Combining biophysical screening and X-ray crystallography for fragment-based drug discovery

Topics in Current Chemistry

Volumn 317, Issue , 2012, Pages 115-144

  Hennig, Michael ^a   Ruf, Armin ^a   Huber, Walter ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

BACE; Chymase; Fragment Based lead discovery; Library Design; Screening; Surface Plasmon Resonance; X ray Crystallography

Indexed keywords

CHEMICAL STRUCTURE; CHEMISTRY; DRUG DEVELOPMENT; HIGH THROUGHPUT SCREENING; METHODOLOGY; MOLECULAR LIBRARY; REVIEW; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; HIGH-THROUGHPUT SCREENING ASSAYS; MODELS, MOLECULAR; SMALL MOLECULE LIBRARIES; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PLASMON RESONANCE;

EID: 84858141881     PISSN: 03401022     EISSN: None     Source Type: Book Series    
DOI: 10.1007/128-2011-225     Document Type: Review

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