DSCR1(Adapt78) modulates expression of SOD1

FASEB Journal

Volumn 18, Issue 1, 2004, Pages 62-69

  Ermak, Gennady ^a   Cheadle, Chris ^b   Becker, Kevin G ^b   Harris, Cathryn D ^a   Davies, Kelvin J A ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Calcipressin 1; Down's syndrome; Oxidative stress; Sod 1

Indexed keywords

COPPER ZINC SUPEROXIDE DISMUTASE; MESSENGER RNA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE DSCR1; GENE EXPRESSION; GENE EXPRESSION REGULATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; TRANSGENE;

ANIMALS; DOWN-REGULATION; ENZYME INDUCTION; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MUSCLE PROTEINS; PC12 CELLS; RATS; RNA, MESSENGER; SUPEROXIDE DISMUTASE;

ANIMALIA;

EID: 0347915659     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.03-0451com     Document Type: Article

References (43)

1. Crawford, D. R., Leahy, K. P., Abramova, N., Lan, L., Wang, Y., and Davies, K. J. (1997) Hamster adapt78 mRNA is a Down syndrome critical region homologue that is inducible by oxidative stress. Arch. Biochem. Biophys. 342, 6-12
2. Fuentes, J. J., Pritchard, M. A., and Estivill, X. (1997) Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene. Genomics 44, 358-361
3. Fuentes, J. J., Genesca, I., Kingsbury, T. J., Cunningham, K. W., Perez-Riba, M., Estivill, X., and de la Luna, S. (2000) DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. Hum. Mol. Genet. 9, 1681-1690
4. Rothermel, B., Vega, R. B., Yang, J., Wu, H., Bassel-Duby, R., and Williams, R. S. (2000) A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. J. Biol. Chem. 275, 8719-8725
5. Liu, J., Farmer, J. D., Jr., Lane, W. S., Friedman, J., Weissman, I., and Schreiber, S. L. (1991) Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66, 807-815
6. Clipstone, N. A., and Crabtree, G. R. (1992) Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature 357, 695-697
7. Cunningham, K. W., and Fink, G. R. (1994) Calcineurin-dependent growth control in Sccharomyces cerevisiae mutants lacking PMC1, a homolog of plasma membrane Ca2+ ATPases. J. Cell Biol. 124, 351-363
8. Matheos, D. P., Kingsbury, T. J., Ahsan, U. S., and Cunningham, K. W. (1997) Tcn1p/Crz1p, a calcineurin-dependent transcription factor that differentially regulates gene expression in Saccharomyces cerevisiae. Genes Dev 11, 3445-3458
9. Stathopoulos-Gerontides, A., Guo, J. J., and Cyert, M. S. (1999) Yeast calcineurin regulates nuclear localization of the Crz1p transcription factor through dephosphorylation. Genes Dev 13, 798-803
10. Krebs, J. (1998) The role of calcimn in apoptosis. Biometals 11, 375-382
11. Asai, A., Qiu, J., Narita, Y., Chi, S., Saito, N., Shinoura, N., Hamada, H., Kuchino, Y., and Kirino, T. (1999) High level calcineurin activity predisposes neuronal cells to apoptosis. J. Biol. Chem. 274, 34450-34458
12. Honig, L. S., and Rosenberg, R. N. (2000) Apoptosis and neurologic disease. Am. J. Med. 108, 317-330
13. Kayyali, U. S., Zhang, W., Yee, A. G., Seidman, J. G., and Potter, H. (1997) Cytoskeletal changes in the brains of mice lacking calcineurin A alpha. J. Neurochem. 68, 1668-1678
14. Zhuo, M., Zhang, W., Son, H., Mansuy, I., Sobel, R. A., Seidman, J., and Kandel, E. R. (1999) A selective role of calcineurin aalpha in synaptic depotentiation in hippocampus. Proc. Natl. Acad. Sci. USA. 96, 4650-4655
15. Mansuy, I. M., Mayford, M., Jacob, B., Kandel, E. R., and Bach, M. E. (1998) Restricted and regulated overexpression reveals calcineurin as a key component in the transition from short-term to long-term memory. Cell 92, 39-49
16. Winder, D. G., Mansuy, I. M., Osman, M., Moallem, T. M., and Kandel, E. R. (1998) Genetic and pharmacological evidence for a novel, intermediate phase of long-term potentiation suppressed by calcineurin. Cell 92, 25-37
17. Chin, E. R., Olson, E. N., Richardson, J. A., Yang, Q., Humphries, C., Shelton, J. M., Wu, H., Zhu, W., Bassel-Duby, R., and Williams, R. S. (1998) A calcineurin-dependent transcriptional pathway cotrols skeletal muscle fiber type. Genes Dev 12, 2499-2509
18. Hughes, S. M. (1998) Muscle development: electrical control of gene expression. Curr. Biol. 8, R892-R894
19. Pardo, J. M., Reddy, M. P., Yang, S., Maggio, A., Huh, G. H., Matsumoto, T., Coca, M. A., Paino-D'Urzo, M., Koiwa, H., Yun, D. J., et al. (1998) Stress signaling through Ca2+/calmodulin-dependent protein phosphatase calcineurin mediates salt adaptation in plants. Proc. Natl. Acad. Sci. USA. 95, 9681-9686
20. Ermak, G., and Davies, K. J. (2002) Calcium and oxidative stress: from cell signaling to cell death. Mol. Immunol. 38, 713-721
21. Yang, J., Rothermel, B., Vega, R. B., Frey, N., McKinsey, T. A., Olson, E, N., Bassel-Duby, R., and Williams, R. S. (2000) Independent signals control expression of the calcineurin inhibitory proteins MCIP1 and MCIP2 in striated muscles. Circ. Res. 87, E61-E68
22. Ermak, G., and Davies, K. J. (2002) Gene expression in Alzheimer's disease. Drugs Today (Barc) 38, 509-516
23. Ermak, G., Harris, C. D., and Davies, K. J. (2002) The DSCRI (Adapt78) isoform 1 protein calcipressin 1 inhibits calcineurin and protects against acute calcium-mediated stress damage, including transient oxidative stress. FASEB J. 16, 814-824
24. Ermak, G., Morgan, T. E., and Davies, K. J. (2001) Chronic overexpression of the calcineurin inhibitory gene DSCR1 (Adapt78) is associated with Alzheimer's disease. J. Biol. Chem. 276, 38787-38794
25. Mayne, M., Cheadle, C., Soldan, S. S., Cermelli, C., Yamano, Y., Akhyani, N., Nagel, J. E., Taub, D. D., Becker, K. G., and Jacobson, S. (2001) Gene expression profile of herpesvirus-infected T cells obtained using immunomicroarrays: induction of proinflammatory mechanisms. J. Virol. 75, 11641-11660
26. Barrett, T., Cheadle, C., Wood, W. B., Teichberg, D., Donovan, D. M., Freed, W. J., Becker, K. G., and Vawter, M. P. (2001) Assembly and use of a broadly applicable neural cDNA microarray. Restor. Neurol. Neurosci. 18, 127-135
27. Vawter, M. P., Barrett, T., Cheadle, C., Sokolov, B. P., Wood, W. H., III, Donovan, D. M., Webster, M., Freed, W. J., and Becker, K. G. (2001) Application of cDNA microarrays to examine gene expression differences in schizophrenia. Brain Res. Bull. 55, 641-650
28. Cheadle, C., Vawter, M. P., Freed, W. J., and Becker, K. G. (2003) Analysis of microarray data using z score transformation. J. Mol. Diag. 5, 73-81
29. Flohe, L., and Otting, F. (1984) Superoxide dismutase assays. Methods Enzymol. 105, 93-104
30. Leahy, K. P., Davies, K. J., Dull, M., Kort, J. J., Lawrence, K. W., and Crawford, D. R. (1999) adapt78, a stress-inducible mRNA, is related to the glucose-regulated protein family of genes. Arch. Biochem. Biophys. 368, 67-74
31. Davies, K. J., Harris, C. D., and Ermak, G. (2001) The essential role of calcium in induction of the DSCR1 (ADAPT78) gene. Biofactors 15, 91-93
32. Gulesserian, T., Seidl, R., Hardmeier, R., Cairns, N., and Lubec, G. (2001) Superoxide dismutase SOD1, encoded on chromosome 21, but not SOD2 is overexpressed in brains of patients with Down syndrome. J. Investig. Med. 49, 41-46
33. Ratovitski, T., Corson, L. B., Strain, J., Wong, P., Cleveland, D. W., Culotta, V. C., and Borchelt, D. R. (1999) Variation in the biochemical/biophysical properties of mutant superoxide dismutase 1 enzymes and the rate of disease progression in familial amyotrophic lateral sclerosis kindreds. Hum. Mol. Genet. 8, 1451-1460
34. Anneren, K. G., and Epstein, C. J. (1987) Lipid peroxidation and superoxide dismutase-1 and glutathione peroxidase activities in trisomy 16 fetal mice and human trisomy 21 fibroblasts. Pediatr. Res. 21, 88-92
35. Brooksbank, B. W., and Balazs, R. (1984) Superoxide dismutase, glutathione peroxidase and lipoperoxidation in Down's syndrome fetal brain. Brain Res. 318, 37-44
36. Groner, Y., Elroy-Stein, O., Avraham, K. B., Schickler, M., Knobler, H., Minc-Golomb, D., Bar-Peled, O., Yarom, R., and Rotshenker, S. (1994) Cell damage by excess CuZnSOD and Down's syndrome. Biomed. Pharmacother. 48, 231-240
37. de Haan, J. B., Cristiano, F., Iannello, R. C., and Kola, I. (1995) Cu/Zn-superoxide dismutase and glutathione peroxidase during aging. Biochem. Mol. Biol. Int. 35, 1281-1297
38. Torsdottir, G., Kristinsson, J., Hreidarsson, S., Snaedal, J., and Johannesson, T. (2001) Copper, ceruloplasmin and superoxide dismutase (SOD1) in patients with Down's syndrome. Pharmacol. Toxicol. 89, 320-325
39. Busciglio, J., and Yankner, B. A. (1995) Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro. Nature 378, 776-779
40. de Haan, J. B., Cristiano, F., Iannello, R., Bladier, C., Kelner, M. J., and Kola, I. (1996) Elevation in the ratio of Cu/Zn-superoxide dismutase to glutathione peroxidase activity induces features of cellular senescence and this effect is mediated by hydrogen peroxide. Hum. Mol. Genet. 5, 283-292
41. Ceballos, I., Javoy-Agid, F., Delacourte, A., Defossez, A., Lafon, M., Hirsch, E., Nicole, A., Sinet, P. M., and Agid, Y. (1991) Neuronal localization of copper-zinc superoxide dismutase protein and mRNA within the human hippocampus from control and Alzheimer's disease brains. Free Radic. Res. Commun. 12-13, 571-580
42. Thase, M. E., Tigner, R., Smeltzer, D. J., and Liss, L. (1984) Age-related neuropsychological deficits in Down's syndrome. Biol. Psychiatry 19, 571-585
43. Strippoli, P., Lenzi, L., Petrini, M., Carinci, P., and Zannotti, M. (2000) A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAK1-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2). Genomics 64, 252-263