-
1
-
-
25844459154
-
NF-kappaB: linking inflammation and immunity to cancer development and progression
-
Karin, M. et al. (2005) NF-kappaB: linking inflammation and immunity to cancer development and progression. Nat. Rev. Immunol., 5, 749-759.
-
(2005)
Nat. Rev. Immunol.
, vol.5
, pp. 749-759
-
-
Karin, M.1
-
2
-
-
47949096781
-
Cancer-related inflammation
-
Mantovani, A. et al. (2008) Cancer-related inflammation. Nature, 454, 436-444.
-
(2008)
Nature
, vol.454
, pp. 436-444
-
-
Mantovani, A.1
-
3
-
-
77952668256
-
Mechanisms of intestinal inflammation and development of associated cancers: lessons learned from mouse models
-
Westbrook, A. M. et al. (2010) Mechanisms of intestinal inflammation and development of associated cancers: lessons learned from mouse models. Mutat. Res., 705, 40-59.
-
(2010)
Mutat. Res.
, vol.705
, pp. 40-59
-
-
Westbrook, A.M.1
-
4
-
-
33644837942
-
Non-steroidal anti-inflammatory drugs for cancer prevention: promise, perils and pharmacogenetics
-
Ulrich, C. M. et al. (2006) Non-steroidal anti-inflammatory drugs for cancer prevention: promise, perils and pharmacogenetics. Nat. Rev. Cancer, 6, 130-140.
-
(2006)
Nat. Rev. Cancer
, vol.6
, pp. 130-140
-
-
Ulrich, C.M.1
-
5
-
-
79960059582
-
Non-steroidal anti-inflammatory drugs and colorectal cancer risk in a large, prospective cohort
-
Ruder, E. H. et al. (2011) Non-steroidal anti-inflammatory drugs and colorectal cancer risk in a large, prospective cohort. Am. J. Gastroenterol., 106, 1340-1350.
-
(2011)
Am. J. Gastroenterol.
, vol.106
, pp. 1340-1350
-
-
Ruder, E.H.1
-
6
-
-
77953479589
-
Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin-Yang interplay between inflammation and cancer
-
Danese, S. et al. (2010) Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin-Yang interplay between inflammation and cancer. Oncogene, 29, 3313-3323.
-
(2010)
Oncogene
, vol.29
, pp. 3313-3323
-
-
Danese, S.1
-
7
-
-
0035865012
-
Cancer risk in patients with inflammatory bowel disease: a population-based study
-
Bernstein, C. N. et al. (2001) Cancer risk in patients with inflammatory bowel disease: a population-based study. Cancer, 91, 854-862.
-
(2001)
Cancer
, vol.91
, pp. 854-862
-
-
Bernstein, C.N.1
-
8
-
-
0037405713
-
The gastritis connection: prevention and early detection of gastric neoplasms
-
discussion S61-S62
-
Genta, R. M. (2003) The gastritis connection: prevention and early detection of gastric neoplasms. J. Clin. Gastroenterol., 36, S44-S49; discussion S61-S62.
-
(2003)
J. Clin. Gastroenterol.
, vol.36
-
-
Genta, R.M.1
-
9
-
-
38149065951
-
Chronic inflammation and pancreatic cancer
-
McKay, C. J. et al. (2008) Chronic inflammation and pancreatic cancer. Best Pract. Res. Clin. Gastroenterol., 22, 65-73.
-
(2008)
Best Pract. Res. Clin. Gastroenterol.
, vol.22
, pp. 65-73
-
-
McKay, C.J.1
-
10
-
-
59549100166
-
Esophageal adenocarcinoma arising in Barrett esophagus
-
Zhang, H. Y. et al. (2009) Esophageal adenocarcinoma arising in Barrett esophagus. Cancer Lett., 275, 170-177.
-
(2009)
Cancer Lett
, vol.275
, pp. 170-177
-
-
Zhang, H.Y.1
-
11
-
-
30344445931
-
Inflammatory bowel disease: epidemiology, pathogenesis, and therapeutic opportunities
-
Hanauer, S. B. (2006) Inflammatory bowel disease: epidemiology, pathogenesis, and therapeutic opportunities. Inflamm. Bowel Dis., 12 (suppl. 1), S3-S9.
-
(2006)
Inflamm. Bowel Dis.
, vol.12
, Issue.SUPPL. 1
-
-
Hanauer, S.B.1
-
12
-
-
77955383804
-
An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer
-
Asquith, M. et al. (2010) An innately dangerous balancing act: intestinal homeostasis, inflammation, and colitis-associated cancer. J. Exp. Med., 207, 1573-1577.
-
(2010)
J. Exp. Med.
, vol.207
, pp. 1573-1577
-
-
Asquith, M.1
-
13
-
-
0033562383
-
Epidemiology of Crohn's disease and ulcerative colitis in a central Canadian province: a population-based study
-
Bernstein, C. N. et al. (1999) Epidemiology of Crohn's disease and ulcerative colitis in a central Canadian province: a population-based study. Am. J. Epidemiol., 149, 916-924.
-
(1999)
Am. J. Epidemiol.
, vol.149
, pp. 916-924
-
-
Bernstein, C.N.1
-
14
-
-
83755219473
-
Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review
-
Molodecky, N. A. et al. (2012) Increasing incidence and prevalence of the inflammatory bowel diseases with time, based on systematic review. Gastroenterology, 142, 46-54.
-
(2012)
Gastroenterology
, vol.142
, pp. 46-54
-
-
Molodecky, N.A.1
-
15
-
-
67650151005
-
Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability
-
Colotta, F. et al. (2009) Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis, 30, 1073-1081.
-
(2009)
Carcinogenesis
, vol.30
, pp. 1073-1081
-
-
Colotta, F.1
-
16
-
-
0036268432
-
Review article: monitoring activity in ulcerative colitis
-
Rizzello, F. et al. (2002) Review article: monitoring activity in ulcerative colitis. Aliment. Pharmacol. Ther., 16 (suppl. 4), 3-6.
-
(2002)
Aliment. Pharmacol. Ther.
, vol.16
, Issue.SUPPL. 4
, pp. 3-6
-
-
Rizzello, F.1
-
17
-
-
79952224171
-
Animal models of colitis-associated carcinogenesis
-
Kanneganti, M. et al. (2011) Animal models of colitis-associated carcinogenesis. J. Biomed. Biotechnol., 2011, 342637.
-
(2011)
J. Biomed. Biotechnol.
, vol.2011
, pp. 342637
-
-
Kanneganti, M.1
-
18
-
-
0032148387
-
Hypermethylation of the p. 16INK4a promoter in colectomy specimens of patients with long-standing and extensive ulcerative colitis
-
Hsieh, C. J. et al. (1998) Hypermethylation of the p. 16INK4a promoter in colectomy specimens of patients with long-standing and extensive ulcerative colitis. Cancer Res., 58, 3942-3945.
-
(1998)
Cancer Res
, vol.58
, pp. 3942-3945
-
-
Hsieh, C.J.1
-
19
-
-
0034282793
-
Microsatellite instability in inflammatory bowel disease-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, hMLH1
-
Fleisher, A. S. et al. (2000) Microsatellite instability in inflammatory bowel disease-associated neoplastic lesions is associated with hypermethylation and diminished expression of the DNA mismatch repair gene, hMLH1. Cancer Res., 60, 4864-4868.
-
(2000)
Cancer Res
, vol.60
, pp. 4864-4868
-
-
Fleisher, A.S.1
-
20
-
-
3042599473
-
Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation
-
Itzkowitz, S. H. et al. (2004) Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation. Am. J. Physiol. Gastrointest. Liver Physiol., 287, G7-G17.
-
(2004)
Am. J. Physiol. Gastrointest. Liver Physiol.
, vol.287
-
-
Itzkowitz, S.H.1
-
21
-
-
10744221150
-
Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis
-
Rutter, M. et al. (2004) Severity of inflammation is a risk factor for colorectal neoplasia in ulcerative colitis. Gastroenterology, 126, 451-459.
-
(2004)
Gastroenterology
, vol.126
, pp. 451-459
-
-
Rutter, M.1
-
22
-
-
34748900060
-
Hypermethylation of p. 14 (ARF) may be predictive of colitic cancer in patients with ulcerative colitis
-
Moriyama, T. et al. (2007) Hypermethylation of p. 14 (ARF) may be predictive of colitic cancer in patients with ulcerative colitis. Dis. Colon Rectum, 50, 1384-1392.
-
(2007)
Dis. Colon Rectum
, vol.50
, pp. 1384-1392
-
-
Moriyama, T.1
-
23
-
-
41549125402
-
Aberrant DNA methylation in ulcerative colitis without neoplasia
-
Wang, F. Y. et al. (2008) Aberrant DNA methylation in ulcerative colitis without neoplasia. Hepatogastroenterology, 55, 62-65.
-
(2008)
Hepatogastroenterology
, vol.55
, pp. 62-65
-
-
Wang, F.Y.1
-
24
-
-
79955566359
-
Recent insights into the genetics of inflammatory bowel disease
-
Cho, J. H. et al. (2011) Recent insights into the genetics of inflammatory bowel disease. Gastroenterology, 140, 1704-1712.
-
(2011)
Gastroenterology
, vol.140
, pp. 1704-1712
-
-
Cho, J.H.1
-
25
-
-
79951619718
-
Genetics of ulcerative colitis
-
Thompson, A. I. et al. (2011) Genetics of ulcerative colitis. Inflamm. Bowel Dis., 17, 831-848.
-
(2011)
Inflamm. Bowel Dis.
, vol.17
, pp. 831-848
-
-
Thompson, A.I.1
-
26
-
-
0030970975
-
Expression of TNF-alpha by human plasma cells in chronic inflammation
-
Di Girolamo, N. et al. (1997) Expression of TNF-alpha by human plasma cells in chronic inflammation. J. Leukoc. Biol., 61, 667-678.
-
(1997)
J. Leukoc. Biol.
, vol.61
, pp. 667-678
-
-
Di Girolamo, N.1
-
27
-
-
0031853981
-
Secretion imbalance between tumour necrosis factor and its inhibitor in inflammatory bowel disease
-
Noguchi, M. et al. (1998) Secretion imbalance between tumour necrosis factor and its inhibitor in inflammatory bowel disease. Gut, 43, 203-209.
-
(1998)
Gut
, vol.43
, pp. 203-209
-
-
Noguchi, M.1
-
28
-
-
0032787604
-
Regulation of tumor growth and metastasis by interleukin-10: the melanoma experience
-
Huang, S. et al. (1999) Regulation of tumor growth and metastasis by interleukin-10: the melanoma experience. J. Interferon Cytokine Res., 19, 697-703.
-
(1999)
J. Interferon Cytokine Res.
, vol.19
, pp. 697-703
-
-
Huang, S.1
-
29
-
-
47949116890
-
Chemokines and chemokine receptors in mucosal homeostasis at the intestinal epithelial barrier in inflammatory bowel disease
-
Zimmerman, N. P. et al. (2008) Chemokines and chemokine receptors in mucosal homeostasis at the intestinal epithelial barrier in inflammatory bowel disease. Inflamm. Bowel Dis., 14, 1000-1011.
-
(2008)
Inflamm. Bowel Dis.
, vol.14
, pp. 1000-1011
-
-
Zimmerman, N.P.1
-
30
-
-
58649101347
-
gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis
-
Bollrath, J. et al. (2009) gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Cancer Cell, 15, 91-102.
-
(2009)
Cancer Cell
, vol.15
, pp. 91-102
-
-
Bollrath, J.1
-
31
-
-
58649108302
-
IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
-
Grivennikov, S. et al. (2009) IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell, 15, 103-113.
-
(2009)
Cancer Cell
, vol.15
, pp. 103-113
-
-
Grivennikov, S.1
-
32
-
-
0033587747
-
CpG island methylator phenotype in colorectal cancer
-
Toyota, M. et al. (1999) CpG island methylator phenotype in colorectal cancer. Proc. Natl Acad. Sci. USA, 96, 8681-8686.
-
(1999)
Proc. Natl Acad. Sci. USA
, vol.96
, pp. 8681-8686
-
-
Toyota, M.1
-
33
-
-
0033370295
-
Dysplasia in inflammatory bowel diseases: definition and clinical impact
-
Geboes, K. et al. (1999) Dysplasia in inflammatory bowel diseases: definition and clinical impact. Can. J. Gastroenterol., 13, 671-678.
-
(1999)
Can. J. Gastroenterol.
, vol.13
, pp. 671-678
-
-
Geboes, K.1
-
34
-
-
0032695798
-
Pancolonic chromosomal instability precedes dysplasia and cancer in ulcerative colitis
-
Rabinovitch, P. S. et al. (1999) Pancolonic chromosomal instability precedes dysplasia and cancer in ulcerative colitis. Cancer Res., 59, 5148-5153.
-
(1999)
Cancer Res
, vol.59
, pp. 5148-5153
-
-
Rabinovitch, P.S.1
-
35
-
-
67650330166
-
Carcinogenesis in IBD: potential targets for the prevention of colorectal cancer
-
Feagins, L. A. et al. (2009) Carcinogenesis in IBD: potential targets for the prevention of colorectal cancer. Nat. Rev. Gastroenterol. Hepatol., 6, 297-305.
-
(2009)
Nat. Rev. Gastroenterol. Hepatol.
, vol.6
, pp. 297-305
-
-
Feagins, L.A.1
-
36
-
-
77950346282
-
Immunity, inflammation, and cancer
-
Grivennikov, S. I. et al. (2010) Immunity, inflammation, and cancer. Cell, 140, 883-899.
-
(2010)
Cell
, vol.140
, pp. 883-899
-
-
Grivennikov, S.I.1
-
37
-
-
57749090255
-
Methylation of polycomb target genes in intestinal cancer is mediated by inflammation
-
Hahn, M. A. et al. (2008) Methylation of polycomb target genes in intestinal cancer is mediated by inflammation. Cancer Res., 68, 10280-10289.
-
(2008)
Cancer Res
, vol.68
, pp. 10280-10289
-
-
Hahn, M.A.1
-
38
-
-
38849171267
-
Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis
-
Popivanova, B. K. et al. (2008) Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis. J. Clin. Invest., 118, 560-570.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 560-570
-
-
Popivanova, B.K.1
-
39
-
-
77958562404
-
Prevention of colitis-associated carcinogenesis with infliximab
-
Kim, Y. J. et al. (2010) Prevention of colitis-associated carcinogenesis with infliximab. Cancer Prev. Res. (Phila.), 3, 1314-1333.
-
(2010)
Cancer Prev. Res. (Phila. )
, vol.3
, pp. 1314-1333
-
-
Kim, Y.J.1
-
40
-
-
55849107422
-
Stat3 mediates myeloid cell-dependent tumor angiogenesis in mice
-
Kujawski, M. et al. (2008) Stat3 mediates myeloid cell-dependent tumor angiogenesis in mice. J. Clin. Invest., 118, 3367-3377.
-
(2008)
J. Clin. Invest.
, vol.118
, pp. 3367-3377
-
-
Kujawski, M.1
-
41
-
-
44849100198
-
NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha
-
Rius, J. et al. (2008) NF-kappaB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1alpha. Nature, 453, 807-811.
-
(2008)
Nature
, vol.453
, pp. 807-811
-
-
Rius, J.1
-
42
-
-
63049104211
-
Microenvironmental regulation of metastasis
-
Joyce, J. A. et al. (2009) Microenvironmental regulation of metastasis. Nat. Rev. Cancer, 9, 239-252.
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 239-252
-
-
Joyce, J.A.1
-
43
-
-
0023192006
-
Macrophage-induced angiogenesis is mediated by tumour necrosis factor-alpha
-
Leibovich, S. J. et al. (1987) Macrophage-induced angiogenesis is mediated by tumour necrosis factor-alpha. Nature, 329, 630-632.
-
(1987)
Nature
, vol.329
, pp. 630-632
-
-
Leibovich, S.J.1
-
44
-
-
0027534917
-
Enhancement of experimental metastasis by tumor necrosis factor
-
Orosz, P. et al. (1993) Enhancement of experimental metastasis by tumor necrosis factor. J. Exp. Med., 177, 1391-1398.
-
(1993)
J. Exp. Med.
, vol.177
, pp. 1391-1398
-
-
Orosz, P.1
-
45
-
-
0031469894
-
Review article: how relevant to human inflammatory bowel disease are current animal models of intestinal inflammation?
-
discussion 96-97
-
Sartor, R. B. (1997) Review article: how relevant to human inflammatory bowel disease are current animal models of intestinal inflammation? Aliment. Pharmacol. Ther., 11 (suppl. 3), 89-96; discussion 96-97.
-
(1997)
Aliment. Pharmacol. Ther.
, vol.11
, Issue.SUPPL. 3
, pp. 89-96
-
-
Sartor, R.B.1
-
46
-
-
35348982262
-
Mouse models of inflammatory bowel disease
-
Wirtz, S. et al. (2007) Mouse models of inflammatory bowel disease. Adv. Drug. Deliv. Rev., 59, 1073-1083.
-
(2007)
Adv. Drug. Deliv. Rev.
, vol.59
, pp. 1073-1083
-
-
Wirtz, S.1
-
47
-
-
34248141100
-
A cytokine-mediated link between innate immunity, inflammation, and cancer
-
Lin, W. W. et al. (2007) A cytokine-mediated link between innate immunity, inflammation, and cancer. J. Clin. Invest., 117, 1175-1183.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 1175-1183
-
-
Lin, W.W.1
-
48
-
-
33646472252
-
Tumour necrosis factor-alpha as a tumour promoter
-
Szlosarek, P. et al. (2006) Tumour necrosis factor-alpha as a tumour promoter. Eur. J. Cancer, 42, 745-750.
-
(2006)
Eur. J. Cancer
, vol.42
, pp. 745-750
-
-
Szlosarek, P.1
-
49
-
-
21044449255
-
Infliximab: use in inflammatory bowel disease
-
Travassos, W. J. et al. (2005) Infliximab: use in inflammatory bowel disease. Curr. Treat. Options Gastroenterol., 8, 187-196.
-
(2005)
Curr. Treat. Options Gastroenterol.
, vol.8
, pp. 187-196
-
-
Travassos, W.J.1
-
50
-
-
33749243559
-
Interleukin-6 level in patients with colorectal cancer
-
Esfandi, F. et al. (2006) Interleukin-6 level in patients with colorectal cancer. Cancer Lett., 244, 76-78.
-
(2006)
Cancer Lett
, vol.244
, pp. 76-78
-
-
Esfandi, F.1
-
51
-
-
77149155643
-
Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis
-
Li, Y. et al. (2010) Disease-related expression of the IL6/STAT3/SOCS3 signalling pathway in ulcerative colitis and ulcerative colitis-related carcinogenesis. Gut, 59, 227-235.
-
(2010)
Gut
, vol.59
, pp. 227-235
-
-
Li, Y.1
-
52
-
-
77949326158
-
Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model
-
Matsumoto, S. et al. (2010) Essential roles of IL-6 trans-signaling in colonic epithelial cells, induced by the IL-6/soluble-IL-6 receptor derived from lamina propria macrophages, on the development of colitis-associated premalignant cancer in a murine model. J. Immunol., 184, 1543-1551.
-
(2010)
J. Immunol.
, vol.184
, pp. 1543-1551
-
-
Matsumoto, S.1
-
53
-
-
77951188458
-
Upregulation of DNA methyltransferase-mediated gene silencing, anchorage-independent growth, and migration of colon cancer cells by interleukin-6
-
Foran, E. et al. (2010) Upregulation of DNA methyltransferase-mediated gene silencing, anchorage-independent growth, and migration of colon cancer cells by interleukin-6. Mol. Cancer Res., 8, 471-481.
-
(2010)
Mol. Cancer Res.
, vol.8
, pp. 471-481
-
-
Foran, E.1
-
54
-
-
0029813545
-
Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses
-
Berg, D. J. et al. (1996) Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J. Clin. Invest., 98, 1010-1020.
-
(1996)
J. Clin. Invest.
, vol.98
, pp. 1010-1020
-
-
Berg, D.J.1
-
55
-
-
0033527549
-
Interleukin-10 signaling blocks inhibitor of kappaB kinase activity and nuclear factor kappaB DNA binding
-
Schottelius, A. J. et al. (1999) Interleukin-10 signaling blocks inhibitor of kappaB kinase activity and nuclear factor kappaB DNA binding. J. Biol. Chem., 274, 31868-31874.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 31868-31874
-
-
Schottelius, A.J.1
-
56
-
-
11244348125
-
STAT3 regulates NF-kappaB recruitment to the IL-12p. 40 promoter in dendritic cells
-
Hoentjen, F. et al. (2005) STAT3 regulates NF-kappaB recruitment to the IL-12p. 40 promoter in dendritic cells. Blood, 105, 689-696.
-
(2005)
Blood
, vol.105
, pp. 689-696
-
-
Hoentjen, F.1
-
57
-
-
0025887808
-
Double blind, placebo controlled trial of metronidazole in Crohn's disease
-
Sutherland, L. et al. (1991) Double blind, placebo controlled trial of metronidazole in Crohn's disease. Gut, 32, 1071-1075.
-
(1991)
Gut
, vol.32
, pp. 1071-1075
-
-
Sutherland, L.1
-
58
-
-
0027933817
-
Role of intestinal microflora in chronic inflammation and ulceration of the rat colon
-
Videla, S. et al. (1994) Role of intestinal microflora in chronic inflammation and ulceration of the rat colon. Gut, 35, 1090-1097.
-
(1994)
Gut
, vol.35
, pp. 1090-1097
-
-
Videla, S.1
-
59
-
-
12144285993
-
An abundance of Escherichia coli is harbored by the mucosa-associated bacterial flora of interleukin-2-deficient mice
-
Schuppler, M. et al. (2004) An abundance of Escherichia coli is harbored by the mucosa-associated bacterial flora of interleukin-2-deficient mice. Infect. Immun., 72, 1983-1990.
-
(2004)
Infect. Immun.
, vol.72
, pp. 1983-1990
-
-
Schuppler, M.1
-
60
-
-
3242664636
-
Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis
-
Rakoff-Nahoum, S. et al. (2004) Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell, 118, 229-241.
-
(2004)
Cell
, vol.118
, pp. 229-241
-
-
Rakoff-Nahoum, S.1
-
61
-
-
20444373390
-
MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis
-
Araki, A. et al. (2005) MyD88-deficient mice develop severe intestinal inflammation in dextran sodium sulfate colitis. J. Gastroenterol., 40, 16-23.
-
(2005)
J. Gastroenterol.
, vol.40
, pp. 16-23
-
-
Araki, A.1
-
62
-
-
3142654210
-
Inferences, questions and possibilities in toll-like receptor signalling
-
Beutler, B. (2004) Inferences, questions and possibilities in toll-like receptor signalling. Nature, 430, 257-263.
-
(2004)
Nature
, vol.430
, pp. 257-263
-
-
Beutler, B.1
-
63
-
-
4043088499
-
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
-
Greten, F. R. et al. (2004) IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell, 118, 285-296.
-
(2004)
Cell
, vol.118
, pp. 285-296
-
-
Greten, F.R.1
-
64
-
-
34047173496
-
Epithelial NEMO links innate immunity to chronic intestinal inflammation
-
Nenci, A. et al. (2007) Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature, 446, 557-561.
-
(2007)
Nature
, vol.446
, pp. 557-561
-
-
Nenci, A.1
-
65
-
-
77549083560
-
Dangerous liaisons: sTAT3 and NF-kappaB collaboration and crosstalk in cancer
-
Grivennikov, S. I. et al. (2010) Dangerous liaisons: sTAT3 and NF-kappaB collaboration and crosstalk in cancer. Cytokine Growth Factor Rev., 21, 11-19.
-
(2010)
Cytokine Growth Factor Rev
, vol.21
, pp. 11-19
-
-
Grivennikov, S.I.1
-
66
-
-
0031595210
-
Nuclear factor kappaB is activated in macrophages and epithelial cells of inflamed intestinal mucosa
-
Rogler, G. et al. (1998) Nuclear factor kappaB is activated in macrophages and epithelial cells of inflamed intestinal mucosa. Gastroenterology, 115, 357-369.
-
(1998)
Gastroenterology
, vol.115
, pp. 357-369
-
-
Rogler, G.1
-
67
-
-
0037972018
-
Increased expression of RelA/nuclear factor-kappa B protein correlates with colorectal tumorigenesis
-
Yu, H. G. et al. (2003) Increased expression of RelA/nuclear factor-kappa B protein correlates with colorectal tumorigenesis. Oncology, 65, 37-45.
-
(2003)
Oncology
, vol.65
, pp. 37-45
-
-
Yu, H.G.1
-
68
-
-
0028349735
-
Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6
-
Zhong, Z. et al. (1994) Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science, 264, 95-98.
-
(1994)
Science
, vol.264
, pp. 95-98
-
-
Zhong, Z.1
-
69
-
-
0032168152
-
Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
-
Heinrich, P. C. et al. (1998) Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem J, 334, (Pt 2), 297-314.
-
(1998)
Biochem J
, vol.334
, Issue.PART. 2
, pp. 297-314
-
-
Heinrich, P.C.1
-
70
-
-
0345492424
-
SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer
-
He, B. et al. (2003) SOCS-3 is frequently silenced by hypermethylation and suppresses cell growth in human lung cancer. Proc. Natl Acad. Sci. USA, 100, 14133-14138.
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 14133-14138
-
-
He, B.1
-
71
-
-
33847381116
-
The fundamental basis of inflammatory bowel disease
-
Strober, W. et al. (2007) The fundamental basis of inflammatory bowel disease. J. Clin. Invest., 117, 514-521.
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 514-521
-
-
Strober, W.1
-
72
-
-
0035978651
-
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
-
Hugot, J. P. et al. (2001) Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature, 411, 599-603.
-
(2001)
Nature
, vol.411
, pp. 599-603
-
-
Hugot, J.P.1
-
73
-
-
0035978533
-
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
-
Ogura, Y. et al. (2001) A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature, 411, 603-606.
-
(2001)
Nature
, vol.411
, pp. 603-606
-
-
Ogura, Y.1
-
74
-
-
33644847555
-
Dissection of the inflammatory bowel disease transcriptome using genome-wide cDNA microarrays
-
Costello, C. M. et al. (2005) Dissection of the inflammatory bowel disease transcriptome using genome-wide cDNA microarrays. PLoS Med, 2, e199.
-
(2005)
PLoS Med
, vol.2
-
-
Costello, C.M.1
-
75
-
-
80051539323
-
DNA methylation of colon mucosa in ulcerative colitis patients: correlation with inflammatory status
-
Saito, S. et al. (2011) DNA methylation of colon mucosa in ulcerative colitis patients: correlation with inflammatory status. Inflamm. Bowel Dis., 17, 1955-1965.
-
(2011)
Inflamm. Bowel Dis.
, vol.17
, pp. 1955-1965
-
-
Saito, S.1
-
76
-
-
70449701913
-
Epigenetic cross-talk between DNA methylation and histone modifications in human cancers
-
Kondo, Y. (2009) Epigenetic cross-talk between DNA methylation and histone modifications in human cancers. Yonsei Med. J., 50, 455-463.
-
(2009)
Yonsei Med. J.
, vol.50
, pp. 455-463
-
-
Kondo, Y.1
-
77
-
-
78049427089
-
Introduction to epigenomics and epigenomewide analysis
-
Fazzari, M. J. et al. (2010) Introduction to epigenomics and epigenomewide analysis. Methods Mol. Biol., 620, 243-265.
-
(2010)
Methods Mol. Biol.
, vol.620
, pp. 243-265
-
-
Fazzari, M.J.1
-
78
-
-
33645775726
-
Histone hyperacetylation is associated with amelioration of experimental colitis in mice
-
Glauben, R. et al. (2006) Histone hyperacetylation is associated with amelioration of experimental colitis in mice. J. Immunol., 176, 5015-5022.
-
(2006)
J. Immunol.
, vol.176
, pp. 5015-5022
-
-
Glauben, R.1
-
79
-
-
0035839136
-
Translating the histone code
-
Jenuwein, T. et al. (2001) Translating the histone code. Science, 293, 1074-1080.
-
(2001)
Science
, vol.293
, pp. 1074-1080
-
-
Jenuwein, T.1
-
80
-
-
42549114401
-
Histone deacetylases: novel targets for prevention of colitis-associated cancer in mice
-
Glauben, R. et al. (2008) Histone deacetylases: novel targets for prevention of colitis-associated cancer in mice. Gut, 57, 613-622.
-
(2008)
Gut
, vol.57
, pp. 613-622
-
-
Glauben, R.1
-
81
-
-
0035755974
-
Histone deacetylases and cancer: causes and therapies
-
Marks, P. et al. (2001) Histone deacetylases and cancer: causes and therapies. Nat. Rev. Cancer, 1, 194-202.
-
(2001)
Nat. Rev. Cancer
, vol.1
, pp. 194-202
-
-
Marks, P.1
-
82
-
-
51649110503
-
Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia
-
Garcia-Manero, G. et al. (2008) Phase 1 study of the oral isotype specific histone deacetylase inhibitor MGCD0103 in leukemia. Blood, 112, 981-989.
-
(2008)
Blood
, vol.112
, pp. 981-989
-
-
Garcia-Manero, G.1
-
83
-
-
0036415141
-
Dnmt3a and Dnmt1 functionally cooperate during de novo methylation of DNA
-
Fatemi, M. et al. (2002) Dnmt3a and Dnmt1 functionally cooperate during de novo methylation of DNA. Eur. J. Biochem., 269, 4981-4984.
-
(2002)
Eur. J. Biochem.
, vol.269
, pp. 4981-4984
-
-
Fatemi, M.1
-
84
-
-
31544467813
-
De novo CpG island methylation in human cancer cells
-
Jair, K. W. et al. (2006) De novo CpG island methylation in human cancer cells. Cancer Res., 66, 682-692.
-
(2006)
Cancer Res
, vol.66
, pp. 682-692
-
-
Jair, K.W.1
-
85
-
-
38449104412
-
On the enzymatic properties of Dnmt1: specificity, processivity, mechanism of linear diffusion and allosteric regulation of the enzyme
-
Jeltsch, A. (2006) On the enzymatic properties of Dnmt1: specificity, processivity, mechanism of linear diffusion and allosteric regulation of the enzyme. Epigenetics, 1, 63-66.
-
(2006)
Epigenetics
, vol.1
, pp. 63-66
-
-
Jeltsch, A.1
-
86
-
-
0032960181
-
Cancer epigenetics comes of age
-
Jones, P. A. et al. (1999) Cancer epigenetics comes of age. Nat. Genet., 21, 163-167.
-
(1999)
Nat. Genet.
, vol.21
, pp. 163-167
-
-
Jones, P.A.1
-
87
-
-
65249157050
-
Epigenetics, DNA methylation, and chromatin modifying drugs
-
Szyf, M. (2009) Epigenetics, DNA methylation, and chromatin modifying drugs. Annu. Rev. Pharmacol. Toxicol., 49, 243-263.
-
(2009)
Annu. Rev. Pharmacol. Toxicol.
, vol.49
, pp. 243-263
-
-
Szyf, M.1
-
88
-
-
44049120882
-
CpG islands in mammalian gene promoters are inherently resistant to de novo methylation
-
Bestor, T. H. et al. (1992) CpG islands in mammalian gene promoters are inherently resistant to de novo methylation. Genet. Anal. Tech. Appl., 9, 48-53.
-
(1992)
Genet. Anal. Tech. Appl.
, vol.9
, pp. 48-53
-
-
Bestor, T.H.1
-
89
-
-
13844320649
-
Aberrant DNA methylation as a cancer inducing mechanism
-
Estellar, M. (2005) Aberrant DNA methylation as a cancer inducing mechanism. Annu. Rev. Pharmacol. Toxicol., 45, 629-656.
-
(2005)
Annu. Rev. Pharmacol. Toxicol.
, vol.45
, pp. 629-656
-
-
Estellar, M.1
-
90
-
-
1542319832
-
Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers
-
Etoh, T. et al. (2004) Increased DNA methyltransferase 1 (DNMT1) protein expression correlates significantly with poorer tumor differentiation and frequent DNA hypermethylation of multiple CpG islands in gastric cancers. Am. J. Pathol., 164, 689-699.
-
(2004)
Am. J. Pathol.
, vol.164
, pp. 689-699
-
-
Etoh, T.1
-
91
-
-
46449115224
-
The expression and clinical significance of DNA methyltransferase proteins in human gastric cancer
-
Ding, W. J. et al. (2008) The expression and clinical significance of DNA methyltransferase proteins in human gastric cancer. Dig. Dis. Sci., 53, 2083-2089.
-
(2008)
Dig. Dis. Sci.
, vol.53
, pp. 2083-2089
-
-
Ding, W.J.1
-
92
-
-
33751280992
-
Interleukin-6 contributes to growth in cholangiocarcinoma cells by aberrant promoter methylation and gene expression
-
Wehbe, H. et al. (2006) Interleukin-6 contributes to growth in cholangiocarcinoma cells by aberrant promoter methylation and gene expression. Cancer Res., 66, 10517-10524.
-
(2006)
Cancer Res
, vol.66
, pp. 10517-10524
-
-
Wehbe, H.1
-
93
-
-
0035328527
-
Accelerated age-related CpG island methylation in ulcerative colitis
-
Issa, J. P. et al. (2001) Accelerated age-related CpG island methylation in ulcerative colitis. Cancer Res., 61, 3573-3577.
-
(2001)
Cancer Res
, vol.61
, pp. 3573-3577
-
-
Issa, J.P.1
-
94
-
-
32944459562
-
High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk
-
Maekita, T. et al. (2006) High levels of aberrant DNA methylation in Helicobacter pylori-infected gastric mucosae and its possible association with gastric cancer risk. Clin. Cancer Res., 12, 989-995.
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 989-995
-
-
Maekita, T.1
-
95
-
-
79959820766
-
An overview of epigenetics and chemoprevention
-
Huang, Y. W. et al. (2010) An overview of epigenetics and chemoprevention. FEBS Lett., 585, 2129-2136.
-
(2010)
FEBS Lett
, vol.585
, pp. 2129-2136
-
-
Huang, Y.W.1
-
96
-
-
79953737588
-
Widespread hypomethylation occurs early and synergizes with gene amplification during esophageal carcinogenesis
-
Alvarez, H. et al. (2011) Widespread hypomethylation occurs early and synergizes with gene amplification during esophageal carcinogenesis. PLoS Genet., 7, e1001356.
-
(2011)
PLoS Genet
, vol.7
-
-
Alvarez, H.1
-
97
-
-
29344449681
-
Prediction of colorectal neoplasia by quantitative methylation analysis of estrogen receptor gene in nonneoplastic epithelium from patients with ulcerative colitis
-
Tominaga, K. et al. (2005) Prediction of colorectal neoplasia by quantitative methylation analysis of estrogen receptor gene in nonneoplastic epithelium from patients with ulcerative colitis. Clin. Cancer Res., 11, 8880-8885.
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 8880-8885
-
-
Tominaga, K.1
-
98
-
-
52549133774
-
Epigenetic regulation ofWNT signaling pathway genes in inflammatory bowel disease (IBD) associated neoplasia
-
Dhir, M. et al. (2008) Epigenetic regulation ofWNT signaling pathway genes in inflammatory bowel disease (IBD) associated neoplasia. J. Gastrointest. Surg., 12, 1745-1753.
-
(2008)
J. Gastrointest. Surg.
, vol.12
, pp. 1745-1753
-
-
Dhir, M.1
-
99
-
-
67349285075
-
Promoter methylation of protease-activated receptor (PAR2) is associated with severe clinical phenotypes of ulcerative colitis (UC)
-
Tahara, T. et al. (2009) Promoter methylation of protease-activated receptor (PAR2) is associated with severe clinical phenotypes of ulcerative colitis (UC). Clin. Exp. Med., 9, 125-130.
-
(2009)
Clin. Exp. Med.
, vol.9
, pp. 125-130
-
-
Tahara, T.1
-
100
-
-
77954663598
-
DNA methylation of ESR-1 and N-33 in colorectal mucosa of patients with ulcerative colitis (UC)
-
Arasaradnam, R. P. et al. (2010) DNA methylation of ESR-1 and N-33 in colorectal mucosa of patients with ulcerative colitis (UC). Epigenetics, 5, 422-426.
-
(2010)
Epigenetics
, vol.5
, pp. 422-426
-
-
Arasaradnam, R.P.1
-
101
-
-
67649451991
-
Effect of MDR1 gene promoter methylation in patients with ulcerative colitis
-
Tahara, T. et al. (2009) Effect of MDR1 gene promoter methylation in patients with ulcerative colitis. Int. J. Mol. Med., 23, 521-527.
-
(2009)
Int. J. Mol. Med.
, vol.23
, pp. 521-527
-
-
Tahara, T.1
-
102
-
-
79958025266
-
An endogenously anti-inflammatory role for methylation in mucosal inflammation identified through metabolite profiling
-
Kominsky, D. J. et al. (2011) An endogenously anti-inflammatory role for methylation in mucosal inflammation identified through metabolite profiling. J. Immunol., 186, 6505-6514.
-
(2011)
J. Immunol.
, vol.186
, pp. 6505-6514
-
-
Kominsky, D.J.1
-
103
-
-
84855968457
-
Early-stage formation of an epigenetic field defect in a mouse colitis model, and non-essential roles of T- and B-cells in DNA methylation induction
-
Katsurano, M. et al. (2012) Early-stage formation of an epigenetic field defect in a mouse colitis model, and non-essential roles of T- and B-cells in DNA methylation induction. Oncogene, 31, 342-351.
-
(2012)
Oncogene
, vol.31
, pp. 342-351
-
-
Katsurano, M.1
-
104
-
-
81255162523
-
Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG islands
-
O'Hagan, H. M. et al. (2011) Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG islands. Cancer Cell, 20, 606-619.
-
(2011)
Cancer Cell
, vol.20
, pp. 606-619
-
-
O'Hagan, H.M.1
-
105
-
-
59849085588
-
Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation
-
Lal, G. et al. (2009) Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation. J. Immunol., 182, 259-273.
-
(2009)
J. Immunol.
, vol.182
, pp. 259-273
-
-
Lal, G.1
-
106
-
-
79959872458
-
Cell type-specific DNA methylation at intragenic CpG islands in the immune system
-
Deaton, A. M. et al. (2011) Cell type-specific DNA methylation at intragenic CpG islands in the immune system. Genome Res., 21, 1074-1086.
-
(2011)
Genome Res
, vol.21
, pp. 1074-1086
-
-
Deaton, A.M.1
-
107
-
-
10344260184
-
CpG island methylator phenotype in cancer
-
Issa, J. P. (2004) CpG island methylator phenotype in cancer. Nat. Rev. Cancer, 4, 988-993.
-
(2004)
Nat. Rev. Cancer
, vol.4
, pp. 988-993
-
-
Issa, J.P.1
-
108
-
-
34247273521
-
Rare CpG island methylator phenotype in ulcerative colitis-associated neoplasias
-
Konishi, K. et al. (2007) Rare CpG island methylator phenotype in ulcerative colitis-associated neoplasias. Gastroenterology, 132, 1254-1260.
-
(2007)
Gastroenterology
, vol.132
, pp. 1254-1260
-
-
Konishi, K.1
-
109
-
-
80755173982
-
Relative role of methylator and tumor suppressor pathways in ulcerative colitis-associated colon cancer
-
Sanchez, J. A. et al. (2011) Relative role of methylator and tumor suppressor pathways in ulcerative colitis-associated colon cancer. Inflamm. Bowel Dis.
-
(2011)
Inflamm. Bowel Dis.
-
-
Sanchez, J.A.1
-
110
-
-
79952119029
-
Insufficient role of cell proliferation in aberrant DNA methylation induction and involvement of specific types of inflammation
-
Hur, K. et al. (2011) Insufficient role of cell proliferation in aberrant DNA methylation induction and involvement of specific types of inflammation. Carcinogenesis, 32, 35-41.
-
(2011)
Carcinogenesis
, vol.32
, pp. 35-41
-
-
Hur, K.1
-
111
-
-
76649145629
-
Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells
-
Niwa, T. et al. (2010) Inflammatory processes triggered by Helicobacter pylori infection cause aberrant DNA methylation in gastric epithelial cells. Cancer Res., 70, 1430-1440.
-
(2010)
Cancer Res
, vol.70
, pp. 1430-1440
-
-
Niwa, T.1
-
112
-
-
64349091471
-
Targeted and genome-scale strategies reveal genebody methylation signatures in human cells
-
Ball, M. P. et al. (2009) Targeted and genome-scale strategies reveal genebody methylation signatures in human cells. Nat. Biotechnol., 27, 361-368.
-
(2009)
Nat. Biotechnol.
, vol.27
, pp. 361-368
-
-
Ball, M.P.1
-
113
-
-
70649095120
-
Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts
-
Doi, A. et al. (2009) Differential methylation of tissue- and cancer-specific CpG island shores distinguishes human induced pluripotent stem cells, embryonic stem cells and fibroblasts. Nat. Genet., 41, 1350-1353.
-
(2009)
Nat. Genet.
, vol.41
, pp. 1350-1353
-
-
Doi, A.1
-
114
-
-
23044514626
-
Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells
-
Weber, M. et al. (2005) Chromosome-wide and promoter-specific analyses identify sites of differential DNA methylation in normal and transformed human cells. Nat. Genet., 37, 853-862.
-
(2005)
Nat. Genet.
, vol.37
, pp. 853-862
-
-
Weber, M.1
-
115
-
-
33746756014
-
Comparative isoschizomer profiling of cytosine methylation: the HELP assay
-
Khulan, B. et al. (2006) Comparative isoschizomer profiling of cytosine methylation: the HELP assay. Genome Res., 16, 1046-1055.
-
(2006)
Genome Res
, vol.16
, pp. 1046-1055
-
-
Khulan, B.1
-
116
-
-
70450217879
-
Human DNA methylomes at base resolution show widespread epigenomic differences
-
Lister, R. et al. (2009) Human DNA methylomes at base resolution show widespread epigenomic differences. Nature, 462, 315-322.
-
(2009)
Nature
, vol.462
, pp. 315-322
-
-
Lister, R.1
-
117
-
-
43149098062
-
Comprehensive high-throughput arrays for relative methylation (CHARM)
-
Irizarry, R. A. et al. (2008) Comprehensive high-throughput arrays for relative methylation (CHARM). Genome Res., 18, 780-790.
-
(2008)
Genome Res
, vol.18
, pp. 780-790
-
-
Irizarry, R.A.1
-
118
-
-
77957932941
-
Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications
-
Harris, R. A. et al. (2010) Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat. Biotechnol., 28, 1097-1105.
-
(2010)
Nat. Biotechnol.
, vol.28
, pp. 1097-1105
-
-
Harris, R.A.1
-
119
-
-
46749153406
-
An integrative genomic and epigenomic approach for the study of transcriptional regulation
-
Figueroa, M. E. et al. (2008) An integrative genomic and epigenomic approach for the study of transcriptional regulation. PLoS One, 3, e1882.
-
(2008)
PLoS One
, vol.3
-
-
Figueroa, M.E.1
-
120
-
-
79956308473
-
Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells
-
Pastor, W. A. et al. (2011) Genome-wide mapping of 5-hydroxymethylcytosine in embryonic stem cells. Nature, 473, 394-397.
-
(2011)
Nature
, vol.473
, pp. 394-397
-
-
Pastor, W.A.1
-
121
-
-
79959209733
-
5-Hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells
-
Stroud, H. et al. (2011) 5-Hydroxymethylcytosine is associated with enhancers and gene bodies in human embryonic stem cells. Genome Biol., 12, R54.
-
(2011)
Genome Biol
, vol.12
-
-
Stroud, H.1
-
122
-
-
77956189495
-
Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
-
Ito, S. et al. (2010) Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature, 466, 1129-1133.
-
(2010)
Nature
, vol.466
, pp. 1129-1133
-
-
Ito, S.1
-
123
-
-
79956302047
-
TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity
-
Williams, K. et al. (2011) TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity. Nature, 473, 343-348.
-
(2011)
Nature
, vol.473
, pp. 343-348
-
-
Williams, K.1
-
124
-
-
79955948324
-
Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells
-
Xu, Y. et al. (2011) Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells. Mol. Cell, 42, 451-464.
-
(2011)
Mol. Cell
, vol.42
, pp. 451-464
-
-
Xu, Y.1
-
125
-
-
84864129535
-
Distribution of 5-hydroxymethylcytosine in different human tissues
-
Li, W. et al. (2011) Distribution of 5-hydroxymethylcytosine in different human tissues. J. Nucleic Acids, 2011, 870726.
-
(2011)
J. Nucleic Acids
, vol.2011
, pp. 870726
-
-
Li, W.1
-
126
-
-
79960768558
-
Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulo-monocytic differentiation of human hematopoietic progenitors
-
Pronier, E. et al. (2011) Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulo-monocytic differentiation of human hematopoietic progenitors. Blood, 118, 2551-2555.
-
(2011)
Blood
, vol.118
, pp. 2551-2555
-
-
Pronier, E.1
-
127
-
-
80052461558
-
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
-
Ito, S. et al. (2011) Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science, 333, 1300-1303.
-
(2011)
Science
, vol.333
, pp. 1300-1303
-
-
Ito, S.1
-
128
-
-
0018860957
-
Cellular differentiation, cytidine analogs and DNA methylation
-
Jones, P. A. et al. (1980) Cellular differentiation, cytidine analogs and DNA methylation. Cell, 20, 85-93.
-
(1980)
Cell
, vol.20
, pp. 85-93
-
-
Jones, P.A.1
-
129
-
-
34250213859
-
DNA methylation as a therapeutic target in cancer
-
Issa, J. P. (2007) DNA methylation as a therapeutic target in cancer. Clin. Cancer Res., 13, 1634-1637.
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 1634-1637
-
-
Issa, J.P.1
-
130
-
-
46949098033
-
Current status of epigenetic treatment in myelodysplastic syndromes
-
Kuendgen, A. et al. (2008) Current status of epigenetic treatment in myelodysplastic syndromes. Ann. Hematol., 87, 601-611.
-
(2008)
Ann. Hematol.
, vol.87
, pp. 601-611
-
-
Kuendgen, A.1
|