Automation of NMR measurements and data evaluation for systematically screening interactions of small molecules with target proteins

Journal of Biomolecular NMR

Volumn 16, Issue 2, 2000, Pages 139-146

  Ross, Alfred ^a   Schlotterbeck, Götz ^a   Klaus, Werner ^a   Senn, Hans ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Flow injection; Protein; Screening

Indexed keywords

LIGAND; PROTEIN;

ARTICLE; LIGAND BINDING; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL;

AMINES; AUTOMATIC DATA PROCESSING; BINDING SITES; EQUIPMENT DESIGN; EQUIPMENT FAILURE; HUMANS; HYDROGEN-ION CONCENTRATION; LIGANDS; NITROGEN ISOTOPES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN BINDING; PROTEINS; REFERENCE STANDARDS; SOLUBILITY;

EID: 0034055620     PISSN: 09252738     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008394910612     Document Type: Article

References (42)

1. Adams, J.M. (1968) J. Mol. Biol., 33, 571-589.
2. Allen, K.N., Bellamacina, C.R., Ding, X., Jeffery, C.J., Mattos, C., Petsko, G.A. and Ringe, D. (1996) J. Phys. Chem., 100, 2605-2611.
3. Balaram, P., Bothner-By, A.A. and Breslow, E. (1972) J. Am. Chem. Soc., 94, 4017-4018.
4. Bax, A., Ikura, M., Kay, L.E., Torchia, D. and Tschudin, R. (1990) J. Magn. Reson., 86, 304-318.
5. Chen, A. and Shapiro, M.J. (1998) J. Am. Chem. Soc., 120, 10258-10259.
6. Chen, Y., Reizer, J., Saier, H., Fairbrother, W.J. and Wright, P. (1993) Biochemistry, 32, 32-37.
7. Clore, G.M. and Gronenborn, A.M. (1982) J. Magn. Reson., 48, 402-417.
8. Dötsch, V., Wider, G., Siegal, G. and Wüthrich, K. (1995) FEBS Lett., 366, 6-10.
9. Dwek, R.A. (1973) Nuclear Magnetic Resonance in Biochemistry. Application to Enzyme Systems, Clarendon Press, Oxford.
10. Eason, R. (1989) In Centrifugation, a Practical Approach (Ed., D. Rickwood), IRL Press, New York, NY
11. Edlund, U. and Grahn, H. (1991) J. Pharm. Biomed. Anal., 9, 655-658.
12. Feher, V.A., Baldwin, E.P. and Dahlquist, F.W (1996) Nat. Struct. Biol., 3, 516-521.
13. Fitzpatrick, P.A., Steinmetz, A.C., Ringe, D. and Klibanov, A.M. (1993) Proc. Natl. Acad. Sci. USA, 90, 8653-8657.
14. Gartland, K.P., Beddell, C.R., Lindon, J.C. and Nicholson, J.K. (1991) Mol. Pharmacol., 39, 629-642.
15. Grzesiek, S. and Bax, A. (1993) J. Am. Chem. Soc., 115, 12593-12594.
16. Hajduk, P.J., Gerfin, T., Boehlen, J.M., Häberli, M., Marek, D. and Fesik, S.W. (1999) J. Med. Chem., 42, 2315-2317.
17. Hajduk, P.J., Olejniczak, E.T. and Fesik, S.W. (1997) J. Am. Chem. Soc., 119, 12257-12261.
18. Henrion, G., Henrion, A. and Henrion, R. (1988) Beispiele zur Datenanalyse mit BASIC Programmen, Deutscher Verlag der Wissenschaften, Berlin.
19. Henrion, R. and Henrion, G. (1995) Multivariate Datenanalyse, Springer, Berlin.
20. Kallen, J., Spitzfaden, C., Zurini, M.G., Wider, G., Widmer, H., Wüthrich, K. and Walkinshaw, M.D. (1991) Nature, 353, 276-279.
21. th European Symposium on Quantitative Structure-Activity Relationships, Plenum Press, Copenhagen, in press.
22. Led, J.J. and Gesmar, H. (1991) J. Biomol. NMR, 1, 237-246.
23. Liepinsh, E. and Otting, G. (1994) J. Am. Chem. Soc., 116, 9670-9674.
24. Liepinsh, E. and Otting, G. (1997) Nat. Biotechnol., 15, 264-268.
25. Lin, M., Shapiro, M.J. and Wareing, J.R. (1997) J. Am. Chem. Soc., 119, 5249-5250.
26. Marion, D., Ikura, M., Tschudin, R. and Bax, A. (1989) J. Magn. Reson., 85, 393-399.
27. Mattos, C. and Ringe, D. (1996) Nat. Biotechnol., 14, 595-599.
28. Meyer, B., Thomas, W. and Peters, T. (1997) Eur. J. Biochem., 246, 705-709.
29. Otting, G. (1993) Curr. Opin. Struct. Biol., 3, 760-768.
30. Otting, G., Liepinsh, E. and Wüthrich, K. (1991) Science, 254, 974-980.
31. Rizo, J., Liu, Z.P. and Gierasch, L.M. (1994) J. Biomol. NMR, 4, 741-760.
32. Ross, A., Salzmann, A. and Senn, H. (1997) J. Biomol. NMR, 10, 389-396.
33. Shaka, A.J., Barker, P.B. and Freeman, R. (1985) J. Magn. Reson., 64, 547-552.
34. Shapiro, M.J. and Wareing, J.R. (1999) Curr. Opin. Drug Discov., 2, 396-400.
35. Shuker, S.B., Hajduk, P.J., Meadows, R.P. and Fesik, S.W. (1996) Science, 274, 1531-1534.
36. Sklenar, V., Piotto, M., Leppik, R. and Saudek, V. (1993) J. Magn. Reson., A102, 241-245.
37. Spraul, M., Hofmann, M., Ackermann, M., Nicholls, A.W., Damment, S.J., Haselden, J.N., Shockor, J.P., Nicholson, J.K. and Lindon, J.C. (1997) Anal. Commun., 34, 339-341.
38. Überla, K. (1968) Faktorenanalyse, Springer, Berlin.
39. van Zijl, P.C.M., Sukumar, S., Johnson, M.O., Webb, P. and Hurd, R.E. (1994) J. Magn. Reson., A111, 203-207.
40. Wang, J., Hinck, A.P., Loh, S.N., LeMaster, D.M. and Markley, J.L. (1992) Biochemistry, 31, 921-936.
41. Wüthrich, K. (1976) NMR in Biological Research: Peptides and Proteins, Elsevier, New York, NY.
42. Yu, H., Rosen, M.K., Shin, T.B., Seidel-Dugan, C., Brugge, J.S. and Schreiber, S.L. (1992) Science, 258, 1665-1668.