S100B and APP promote a gliocentric shift and impaired neurogenesis in down syndrome neural progenitors

PLoS ONE

Volumn 6, Issue 7, 2011, Pages

  Lu, Jie ^a   Esposito, Giuseppe ^b   Scuderi, Caterina ^b   Steardo, Luca ^b   Delli Bovi, Laurent C ^c   Hecht, Jonathan L ^a   Dickinson, Bryan C ^d   Chang, Christopher J ^d   Mori, Takashi ^e   Sheen, Volney ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT; AMYLOID PRECURSOR PROTEIN; HYDROGEN PEROXIDE; PROTEIN S100B; NERVE GROWTH FACTOR; PROTEIN S 100; S 100 CALCIUM BINDING PROTEIN BETA SUBUNIT; S-100 CALCIUM-BINDING PROTEIN BETA SUBUNIT;

ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN REGION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DOWN SYNDROME; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FRONTAL CORTEX; HUMAN; HUMAN TISSUE; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOLECULAR DYNAMICS; MOUSE; NERVE CELL LESION; NERVE CELL NECROSIS; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN SYNTHESIS; UPREGULATION; WESTERN BLOTTING; ANIMAL; CELL CULTURE; CYTOLOGY; GENETICS; IN VITRO STUDY; METABOLISM; NERVE CELL; NICK END LABELING; PHYSIOLOGY; STEM CELL; TRANSGENIC MOUSE;

AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELLS, CULTURED; DOWN SYNDROME; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IN SITU NICK-END LABELING; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, TRANSGENIC; NERVE GROWTH FACTORS; NEUROGENESIS; NEURONS; OXIDATIVE STRESS; S100 PROTEINS; STEM CELLS;

EID: 79960142173     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0022126     Document Type: Article

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