Electron transfer in the complex of membrane-bound human cytochrome P450 3A4 with the flavin domain of P450BM-3: The effect of oligomerization of the heme protein and intermittent modulation of the spin equilibrium

Biochimica et Biophysica Acta - Bioenergetics

Volumn 1797, Issue 3, 2010, Pages 378-390

  Davydov, Dmitri R ^a   Sineva, Elena V ^a   Sistla, Srinivas ^a   Davydova, Nadezhda Y ^a   Frank, Daniel J ^b   Sligar, Stephen G ^b   Halpert, James R ^a  

^a UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^b UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

BODIPY; Cysteine depleted mutant; Cytochrome P450 3A4; Flavin domain of cytochrome P450BM 3; FRET; Kinetics of electron transfer; Lifetime; Liposome; Nanodisc; Oligomerization; Spin equilibrium

Indexed keywords

CYSTEINE; CYTOCHROME P450 3A4; CYTOCHROME P450 BM3; FLAVOPROTEIN; HEMOPROTEIN; IODOACETAMIDE; MEMBRANE ENZYME; NANODISC; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

ACCELERATION; ARTICLE; COMPLEX FORMATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DENSITY; DISSOCIATION; ELECTRON TRANSPORT; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; MODULATION; NONHUMAN; OLIGOMERIZATION; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEOLIPOSOME; REDUCTION KINETICS; SPECTRAL SENSITIVITY; SURFACE PROPERTY;

BACTERIAL PROTEINS; BORON COMPOUNDS; CELL MEMBRANE; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; ELECTRON TRANSPORT; FLAVINS; FLUORESCENCE RESONANCE ENERGY TRANSFER; FLUORESCENT DYES; HUMANS; KINETICS; MUTATION; NADP; NADPH-FERRIHEMOPROTEIN REDUCTASE; NANOTECHNOLOGY; OXIDATION-REDUCTION; PROTEOLIPIDS; SUBSTRATE SPECIFICITY;

EID: 75649112318     PISSN: 00052728     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbabio.2009.12.008     Document Type: Article

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