Detecting binding affinity to immobilized receptor proteins in compound libraries by HR-MAS STD NMR

Journal of the American Chemical Society

Volumn 121, Issue 22, 1999, Pages 5336-5337

  Klein, Jens ^a   Meinecke, Robert ^a   Mayer, Moriz ^a   Meyer, Bernd ^a  

^a UNIVERSITY OF HAMBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN;

ARTICLE; BINDING AFFINITY; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOBLOTTING; NUCLEAR MAGNETIC RESONANCE; PROTEIN ANALYSIS; RADIOIMMUNOASSAY; SIGNAL TRANSDUCTION;

EID: 0033538283     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja990706x     Document Type: Article

References (25)

1. Mayer, M.; Meyer, B. Angew. Chem. 1999, in press.
2. Gordon, E. M.; Gallop, M. A.; Patel, D. V. Acc. Chem. Res. 1996, 29, 144-154.
3. Meyer, B.; Weimar, T.; Peters, T. Eur. J. Biochem. 1997, 246, 705-709; German Patent 19649359; Intl. Patent pending.
4. (a) Hajduk, P. J.; Olejniczak, E. T.; Fesik, S. W. J. Am. Chem. Soc. 1997, 119, 12257-12261;
5. (b) Shuker, S. B.; Hajduk, P. J.; Meadows, R. P.; Fesik, S. W. Science 1996, 274, 1531-1537.
6. (a) Chen, A.; Shapiro, M. J. J. Am. Chem. Soc. 1998, 120, 10258-10259;
7. (b) Lin, M.; Shapiro, M. J.; Wareing, J. R. J. Org. Chem. 1997, 62, 8930-8931;
8. (c) Lin, M.; Shapiro, M. J.; Wareing, J. R. J. Am. Chem. Soc. 1997, 119, 5249-5250.
9. Ni, F. Prog. Nucl. Magn. Reson. Spectrosc. 1994, 26, 517-606.
10. (a) Clore, G. M.; Gronenborn, A. M. J. Magn. Reson. 1982, 48, 402-417;
11. (b) Clore, G. M.; Gronenborn, A. M. J. Magn. Reson. 1983, 53, 423-442.
12. Zvi, A.; Feigelson, D. J.; Hayek, Y.; Anglister, J. Biochemistry 1997, 36, 8619-8627.
13. Akasaka, K. J. Magn. Reson. 1979, 36, 135-140.
14. Reid, D. G.; Salisbury, S. A.; Williams, D. H. Biochemistry 1983, 22, 1377-1385.
15. (a) Fitch, W. L.; Detre, G.; Holmes, C. P.; Shoolery, J. N.; Keifer, P. A. J. Org. Chem. 1994, 59, 7955-7956;
16. (b) Keifer, P. A. Drugs Future 1998, 23(3), 301-317;
17. (c) Keifer, P. A.; Baltusis, L.; Rice, D. M.; Tymiak, A. A.; Shoolery, J. N. J. Magn. Reson, Ser. A 1996, 119, 65-75.
18. Doskocilová, D.; Schneider, B. Chem. Phys. Lett. 1970, 6(4), 381-384.
19. Zelaya, F. O.; Crotier, S.; Dodd, S.; McKenna, R.; Dodrell, D. M. J. Magn. Reson., Ser. A 1995, 115, 131-136.
20. Wright, C. S.; Kellogg, G. E. Protein Sci. 1996, 5, 1466-1476.
21. The oligosaccharide library contained the following: 1.5 μmol of N,N′-diacetylchitobiose and 2.1 μmol of the nonbinding sugars maltose, D-lactose, sucrose, cellobiose, trehalose, and D-raffinose.
22. Habeeb, A. F. S. A.; Cassidy, H. G.; Singer, S. J. Biochim. Biophys. Acta 1958, 29, 587-593.
23. Cuatrecasas, P.; Parikh, I. J. Biochem. 1972, 11, 2291-2299
24. Matsumoto, I.; Mizuno, Y.; Seno, N. J. Biochem. (Tokyo) 1979, 85, 1091-1098.
25. Keifer, P. A. J. Org. Chem. 1996, 61, 1558-1559.