Tyramine fragment binding to BACE-1

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 4, 2008, Pages 1304-1307

  Kuglstatter, Andreas ^a   Stahl, Martin ^a   Peters, Jens Uwe ^a   Huber, Walter ^a   Stihle, Martine ^a   Schlatter, Daniel ^a   Benz, Jörg ^a   Ruf, Armin ^a   Roth, Doris ^a   Enderle, Thilo ^a   Hennig, Michael ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Alzheimer; BACE 1; Fragment screening; Structure based design; Surface plasmon resonance; Tyramine; X ray structure

Indexed keywords

BETA SECRETASE; BETA SECRETASE INHIBITOR; LEAD; TYRAMINE; WATER;

ALZHEIMER DISEASE; ARTICLE; BINDING AFFINITY; BLOOD BRAIN BARRIER; CATALYSIS; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG TARGETING; ENZYME INHIBITION; HUMAN; HYDROGEN BOND; MOLECULAR WEIGHT; SURFACE PLASMON RESONANCE; X RAY CRYSTALLOGRAPHY;

AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ENDOPEPTIDASES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; HUMANS; KINETICS; MODELS, MOLECULAR; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN CONFORMATION; TYRAMINE;

EID: 39049094722     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.01.032     Document Type: Article

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