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Volumn 585, Issue 13, 2011, Pages 2129-2136

An overview of epigenetics and chemoprevention

Author keywords

Cancer prevention; DNA methylation; Epigenome

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; APC PROTEIN; AZACITIDINE; CADHERIN; CADHERIN 13; CAFFEIC ACID; CARMUSTINE; CATECHOL METHYLTRANSFERASE; CHLOROGENIC ACID; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYTOCHROME P450 1A1; CYTOCHROME P450 2D6; DNA METHYLTRANSFERASE; DNA METHYLTRANSFERASE INHIBITOR; EPIGALLOCATECHIN GALLATE; GENISTEIN; HISTONE DEACETYLASE; HYDRALAZINE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; MG 98; PANOBINOSTAT; RAS ASSOCIATION DOMAIN FAMILY PROTEIN 1A; RETINOIC ACID; ROMIDEPSIN; TAMOXIFEN; TEMOZOLOMIDE; TRANSCRIPTION FACTOR PITX2; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALPROIC ACID; VORINOSTAT;

EID: 79959820766     PISSN: 00145793     EISSN: 18733468     Source Type: Journal    
DOI: 10.1016/j.febslet.2010.11.002     Document Type: Review
Times cited : (49)

References (74)
  • 1
    • 0037354085 scopus 로고    scopus 로고
    • Epigenetics in cancer prevention: Early detection and risk assessment
    • K.D. Barbara, V. Mukesh, and U. Asad Epigenetics in cancer prevention: early detection and risk assessment Ann. N.Y. Acad. Sci. 983 2003 1 4
    • (2003) Ann. N.Y. Acad. Sci. , vol.983 , pp. 1-4
    • Barbara, K.D.1    Mukesh, V.2    Asad, U.3
  • 2
    • 33644846509 scopus 로고    scopus 로고
    • Epigenetic gene silencing in cancer - A mechanism for early oncogenic pathway addiction?
    • DOI 10.1038/nrc1799, PII N1799
    • S.B. Baylin, and J.E. Ohm Epigenetic gene silencing in cancer - a mechanism for early oncogenic pathway addiction? Nat. Rev. Cancer 6 2006 107 116 (Pubitemid 43361543)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.2 , pp. 107-116
    • Baylin, S.B.1    Ohm, J.E.2
  • 3
    • 33644856123 scopus 로고    scopus 로고
    • Epigenetic therapy of cancer: Past, present and future
    • C.B. Yoo, and P.A. Jones Epigenetic therapy of cancer: past, present and future Nat. Rev. Drug Discov. 5 2006 37 50
    • (2006) Nat. Rev. Drug Discov. , vol.5 , pp. 37-50
    • Yoo, C.B.1    Jones, P.A.2
  • 4
    • 75649094543 scopus 로고    scopus 로고
    • Aberrant DNA methylation in contrast with mutations
    • T. Ushijima, and K. Asada Aberrant DNA methylation in contrast with mutations Cancer Sci. 101 2010 300 305
    • (2010) Cancer Sci. , vol.101 , pp. 300-305
    • Ushijima, T.1    Asada, K.2
  • 5
    • 39649122136 scopus 로고    scopus 로고
    • Cancer epigenetics: Modifications, screening, and therapy
    • DOI 10.1146/annurev.med.59.061606.095816
    • E.N. Gal-Yam, Y. Saito, G. Egger, and P.A. Jones Cancer epigenetics: modifications, screening, and therapy Annu. Rev. Med. 59 2008 267 280 (Pubitemid 351287937)
    • (2008) Annual Review of Medicine , vol.59 , pp. 267-280
    • Gal-Yam, E.N.1    Saito, Y.2    Egger, G.3    Jones, P.A.4
  • 6
    • 79952111066 scopus 로고    scopus 로고
    • Chromatin remodeling in mammary gland differentiation and breast tumorigenesis
    • T.H. Huang, and M. Esteller Chromatin remodeling in mammary gland differentiation and breast tumorigenesis Cold Spring Harb. Perspect. Biol. 2 2010 a004515
    • (2010) Cold Spring Harb. Perspect. Biol. , vol.2 , pp. 004515
    • Huang, T.H.1    Esteller, M.2
  • 7
    • 14644396228 scopus 로고    scopus 로고
    • Detection and interpretation of altered methylation patterns in cancer cells
    • DOI 10.1038/nrc1571
    • T. Ushijima Detection and interpretation of altered methylation patterns in cancer cells Nat. Rev. Cancer 5 2005 223 231 (Pubitemid 40314953)
    • (2005) Nature Reviews Cancer , vol.5 , Issue.3 , pp. 223-231
    • Ushijima, T.1
  • 8
    • 0345357773 scopus 로고    scopus 로고
    • Gene Silencing in Cancer in Association with Promoter Hypermethylation
    • DOI 10.1056/NEJMra023075
    • J.G. Herman, and S.B. Baylin Gene silencing in cancer in association with promoter hypermethylation N. Engl. J. Med. 349 2003 2042 2054 (Pubitemid 37448928)
    • (2003) New England Journal of Medicine , vol.349 , Issue.21 , pp. 2042-2054
    • Herman, J.G.1    Baylin, S.B.2
  • 9
    • 0036386996 scopus 로고    scopus 로고
    • Mechanisms underlying epigenetically mediated gene silencing in cancer
    • S.B. Baylin Mechanisms underlying epigenetically mediated gene silencing in cancer Semin. Cancer Biol. 12 2002 331 337
    • (2002) Semin. Cancer Biol. , vol.12 , pp. 331-337
    • Baylin, S.B.1
  • 10
    • 33749032436 scopus 로고    scopus 로고
    • A profile of methyl-CpG binding domain protein occupancy of hypermethylated promoter CpG islands of tumor suppressor genes in human cancer
    • DOI 10.1158/0008-5472.CAN-06-1932
    • L. Lopez-Serra, E. Ballestar, M.F. Fraga, M. Alaminos, F. Setien, and M. Esteller A profile of methyl-CpG binding domain protein occupancy of hypermethylated promoter CpG islands of tumor suppressor genes in human cancer Cancer Res. 66 2006 8342 8346 (Pubitemid 44449141)
    • (2006) Cancer Research , vol.66 , Issue.17 , pp. 8342-8346
    • Lopez-Serra, L.1    Ballestar, E.2    Fraga, M.F.3    Alaminos, M.4    Setien, F.5    Esteller, M.6
  • 11
    • 34247860920 scopus 로고    scopus 로고
    • Mechanisms of disease: Methyl-binding domain proteins as potential therapeutic targets in cancer
    • O. Sansom, K. Maddison, and A. Clarke Mechanisms of disease: methyl-binding domain proteins as potential therapeutic targets in cancer Nat. Clin. Pract. Oncol. 4 2007 301 315
    • (2007) Nat. Clin. Pract. Oncol. , vol.4 , pp. 301-315
    • Sansom, O.1    Maddison, K.2    Clarke, A.3
  • 12
    • 0035522894 scopus 로고    scopus 로고
    • Two genetic hits (more or less) to cancer
    • A.G. Knudson Two genetic hits (more or less) to cancer Nat. Rev. Cancer 1 2001 157 162 (Pubitemid 33741891)
    • (2001) Nature Reviews Cancer , vol.1 , Issue.2 , pp. 157-162
    • Knudson, A.G.1
  • 13
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • P.A. Jones, and S.B. Baylin The fundamental role of epigenetic events in cancer Nat. Rev. Genet. 3 2002 415 428 (Pubitemid 34587077)
    • (2002) Nature Reviews Genetics , vol.3 , Issue.6 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 16
    • 0032401808 scopus 로고    scopus 로고
    • Aging and DNA methylation in colorectal mucosa and cancer
    • N. Ahuja, Q. Li, A.L. Mohan, S.B. Baylin, and J.P. Issa Aging and DNA methylation in colorectal mucosa and cancer Cancer Res. 58 1998 5489 5494 (Pubitemid 28551135)
    • (1998) Cancer Research , vol.58 , Issue.23 , pp. 5489-5494
    • Ahuja, N.1    Li, Q.2    Mohan, A.L.3    Baylin, S.B.4    Issa, J.-P.J.5
  • 19
    • 53049087109 scopus 로고    scopus 로고
    • Genomic and epigenetic instability in colorectal cancer pathogenesis
    • W.M. Grady, and J.M. Carethers Genomic and epigenetic instability in colorectal cancer pathogenesis Gastroenterology 135 2008 1079 1099
    • (2008) Gastroenterology , vol.135 , pp. 1079-1099
    • Grady, W.M.1    Carethers, J.M.2
  • 22
    • 17444423289 scopus 로고    scopus 로고
    • Wnt signaling in the intestinal epithelium: From endoderm to cancer
    • DOI 10.1101/gad.1295405
    • A. Gregorieff, and H. Clevers Wnt signaling in the intestinal epithelium: from endoderm to cancer Genes Dev. 19 2005 877 890 (Pubitemid 40548056)
    • (2005) Genes and Development , vol.19 , Issue.8 , pp. 877-890
    • Gregorieff, A.1    Clevers, H.2
  • 23
    • 0037354509 scopus 로고    scopus 로고
    • Epidemiologic considerations to assess altered DNA methylation from environmental exposures in cancer
    • L.E. Moore, W.Y. Huang, J. Chung, and R.B. Hayes Epidemiologic considerations to assess altered DNA methylation from environmental exposures in cancer Ann. N.Y. Acad. Sci. 983 2003 181 196 (Pubitemid 36399331)
    • (2003) Annals of the New York Academy of Sciences , vol.983 , pp. 181-196
    • Moore, L.E.1    Huang, W.-Y.2    Chung, J.3    Hayes, R.B.4
  • 24
    • 1042278765 scopus 로고    scopus 로고
    • The history of cancer epigenetics
    • A.P. Feinberg, and B. Tycko The history of cancer epigenetics Nat. Rev. Cancer 4 2004 143 153 (Pubitemid 38198742)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.2 , pp. 143-153
    • Feinberg, A.P.1    Tycko, B.2
  • 26
    • 0035360280 scopus 로고    scopus 로고
    • Uterine adenocarcinoma in mice treated neonatally with genistein
    • R.R. Newbold, E.P. Banks, B. Bullock, and W.N. Jefferson Uterine adenocarcinoma in mice treated neonatally with genistein Cancer Res. 61 2001 4325 4328 (Pubitemid 32685752)
    • (2001) Cancer Research , vol.61 , Issue.11 , pp. 4325-4328
    • Newbold, R.R.1    Padilla Banks, E.2    Bullock, B.3    Jefferson, W.N.4
  • 27
    • 0018751070 scopus 로고
    • Prenatal diethylstilbestrol exposure and human genital tract abnormalities
    • A.L. Herbst, R.E. Scully, and S.J. Robboy Prenatal diethylstilbestrol exposure and human genital tract abnormalities Natl. Cancer Inst. Monogr. 51 1979 25 35 (Pubitemid 9239325)
    • (1979) National Cancer Institute Monograph , vol.51 , pp. 25-35
    • Herbst, A.L.1    Scully, R.E.2    Robboy, S.J.3
  • 32
    • 77649324591 scopus 로고    scopus 로고
    • New endogenous regulators of class i histone deacetylases
    • A. Riccio New endogenous regulators of class I histone deacetylases Sci. Signal. 3 2010 pe1
    • (2010) Sci. Signal. , vol.3 , pp. 1
    • Riccio, A.1
  • 33
    • 34250213859 scopus 로고    scopus 로고
    • DNA methylation as a therapeutic target in cancer
    • J.P. Issa DNA methylation as a therapeutic target in cancer Clin. Cancer Res. 13 2007 1634 1637
    • (2007) Clin. Cancer Res. , vol.13 , pp. 1634-1637
    • Issa, J.P.1
  • 36
    • 10744233452 scopus 로고    scopus 로고
    • Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies
    • DOI 10.1182/blood-2003-03-0687
    • J.P. Issa, G. Garcia-Manerom, F.J. Giles, R. Mannari, D. Thomas, S. Faderl, E. Bayar, J. Lyons, C.S. Rosenfeld, J. Cortes, and H.M. Kantarjian Phase 1 study of low-dose prolonged exposure schedules of the hypomethylating agent 5-aza-2′-deoxycytidine (decitabine) in hematopoietic malignancies Blood 103 2004 1635 1640 (Pubitemid 38268953)
    • (2004) Blood , vol.103 , Issue.5 , pp. 1635-1640
    • Issa, J.-P.J.1    Garcia-Manero, G.2    Giles, F.J.3    Mannari, R.4    Thomas, D.5    Faderl, S.6    Bayar, E.7    Lyons, J.8    Rosenfeld, C.S.9    Cortes, J.10    Kantarjian, H.M.11
  • 38
    • 4744338655 scopus 로고    scopus 로고
    • Nonclonal neutrophil responses after successful treatment of myelodysplasia with low-dose 5-aza-2'-deoxycytidine (decitabine)
    • DOI 10.1016/j.leukres.2004.04.002, PII S0145212604001304
    • M. Lubbert, M. Daskalakis, R. Kunzmann, M. Engelhardt, Y. Guo, and P. Wijermans Nonclonal neutrophil responses after successful treatment of myelodysplasia with low-dose 5-aza-2′-deoxycytidine (decitabine) Leuk. Res. 28 2004 1267 1271 (Pubitemid 39314406)
    • (2004) Leukemia Research , vol.28 , Issue.12 , pp. 1267-1271
    • Lubbert, M.1    Daskalakis, M.2    Kunzmann, R.3    Engelhardt, M.4    Guo, Y.5    Wijermans, P.6
  • 41
    • 22544466164 scopus 로고    scopus 로고
    • Treatment of elderly acute myeloid leukemia with valproic acid and all-trans retinoic acid
    • E. Raffoux, P. Chaibi, H. Dombret, and L. Degos Valproic acid and all-trans retinoic acid for the treatment of elderly patients with acute myeloid leukemia Haematologica 90 2005 986 988 (Pubitemid 41020306)
    • (2005) Haematologica , vol.90 , Issue.7 , pp. 986-988
    • Raffoux, E.1    Chaibi, P.2    Dombret, H.3    Degos, L.4
  • 45
    • 0032948005 scopus 로고    scopus 로고
    • Synergy of demethylation and histone deacetylase inhibition in the re- expression of genes silenced in cancer
    • DOI 10.1038/5047
    • E.E. Cameron, K.E. Bachman, S. Myohanen, J.G. Herman, and S.B. Baylin Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer Nat. Genet. 21 1999 103 107 (Pubitemid 29036293)
    • (1999) Nature Genetics , vol.21 , Issue.1 , pp. 103-107
    • Cameron, E.E.1    Bachman, K.E.2    Myohanen, S.3    Herman, J.G.4    Baylin, S.B.5
  • 46
    • 0037357210 scopus 로고    scopus 로고
    • Diet and DNA methylation interactions in cancer prevention
    • A.R. Sharon Diet and DNA methylation interactions in cancer prevention Ann. N.Y. Acad. Sci. 983 2003 197 207
    • (2003) Ann. N.Y. Acad. Sci. , vol.983 , pp. 197-207
    • Sharon, A.R.1
  • 48
    • 77953506826 scopus 로고    scopus 로고
    • Flavonoids influence epigenetic-modifying enzyme activity: Structure-function relationships and the therapeutic potential for cancer
    • E. Gilbert, and D. Liu Flavonoids influence epigenetic-modifying enzyme activity: structure-function relationships and the therapeutic potential for cancer Curr. Med. Chem. 17 2010 1756 1768
    • (2010) Curr. Med. Chem. , vol.17 , pp. 1756-1768
    • Gilbert, E.1    Liu, D.2
  • 49
    • 0345275879 scopus 로고    scopus 로고
    • Tea Polyphenol (-)-Epigallocatechin-3-Gallate Inhibits DNA Methyltransferase and Reactivates Methylation-Silenced Genes in Cancer Cell Lines
    • M.Z. Fang, Y. Wang, N. Ai, Z. Hou, Y. Sun, H. Lu, W. Welsh, and C.S. Yang Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines Cancer Res. 63 2003 7563 7570 (Pubitemid 37466673)
    • (2003) Cancer Research , vol.63 , Issue.22 , pp. 7563-7570
    • Fang, M.Z.1    Wang, Y.2    Ai, N.3    Hou, Z.4    Sun, Y.5    Lu, H.6    Welsh, W.7    Yang, C.S.8
  • 51
    • 25144507259 scopus 로고    scopus 로고
    • Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids
    • DOI 10.1124/mol.104.008367
    • W.J. Lee, J.Y. Shim, and B.T. Zhu Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids Mol. Pharmacol. 68 2005 1018 1030 (Pubitemid 41345793)
    • (2005) Molecular Pharmacology , vol.68 , Issue.4 , pp. 1018-1030
    • Won, J.L.1    Shim, J.-Y.2    Zhu, B.T.3
  • 52
    • 20344382068 scopus 로고    scopus 로고
    • Promoter hypermethylation and inactivation of O(6)-methylguanine-DNA methyltransferase in esophageal squamous cell carcinomas and its reactivation in cell lines
    • M. Fang, Z. Jin, Y. Wang, J. Liao, G. Yang, L. Wang, and C. Yang Promoter hypermethylation and inactivation of O(6)-methylguanine-DNA methyltransferase in esophageal squamous cell carcinomas and its reactivation in cell lines Int. J. Oncol. 26 2005 615 622
    • (2005) Int. J. Oncol. , vol.26 , pp. 615-622
    • Fang, M.1    Jin, Z.2    Wang, Y.3    Liao, J.4    Yang, G.5    Wang, L.6    Yang, C.7
  • 53
    • 42349103444 scopus 로고    scopus 로고
    • Genistein induces the p21WAF1/CIP1 and p16INK4a tumor suppressor genes in prostate cancer cells by epigenetic mechanisms involving active chromatin modification
    • DOI 10.1158/0008-5472.CAN-07-2290
    • S. Majid, N. Kikuno, J. Nelles, E. Noonan, Y. Tanaka, K. Kawamoto, H. Hirata, L.C. Li, H. Zhao, S.T. Okino, R.F. Place, D. Pookot, and R. Dahiya Genistein induces the p21WAF1/CIP1 and p16INK4a tumor suppressor genes in prostate cancer cells by epigenetic mechanisms involving active chromatin modification Cancer Res. 68 2008 2736 2744 (Pubitemid 351556271)
    • (2008) Cancer Research , vol.68 , Issue.8 , pp. 2736-2744
    • Majid, S.1    Kikuno, N.2    Nelles, J.3    Noonan, E.4    Tanaka, Y.5    Kawamoto, K.6    Hirata, H.7    Li, L.C.8    Zhao, H.9    Okino, S.T.10    Place, R.F.11    Pookot, D.12    Dahiya, R.13
  • 55
    • 31544441371 scopus 로고    scopus 로고
    • Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols
    • DOI 10.1093/carcin/bgi206
    • W.J. Lee, and B.T. Zhu Inhibition of DNA methylation by caffeic acid and chlorogenic acid, two common catechol-containing coffee polyphenols Carcinogenesis 27 2006 269 277 (Pubitemid 43159879)
    • (2006) Carcinogenesis , vol.27 , Issue.2 , pp. 269-277
    • Lee, W.J.1    Zhu, B.T.2
  • 56
    • 0037357210 scopus 로고    scopus 로고
    • Diet and DNA methylation interactions in cancer prevention
    • S.A. Ross Diet and DNA methylation interactions in cancer prevention Ann. N.Y. Acad. Sci. 983 2003 197 207 (Pubitemid 36399332)
    • (2003) Annals of the New York Academy of Sciences , vol.983 , pp. 197-207
    • Ross, S.A.1
  • 61
    • 68349114819 scopus 로고    scopus 로고
    • Foodstuffs for preventing cancer: The preclinical and clinical development of berries
    • G.D. Stoner Foodstuffs for preventing cancer: the preclinical and clinical development of berries Cancer Prev. Res. 2 2009 187 194
    • (2009) Cancer Prev. Res. , vol.2 , pp. 187-194
    • Stoner, G.D.1
  • 66
    • 34447262607 scopus 로고    scopus 로고
    • DNA-methylation of the homeodomain transcription factor PITX2 reliably predicts risk of distant disease recurrence in tamoxifen-treated, node-negative breast cancer patients - Technical and clinical validation in a multi-centre setting in collaboration with the European Organisation for Research and Treatment of Cancer (EORTC) PathoBiology group
    • DOI 10.1016/j.ejca.2007.04.025, PII S0959804907003541
    • S. Maier, I. Nimmrich, T. Koenig, S. Eppenberger-Castori, I. Bohlmann, A. Paradiso, F. Spyratos, C. Thomssen, V. Mueller, J. Nährig, F. Schittulli, R. Kates, R. Lesche, I. Schwope, A. Kluth, A. Marx, J.W. Martens, J.A. Foekens, M. Schmitt, N. Harbeck European Organisation for Research and Treatment of Cancer (EORTC) PathoBiology group DNA-methylation of the homeodomain transcription factor PITX2 reliably predicts risk of distant disease recurrence in tamoxifen-treated, node-negative breast cancer patients - technical and clinical validation in a multi-centre setting in collaboration with the European Organisation for Research and Treatment of Cancer (EORTC) PathoBiology group Eur. J. Cancer 43 2007 1679 1686 (Pubitemid 47042374)
    • (2007) European Journal of Cancer , vol.43 , Issue.11 , pp. 1679-1686
    • Maier, S.1    Nimmrich, I.2    Koenig, T.3    Eppenberger-Castori, S.4    Bohlmann, I.5    Paradiso, A.6    Spyratos, F.7    Thomssen, C.8    Mueller, V.9    Nahrig, J.10    Schittulli, F.11    Kates, R.12    Lesche, R.13    Schwope, I.14    Kluth, A.15    Marx, A.16    Martens, J.W.M.17    Foekens, J.A.18    Schmitt, M.19    Harbeck, N.20    more..
  • 69
    • 78149406498 scopus 로고    scopus 로고
    • Methylation patterns of genes coding for drug-metabolizing enzymes in tamoxifen-resistant breast cancer tissues
    • (Epub ahead of print)
    • S.J. Kim, H.S. Kang, S.Y. Jung, S.Y. Min, S. Lee, S.W. Kim, Y. Kwon, K.S. Lee, K.H. Shin, and J. Ro Methylation patterns of genes coding for drug-metabolizing enzymes in tamoxifen-resistant breast cancer tissues J. Mol. Med. 2010 (Epub ahead of print)
    • (2010) J. Mol. Med.
    • Kim, S.J.1    Kang, H.S.2    Jung, S.Y.3    Min, S.Y.4    Lee, S.5    Kim, S.W.6    Kwon, Y.7    Lee, K.S.8    Shin, K.H.9    Ro, J.10
  • 70
    • 34247638013 scopus 로고    scopus 로고
    • CpG island methylation, response to combination chemotherapy, and patient survival in advanced microsatellite stable colorectal carcinoma
    • DOI 10.1007/s00428-007-0398-3
    • S. Ogino, J.A. Meyerhardt, T. Kawasaki, J.W. Clark, D.P. Ryan, M.H. Kulke, P.C. Enzinger, B.M. Wolpin, M. Loda, and C.S. Fuchs CpG island methylation, response to combination chemotherapy, and patient survival in advanced microsatellite stable colorectal carcinoma Virchows Arch. 450 2007 529 537 (Pubitemid 46676250)
    • (2007) Virchows Archiv , vol.450 , Issue.5 , pp. 529-537
    • Ogino, S.1    Meyerhardt, J.A.2    Kawasaki, T.3    Clark, J.W.4    Ryan, D.P.5    Kulke, M.H.6    Enzinger, P.C.7    Wolpin, B.M.8    Loda, M.9    Fuchs, C.S.10
  • 73
    • 36348951021 scopus 로고    scopus 로고
    • Aberrant methylation of p16 predicts candidates for 5-fluorouracil-based adjuvant therapy in gastric cancer patients
    • DOI 10.1007/s00535-007-2113-1
    • M. Mitsuno, Y. Kitajima, T. Ide, K. Ohtaka, M. Tanaka, S. Satoh, and K. Miyazaki Aberrant methylation of p16 predicts candidates for 5-fluorouracil-based adjuvant therapy in gastric cancer patients J. Gastroenterol. 42 2007 866 873 (Pubitemid 350142766)
    • (2007) Journal of Gastroenterology , vol.42 , Issue.11 , pp. 866-873
    • Mitsuno, M.1    Kitajima, Y.2    Ide, T.3    Ohtaka, K.4    Tanaka, M.5    Satoh, S.6    Miyazaki, K.7
  • 74
    • 77952085655 scopus 로고    scopus 로고
    • Profiling DNA methylomes from microarray to genome-scale sequencing
    • Y.W. Huang, T. Huang, and L.S. Wang Profiling DNA methylomes from microarray to genome-scale sequencing Technol. Cancer Res. Treat. 9 2010 139 147
    • (2010) Technol. Cancer Res. Treat. , vol.9 , pp. 139-147
    • Huang, Y.W.1    Huang, T.2    Wang, L.S.3


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