-
1
-
-
58149380025
-
Animal models of Alzheimer's disease: Therapeutic implications
-
Woodruff-Pak DS (2008) Animal models of Alzheimer's disease: therapeutic implications. J Alzheimers Dis 15, 507-521.
-
(2008)
J Alzheimers Dis
, vol.15
, pp. 507-521
-
-
Woodruff-Pak, D.S.1
-
2
-
-
0030013083
-
β-amyloid accumulation correlates with cognitive dysfunction in the aged canine
-
DOI 10.1006/nlme.1996.0039
-
Cummings BJ, Head E, Afagh AJ, Milgram NW, Cotman CW (1996) Beta-amyloid accumulation correlates with cognitive dysfunction in the aged canine. Neurobiol Learn Mem 66, 11-23. (Pubitemid 26195731)
-
(1996)
Neurobiology of Learning and Memory
, vol.66
, Issue.1
, pp. 11-23
-
-
Cummings, B.J.1
Head, E.2
Afagh, A.J.3
Milgram, N.W.4
Cotman, C.W.5
-
3
-
-
0029835167
-
Diffuse plaques contain C-terminal A beta 42 and not A beta 40: Evidence from cats and dogs
-
Cummings BJ, Satou T, Head E, Milgram NW, Cole GM, Savage MJ, Podlisny MB, Selkoe DJ, Siman R, Greenberg BD, Cotman CW (1996) Diffuse plaques contain C-terminal A beta 42 and not A beta 40: evidence from cats and dogs. Neurobiol Aging 17, 653-659.
-
(1996)
Neurobiol Aging
, vol.17
, pp. 653-659
-
-
Cummings, B.J.1
Satou, T.2
Head, E.3
Milgram, N.W.4
Cole, G.M.5
Savage, M.J.6
Podlisny, M.B.7
Selkoe, D.J.8
Siman, R.9
Greenberg, B.D.10
Cotman, C.W.11
-
4
-
-
0032410562
-
Visual-discrimination learning ability and β-amyloid accumulation in the dog
-
DOI 10.1016/S0197-4580(98)00084-0, PII S0197458098000840
-
Head E, Callahan H, Muggenburg BA, Cotman CW, Milgram NW (1998) Visual-discrimination learning ability and beta-amyloid accumulation in the dog. Neurobiol Aging 19, 415-425. (Pubitemid 29065491)
-
(1998)
Neurobiology of Aging
, vol.19
, Issue.5
, pp. 415-425
-
-
Head, E.1
Callahan, H.2
Muggenburg, B.A.3
Cotman, C.W.4
Milgram, N.W.5
-
5
-
-
0034594462
-
Region-specific age at onset of β-amyloid in dogs
-
DOI 10.1016/S0197-4580(00)00093-2, PII S0197458000000932
-
Head E, McCleary R, Hahn FF, Milgram NW, Cotman CW (2000) Region-specific age at onset of beta-amyloid in dogs. Neurobiol Aging 21, 89-96. (Pubitemid 30224790)
-
(2000)
Neurobiology of Aging
, vol.21
, Issue.1
, pp. 89-96
-
-
Head, E.1
McCleary, R.2
Hahn, F.F.3
Milgram, N.W.4
Cotman, C.W.5
-
6
-
-
29244445067
-
Application of an automated voxel-based morphometry technique to assess regional gray and white matter brain atrophy in a canine model of aging
-
DOI 10.1016/j.neuroimage.2005.07.043, PII S1053811905005380
-
Tapp PD, Head K, Head E, Milgram NW, Muggenburg BA, Su MY (2006) Application of an automated voxel-based mor-phometry technique to assess regional gray and white matter brain atrophy in a canine model of aging. Neuroimage 29, 234-244. (Pubitemid 41828046)
-
(2006)
NeuroImage
, vol.29
, Issue.1
, pp. 234-244
-
-
Tapp, P.D.1
Head, K.2
Head, E.3
Milgram, N.W.4
Muggenburg, B.A.5
Su, M.-Y.6
-
7
-
-
4644343710
-
Frontal lobe volume, function, and β-amyloid pathology in a canine model of aging
-
DOI 10.1523/JNEUROSCI.1339-04.2004
-
Tapp PD, Siwak CT, Gao FQ, Chiou JY, Black SE, Head E, Muggenburg BA, Cotman CW, Milgram NW, Su MY (2004) Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging. J Neurosci 24, 8205-8213. (Pubitemid 39280799)
-
(2004)
Journal of Neuroscience
, vol.24
, Issue.38
, pp. 8205-8213
-
-
Tapp, P.D.1
Siwak, C.T.2
Gao, F.Q.3
Chiou, J.-Y.4
Black, S.E.5
Head, E.6
Muggenburg, B.A.7
Cotman, C.W.8
Milgram, N.W.9
Su, M.-Y.10
-
8
-
-
36049021799
-
Region specific neuron loss in the aged canine hippocampus is reduced by enrichment
-
DOI 10.1016/j.neurobiolaging.2006.09.018, PII S0197458006003551
-
Siwak-Tapp CT, Head E, Muggenburg BA, Milgram NW, Cotman CW (2008) Region specific neuron lossinthe aged canine hippocampus is reduced by enrichment. Neurobiol Aging 29, 39-50. (Pubitemid 350102716)
-
(2008)
Neurobiology of Aging
, vol.29
, Issue.1
, pp. 39-50
-
-
Siwak-Tapp, C.T.1
Head, E.2
Muggenburg, B.A.3
Milgram, N.W.4
Cotman, C.W.5
-
9
-
-
34547662888
-
Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function
-
DOI 10.1016/j.nlm.2007.05.001, PII S1074742707000652
-
Siwak-Tapp CT, Head E, Muggenburg BA, Milgram NW, Cotman CW (2007) Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function. Neurobiol Learn Mem 88, 249-259. (Pubitemid 47223756)
-
(2007)
Neurobiology of Learning and Memory
, vol.88
, Issue.2
, pp. 249-259
-
-
Siwak-Tapp, C.T.1
Head, E.2
Muggenburg, B.A.3
Milgram, N.W.4
Cotman, C.W.5
-
10
-
-
0036069450
-
Oxidative damage increases with age in a canine model of human brain aging
-
DOI 10.1046/j.1471-4159.2002.00969.x
-
Head E, Liu J, Hagen TM, Muggenburg BA, Milgram NW, Ames BN, Cotman CW (2002) Oxidative damage increases with ageinacanine modelofhuman brain aging.J Neurochem 82, 375-381. (Pubitemid 34774628)
-
(2002)
Journal of Neurochemistry
, vol.82
, Issue.2
, pp. 375-381
-
-
Head, E.1
Liu, J.2
Hagen, T.M.3
Muggenburg, B.A.4
Milgram, N.W.5
Ames, B.N.6
Cotman, C.W.7
-
11
-
-
0032440880
-
Magnetic resonance imaging of anatomic and vascular characteristics in a canine model of human aging
-
DOI 10.1016/S0197-4580(98)00081-5, PII S0197458098000815
-
Su MY, Head E, Brooks WM, Wang Z, Muggenburg BA, Adam GE, Sutherland R, Cotman CW, Nalcioglu O (1998) Magnetic resonance imaging of anatomic and vascular characteristics in a canine model of human aging. Neurobiol Aging 19, 479-485. (Pubitemid 29065497)
-
(1998)
Neurobiology of Aging
, vol.19
, Issue.5
, pp. 479-485
-
-
Su, M.-Y.1
Head, E.2
Brooks, W.M.3
Wang, Z.4
Muggenburg, B.A.5
Adam, G.E.6
Sutherland, R.7
Cotman, C.W.8
Nalcioglu, O.9
-
12
-
-
39049181276
-
Diffuse beta-amyloid plaques and hyperphosphorylated tau are unrelated processes in aged dogs with behavioral deficits
-
Pugliese M, Mascort J, Mahy N, Ferrer I (2006) Diffuse beta-amyloid plaques and hyperphosphorylated tau are unrelated processes in aged dogs with behavioral deficits. Acta Neu-ropathol 112, 175-183.
-
(2006)
Acta Neu-ropathol
, vol.112
, pp. 175-183
-
-
Pugliese, M.1
Mascort, J.2
Mahy, N.3
Ferrer, I.4
-
13
-
-
0035999629
-
Visuospatial impairments in aged canines (Canis familiaris): The role of cognitive-behavioral flexibility
-
DOI 10.1037
-
Chan AD, Nippak PM, Murphey H, Ikeda-Douglas CJ, Muggenburg B, Head E, Cotman CW, Milgram NW (2002) Visuospatial impairments in aged canines (Canis familiaris): the role of cognitive-behavioral flexibility. Behav Neurosci 116, 443-454. (Pubitemid 34533580)
-
(2002)
Behavioral Neuroscience
, vol.116
, Issue.3
, pp. 443-454
-
-
Chan, A.D.F.1
Nippak, P.M.D.2
Murphey, H.3
Ikeda-Douglas, C.J.4
Muggenburg, B.5
Head, E.6
Cotman, C.W.7
Milgram, N.W.8
-
14
-
-
0028784660
-
Spatial learning and memory as a function of age in the dog
-
Head E, Mehta R, Hartley J, Kameka M, Cummings BJ, Cot-man CW, Ruehl WW, Milgram NW (1995) Spatial learning and memory as a function of age in the dog. Behav Neurosci 109, 851-858.
-
(1995)
Behav Neurosci
, vol.109
, pp. 851-858
-
-
Head, E.1
Mehta, R.2
Hartley, J.3
Kameka, M.4
Cummings, B.J.5
Cot-Man, C.W.6
Ruehl, W.W.7
Milgram, N.W.8
-
15
-
-
33747857634
-
Visuospatial function in the beagle dog: An early marker of cognitive decline in a model of human aging and dementia
-
DOI 10.1016/j.nlm.2006.02.005, PII S1074742706000293
-
Studzinski CM, Christie LA, Araujo JA, Burnham WM, Head E, Cotman CW, Milgram NW (2006) Visuospatial function in the beagle dog: an early marker of cognitive decline in a model of human aging and dementia. Neurobiol Learn Mem 86, 197-204. (Pubitemid 44287579)
-
(2006)
Neurobiology of Learning and Memory
, vol.86
, Issue.2
, pp. 197-204
-
-
Studzinski, C.M.1
Christie, L.-A.2
Araujo, J.A.3
Burnham, W.M.4
Head, E.5
Cotman, C.W.6
Milgram, N.W.7
-
16
-
-
0032955087
-
Landmark discrimination learning in the dog
-
Milgram NW, Adams B, Callahan H, Head E, Mackay B, Thirlwell C, Cotman CW (1999) Landmark discrimination learning in the dog. Learn Mem 6, 54-61. (Pubitemid 29164546)
-
(1999)
Learning and Memory
, vol.6
, Issue.1
, pp. 54-61
-
-
Milgram, N.W.1
Adams, B.2
Callahan, H.3
Head, E.4
Mackay, B.5
Thirlwell, C.6
Cotman, C.W.7
-
17
-
-
0028331373
-
Cognitive functions and aging in the dog: Acquisition of nonspatial visual tasks
-
DOI 10.1037//0735-7044.108.1.57
-
Milgram NW, Head E, Weiner E, Thomas E (1994) Cognitive functions and aging in the dog: acquisition of nonspatial visual tasks. Behav Neurosci 108, 57-68. (Pubitemid 24097744)
-
(1994)
Behavioral Neuroscience
, vol.108
, Issue.1
, pp. 57-68
-
-
Milgram, N.W.1
Head, E.2
Weiner, E.3
Thomas, E.4
-
18
-
-
0036752043
-
Dietary enrichment counteracts age-associated cognitive dysfunction in canines
-
DOI 10.1016/S0197-4580(02)00020-9, PII S0197458002000209
-
Milgram NW, Zicker SC, Head E, Muggenburg BA, Murphey H, Ikeda-Douglas CJ, Cotman CW (2002) Dietary enrichment counteracts age-associated cognitive dysfunction in canines. Neurobiol Aging 23, 737-745. (Pubitemid 35217699)
-
(2002)
Neurobiology of Aging
, vol.23
, Issue.5
, pp. 737-745
-
-
Milgram, N.W.1
Zicker, S.C.2
Head, E.3
Muggenburg, B.A.4
Murphey, H.5
Ikeda-Douglas, C.J.6
Cotman, C.W.7
-
19
-
-
0013015637
-
Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging
-
DOI 10.1101/lm.54403
-
Tapp PD, Siwak CT, Estrada J, Head E, Muggenburg BA, Cotman CW, Milgram NW (2003) Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging. Learn Mem 10, 64-73. (Pubitemid 36177022)
-
(2003)
Learning and Memory
, vol.10
, Issue.1
, pp. 64-73
-
-
Tapp, P.D.1
Siwak, C.T.2
Estrada, J.3
Head, E.4
Muggenburg, B.A.5
Cotman, C.W.6
Milgram, N.W.7
-
20
-
-
12444298979
-
Effects of age on measures of complex working memory span in the beagle dog (Canis familiaris) using two versions of a spatial list learning paradigm
-
DOI 10.1101/lm.56503
-
Tapp PD, Siwak CT, Estrada J, Holowachuk D, Milgram NW (2003) Effects of age on measures of complex working memory span in the beagle dog (Canis familiaris) using two versions of a spatial list learning paradigm. Learn Mem 10, 148-160. (Pubitemid 36418725)
-
(2003)
Learning and Memory
, vol.10
, Issue.2
, pp. 148-160
-
-
Tapp, P.D.1
Siwak, C.T.2
Estrada, J.3
Holowachuk, D.4
Milgram, N.W.5
-
21
-
-
0035678441
-
Effect of age and level of cognitive function on spontaneous and exploratory behaviors in the beagle dog
-
DOI 10.1101/lm.41701
-
Siwak CT, Tapp PD, Milgram NW (2001) Effect of age and level of cognitive function on spontaneous and exploratory behaviors in the beagle dog. Learn Mem 8, 317-325. (Pubitemid 34037575)
-
(2001)
Learning and Memory
, vol.8
, Issue.6
, pp. 317-325
-
-
Siwak, C.T.1
Tapp, P.D.2
Milgram, N.W.3
-
22
-
-
0042165925
-
Locomotor activity rhythms in dogs vary with age and cognitive status
-
DOI 10.1037/0735-7044.117.4.813
-
Siwak CT, Tapp PD, Zicker SC, Murphey HL, Muggenburg BA, Head E, Cotman CW, Milgram NW (2003) Locomotor activity rhythms in dogs vary with age and cognitive status. Behav Neurosci 117, 813-824. (Pubitemid 36935391)
-
(2003)
Behavioral Neuroscience
, vol.117
, Issue.4
, pp. 813-824
-
-
Siwak, C.T.1
Tapp, P.D.2
Murphey, H.L.3
Muggenburg, B.A.4
Zicker, S.C.5
Head, E.6
Cotman, C.W.7
Milgram, N.W.8
-
23
-
-
0033898474
-
The canine as a model of human cognitive aging: Recent developments
-
DOI 10.1016/S0278-5846(00)00101-9, PII S0278584600001019
-
Adams B, Chan A, Callahan H, Milgram NW (2000) The canine as a model of human cognitive aging: recent developments. Prog Neuropsychopharmacol Biol Psychiatry 24, 675-692. (Pubitemid 30640154)
-
(2000)
Progress in Neuro-Psychopharmacology and Biological Psychiatry
, vol.24
, Issue.5
, pp. 675-692
-
-
Adams, B.1
Chan, A.2
Callahan, H.3
Milgram, N.W.4
-
24
-
-
0036751980
-
Brain aging in the canine: A diet enriched in antioxidants reduces cognitive dysfunction
-
DOI 10.1016/S0197-4580(02)00073-8, PII S0197458002000738
-
Cotman CW, Head E, Muggenburg BA, Zicker S, Milgram NW (2002) Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction. Neurobiol Aging 23, 809-818. (Pubitemid 35217705)
-
(2002)
Neurobiology of Aging
, vol.23
, Issue.5
, pp. 809-818
-
-
Cotman, C.W.1
Head, E.2
Muggenburg, B.A.3
Zicker, S.4
Milgram, N.W.5
-
25
-
-
43649096717
-
A two-year study with fibrillar beta-amyloid (Abeta) immunization in aged canines: Effects on cognitive function and brain Abeta
-
Head E, Pop V, Vasilevko V, Hill M, Saing T, Sarsoza F, Nistor M, Christie LA, Milton S, Glabe C, Barrett E, Cribbs D (2008) A two-year study with fibrillar beta-amyloid (Abeta) immunization in aged canines: effects on cognitive function and brain Abeta. J Neurosci 28, 3555-3566.
-
(2008)
J Neurosci
, vol.28
, pp. 3555-3566
-
-
Head, E.1
Pop, V.2
Vasilevko, V.3
Hill, M.4
Saing, T.5
Sarsoza, F.6
Nistor, M.7
Christie, L.A.8
Milton, S.9
Glabe, C.10
Barrett, E.11
Cribbs, D.12
-
26
-
-
15744400473
-
The canine model of human cognitive aging and dementia: Pharmacological validity of the model for assessment of human cognitive-enhancing drugs
-
DOI 10.1016/j.pnpbp.2004.12.014, Canine Model of Cognitive Aging: Further Developments and Practical Applications
-
Studzinski CM, Araujo JA, Milgram NW (2005) The canine model of human cognitive aging and dementia: pharmacological validity of the model for assessment of human cognitive-enhancing drugs. Prog Neuropsychophar-macol Biol Psychiatry 29, 489-498. (Pubitemid 40417601)
-
(2005)
Progress in Neuro-Psychopharmacology and Biological Psychiatry
, vol.29
, Issue.3
, pp. 489-498
-
-
Studzinski, C.M.1
Araujo, J.A.2
Milgram, N.W.3
-
27
-
-
0019972810
-
The choliner-gic hypothesis of geriatric memory dysfunction
-
Bartus RT, Dean RL, Beer B, Lippa AS (1982) The choliner-gic hypothesis of geriatric memory dysfunction. Science 217, 408-414.
-
(1982)
Science
, vol.217
, pp. 408-414
-
-
Bartus, R.T.1
Dean, R.L.2
Beer, B.3
Lippa, A.S.4
-
28
-
-
84886631402
-
Neurotransmitter enzyme abnormalities in senile dementia. Choline acetyltransferase and glutamic acid decarboxylase activities in necropsy brain tissue
-
DOI 10.1016/0022-510X(77)90073-9
-
Perry EK, Gibson PH, Blessed G, Perry RH, Tomlinson BE (1977) Neurotransmitter enzyme abnormalities in senile dementia. Choline acetyltransferase and glutamic acid decar-boxylase activities in necropsy brain tissue. J Neurol Sci 34, 247-265. (Pubitemid 8188071)
-
(1977)
Journal of the Neurological Sciences
, vol.34
, Issue.2
, pp. 247-265
-
-
Perry, E.K.1
Gibson, P.H.2
Blessed, G.3
-
29
-
-
0017360731
-
Necropsy evidence of central cholinergic deficits in senile dementia
-
Perry EK, Perry RH, Blessed G, Tomlinson BE (1977) Necropsy evidence of central cholinergic deficits in senile dementia. Lancet 1, 189. (Pubitemid 8020501)
-
(1977)
Lancet
, vol.1
, Issue.8004
, pp. 189
-
-
Perry, E.K.1
Perry, R.H.2
Blessed, G.3
Tomlinson, B.E.4
-
30
-
-
0018129338
-
Changes in brain cholinesterases in senile dementia of Alzheimer type
-
Perry EK, Perry RH, Blessed G, Tomlinson BE (1978) Changes in brain cholinesterases in senile dementia of Alzheimer type. Neuropathol Appl Neurobiol 4, 273-277. (Pubitemid 9001675)
-
(1978)
Neuropathology and Applied Neurobiology
, vol.4
, Issue.4
, pp. 273-277
-
-
Perry, E.K.1
Perry, R.H.2
Blessed, G.3
Tomlinson, B.E.4
-
31
-
-
0018078940
-
Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia
-
Perry EK, Tomlinson BE, Blessed G, Bergmann K, Gibson PH, Perry RH (1978) Correlation of cholinergic abnormalities with senile plaques and mental test scores in senile dementia. Br Med J 2, 1457-1459. (Pubitemid 9061468)
-
(1978)
British Medical Journal
, vol.2
, Issue.6150
, pp. 1457-1459
-
-
Perry, E.K.1
Tomlinson, B.E.2
Blessed, G.3
-
32
-
-
0020632128
-
Pathological changes in the nucleus of Meynert in Alzheimer's and Parkinson's diseases
-
DOI 10.1016/0022-510X(83)90045-X
-
Candy JM, Perry RH, Perry EK, Irving D, Blessed G, Fair-bairn AF, Tomlinson BE (1983) Pathological changes in the nucleus of Meynert in Alzheimer's and Parkinson's diseases. J Neurol Sci 59, 277-289. (Pubitemid 13113569)
-
(1983)
Journal of the Neurological Sciences
, vol.59
, Issue.2
, pp. 277-289
-
-
Candy, J.M.1
Perry, R.H.2
Perry, E.K.3
-
33
-
-
0011162190
-
Selective loss of central cholinergic neurons in Alzheimer's disease
-
Davies P, Maloney AJ (1976) Selective loss of central cholin-ergic neurons in Alzheimer's disease. Lancet 2, 1403. (Pubitemid 8004505)
-
(1976)
Lancet
, vol.2
, Issue.8000
, pp. 1403
-
-
Davies, P.1
Maloney, A.J.F.2
-
34
-
-
0023943181
-
Differential alteration of various cholinergic markers in cortical and subcortical regions of human brain in Alzheimer's disease
-
Araujo DM, Lapchak PA, Robitaille Y, Gauthier S, Quirion R (1988) Differential alteration of various cholinergic markers in cortical and subcortical regions of human brain in Alzheimer's disease. J Neurochem 50, 1914-1923.
-
(1988)
J Neurochem
, vol.50
, pp. 1914-1923
-
-
Araujo, D.M.1
Lapchak, P.A.2
Robitaille, Y.3
Gauthier, S.4
Quirion, R.5
-
35
-
-
0037449340
-
4 receptors in hippocampus of Alzheimer patients
-
DOI 10.1016/S0006-8993(02)03542-4, PII S0006899302035424
-
Mulugeta E, Karlsson E, Islam A, Kalaria R, Mangat H, Winblad B, Adem A (2003) Loss of muscarinic M4 receptors in hippocampus of Alzheimer patients. Brain Res 960, 259-262. (Pubitemid 36044584)
-
(2003)
Brain Research
, vol.960
, Issue.1-2
, pp. 259-262
-
-
Mulugeta, E.1
Karlsson, E.2
Islam, A.3
Kalaria, R.4
Mangat, H.5
Winblad, B.6
Adem, A.7
-
36
-
-
0023274110
-
Decreased muscarinic receptor binding in cerebral cortex and hippocampus in Alzheimer's disease
-
DOI 10.1016/0024-3205(87)90221-9
-
Reinikainen KJ, Riekkinen PJ, Halonen T, Laakso M (1987) Decreased muscarinic receptor binding in cerebral cortex and hippocampus in Alzheimer's disease. Life Sci 41, 453-461. (Pubitemid 17105224)
-
(1987)
Life Sciences
, vol.41
, Issue.4
, pp. 453-461
-
-
Reinikainen, K.J.1
Riekkinen, P.J.2
Halonen, T.3
Laakso, M.4
-
37
-
-
0022259332
-
Brain muscarinic receptors in senile dementia
-
DOI 10.1016/0006-8993(85)90411-1
-
Rinne JO, Laakso K, Lonnberg P, Molsa P, Paljarvi L, Rinne JK, Sako E, Rinne UK (1985) Brain muscarinic receptors in senile dementia. Brain Res 336, 19-25. (Pubitemid 15013857)
-
(1985)
Brain Research
, vol.336
, Issue.1
, pp. 19-25
-
-
Rinne, J.O.1
Laakso, K.2
Lonnberg, P.3
-
38
-
-
1842407763
-
Autoradiographic distribution of M1, M2, M3, and m4 muscarinic receptor subtypes in Alzheimer's disease
-
DOI 10.1002/(SICI)1098-2396(199708)26:4<341::AID-SYN2>3.0.CO;2-6
-
Rodriguez-Puertas R, Pascual J, Vilaro T, Pazos A (1997) Autoradiographic distribution of M1, M2, M3, and M4 mus-carinic receptor subtypes in Alzheimer's disease. Synapse 26, 341-350. (Pubitemid 27284105)
-
(1997)
Synapse
, vol.26
, Issue.4
, pp. 341-350
-
-
Rodriguez-Puertas, R.1
Pascual, J.2
Vilaro, T.3
Pazos, A.4
-
40
-
-
0023516670
-
Nicotinic and muscarinic cholinergic receptors in Alzheimer's disease and related disorders
-
Whitehouse PJ, Kellar KJ (1987) Nicotinic and muscarinic cholinergic receptors in Alzheimer's disease and related disorders. J Neural Transm Suppl 24, 175-182.
-
(1987)
J Neural Transm Suppl
, vol.24
, pp. 175-182
-
-
Whitehouse, P.J.1
Kellar, K.J.2
-
41
-
-
0015965912
-
Human memory and the cholinergic system. A relationship to aging?
-
Drachman DA, Leavitt J (1974) Human memory and the cholinergic system. A relationship to aging? Arch Neurol 30, 113-121.
-
(1974)
Arch Neurol
, vol.30
, pp. 113-121
-
-
Drachman, D.A.1
Leavitt, J.2
-
42
-
-
32844464758
-
Muscarinic and nicotinic receptors synergistically modulate working memory and attention in humans
-
DOI 10.1017/S1461145705005407, PII S1461145705005407
-
Ellis JR, Ellis KA, Bartholomeusz CF, Harrison BJ, Wesnes KA, Erskine FF, Vitetta L, Nathan PJ (2006) Muscarinic and nicotinic receptors synergistically modulate working memory and attention in humans. Int J Neuropsychopharmacol 9, 175-189. (Pubitemid 43255831)
-
(2006)
International Journal of Neuropsychopharmacology
, vol.9
, Issue.2
, pp. 175-189
-
-
Ellis, J.R.1
Ellis, K.A.2
Bartholomeusz, C.F.3
Harrison, B.J.4
Wesnes, K.A.5
Erskine, F.F.6
Vitetta, L.7
Nathan, P.J.8
-
43
-
-
0022240079
-
Scopolamine challenges in Alzheimer's disease
-
DOI 10.1007/BF00431817
-
Sunderland T, Tariot P, Murphy DL, Weingartner H, Mueller EA, Cohen RM (1985) Scopolamine challenges in Alzheimer's disease. Psychopharmacology 87, 247-249. (Pubitemid 16253356)
-
(1985)
Psychopharmacology
, vol.87
, Issue.2
, pp. 247-249
-
-
Sunderland, T.1
Tariot, P.2
Murphy, D.L.3
-
44
-
-
0022931112
-
Pharmacologic modelling of Alzheimer's disease
-
Sunderland T, Tariot PN, Weingartner H, Murphy DL, New-house PA, Mueller EA, Cohen RM (1986) Pharmacologic modelling of Alzheimer's disease. Prog Neuropsychophar-macol Biol Psychiatry 10, 599-610.
-
(1986)
Prog Neuropsychophar-macol Biol Psychiatry
, vol.10
, pp. 599-610
-
-
Sunderland, T.1
Tariot, P.N.2
Weingartner, H.3
Murphy, D.L.4
New-House, P.A.5
Mueller, E.A.6
Cohen, R.M.7
-
45
-
-
0026602375
-
Central anticholinergic hypersensitivity in aging
-
Ray PG, Meador KJ, Loring DW, Zamrini EW, Yang XH, Buccafusco JJ (1992) Central anticholinergic hypersensitivity in aging. J Geriatr Psychiatry Neurol 5, 72-77.
-
(1992)
J Geriatr Psychiatry Neurol
, vol.5
, pp. 72-77
-
-
Ray, P.G.1
Meador, K.J.2
Loring, D.W.3
Zamrini, E.W.4
Yang, X.H.5
Buccafusco, J.J.6
-
46
-
-
0023185856
-
Anticholinergic sensitivity in patients with dementia of the Alzheimer type and age-matched controls. A dose-response study
-
Sunderland T, Tariot PN, Cohen RM, Weingartner H, Mueller EA, Murphy DL (1987) Anticholinergic sensitivity in patients with dementia of the Alzheimer type and age-matched controls. A dose-response study. Arch Gen Psychiatry 44, 418-426. (Pubitemid 17064486)
-
(1987)
Archives of General Psychiatry
, vol.44
, Issue.5
, pp. 418-426
-
-
Sunderland, T.1
Tariot, P.N.2
Cohen, R.M.3
-
47
-
-
0022404452
-
Cognitive and behavioral sensitivity to scopolamine in Alzheimer patients and controls
-
Sunderland T, Tariot PN, Mueller EA, Murphy DL, Weingart-ner H, Cohen RM (1985) Cognitive and behavioral sensitivity to scopolamine in Alzheimer patients and controls. Psy-chopharmacol Bull 21, 676-679. (Pubitemid 16240089)
-
(1985)
Psychopharmacology Bulletin
, vol.21
, Issue.3
, pp. 676-679
-
-
Sunderland, T.1
Tariot, P.N.2
Mueller, E.A.3
-
48
-
-
0041921105
-
Current treatments for Alzheimer's disease: Cholinesterase inhibitors
-
Doody RS (2003) Current treatments for Alzheimer's disease: cholinesterase inhibitors. J Clin Psychiatry 64, S7.
-
(2003)
J Clin Psychiatry
, vol.64
-
-
Doody, R.S.1
-
49
-
-
4544305971
-
Dose-specific effects of scopolamine on canine cognition: Impairment of visuospatial memory, but not visuospatial discrimination
-
DOI 10.1007/s00213-004-1777-y
-
Araujo JA, Chan AD, Winka LL, Seymour PA, Milgram NW (2004) Dose-specific effects of scopolamine on canine cognition: impairment of visuospatial memory, but not visuospatial discrimination. Psychopharmacology 175, 92-98. (Pubitemid 39215535)
-
(2004)
Psychopharmacology
, vol.175
, Issue.1
, pp. 92-98
-
-
Araujo, J.A.1
Chan, A.D.F.2
Winka, L.L.3
Seymour, P.A.4
Milgram, N.W.5
-
50
-
-
15744390329
-
Further evidence for the cholinergic hypothesis of aging and dementia from the canine model of aging
-
DOI 10.1016/j.pnpbp.2004.12.008, Canine Model of Cognitive Aging: Further Developments and Practical Applications
-
Araujo JA, Studzinski CM, Milgram NW (2005) Further evidence for the cholinergic hypothesis of aging and dementia from the canine modelofaging. Prog Neuropsychopharmacol Biol Psychiatry 29, 411-422. (Pubitemid 40417593)
-
(2005)
Progress in Neuro-Psychopharmacology and Biological Psychiatry
, vol.29
, Issue.3
, pp. 411-422
-
-
Araujo, J.A.1
Studzinski, C.M.2
Milgram, N.W.3
-
51
-
-
78951488644
-
Aged dogs demonstrate both increased sensitivity to scopo-lamine impairment and decreased muscarinic receptor density
-
Araujo JA, Nobrega JN, Raymond R, Milgram NW (2011) Aged dogs demonstrate both increased sensitivity to scopo-lamine impairment and decreased muscarinic receptor density. Pharmacol Biochem Behav 98, 203-209.
-
(2011)
Pharmacol Biochem Behav
, vol.98
, pp. 203-209
-
-
Araujo, J.A.1
Nobrega, J.N.2
Raymond, R.3
Milgram, N.W.4
-
52
-
-
24644497684
-
Anticholinesterase and pharmacokinetic profile of phenserine in healthy elderly human subjects
-
DOI 10.2174/156720505774330564
-
Greig NH, Ruckle J, Comer P, Brownell L, Holloway HW, Flanagan DR, Canfield CJ, Burford RG (2005) Anti-cholinesterase and pharmacokinetic profile of phenserine in healthy elderly human subjects. Curr Alzheimer Res 2, 483-492. (Pubitemid 41277760)
-
(2005)
Current Alzheimer Research
, vol.2
, Issue.4
, pp. 483-492
-
-
Greig, N.H.1
Ruckle, J.2
Comer, P.3
Brownell, L.4
Holloway, H.W.5
Flanagan Jr., D.R.6
Canfield, C.J.7
Burford, R.G.8
-
53
-
-
22144494112
-
An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease
-
DOI 10.2174/1567205054367829
-
Greig NH, Sambamurti K, Yu QS, Brossi A, Bruinsma GB, Lahiri DK (2005) An overview of phenserine tartrate, a novel acetylcholinesterase inhibitor for the treatment of Alzheimer's disease. Curr Alzheimer Res 2, 281-290. (Pubitemid 40980186)
-
(2005)
Current Alzheimer Research
, vol.2
, Issue.3
, pp. 281-290
-
-
Greig, N.H.1
Sambamurti, K.2
Yu, Q.-S.3
Brossi, A.4
Bruinsma, G.B.5
Lahiri, D.K.6
-
54
-
-
41149127264
-
Effect of phenserine treatment on brain functional activity and amyloid in Alzheimer's disease
-
Kadir A, Andreasen N, Almkvist O, Wall A, Forsberg A, Engler H, Hagman G, Larksater M, Winblad B, Zetterberg H, Blennow K, Langstrom B, Nordberg A (2008) Effect of phenserine treatment on brain functional activity and amyloid in Alzheimer's disease. Ann Neurol 63, 621-631.
-
(2008)
Ann Neurol
, vol.63
, pp. 621-631
-
-
Kadir, A.1
Andreasen, N.2
Almkvist, O.3
Wall, A.4
Forsberg, A.5
Engler, H.6
Hagman, G.7
Larksater, M.8
Winblad, B.9
Zetterberg, H.10
Blennow, K.11
Langstrom, B.12
Nordberg, A.13
-
56
-
-
79751501738
-
Phenserine efficacy in Alzheimer's disease
-
Winblad B, Giacobini E, Frölich L, Bruinsma G, Becker RE, Greig NH (2010) Phenserine efficacy in Alzheimer's disease. J Alzheimers Dis 22, 1201-1208.
-
(2010)
J Alzheimers Dis
, vol.22
, pp. 1201-1208
-
-
Winblad, B.1
Giacobini, E.2
Frölich, L.3
Bruinsma, G.4
Becker, R.E.5
Greig, N.H.6
-
57
-
-
80052839709
-
The experimental Alzheimer drug phenserine: Preclin-ical pharmacokinetics and pharmacodynamics
-
Greig NH, De ME, Holloway HW, Yu QS, Utsuki T, Perry TA, Brossi A, Ingram DK, Deutsch J, Lahiri DK, Soncrant TT (2000) The experimental Alzheimer drug phenserine: preclin-ical pharmacokinetics and pharmacodynamics. Acta Neurol Scand Suppl, 176-184.
-
(2000)
Acta Neurol Scand Suppl
, pp. 176-184
-
-
Greig, N.H.1
De Me Holloway, H.W.2
Yu, Q.S.3
Utsuki, T.4
Perry, T.A.5
Brossi, A.6
Ingram, D.K.7
Deutsch, J.8
Lahiri, D.K.9
Soncrant, T.T.10
-
58
-
-
0030014585
-
An inverted U-shaped curve for heptylphysostigmine on radial maze performance in rats: Comparison with other cholinesterase inhibitors
-
DOI 10.1016/0014-2999(96)00072-6
-
Braida D, Paladini E, Griffini P, Lamperti M, Maggi A, Sala M (1996) An inverted U-shaped curve for heptylphysostigmine on radial maze performance in rats: comparison with other cholinesterase inhibitors. Eur J Pharmacol 302, 13-20. (Pubitemid 26179925)
-
(1996)
European Journal of Pharmacology
, vol.302
, Issue.1-3
, pp. 13-20
-
-
Braida, D.1
Paladini, E.2
Griffini, P.3
Lamperti, M.4
Maggi, A.5
Sala, M.6
-
59
-
-
16544394141
-
Donepezil-induced improvement in delayed matching accuracy by young and old rhesus monkeys
-
Buccafusco JJ, Terry AV (2004) Donepezil-induced improvement in delayed matching accuracy by young and old rhesus monkeys. J Mol Neurosci 24, 85-91. (Pubitemid 41359172)
-
(2004)
Journal of Molecular Neuroscience
, vol.24
, Issue.1
, pp. 85-91
-
-
Buccafusco, J.J.1
Terry Jr., A.V.2
-
60
-
-
46649086754
-
The scopolamine-reversal paradigm in rats and monkeys: The importance of computer-assisted operant-conditioning memory tasks for screening drug candidates
-
DOI 10.1007/s00213-007-0887-8
-
Buccafusco JJ, Terry AV, Webster SJ, Martin D, Hohnadel EJ, Bouchard KA, Warner SE (2008) The scopolamine-reversal paradigm in rats and monkeys: the importance of computer-assisted operant-conditioning memory tasks for screening drug candidates. Psychopharmacology 199, 481-494. (Pubitemid 351938233)
-
(2008)
Psychopharmacology
, vol.199
, Issue.3
, pp. 481-494
-
-
Buccafusco, J.J.1
Terry Jr., A.V.2
Webster, S.J.3
Martin, D.4
Hohnadel, E.J.5
Bouchard, K.A.6
Warner, S.E.7
-
61
-
-
0036460387
-
Donepezil reverses a mnemonic deficit produced by scopolamine but not by perforant path lesion or transient cerebral ischaemia
-
DOI 10.1046/j.1460-9568.2002.02018.x
-
Higgins GA, Enderlin M, Fimbel R, Haman M, Grottick AJ, Soriano M, Richards JG, Kemp JA, Gill R (2002) Donepezil reverses a mnemonic deficit produced by scopolamine but not by perforant path lesion or transient cerebral ischaemia. Eur J Neurosci 15, 1827-1840. (Pubitemid 35471908)
-
(2002)
European Journal of Neuroscience
, vol.15
, Issue.11
, pp. 1827-1840
-
-
Higgins, G.A.1
Enderlin, M.2
Fimbel, R.3
Haman, M.4
Grottick, A.J.5
Soriano, M.6
Richards, J.G.7
Kemp, J.A.8
Gill, R.9
-
62
-
-
0028894038
-
Maze learning in aged rats is enhanced by phenserine, a novel anticholinesterase
-
Ikari H, Spangler EL, Greig NH, Pei XF, Brossi A, Speer D, Patel N, Ingram DK (1995) Maze learning in aged rats is enhanced by phenserine, a novel anticholinesterase. Neurore-port 6, 481-484.
-
(1995)
Neurore-port
, vol.6
, pp. 481-484
-
-
Ikari, H.1
Spangler, E.L.2
Greig, N.H.3
Pei, X.F.4
Brossi, A.5
Speer, D.6
Patel, N.7
Ingram, D.K.8
-
63
-
-
0028125054
-
Rodent models of memory dysfunction in Alzheimer's disease and normal aging: Moving beyond the cholinergic hypothesis
-
Ingram DK, Spangler EL, Iijima S, Ikari H, Kuo H, Greig NH, London ED (1994) Rodent models of memory dysfunction in Alzheimer's disease and normal aging: moving beyond the cholinergic hypothesis. Life Sci 55, 2037-2049.
-
(1994)
Life Sci
, vol.55
, pp. 2037-2049
-
-
Ingram, D.K.1
Spangler, E.L.2
Iijima, S.3
Ikari, H.4
Kuo, H.5
Greig, N.H.6
London, E.D.7
-
64
-
-
19944387894
-
The cholinesterase inhibitor, phenserine, improves Morris water maze performance of scopolamine-treated rats
-
DOI 10.1016/j.lfs.2004.06.028, PII S0024320504009440
-
Janas AM, Cunningham SC, Duffy KB, Devan BD, Greig NH, Holloway HW, Yu QS, Markowska AL, Ingram DK, Spangler EL (2005) The cholinesterase inhibitor, phenserine, improves Morris water maze performance of scopolamine-treated rats. Life Sci 76, 1073-1081. (Pubitemid 40037530)
-
(2005)
Life Sciences
, vol.76
, Issue.10
, pp. 1073-1081
-
-
Janas, A.M.1
Cunningham, S.C.2
Duffy, K.B.3
Devan, B.D.4
Greig, N.H.5
Holloway, H.W.6
Yu, Q.-S.7
Markowska, A.L.8
Ingram, D.K.9
Spangler, E.L.10
-
65
-
-
0032484682
-
Phenserine, a novel acetylcholinesterase inhibitor, attenuates impaired learning of rats in a 14-unit T-maze induced by blockade of the N-methyl-D- aspartate receptor
-
Patel N, Spangler EL, Greig NH, Yu QS, Ingram DK, Meyer RC (1998) Phenserine, a novel acetylcholinesterase inhibitor, attenuates impaired learning of rats in a 14-unit T-maze induced by blockade of the N-methyl-D-aspartate receptor. Neuroreport 9, 171-176. (Pubitemid 28046677)
-
(1998)
NeuroReport
, vol.9
, Issue.1
, pp. 171-176
-
-
Patel, N.1
Spangler, E.L.2
Greig, N.H.3
Yu, Q.-S.4
Ingram, D.K.5
Meyer, R.C.6
-
66
-
-
0030803829
-
Enhanced performance of spatial and visual recognition memory tasks by the selective acetylcholinesterase inhibitor e2020 in rhesus monkeys
-
DOI 10.1007/s002130050310
-
Rupniak NM, Tye SJ, Field MJ (1997) Enhanced performance of spatial and visual recognition memory tasks by the selec-tive acetylcholinesterase inhibitor E2020 in rhesus monkeys. Psychopharmacology 131, 406-410. (Pubitemid 27348708)
-
(1997)
Psychopharmacology
, vol.131
, Issue.4
, pp. 406-410
-
-
Rupniak, N.M.J.1
Tye, S.J.2
Field, M.J.3
-
67
-
-
33745646986
-
Assessment of nutritional interventions for modification of age-associated cognitive decline using a canine model of human aging
-
DOI 10.1007/s11357-005-4001-z
-
Araujo JA, Studzinski CM, Head E, Cotman CW, Milgram NW (2005) Assessment of nutritional interventions for modification of age-associated cognitive decline using a canine model of human aging. Age 27, 27-37. (Pubitemid 43971791)
-
(2005)
Age
, vol.27
, Issue.1
, pp. 27-37
-
-
Araujo, J.A.1
Studzinski, C.M.2
Head, E.3
Cotman, C.W.4
Milgram, N.W.5
-
68
-
-
10044265541
-
Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: A two-year longitudinal study
-
DOI 10.1016/j.neurobiolaging.2004.02.014, PII S0197458004001149
-
Milgram NW, Head E, Zicker SC, Ikeda-Douglas CJ, Mur-phey H, Muggenberg B, Siwak C, Tapp D, Cotman CW (2005) Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: a two-year longitudinal study. Neurobiol Aging 26, 77-90. (Pubitemid 39600593)
-
(2005)
Neurobiology of Aging
, vol.26
, Issue.1
, pp. 77-90
-
-
Milgram, N.W.1
Head, E.2
Zicker, S.C.3
Ikeda-Douglas, C.J.4
Murphey, H.5
Muggenburg, B.6
Siwak, C.7
Tapp, D.8
Cotman, C.W.9
-
69
-
-
0031744035
-
Scopolamine model of dementia: Electroencephalogram findings and cognitive performance
-
DOI 10.1046/j.1365-2362.1998.00393.x
-
Ebert U, Kirch W (1998) Scopolamine model of dementia: electroencephalogram findings and cognitive performance. Eur J Clin Invest 28, 944-949. (Pubitemid 28521587)
-
(1998)
European Journal of Clinical Investigation
, vol.28
, Issue.11
, pp. 944-949
-
-
Ebert, U.1
Kirch, W.2
-
70
-
-
0027743382
-
The effects of novel cholinesterase inhibitors and selective muscarinic receptor agonists in tests of reference and working memory
-
DOI 10.1016/0166-4328(93)90130-I
-
Dawson GR, Iverson SD (1993) The effect of novel cholin-esterase inhibitors and selective muscarinic receptor agonists in tests of reference and working memory. Behav Brain Res 57, 143-153. (Pubitemid 24027144)
-
(1993)
Behavioural Brain Research
, vol.57
, Issue.2
, pp. 143-153
-
-
Dawson, G.R.1
Iversen, S.D.2
-
71
-
-
0030462894
-
3 antagonist thioperamide, in models of cognition and cholinergic function
-
Kirkby DL, Jones DN, Barnes JC, Higgins GA (1996) Effects of anticholinesterase drugs tacrine and E2020, the 5-HT (3) antagonist ondansetron, and the H (3) antagonist thi-operamide, in models of cognition and cholinergic function. Behav Pharmacol 7, 513-525. (Pubitemid 27046781)
-
(1996)
Behavioural Pharmacology
, vol.7
, Issue.6
, pp. 513-525
-
-
Kirkby, D.L.1
Jones, D.N.C.2
Barnes, J.C.3
Higgins, G.A.4
-
72
-
-
0031973559
-
Effects of the potassium channel blockers, apamin and 4-aminopyridine, on scopolamine-induced deficits in the delayed matching to position task in rats: A comparison with the cholinesterase inhibitor E2020
-
DOI 10.1007/s002130050506
-
Poorheidari G, Stanhope KJ, Pratt JA (1998) Effects of the potassium channel blockers, apamin and 4-aminopyridine, on scopolamine-induced deficits inthe delayed matchingto position taskinrats:acomparison with the cholinesterase inhibitor E2020. Psychopharmacology 135, 242-255. (Pubitemid 28055459)
-
(1998)
Psychopharmacology
, vol.135
, Issue.3
, pp. 242-255
-
-
Poorheidari, G.1
Stanhope, K.J.2
Pratt, J.A.3
-
73
-
-
0027367122
-
Phenserine: A physostigmine derivative that is a long-acting inhibitor of cholinesterase and demonstrates a wide dose range for attenuating a scopolamine-induced learning impairment of rats in a 14-unit T-maze
-
DOI 10.1007/BF02244888
-
Iijima S, Greig NH, Garofalo P, Spangler EL, Heller B, Brossi A, Ingram DK (1993) Phenserine: a physostigmine derivative that is a long-acting inhibitor of cholinesterase and demonstrates a wide dose range for attenuating a scopolamine-induced learning impairment of rats in a 14-unit T-maze. Psychopharmacology 112, 415-420. (Pubitemid 23324161)
-
(1993)
Psychopharmacology
, vol.112
, Issue.4
, pp. 415-420
-
-
Iijima, S.1
Greig, N.H.2
Garofalo, P.3
Spangler, E.L.4
Heller, B.5
Brossi, A.6
Ingram, D.K.7
-
74
-
-
33748571875
-
Neu-roprotective effects of cognitive enrichment
-
Milgram NW, Siwak-Tapp CT, Araujo J, Head E (2006) Neu-roprotective effects of cognitive enrichment. Ageing Res Rev 5, 354-369.
-
(2006)
Ageing Res Rev
, vol.5
, pp. 354-369
-
-
Milgram, N.W.1
Siwak-Tapp, C.T.2
Araujo, J.3
Head, E.4
-
75
-
-
0030986003
-
Pharmacological modulation of Alzheimer's β-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions
-
DOI 10.1016/S0169-328X(96)00297-5, PII S0169328X96002975
-
Haroutunian V, Greig N, Pei XF, Utsuki T, Gluck R, Acevedo LD, Davis KL, Wallace WC (1997) Pharmacological modulation of Alzheimer's beta-amyloid precursor protein levels in the CSF of rats with forebrain cholinergic system lesions. Brain Res Mol Brain Res 46, 161-168. (Pubitemid 27214367)
-
(1997)
Molecular Brain Research
, vol.46
, Issue.1-2
, pp. 161-168
-
-
Haroutunian, V.1
Greig, N.2
Pei, X.-F.3
Utsuki, T.4
Gluck, R.5
Acevedo, L.D.6
Davis, K.L.7
Wallace, W.C.8
-
76
-
-
0034489269
-
Cholinesterase inhibitors, beta-amyloid precursor protein and amyloid beta-peptides in Alzheimer's disease
-
Lahiri DK, Farlow MR, Hintz N, Utsuki T, Greig NH (2000) Cholinesterase inhibitors, beta-amyloid precursor protein and amyloid beta-peptides in Alzheimer's disease. Acta Neurol Scand Suppl, 176-177.
-
(2000)
Acta Neurol Scand Suppl
, pp. 176-177
-
-
Lahiri, D.K.1
Farlow, M.R.2
Hintz, N.3
Utsuki, T.4
Greig, N.H.5
-
77
-
-
33845905829
-
The experimental Alzheimer's Disease drug posiphen [(+)-phenserine] lowers amyloid-β peptide levels in cell culture and mice
-
DOI 10.1124/jpet.106.112102
-
Lahiri DK, Chen D, Maloney B, Holloway HW, Yu QS, Utsuki T, Giordano T, Sambamurti K, Greig NH (2007) The experimental Alzheimer's disease drug posiphen [(+)-phenserine] lowers amyloid-beta peptide levels in cell culture and mice. J Pharmacol Exp Ther 320, 386-396. (Pubitemid 46025753)
-
(2007)
Journal of Pharmacology and Experimental Therapeutics
, vol.320
, Issue.1
, pp. 386-396
-
-
Lahiri, D.K.1
Chen, D.2
Maloney, B.3
Holloway, H.W.4
Yu, Q.-S.5
Utsuki, T.6
Giordano, T.7
Sambamurti, K.8
Greig, N.H.9
-
78
-
-
0035912825
-
Phenserine regulates translation of β-amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development
-
DOI 10.1073/pnas.131152998
-
Shaw KT, Utsuki T, Rogers J, Yu QS, Sambamurti K, Brossi A, Ge YW, Lahiri DK, Greig NH (2001) Phenserine regulates translation of beta-amyloid precursor protein mRNA by a putative interleukin-1 responsive element, a target for drug development. Proc Natl Acad Sci USA 98, 7605-7610. (Pubitemid 32567995)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.13
, pp. 7605-7610
-
-
Shaw, K.T.Y.1
Utsuki, T.2
Rogers, J.3
Yu, Q.-S.4
Sambamurti, K.5
Brossi, A.6
Ge, Y.-W.7
Lahiri, D.K.8
Greig, N.H.9
-
79
-
-
14944344156
-
Integrated role of desferrioxamine and phenserine targeted to an iron-responsive element in the APP-mRNA 5′-untranslated region
-
DOI 10.1196/annals.1332.003
-
Venti A, Giordano T, Eder P, Bush AI, Lahiri DK, Greig NH, Rogers JT (2004) The integrated role of desferrioxamine and phenserine targeted to an iron-responsive element in the APP-mRNA 5'-untranslated region. Ann N YAcad Sci 1035, 34-48. (Pubitemid 40362325)
-
(2004)
Annals of the New York Academy of Sciences
, vol.1035
, pp. 34-48
-
-
Venti, A.1
Giordano, T.2
Eder, P.3
Bush, A.I.4
Lahiri, D.K.5
Greig, N.H.6
Rogers, J.T.7
-
80
-
-
0034010703
-
The β-amyloid precursor protein and its derivatives: From biology to learning and memory processes
-
Dodart JC, Mathis C, Ungerer A (2000) The beta-amyloid precursor protein and its derivatives: from biology to learning and memory processes. Rev Neurosci 11, 75-93. (Pubitemid 30133162)
-
(2000)
Reviews in the Neurosciences
, vol.11
, Issue.2-3
, pp. 75-93
-
-
Dodart, J.-C.1
Mathis, C.2
Ungerer, A.3
-
81
-
-
33947262557
-
Soluble beta-amyloid[25-35] reversibly impairs hippocampal synaptic plasticity and spatial learning
-
DOI 10.1016/j.ejphar.2007.01.040, PII S001429990700088X
-
Holscher C, Gengler S, Gault VA, Harriott P, Mallot HA (2007) Soluble beta-amyloid [25-35] reversibly impairs hip-pocampal synaptic plasticity and spatial learning. Eur J Pharmacol 561, 85-90. (Pubitemid 46435857)
-
(2007)
European Journal of Pharmacology
, vol.561
, Issue.1-3
, pp. 85-90
-
-
Holscher, C.1
Gengler, S.2
Gault, V.A.3
Harriott, P.4
Mallot, H.A.5
-
82
-
-
33645038471
-
A specific amyloid-beta protein assembly in the brain impairs memory
-
Lesné S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, Gallagher M, Ashe KH (2006) A specific amyloid-beta protein assembly in the brain impairs memory. Nature 440, 352-357.
-
(2006)
Nature
, vol.440
, pp. 352-357
-
-
Lesné, S.1
Koh, M.T.2
Kotilinek, L.3
Kayed, R.4
Glabe, C.G.5
Yang, A.6
Gallagher, M.7
Ashe, K.H.8
-
83
-
-
0035793310
-
Effects of amyloid-β-(25-35) on passive avoidance, radial-arm maze learning and choline acetyltransferase activity in the rat
-
DOI 10.1016/S0014-2999(01)00730-0, PII S0014299901007300
-
Yamaguchi Y, Kawashima S (2001) Effects of amyloid-beta-(25-35) on passive avoidance, radial-arm maze learning and choline acetyltransferase activity in the rat. Eur J Pharmacol 412, 265-272. (Pubitemid 32144942)
-
(2001)
European Journal of Pharmacology
, vol.412
, Issue.3
, pp. 265-272
-
-
Yamaguchi, Y.1
Kawashima, S.2
-
84
-
-
33745966453
-
Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-β peptide
-
DOI 10.1124/jpet.106.103309
-
Utsuki T, Yu QS, Davidson D, Chen D, Holloway HW, Brossi A, Sambamurti K, Lahiri DK, Greig NH, Giordano T (2006) Identification of novel small molecule inhibitors of amyloid precursor protein synthesis as a route to lower Alzheimer's disease amyloid-beta peptide. J Pharmacol Exp Ther 318, 855-862. (Pubitemid 44061261)
-
(2006)
Journal of Pharmacology and Experimental Therapeutics
, vol.318
, Issue.2
, pp. 855-862
-
-
Utsuki, T.1
Yu, Q.-S.2
Davidson, D.3
Chen, D.4
Holloway, H.W.5
Brossi, A.6
Sambamurti, K.7
Lahiri, D.K.8
Greig, N.H.9
Giordano, T.10
-
85
-
-
78650203665
-
Why so few drugs for Alzheimer's disease? Are methods failing drugs?
-
Becker RE, Greig NH (2010) Why so few drugs for Alzheimer's disease? Are methods failing drugs? Curr Alzheimer Res 7, 642-651.
-
(2010)
Curr Alzheimer Res
, vol.7
, pp. 642-651
-
-
Becker, R.E.1
Greig, N.H.2
-
86
-
-
58149385516
-
Estimation of working memory in macaques for studying drugs for the treatment of cognitive disorders
-
Buccafusco JJ (2008) Estimation of working memory in macaques for studying drugs for the treatment of cognitive disorders. J Alzheimers Dis 15, 709-720.
-
(2008)
J Alzheimers Dis
, vol.15
, pp. 709-720
-
-
Buccafusco, J.J.1
-
87
-
-
34548459892
-
Anti-dementia drugs and hippocampal-dependent memory in rodents
-
DOI 10.1097/FBP.0b013e3282da278d, PII 0000887720070900000005
-
Yuede CM, Dong H, Csernansky JG (2007) Anti-dementia drugs and hippocampal-dependent memory in rodents. Behav Pharmacol 18, 347-363. (Pubitemid 47356364)
-
(2007)
Behavioural Pharmacology
, vol.18
, Issue.5-6
, pp. 347-363
-
-
Yuede, C.M.1
Dong, H.2
Csernansky, J.G.3
-
88
-
-
0032797870
-
Donepezil. Pharmacoeconomic implications of therapy
-
Foster RH, Plosker GL (1999) Donepezil. Pharmacoeconomic implications of therapy. Pharmacoeconomics 16, 99-114.
-
(1999)
Pharmacoeconomics
, vol.16
, pp. 99-114
-
-
Foster, R.H.1
Plosker, G.L.2
-
89
-
-
0030612202
-
Possible role of the cholinergic system and disease models
-
Weinstock M (1997) Possible role of the cholinergic system and disease models. J Neural Transm Suppl, 49-102.
-
(1997)
J Neural Transm Suppl
, pp. 49-102
-
-
Weinstock, M.1
-
90
-
-
58149380028
-
The canine (dog) model of human aging and disease: Dietary, environmental and immunotherapy approaches
-
Cotman CW, Head E (2008) The canine (dog) model of human aging and disease: dietary, environmental and immunotherapy approaches. J Alzheimers Dis 15, 685-707.
-
(2008)
J Alzheimers Dis
, vol.15
, pp. 685-707
-
-
Cotman, C.W.1
Head, E.2
-
91
-
-
46749118974
-
Cholinergic Treatments with Emphasis on M1 Muscarinic Agonists as Potential Disease-Modifying Agents for Alzheimer's Disease
-
DOI 10.1016/j.nurt.2008.05.002, PII S1933721308000913
-
Fisher A (2008) Cholinergic treatments with emphasis on m1 muscarinic agonists as potential disease-modifying agents for Alzheimer's disease. Neurotherapeutics 5, 433-442. (Pubitemid 351952486)
-
(2008)
Neurotherapeutics
, vol.5
, Issue.3
, pp. 433-442
-
-
Fisher, A.1
-
92
-
-
52049105166
-
Interactions between the amyloid and cholinergic mechanisms in Alzheimer's disease
-
Pakaski M, Kalman J (2008) Interactions between the amyloid and cholinergic mechanisms in Alzheimer's disease. Neu-rochem Int 53, 103-111.
-
(2008)
Neu-rochem Int
, vol.53
, pp. 103-111
-
-
Pakaski, M.1
Kalman, J.2
-
93
-
-
0042970733
-
Role of acetylcholinesterase inhibitors in the metabolism of amyloid precursor protein
-
Pakaski M, Kasa P (2003) Role of acetylcholinesterase inhibitors in the metabolism of amyloid precursor protein. Curr Drug Targets CNS Neurol Disord 2, 163-171.
-
(2003)
Curr Drug Targets CNS Neurol Disord
, vol.2
, pp. 163-171
-
-
Pakaski, M.1
Kasa, P.2
-
96
-
-
0032717488
-
Correlation of the intrinsic clearance of donepezil (Aricept) between in vivo and in vitro studies in rat, dog and human
-
Matsui K, Taniguchi S, Yoshimura T (1999) Correlation of the intrinsic clearance of donepezil (Aricept) between in vivo and in vitro studies in rat, dog and human. Xenobiotica 29, 1059-1072.
-
(1999)
Xenobiotica
, vol.29
, pp. 1059-1072
-
-
Matsui, K.1
Taniguchi, S.2
Yoshimura, T.3
|