Recombinant polyclonal antibodies: the next generation of antibody therapeutics?

Drug Discovery Today

Volumn 11, Issue 13-14, 2006, Pages 655-660

  Haurum, John S ^a  

^a Symphogen AS   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ABCIXIMAB; ADALIMUMAB; ANTIGEN; BEVACIZUMAB; CANCER ANTIBODY; CETUXIMAB; DIGOXIN; HYPERIMMUNE GLOBULIN; HYPERIMMUNE VACCINIA IMMUNOGLOBULIN; IMMUNOGLOBULIN; INFLIXIMAB; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY CD3; MUROMAB; PALIVIZUMAB; POLYCLONAL ANTIBODY; RECOMBINANT ANTIBODY; RESPIRATORY SYNCYTIAL VIRUS ANTIBODY; RHESUS D ANTIBODY; RITUXIMAB; SYM 002; SYM 003; TETANUS ANTIBODY; THYMOCYTE ANTIBODY; TRASTUZUMAB; UNCLASSIFIED DRUG; VIRUS ANTIBODY;

ALLOIMMUNIZATION; ANTIBODY ENGINEERING; ANTIBODY PRODUCTION; BOTULISM; BREAST CANCER; CANCER; CANCER IMMUNOTHERAPY; CANCER RESISTANCE; COLORECTAL CANCER; CROSS REACTION; DRUG EFFICACY; DRUG INDUSTRY; DRUG MARKETING; DRUG OVERDOSE; DRUG SPECIFICITY; DRUG TARGETING; GRAFT REJECTION; HEMOLYTIC ANEMIA; HISTORY; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; IMMUNE RESPONSE; INFECTION; INFLUENZA; LOWER RESPIRATORY TRACT INFECTION; MUTAGENICITY; NONHODGKIN LYMPHOMA; NONHUMAN; RECOMBINANT DNA TECHNOLOGY; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; REVIEW; RHEUMATOID ARTHRITIS; SNAKEBITE; TETANUS; THROMBOSIS; UNSPECIFIED SIDE EFFECT; VIRUS INFECTION;

ANIMALS; ANTIBODIES; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; EPITOPES; HUMANS; IMMUNOTHERAPY; LYMPHOMA; RECOMBINANT PROTEINS; TECHNOLOGY, PHARMACEUTICAL;

EID: 33745192259     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.drudis.2006.05.009     Document Type: Review

References (32)

1. Gavilondo J.V., and Larrick J.W. Antibody engineering at the millennium. BioTechniques 29 (2000) 128-132, 134-136, 138
2. Casadevall A., and Scharff M.D. Return to the past: the case for antibody-based therapies in infectious diseases. Clin. Infect. Dis. 21 (1995) 150-161
3. Farrugia A., and Poulis P. Intravenous immunoglobulin: regulatory perspectives on use and supply. Transfus. Med. 11 (2001) 63-74
4. Kohler G., and Milstein C. Continuous cultures of fused cells secreting antibody of predefined specificity. Nature 256 (1975) 495-497
5. Das, R.C. and Morrow, K.J. (2004) Antibody therapeutics: product development, market trends and strategic issues. Report 9141, D & MD publications.
6. Cane P.A. Molecular epidemiology of respiratory syncytial virus. Rev. Med. Virol. 11 (2001) 103-116
7. Sullender W.M. Respiratory syncytial virus genetic and antigenic diversity. Clin. Microbiol. Rev. 13 (2000) 1-15
8. Casadevall A., et al. Passive antibody therapy for infectious diseases. Nat. Rev. Microbiol. 2 (2004) 695-703
9. Jerne N.K. Towards a network theory of the immune system. Ann. Immunol. (Paris) 125 (1974) 373-389
10. Snydman D.R. Historical overview of the use of cytomegalovirus hyperimmune globulin in organ transplantation. Transpl. Infect. Dis. 3 Suppl. 2 (2001) 6-13
11. Scaradavou A., et al. Intravenous anti-D treatment of immune thrombocytopenic purpura: experience in 272 patients. Blood 89 (1997) 2689-2700
12. Robson S.C., et al. Anti-D immunoglobulin in RhD prophylaxis. Br. J. Obstet. Gynaecol. 105 (1998) 129-134
13. Wilde H., et al. Heterologous antisera and antivenins are essential biologicals: perspectives on a worldwide crisis. Ann. Intern. Med. 125 (1996) 233-236
14. Kellermann S.A., and Green L.L. Antibody discovery: the use of transgenic mice to generate human monoclonal antibodies for therapeutics. Curr. Opin. Biotechnol. 13 (2002) 593-597
15. Brekke O.H., and Sandlie I. Therapeutic antibodies for human diseases at the dawn of the twenty-first century. Nat. Rev. Drug Discov. 2 (2003) 52-62
16. Clackson T., et al. Making antibody fragments using phage display libraries. Nature 352 (1991) 624-628
17. Marks J.D., et al. By-passing immunization. Human antibodies from V-gene libraries displayed on phage. J. Mol. Biol. 222 (1991) 581-597
18. Lipman N.S., et al. Monoclonal versus polyclonal antibodies: distinguishing characteristics, applications, and information resources. ILAR J. 46 (2005) 258-268
19. Rodkey L.S. Comparative properties of polyclonal and monoclonal antibodies. Methods Mol. Biol. 51 (1995) 139-150
20. Sharon J., et al. Recombinant polyclonal antibodies for cancer therapy. J. Cell. Biochem. 96 (2005) 305-313
21. Haurum J., and Bregenholt S. Recombinant polyclonal antibodies: therapeutic antibody technologies come full circle. IDrugs 8 (2005) 404-409
22. Bregenholt S., and Haurum J. Pathogen-specific recombinant human polyclonal antibodies: biodefence applications. Expert Opin. Biol. Ther. 4 (2004) 387-396
23. Bregenholt S., et al. Recombinant human polyclonal antibodies: a new class of therapeutic antibodies against viral infections. Curr. Pharm. Design 12 (2006) 2007-2015
24. Sarantopoulos S., et al. A method for linking VL and VH region genes that allows bulk transfer between vectors for use in generating polyclonal IgG libraries. J. Immunol. 152 (1994) 5344-5351
25. Chen L., et al. Expression of a prototypic anti-colorectal cancer polyclonal antibody library in mammalian cells. Immunol. Lett. 88 (2003) 135-140
26. Sharon J., et al. Recombinant polyclonal antibodies for cancer therapy. J. Cell. Biochem. 96 (2005) 305-313
27. Liebman M.A., et al. Generation and preliminary characterization of an antibody library with preferential reactivity to human colorectal cancer cells as compared to normal human blood cells. Immunol. Lett. 91 (2004) 179-188
28. Baecher-Allan C.M., et al. Generation of a polyclonal Fab phage display library to the protozoan parasite Cryptosporidium parvum. Comb. Chem. High Throughput Screen. 2 (1999) 319-325
29. Baker M. Upping the ante on antibodies. Nat. Biotechnol. 23 (2005) 1065-1072
30. Reichert J.M., et al. Monoclonal antibody successes in the clinic. Nat. Biotechnol. 23 (2005) 1073-1078
31. Meijier P.J., et al. Isolation of human antibody repertoires with preservation of the natural heavy and light chain pairing. J. Mol. Biol. 358 (2006) 764-772
32. Wiberg F.C., et al. Production of target-specific recombinant human polyclonal antibodies in mammalian cells. Biotechnol. Bioeng. 94 (2006) 396-405