Thermodynamic characterization of pyrazole and azaindole derivatives binding to p38 mitogen-activated protein kinase using Biacore T100 technology and van't Hoff analysis

Analytical Biochemistry

Volumn 383, Issue 2, 2008, Pages 255-264

  Papalia, Giuseppe A ^a   Giannetti, Anthony M ^b   Arora, Nidhi ^b   Myszka, David G ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b Roche   (United States)

Author keywords

Biacore; Double mutant cycles; Kinetics; Optical biosensor; Small molecule; Surface plasmon resonance; Thermodynamics; van't Hoff analysis

Indexed keywords

ADENOSINETRIPHOSPHATE; ENZYME KINETICS; ENZYMES; KINETICS; MOLECULES; SURFACE PLASMON RESONANCE; THERMODYNAMIC PROPERTIES; THERMODYNAMICS;

BIACORE; DOUBLE MUTANTS; OPTICAL BIO-SENSORS; SMALL MOLECULES; VAN'T HOFF ANALYSIS;

BINDING ENERGY;

AZAINDOLE DERIVATIVE; INDOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOSENSOR; DRUG PROTEIN BINDING; ENTHALPY; ENTROPY; FLUORINATION; IC 50; PRIORITY JOURNAL; THERMODYNAMICS;

EID: 54249153180     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1016/j.ab.2008.08.010     Document Type: Article

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