Dual role of human cytochrome P450 3A4 residue Phe-304 in substrate specificity and cooperativity

Journal of Pharmacology and Experimental Therapeutics

Volumn 293, Issue 2, 2000, Pages 585-591

  Domanski, Tammy L ^a   He, You Ai ^a   Harlow, Greg R ^a   Halpert, James R ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA NAPHTHOFLAVONE; CYTOCHROME P450 3A4; PROGESTERONE;

ARTICLE; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HYDROXYLATION; MOLECULAR MODEL; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ARYL HYDROCARBON HYDROXYLASES; BENZOFLAVONES; BINDING SITES; CLONING, MOLECULAR; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; HYDROXYLATION; KINETICS; MIXED FUNCTION OXYGENASES; MODELS, MOLECULAR; MUTATION; OXIDATION-REDUCTION; PHENYLALANINE; PROGESTERONE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STEROID HYDROXYLASES; SUBSTRATE SPECIFICITY;

EID: 0034108229     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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