0034087954 scopus 로고    scopus 로고
    • An efficient route to the production of an IgG-like bispecific antibody
    • Zhuang Z., Jimenez X., Witte L., Zhu Z. An efficient route to the production of an IgG-like bispecific antibody. Protein Eng. 13:2000;361-367.
    • (2000) Protein Eng. , vol.13 , pp. 361-367
    • Zhuang, Z.1    Jimenez, X.2    Witte, L.3    Zhu, Z.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.