The use of mouse models to understand and improve cognitive deficits in down syndrome

DMM Disease Models and Mechanisms

Volumn 4, Issue 5, 2011, Pages 596-606

  Das, Ishita ^a   Reeves, Roger H ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBIDOPA; CENTRAL NERVOUS SYSTEM AGENTS; FLUOXETINE; GAMMA SECRETASE INHIBITOR; MEMANTINE; N [(3,DIFLUOROPHENYL)ACETYL]ALANYL 2 PHENYLGLYCINE 1,1 DIMETHYLETHYLESTER; NERVE GROWTH FACTOR; PENTETRAZOLE; PICROTOXIN; SAG 1.1; THREONINE DIHYDROXYPHENYLSERINE; UNCLASSIFIED DRUG; XAMOTEROL;

ALZHEIMER DISEASE; ANIMAL BEHAVIOR; AUDITORY CONDITIONING; BRAIN ELECTROPHYSIOLOGY; COGNITIVE DEFECT; CONTEXTUAL FEAR CONDITIONING; DENTATE GYRUS; DISEASE MODEL; DOWN SYNDROME; DRUG EFFICACY; DRUG MECHANISM; DRUG PENETRATION; ENZYME INHIBITION; EXPERIMENTAL TEST; HIPPOCAMPAL CA1 REGION; HIPPOCAMPAL CA3 REGION; HIPPOCAMPUS; HUMAN; INSTRUMENTAL CONDITIONING; LONG TERM DEPRESSION; LONG TERM POTENTIATION; MAZE TEST; MOUSE STRAIN; NERVE CELL PLASTICITY; NEUROCHEMISTRY; NONHUMAN; NOVEL OBJECT RECOGNITION TEST; OBJECT IN PLASE TEST; PHENOTYPE; PRIORITY JOURNAL; RECEPTOR BLOCKING; RECEPTOR UPREGULATION; RECOGNITION; REVIEW; SINGLE DRUG DOSE; SPONTANEOUS ALTERNATION TEST; TARGET ORGAN;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN; CLINICAL TRIALS AS TOPIC; COGNITION DISORDERS; DISEASE MODELS, ANIMAL; DOWN SYNDROME; HUMANS; MICE;

EID: 80052298841     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.007716     Document Type: Review

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