Practical aspects of NMR-based fragment discovery

Current Topics in Medicinal Chemistry

Volumn 7, Issue 16, 2007, Pages 1592-1599

  Zartler, Edward R ^a,c   Mo, Huaping ^b  

^a Tessera Drug Discovery Consulting   (United States)

^b PURDUE UNIVERSITY   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Fragment; Ligand based; NMR; Protein based; Screening

Indexed keywords

DNA; NEW DRUG; RNA;

BINDING AFFINITY; BIOASSAY; BIOPHYSICS; CARBON NUCLEAR MAGNETIC RESONANCE; DIFFUSION; DRUG DNA INTERACTION; DRUG PROTEIN BINDING; DRUG RESEARCH; DRUG SCREENING; DRUG STRUCTURE; DRUG TARGETING; LIGAND BINDING; NITROGEN NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PRINCIPAL COMPONENT ANALYSIS; PROTON NUCLEAR MAGNETIC RESONANCE; REVIEW; STRUCTURE ACTIVITY RELATION;

COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN BINDING; PROTEINS; SMALL MOLECULE LIBRARIES;

EID: 36248932680     PISSN: 15680266     EISSN: None     Source Type: Journal    
DOI: 10.2174/156802607782341055     Document Type: Review

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