Use of homology modeling in conjunction with site-directed mutagenesis for analysis of structure-function relationships of mammalian cytochromes P450

Life Sciences

Volumn 61, Issue 26, 1997, Pages 2507-2520

  Szklarz, Grazyna D ^a   Halpert, James R ^a  

^a UNIVERSITY OF ARIZONA   (United States)

Author keywords

Cytochromes P450; Homology modeling; P450 inhibition inactivation; P450 structure function relationships; Site directed mutagenesis; Substrate docking

Indexed keywords

ALPHA NAPHTHOFLAVONE; AMINO ACID; ANDROSTENEDIONE; BACTERIAL ENZYME; CHLORAMPHENICOL; CYTOCHROME P450; PROGESTERONE; RESORUFIN DERIVATIVE;

ENZYME ACTIVE SITE; ENZYME SUBSTRATE; HYDROGEN BOND; MAMMAL; MOLECULAR MODEL; NONHUMAN; PROTEIN STABILITY; SEQUENCE HOMOLOGY; SHORT SURVEY; SITE DIRECTED MUTAGENESIS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING SITES; CYTOCHROME P-450 ENZYME SYSTEM; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; SEQUENCE HOMOLOGY; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); MAMMALIA;

EID: 0031457404     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(97)00717-0     Document Type: Short Survey

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