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Volumn 1822, Issue 5, 2012, Pages 657-663

Antioxidants in Down syndrome

Author keywords

Alzheimer disease; Antioxidant; Antioxidant clinical trial; Down syndrome; Mitochondrial disorder; Oxidative stress

Indexed keywords

ALPHA TOCOPHEROL; AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; APOLIPOPROTEIN E4; ASCORBIC ACID; BIOLOGICAL MARKER; COPPER ZINC SUPEROXIDE DISMUTASE; DSCR1 PROTEIN; DYRK1A PROTEIN; F ISOPROSTANE; FOLIC ACID; GELSOLIN; GLUTATHIONE PEROXIDASE; HOMOCYSTEINE; HYDROXYL RADICAL; ISOPROSTANE DERIVATIVE; MITOCHONDRIAL DNA; NITRIC OXIDE; PLACEBO; REACTIVE OXYGEN METABOLITE; THIOCTIC ACID; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ETS 2; UNCLASSIFIED DRUG;

EID: 84858154824     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2011.12.010     Document Type: Review
Times cited : (73)

References (112)
  • 2
    • 80051549592 scopus 로고    scopus 로고
    • Transcript catalogs of human chromosome 21 and orthologous chimpanzee and mouse regions
    • Sturgeon X., Gardiner K.J. Transcript catalogs of human chromosome 21 and orthologous chimpanzee and mouse regions. Mamm. Genome 2011, 22:261-271.
    • (2011) Mamm. Genome , vol.22 , pp. 261-271
    • Sturgeon, X.1    Gardiner, K.J.2
  • 3
    • 5044234361 scopus 로고    scopus 로고
    • Chromosome 21 and down syndrome: from genomics to pathophysiology, nature reviews
    • Antonarakis S.E., Lyle R., Dermitzakis E.T., Reymond A., Deutsch S. Chromosome 21 and down syndrome: from genomics to pathophysiology, nature reviews. Genetics 2004, 5:725-738.
    • (2004) Genetics , vol.5 , pp. 725-738
    • Antonarakis, S.E.1    Lyle, R.2    Dermitzakis, E.T.3    Reymond, A.4    Deutsch, S.5
  • 4
    • 14644396515 scopus 로고    scopus 로고
    • Ets-2 promotes the activation of a mitochondrial death pathway in Down's syndrome neurons
    • Helguera P., Pelsman A., Pigino G., Wolvetang E., Head E., Busciglio J. ets-2 promotes the activation of a mitochondrial death pathway in Down's syndrome neurons. J. Neurosci. 2005, 25:2295-2303.
    • (2005) J. Neurosci. , vol.25 , pp. 2295-2303
    • Helguera, P.1    Pelsman, A.2    Pigino, G.3    Wolvetang, E.4    Head, E.5    Busciglio, J.6
  • 5
    • 27644557511 scopus 로고    scopus 로고
    • Drosophila melanogaster homolog of Down syndrome critical region 1 is critical for mitochondrial function
    • Chang K.T., Min K.T. Drosophila melanogaster homolog of Down syndrome critical region 1 is critical for mitochondrial function. Nat. Neurosci. 2005, 8:1577-1585.
    • (2005) Nat. Neurosci. , vol.8 , pp. 1577-1585
    • Chang, K.T.1    Min, K.T.2
  • 7
    • 80052298841 scopus 로고    scopus 로고
    • The use of mouse models to understand and improve cognitive deficits in Down syndrome
    • Das I., Reeves R.H. The use of mouse models to understand and improve cognitive deficits in Down syndrome. Dis. Models Mech. 2011, 4:596-606.
    • (2011) Dis. Models Mech. , vol.4 , pp. 596-606
    • Das, I.1    Reeves, R.H.2
  • 8
    • 78049400024 scopus 로고    scopus 로고
    • Mouse models of cognitive disabilities in trisomy 21 (Down syndrome), American journal of medical genetics, part C
    • Roubertoux P.L., Carlier M. Mouse models of cognitive disabilities in trisomy 21 (Down syndrome), American journal of medical genetics, part C. Semin. Med. Genet. 2010, 154C:400-416.
    • (2010) Semin. Med. Genet. , vol.154 C , pp. 400-416
    • Roubertoux, P.L.1    Carlier, M.2
  • 9
    • 0037303935 scopus 로고    scopus 로고
    • Traffic at the intersection of neurotrophic factor signaling and neurodegeneration
    • Salehi A., Delcroix J.D., Mobley W.C. Traffic at the intersection of neurotrophic factor signaling and neurodegeneration. Trends Neurosci. 2003, 26:73-80.
    • (2003) Trends Neurosci. , vol.26 , pp. 73-80
    • Salehi, A.1    Delcroix, J.D.2    Mobley, W.C.3
  • 10
    • 4644250821 scopus 로고    scopus 로고
    • Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome
    • Kleschevnikov A.M., Belichenko P.V., Villar A.J., Epstein C.J., Malenka R.C., Mobley W.C. Hippocampal long-term potentiation suppressed by increased inhibition in the Ts65Dn mouse, a genetic model of Down syndrome. J. Neurosci. 2004, 24:8153-8160.
    • (2004) J. Neurosci. , vol.24 , pp. 8153-8160
    • Kleschevnikov, A.M.1    Belichenko, P.V.2    Villar, A.J.3    Epstein, C.J.4    Malenka, R.C.5    Mobley, W.C.6
  • 11
    • 4444336568 scopus 로고    scopus 로고
    • Deficits of neuronal density in CA1 and synaptic density in the dentate gyrus, CA3 and CA1, in a mouse model of Down syndrome
    • Kurt M.A., Kafa M.I., Dierssen M., Davies D.C. Deficits of neuronal density in CA1 and synaptic density in the dentate gyrus, CA3 and CA1, in a mouse model of Down syndrome. Brain Res. 2004, 1022:101-109.
    • (2004) Brain Res. , vol.1022 , pp. 101-109
    • Kurt, M.A.1    Kafa, M.I.2    Dierssen, M.3    Davies, D.C.4
  • 12
    • 19544393555 scopus 로고    scopus 로고
    • Deficits in hippocampal CA1 LTP induced by TBS but not HFS in the Ts65Dn mouse: a model of Down syndrome
    • Costa A.C., Grybko M.J. Deficits in hippocampal CA1 LTP induced by TBS but not HFS in the Ts65Dn mouse: a model of Down syndrome. Neurosci. Lett. 2005, 382:317-322.
    • (2005) Neurosci. Lett. , vol.382 , pp. 317-322
    • Costa, A.C.1    Grybko, M.J.2
  • 13
    • 0035825304 scopus 로고    scopus 로고
    • Ts65Dn mice, a model for Down syndrome, have deficits in context discrimination learning suggesting impaired hippocampal function
    • Hyde L.A., Frisone D.F., Crnic L.S. Ts65Dn mice, a model for Down syndrome, have deficits in context discrimination learning suggesting impaired hippocampal function. Behav. Brain Res. 2001, 118:53-60.
    • (2001) Behav. Brain Res. , vol.118 , pp. 53-60
    • Hyde, L.A.1    Frisone, D.F.2    Crnic, L.S.3
  • 14
    • 67651124806 scopus 로고    scopus 로고
    • Molecular genetic analysis of Down syndrome
    • Patterson D. Molecular genetic analysis of Down syndrome. Hum. Genet. 2009, 126:195-214.
    • (2009) Hum. Genet. , vol.126 , pp. 195-214
    • Patterson, D.1
  • 17
    • 79956146841 scopus 로고    scopus 로고
    • Alpha-Tocopherol suppresses lipid peroxidation and behavioral and cognitive impairments in the Ts65Dn mouse model of Down syndrome
    • Shichiri M., Yoshida Y., Ishida N., Hagihara Y., Iwahashi H., Tamai H., Niki E. alpha-Tocopherol suppresses lipid peroxidation and behavioral and cognitive impairments in the Ts65Dn mouse model of Down syndrome. Free Radic. Biol. Med. 2011, 50:1801-1811.
    • (2011) Free Radic. Biol. Med. , vol.50 , pp. 1801-1811
    • Shichiri, M.1    Yoshida, Y.2    Ishida, N.3    Hagihara, Y.4    Iwahashi, H.5    Tamai, H.6    Niki, E.7
  • 19
    • 39149135216 scopus 로고    scopus 로고
    • Effects of chronic administration of SGS-111 during adulthood and during the pre- and post-natal periods on the cognitive deficits of Ts65Dn mice, a model of Down syndrome
    • Rueda N., Florez J., Martinez-Cue C. Effects of chronic administration of SGS-111 during adulthood and during the pre- and post-natal periods on the cognitive deficits of Ts65Dn mice, a model of Down syndrome. Behav. Brain Res. 2008, 188:355-367.
    • (2008) Behav. Brain Res. , vol.188 , pp. 355-367
    • Rueda, N.1    Florez, J.2    Martinez-Cue, C.3
  • 20
    • 0024503377 scopus 로고
    • The pattern of acquisition of plaques and tangles in the brains of patients under 50years of age with Down's syndrome
    • Mann D.M., Esiri M.M. The pattern of acquisition of plaques and tangles in the brains of patients under 50years of age with Down's syndrome. J. Neurol. Sci. 1989, 89:169-179.
    • (1989) J. Neurol. Sci. , vol.89 , pp. 169-179
    • Mann, D.M.1    Esiri, M.M.2
  • 21
    • 11444269588 scopus 로고    scopus 로고
    • Alzheimer disease and Down syndrome: factors in pathogenesis
    • Lott I.T., Head E. Alzheimer disease and Down syndrome: factors in pathogenesis. Neurobiol. Aging 2005, 26:383-389.
    • (2005) Neurobiol. Aging , vol.26 , pp. 383-389
    • Lott, I.T.1    Head, E.2
  • 22
    • 0021956826 scopus 로고
    • Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome
    • Wisniewski K.E., Wisniewski H.M., Wen G.Y. Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Ann. Neurol. 1985, 17:278-282.
    • (1985) Ann. Neurol. , vol.17 , pp. 278-282
    • Wisniewski, K.E.1    Wisniewski, H.M.2    Wen, G.Y.3
  • 23
    • 0023880939 scopus 로고
    • Down's syndrome: a pathology involving the lack of balance of reactive oxygen species
    • Kedziora J., Bartosz G. Down's syndrome: a pathology involving the lack of balance of reactive oxygen species. Free Radic. Biol. Med. 1988, 4:317-330.
    • (1988) Free Radic. Biol. Med. , vol.4 , pp. 317-330
    • Kedziora, J.1    Bartosz, G.2
  • 27
    • 0021940314 scopus 로고
    • Altered composition of polyunsaturated fatty acyl groups in phosphoglycerides of Down's syndrome fetal brain
    • Brooksbank B.W., Martinez M., Balazs R. Altered composition of polyunsaturated fatty acyl groups in phosphoglycerides of Down's syndrome fetal brain. J. Neurochem. 1985, 44:869-874.
    • (1985) J. Neurochem. , vol.44 , pp. 869-874
    • Brooksbank, B.W.1    Martinez, M.2    Balazs, R.3
  • 29
    • 0029417023 scopus 로고
    • Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro
    • Busciglio J., Yankner B.A. Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature 1995, 378:776-779.
    • (1995) Nature , vol.378 , pp. 776-779
    • Busciglio, J.1    Yankner, B.A.2
  • 31
    • 0028152717 scopus 로고
    • Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease
    • Mecocci P., MacGarvey U., Beal M.F. Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease. Ann. Neurol. 1994, 36:747-751.
    • (1994) Ann. Neurol. , vol.36 , pp. 747-751
    • Mecocci, P.1    MacGarvey, U.2    Beal, M.F.3
  • 34
    • 77952537062 scopus 로고    scopus 로고
    • Superoxide anion, uncoupling proteins and Alzheimer's disease
    • Wu Z., Zhao Y., Zhao B. Superoxide anion, uncoupling proteins and Alzheimer's disease. J. Clin. Biochem. Nutr. 2010, 46:187-194.
    • (2010) J. Clin. Biochem. Nutr. , vol.46 , pp. 187-194
    • Wu, Z.1    Zhao, Y.2    Zhao, B.3
  • 35
    • 77954979874 scopus 로고    scopus 로고
    • The mitochondrial secret(ase) of Alzheimer's disease
    • Young K.J., Bennett J.P. The mitochondrial secret(ase) of Alzheimer's disease. J. Alzheimer's Dis. 2010, 20(Suppl 2):S381-S400.
    • (2010) J. Alzheimer's Dis. , vol.20 , Issue.SUPPL. 2
    • Young, K.J.1    Bennett, J.P.2
  • 38
    • 0018873524 scopus 로고
    • Active oxygen species and the functions of phagocytic leukocytes
    • Badwey J.A., Karnovsky M.L. Active oxygen species and the functions of phagocytic leukocytes. Annu. Rev. Biochem. 1980, 49:695-726.
    • (1980) Annu. Rev. Biochem. , vol.49 , pp. 695-726
    • Badwey, J.A.1    Karnovsky, M.L.2
  • 39
    • 75149126136 scopus 로고    scopus 로고
    • Neutrophil oxidative metabolism in Down syndrome patients with congenital heart defects
    • Akinci O., Mihci E., Tacoy S., Kardelen F., Keser I., Aslan M. Neutrophil oxidative metabolism in Down syndrome patients with congenital heart defects. Environ. Mol. Mutagen. 2010, 51:57-63.
    • (2010) Environ. Mol. Mutagen. , vol.51 , pp. 57-63
    • Akinci, O.1    Mihci, E.2    Tacoy, S.3    Kardelen, F.4    Keser, I.5    Aslan, M.6
  • 42
    • 57049106701 scopus 로고    scopus 로고
    • Differential MRI patterns of brain atrophy in double or single transgenic mice for APP and/or SOD
    • Borg J., Chereul E. Differential MRI patterns of brain atrophy in double or single transgenic mice for APP and/or SOD. J. Neurosci. Res. 2008, 86:3275-3284.
    • (2008) J. Neurosci. Res. , vol.86 , pp. 3275-3284
    • Borg, J.1    Chereul, E.2
  • 44
    • 0027458366 scopus 로고
    • The Ets family of transcription factors
    • FEBS
    • Wasylyk B., Hahn S.L., Giovane A. The Ets family of transcription factors. Eur. J. Biochem. 1993, 211:7-18. FEBS.
    • (1993) Eur. J. Biochem. , vol.211 , pp. 7-18
    • Wasylyk, B.1    Hahn, S.L.2    Giovane, A.3
  • 45
    • 79956087421 scopus 로고    scopus 로고
    • Increased survival following tumorigenesis in Ts65Dn mice that model Down syndrome
    • Yang A., Reeves R.H. Increased survival following tumorigenesis in Ts65Dn mice that model Down syndrome. Cancer Res. 2011, 71:3573-3581.
    • (2011) Cancer Res. , vol.71 , pp. 3573-3581
    • Yang, A.1    Reeves, R.H.2
  • 52
    • 0031172775 scopus 로고    scopus 로고
    • Hamster adapt78 mRNA is a Down syndrome critical region homologue that is inducible by oxidative stress
    • Crawford D.R., Leahy K.P., Abramova N., Lan L., Wang Y., Davies K.J. Hamster adapt78 mRNA is a Down syndrome critical region homologue that is inducible by oxidative stress. Arch. Biochem. Biophys. 1997, 342:6-12.
    • (1997) Arch. Biochem. Biophys. , vol.342 , pp. 6-12
    • Crawford, D.R.1    Leahy, K.P.2    Abramova, N.3    Lan, L.4    Wang, Y.5    Davies, K.J.6
  • 54
    • 29144484163 scopus 로고    scopus 로고
    • Multiple roles of the DSCR1 (Adapt78 or RCAN1) gene and its protein product calcipressin 1 (or RCAN1) in disease, cellular and molecular life sciences
    • Harris C.D., Ermak G., Davies K.J. Multiple roles of the DSCR1 (Adapt78 or RCAN1) gene and its protein product calcipressin 1 (or RCAN1) in disease, cellular and molecular life sciences. CMLS 2005, 62:2477-2486.
    • (2005) CMLS , vol.62 , pp. 2477-2486
    • Harris, C.D.1    Ermak, G.2    Davies, K.J.3
  • 57
    • 70349758084 scopus 로고    scopus 로고
    • Age-associated motor and visuo-spatial learning phenotype in Dyrk1A heterozygous mutant mice
    • Arque G., de Lagran M.M., Arbones M.L., Dierssen M. Age-associated motor and visuo-spatial learning phenotype in Dyrk1A heterozygous mutant mice. Neurobiol. Dis. 2009, 36:312-319.
    • (2009) Neurobiol. Dis. , vol.36 , pp. 312-319
    • Arque, G.1    de Lagran, M.M.2    Arbones, M.L.3    Dierssen, M.4
  • 61
    • 78650213615 scopus 로고    scopus 로고
    • Association of variants within APOE, SORL1, RUNX1, BACE1 and ALDH18A1 with dementia in Alzheimer's disease in subjects with Down syndrome
    • Patel A., Rees S.D., Kelly M.A., Bain S.C., Barnett A.H., Thalitaya D., Prasher V.P. Association of variants within APOE, SORL1, RUNX1, BACE1 and ALDH18A1 with dementia in Alzheimer's disease in subjects with Down syndrome. Neurosci. Lett. 2011, 487:144-148.
    • (2011) Neurosci. Lett. , vol.487 , pp. 144-148
    • Patel, A.1    Rees, S.D.2    Kelly, M.A.3    Bain, S.C.4    Barnett, A.H.5    Thalitaya, D.6    Prasher, V.P.7
  • 62
    • 29444436680 scopus 로고    scopus 로고
    • Huang, lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity
    • Chang S., ran Ma T., Miranda R.D., Balestra M.E., Mahley R.W. Huang, lipid- and receptor-binding regions of apolipoprotein E4 fragments act in concert to cause mitochondrial dysfunction and neurotoxicity. Proc. Natl. Acad. Sci. U. S. A. 2005, 102:18694-18699.
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 18694-18699
    • Chang, S.1    ran Ma, T.2    Miranda, R.D.3    Balestra, M.E.4    Mahley, R.W.5
  • 64
    • 0025024024 scopus 로고
    • Cytochrome oxidase deficiency in Alzheimer's disease
    • Parker W.D., Filley C.M., Parks J.K. Cytochrome oxidase deficiency in Alzheimer's disease. Neurology 1990, 40:1302-1303.
    • (1990) Neurology , vol.40 , pp. 1302-1303
    • Parker, W.D.1    Filley, C.M.2    Parks, J.K.3
  • 66
    • 57649194935 scopus 로고    scopus 로고
    • Oxidant-induced changes in mitochondria and calcium dynamics in the pathophysiology of Alzheimer's disease
    • Gibson G.E., Karuppagounder S.S., Shi Q. Oxidant-induced changes in mitochondria and calcium dynamics in the pathophysiology of Alzheimer's disease. Ann. N. Y. Acad. Sci. 2008, 1147:221-232.
    • (2008) Ann. N. Y. Acad. Sci. , vol.1147 , pp. 221-232
    • Gibson, G.E.1    Karuppagounder, S.S.2    Shi, Q.3
  • 69
    • 0032401643 scopus 로고    scopus 로고
    • Biomarkers of oxidative stress are significantly elevated in Down syndrome
    • Jovanovic S.V., Clements D., MacLeod K. Biomarkers of oxidative stress are significantly elevated in Down syndrome. Free Radic. Biol. Med. 1998, 25:1044-1048.
    • (1998) Free Radic. Biol. Med. , vol.25 , pp. 1044-1048
    • Jovanovic, S.V.1    Clements, D.2    MacLeod, K.3
  • 72
    • 79954497176 scopus 로고    scopus 로고
    • Deficit of complex I activity in human skin fibroblasts with chromosome 21 trisomy and overproduction of reactive oxygen species by mitochondria: involvement of the cAMP/PKA signalling pathway
    • Valenti D., Manente G.A., Moro L., Marra E., Vacca R.A. Deficit of complex I activity in human skin fibroblasts with chromosome 21 trisomy and overproduction of reactive oxygen species by mitochondria: involvement of the cAMP/PKA signalling pathway. Biochem. J. 2011, 435:679-688.
    • (2011) Biochem. J. , vol.435 , pp. 679-688
    • Valenti, D.1    Manente, G.A.2    Moro, L.3    Marra, E.4    Vacca, R.A.5
  • 74
    • 79851512298 scopus 로고    scopus 로고
    • Impairment of methyl cycle affects mitochondrial methyl availability and glutathione level in Down's syndrome
    • Infantino V., Castegna A., Iacobazzi F., Spera I., Scala I., Andria G., Iacobazzi V. Impairment of methyl cycle affects mitochondrial methyl availability and glutathione level in Down's syndrome. Mol. Genet. Metab. 2011, 102:378-382.
    • (2011) Mol. Genet. Metab. , vol.102 , pp. 378-382
    • Infantino, V.1    Castegna, A.2    Iacobazzi, F.3    Spera, I.4    Scala, I.5    Andria, G.6    Iacobazzi, V.7
  • 75
    • 80053467489 scopus 로고    scopus 로고
    • Oxidative stress induced mitochondrial DNA deletion as a hallmark for the drug development in the context of the cerebrovascular diseases
    • Aliev G., Li Y., Palacios H.H., Obrenovich M.E. Oxidative stress induced mitochondrial DNA deletion as a hallmark for the drug development in the context of the cerebrovascular diseases. Recent patents on cardiovascular drug discovery 2011, 6:222-241.
    • (2011) Recent patents on cardiovascular drug discovery , vol.6 , pp. 222-241
    • Aliev, G.1    Li, Y.2    Palacios, H.H.3    Obrenovich, M.E.4
  • 77
    • 74249096152 scopus 로고    scopus 로고
    • Urinary uric acid and antioxidant capacity in children and adults with Down syndrome
    • Campos C., Guzman R., Lopez-Fernandez E., Casado A. Urinary uric acid and antioxidant capacity in children and adults with Down syndrome. Clin. Biochem. 2010, 43:228-233.
    • (2010) Clin. Biochem. , vol.43 , pp. 228-233
    • Campos, C.1    Guzman, R.2    Lopez-Fernandez, E.3    Casado, A.4
  • 82
    • 78650817812 scopus 로고    scopus 로고
    • Relationship between proteolytically cleaved gelsolin and levels of amyloid-beta protein in the brains of Down syndrome subjects
    • Ji L., Chauhan V., Mehta P., Wegiel J., Mehta S., Chauhan A. Relationship between proteolytically cleaved gelsolin and levels of amyloid-beta protein in the brains of Down syndrome subjects. J. Alzheimer's Dis. 2010, 22:609-617.
    • (2010) J. Alzheimer's Dis. , vol.22 , pp. 609-617
    • Ji, L.1    Chauhan, V.2    Mehta, P.3    Wegiel, J.4    Mehta, S.5    Chauhan, A.6
  • 86
    • 77951666984 scopus 로고    scopus 로고
    • Plasma levels of nitric oxide related amino acids in demented subjects with Down syndrome are related to neopterin concentrations
    • Coppus A.M., Fekkes D., Verhoeven W.M., Tuinier S., van Duijn C.M. Plasma levels of nitric oxide related amino acids in demented subjects with Down syndrome are related to neopterin concentrations. Amino acids 2010, 38:923-928.
    • (2010) Amino acids , vol.38 , pp. 923-928
    • Coppus, A.M.1    Fekkes, D.2    Verhoeven, W.M.3    Tuinier, S.4    van Duijn, C.M.5
  • 88
    • 77951689435 scopus 로고    scopus 로고
    • Biomarkers of oxidative damage and inflammation in Alzheimer's disease
    • Galasko D., Montine T.J. Biomarkers of oxidative damage and inflammation in Alzheimer's disease. Biomarkers Med. 2010, 4:27-36.
    • (2010) Biomarkers Med. , vol.4 , pp. 27-36
    • Galasko, D.1    Montine, T.J.2
  • 90
    • 79551538975 scopus 로고    scopus 로고
    • Revisiting dietary antioxidants, neurodegeneration and dementia
    • Craggs L., Kalaria R.N. Revisiting dietary antioxidants, neurodegeneration and dementia. NeuroReport 2011, 22:1-3.
    • (2011) NeuroReport , vol.22 , pp. 1-3
    • Craggs, L.1    Kalaria, R.N.2
  • 92
    • 0037178579 scopus 로고    scopus 로고
    • Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study
    • Morris M.C., Evans D.A., Bienias J.L., Tangney C.C., Bennett D.A., Aggarwal N., Wilson R.S., Scherr P.A. Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study. JAMA 2002, 287:3230-3237.
    • (2002) JAMA , vol.287 , pp. 3230-3237
    • Morris, M.C.1    Evans, D.A.2    Bienias, J.L.3    Tangney, C.C.4    Bennett, D.A.5    Aggarwal, N.6    Wilson, R.S.7    Scherr, P.A.8
  • 94
    • 0037320324 scopus 로고    scopus 로고
    • Antioxidant vitamin intake and risk of Alzheimer disease
    • Luchsinger J.A., Tang M.X., Shea S., Mayeux R. Antioxidant vitamin intake and risk of Alzheimer disease. Arch. Neurol. 2003, 60:203-208.
    • (2003) Arch. Neurol. , vol.60 , pp. 203-208
    • Luchsinger, J.A.1    Tang, M.X.2    Shea, S.3    Mayeux, R.4
  • 95
    • 2342608923 scopus 로고    scopus 로고
    • Midlife dietary intake of antioxidants and risk of late-life incident dementia: the Honolulu-Asia Aging Study
    • Laurin D., Masaki K.H., Foley D.J., White L.R., Launer L.J. Midlife dietary intake of antioxidants and risk of late-life incident dementia: the Honolulu-Asia Aging Study. Am. J. Epidemiol. 2004, 159:959-967.
    • (2004) Am. J. Epidemiol. , vol.159 , pp. 959-967
    • Laurin, D.1    Masaki, K.H.2    Foley, D.J.3    White, L.R.4    Launer, L.J.5
  • 97
    • 33845533439 scopus 로고    scopus 로고
    • Mediterranean diet, Alzheimer disease, and vascular mediation
    • Scarmeas N., Stern Y., Mayeux R., Luchsinger J.A. Mediterranean diet, Alzheimer disease, and vascular mediation. Arch. Neurol. 2006, 63:1709-1717.
    • (2006) Arch. Neurol. , vol.63 , pp. 1709-1717
    • Scarmeas, N.1    Stern, Y.2    Mayeux, R.3    Luchsinger, J.A.4
  • 98
    • 58149380028 scopus 로고    scopus 로고
    • The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches
    • Cotman C.W., Head E. The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches. J. Alzheimer's Dis. 2008, 15:685-707.
    • (2008) J. Alzheimer's Dis. , vol.15 , pp. 685-707
    • Cotman, C.W.1    Head, E.2
  • 100
    • 78650179591 scopus 로고    scopus 로고
    • Cloning, sequencing and expression in the dog of the main amyloid precursor protein isoforms and some of the enzymes related with their processing
    • Sarasa L., Gallego C., Monleon I., Olvera A., Canudas J., Montanes M., Pesini P., Sarasa M. Cloning, sequencing and expression in the dog of the main amyloid precursor protein isoforms and some of the enzymes related with their processing. Neuroscience 2010, 171:1091-1101.
    • (2010) Neuroscience , vol.171 , pp. 1091-1101
    • Sarasa, L.1    Gallego, C.2    Monleon, I.3    Olvera, A.4    Canudas, J.5    Montanes, M.6    Pesini, P.7    Sarasa, M.8
  • 102
    • 70349736400 scopus 로고    scopus 로고
    • Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging
    • Head E., Nukala V.N., Fenoglio K.A., Muggenburg B.A., Cotman C.W., Sullivan P.G. Effects of age, dietary, and behavioral enrichment on brain mitochondria in a canine model of human aging. Exp. Neurol. 2009, 220:171-176.
    • (2009) Exp. Neurol. , vol.220 , pp. 171-176
    • Head, E.1    Nukala, V.N.2    Fenoglio, K.A.3    Muggenburg, B.A.4    Cotman, C.W.5    Sullivan, P.G.6
  • 103
    • 0036751980 scopus 로고    scopus 로고
    • Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction
    • Cotman C.W., Head E., Muggenburg B.A., Zicker S., Milgram N.W. Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction. Neurobiol. Aging 2002, 23:809-818.
    • (2002) Neurobiol. Aging , vol.23 , pp. 809-818
    • Cotman, C.W.1    Head, E.2    Muggenburg, B.A.3    Zicker, S.4    Milgram, N.W.5
  • 105
    • 79960555491 scopus 로고    scopus 로고
    • Down syndrome and dementia: a randomized, controlled trial of antioxidant supplementation, part A
    • Lott I.T., Doran E., Nguyen V.Q., Tournay A., Head E., Gillen D.L. Down syndrome and dementia: a randomized, controlled trial of antioxidant supplementation, part A. Am. J. Med. Genet. 2011, 155A:1939-1948.
    • (2011) Am. J. Med. Genet. , vol.155 A , pp. 1939-1948
    • Lott, I.T.1    Doran, E.2    Nguyen, V.Q.3    Tournay, A.4    Head, E.5    Gillen, D.L.6
  • 107
    • 77951295329 scopus 로고    scopus 로고
    • Exercise and time-dependent benefits to learning and memory
    • Berchtold N.C., Castello N., Cotman C.W. Exercise and time-dependent benefits to learning and memory. Neuroscience 2010, 167:588-597.
    • (2010) Neuroscience , vol.167 , pp. 588-597
    • Berchtold, N.C.1    Castello, N.2    Cotman, C.W.3
  • 108
    • 79955840459 scopus 로고    scopus 로고
    • Applicability and effects of physical exercise on physical and cognitive functions and activities of daily living among people with dementia: a systematic review
    • Littbrand H., Stenvall M., Rosendahl E. Applicability and effects of physical exercise on physical and cognitive functions and activities of daily living among people with dementia: a systematic review. Am. J. Phys. Med. Rehabil. / Assoc. Acad. Phyciatrists 2011, 90:495-518.
    • (2011) Am. J. Phys. Med. Rehabil. / Assoc. Acad. Phyciatrists , vol.90 , pp. 495-518
    • Littbrand, H.1    Stenvall, M.2    Rosendahl, E.3
  • 112
    • 77957983169 scopus 로고    scopus 로고
    • Alzheimer's disease: the pros and cons of pharmaceutical, nutritional, botanical, and stimulatory therapies, with a discussion of treatment strategies from the perspective of patients and practitioners
    • Wollen K.A. Alzheimer's disease: the pros and cons of pharmaceutical, nutritional, botanical, and stimulatory therapies, with a discussion of treatment strategies from the perspective of patients and practitioners. Altern. Med. Rev. 2010, 15:223-244.
    • (2010) Altern. Med. Rev. , vol.15 , pp. 223-244
    • Wollen, K.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.