Lifestyle factors and endothelial function

Current Vascular Pharmacology

Volumn 10, Issue 1, 2012, Pages 94-106

  Papageorgiou, Nikolaos ^a   Tousoulis, Dimitris ^a   Androulakis, Emmanuel ^a   Giotakis, Aris ^a   Siasos, Gerasimos ^a   Latsios, George ^a   Stefanadis, Christodoulos ^a  

^a UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Atherosclerosis; Endothelial dysfunction; Genetics; Lifestyle; Modifications

Indexed keywords

ADIPONECTIN; ANTHOCYANIN; C REACTIVE PROTEIN; COD LIVER OIL; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; ENDOTHELIAL NITRIC OXIDE SYNTHASE; EPIGALLOCATECHIN GALLATE; FLAVANONE DERIVATIVE; HIGH DENSITY LIPOPROTEIN; INTERLEUKIN 6; LEPTIN; LOW DENSITY LIPOPROTEIN; MALONALDEHYDE; MONOCYTE CHEMOTACTIC PROTEIN 1; NITRIC OXIDE; OLIVE OIL; OMEGA 3 FATTY ACID; OXIDIZED LOW DENSITY LIPOPROTEIN; PLASMINOGEN ACTIVATOR INHIBITOR 1; POLYPHENOL; QUERCETIN; REACTIVE OXYGEN METABOLITE; RESISTIN; SOYBEAN OIL; TANNIN; THROMBOMODULIN; TISSUE PLASMINOGEN ACTIVATOR; TUMOR NECROSIS FACTOR ALPHA; VON WILLEBRAND FACTOR;

AEROBIC EXERCISE; ALCOHOL CONSUMPTION; ARTERY DIAMETER; ARTICLE; ATHEROGENESIS; CACAO; CARDIOVASCULAR RISK; CIGARETTE SMOKING; CORONARY ARTERY ATHEROSCLEROSIS; DISEASE ASSOCIATION; DISEASE COURSE; DNA POLYMORPHISM; ENDOTHELIAL DYSFUNCTION; ENDOTHELIAL PROGENITOR CELL; ENDOTHELIUM CELL; EXON; GENE EXPRESSION; GENETIC SUSCEPTIBILITY; HEART PROTECTION; HUMAN; HYPERCHOLESTEROLEMIA; HYPEREMIA; HYPERTENSION; INSULIN RESISTANCE; LIFESTYLE MODIFICATION; LIPID PEROXIDATION; MEDITERRANEAN DIET; MICROVASCULATURE; MOOD DISORDER; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; OXIDATIVE STRESS; PASSIVE SMOKING; PATHOGENESIS; PHYSICAL ACTIVITY; PREHYPERTENSION; PROGNOSIS; RED WINE; SAUNA; SEX DIFFERENCE; SMOKING CESSATION; SYSTOLIC HYPERTENSION; THROMBOCYTE AGGREGATION INHIBITION; VASCULAR ENDOTHELIUM; VASODILATATION; WAIST CIRCUMFERENCE; WEIGHT REDUCTION; WELLBEING; YOGA;

ANIMALS; ENDOTHELIUM, VASCULAR; HUMANS; LIFE STYLE; RISK FACTORS; RISK REDUCTION BEHAVIOR; VASCULAR DISEASES;

EID: 84857126352     PISSN: 15701611     EISSN: 18756212     Source Type: Journal    
DOI: 10.2174/157016112798829788     Document Type: Article

References (184)

1. Sandoo A, van Zanten JJ, Metsios GS, Carroll D, Kitas GD. The endothelium and its role in regulating vascular tone. Open Cardiovasc Med J 2010; 4: 302-12.
2. Kasprzak JD, Kosiska M, Drozdz J. Clinical aspects of assessment of endothelial function. Pharmacol Rep 2006; 58 Suppl: 33-40.
3. Tousoulis D, Koutsogiannis M, Papageorgiou N, et al. Endothelial dysfunction: potential clinical implications. Minerva Med 2010; 101: 271-84.
4. Tousoulis D, Papageorgiou N, Androulakis E, Paroutoglou K, Stefanadis C. Novel therapeutic strategies targeting vascular endothelium in essential hypertension. Expert Opin Investig Drugs 2010; 19: 1395-412.
5. Celermajer DS, Sorensen KE, Gooch VM, et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992; 340: 1111-5.
6. Ross R. Atherosclerosis-an inflammatory disease. N Engl J Med 1999; 340: 115-26.
7. Nozaki T, Sugiyama S, Koga H, et al. Significance of a multiple biomarkers strategy including endothelial dysfunction to improve risk stratification for cardiovascular events in patients at high risk for coronary heart disease. J Am Coll Cardiol 2009; 54: 601-8.
8. Yeboah J, Folsom AR, Burke GL, et al. Predictive value of brachial flow-mediated dilation for incident cardiovascular events in a population-based study: the multi-ethnic study of atherosclerosis. Circulation 2009; 120: 502-9.
9. Krentz AJ, Clough G, Byrne CD. Interactions between microvascular and macrovascular disease in diabetes: pathophysiology and therapeutic implications. Diabetes Obes Metab 2007; 9: 781-91.
10. Androulakis ES, Tousoulis D, Papageorgiou N, Tsioufis C, Kallikazaros I, Stefanadis C. Essential hypertension: is there a role for inflammatory mechanisms? Cardiol Rev 2009; 17: 216-21.
11. Vardavas CI, Panagiotakos DB. The causal relationship between passive smoking and inflammation on the development of cardiovascular disease: a review of the evidence. Inflamm Allergy Drug Targets 2009; 8: 328-33.
12. Salmoirago-Blotcher E, Ockene IS. Methodological limitations of psychosocial interventions in patients with an implantable cardioverter-defibrillator (ICD). A systematic review. BMC Cardiovasc Disord 2009; 9: 56.
13. Schiffrin EL. A critical review of the role of endothelial factors in the pathogenesis of hypertension. J Cardiovasc Pharmacol 2001; 38 (Suppl 2): S3-6.
14. Schini-Kerth VB, Auger C, Etienne-Selloum N, Chataigneau T. Polyphenol-induced endothelium-dependent relaxations role of NO and EDHF. Adv Pharmacol 2010; 60: 133-75.
15. Widlansky ME, Gokce N, Keaney JF Jr, Vita JA. The clinical implications of endothelial dysfunction. J Am Coll Cardiol 2003; 42: 1149-60.
16. Kiowski W. Endothelial dysfunction in hypertension. Clin Exp Hypertens 1999; 21: 635-646.
17. Cines DB, Pollak ES, Buck CA, et al. Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood 1998; 91: 3527-61.
18. Deanfield J, Donald A, Ferri C, et al. Working Group on Endothelin and Endothelial Factors of the European Society of Hypertension. Endothelial function and dysfunction. Part I: Methodological issues for assessment in the different vascular beds: a statement by the Working Group on Endothelin and Endothelial Factors of the European Society of Hypertension. J Hypertens 2005; 23: 7-17.
19. Esper RJ, Nordaby RA, Vilariño JO, Paragano A, Cacharrón JL, Machado RA. Endothelial dysfunction: a comprehensive appraisal. Cardiovasc Diabetol 2006; 5: 4.
20. Vita JA. Nitric oxide-dependent vasodilation in human subjects. Methods Enzymol 2002; 359: 186-200.
21. Bonetti PO, Lerman LO, Lerman A. Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol 2003; 23: 168-175.
22. John S, Schmieder RE. Potential mechanisms of impaired endothelial function in arterial hypertension and hypercholesterolemia. Curr Hypertens Rep 2003; 5: 199-207.
23. Tousoulis D, Antoniades C, Koumallos N, et al. Novel therapies targeting vascular endothelium. Endothelium. 2006; 13: 411-21.
24. Laursen JB, Somers M, Kurz S, et al. Endothelial regulation of vasomotion in apoE-deficient mice: Implications for interactions between peroxynitrite and tetrahydrobiopterin. Circulation; 103: 1282-8.
25. Behrendt D, Ganz P. Endothelial function. From vascular biology to clinical applications. Am J Cardiol 2002; 90: 40L-8.
26. Tousoulis D, Charakida M, Stefanadis C. Endothelial function and inflammation in coronary artery disease. Heart 2006; 92: 441-4.
27. Le Brocq M, Leslie SJ, Milliken P, Megson IL. Endothelial dysfunction: from molecular mechanisms to measurement, clinical implications, and therapeutic opportunities. Antioxid Redox Signal 2008; 9: 1631-1674.
28. Münzel T, Sinning C, Post F, Warnholtz A, Schulz E. Pathophysiology, diagnosis and prognostic implications of endothelial dysfunction. Ann Med 2009; 40: 180-96.
29. Martin BJ, Anderson TJ. Risk prediction in cardiovascular disease: the prognostic significance of endothelial dysfunction. Can J Cardiol 2009; 25: 15A-20A.
30. Shimbo D, Grahame-Clarke C, Miyake Y, et al. The association between endothelial dysfunction and cardiovascular outcomes in a population-based multi-ethnic cohort. Atherosclerosis 2007; 192: 197-203.
31. Perticone F, Ceravolo R, Pujia A, et al. Prognostic significance of endothelial dysfunction in hypertensive patients. Circulation 2001; 104: 191-6.
32. Simova I, Denchev S.Endothelial functional and structural impairment in patients with different degrees of coronary artery disease development. Heart Vessels 2008; 23: 308-15.
33. Irace C, Fiaschi E, Cortese C, Gnasso A. Flow-mediated vasodilatation of the brachial artery and intima-media thickness of carotid artery in never-treated subjects. Int Angiol 2006; 25: 274-9.
34. Böhm M. Angiotensin receptor blockers vs. angiotensin-converting enzyme inhibitors: where do we stand now? Am J Cardiol 2007; 100: 38J-44.
35. Stefanadi E, Tousoulis D, Androulakis ES, et al. Inflammatory Markers in Essential Hypertension: Potential Clinical Implications. Curr Vasc Pharmacol 2010; 8: 509-16.
36. Tousoulis D, Kourtellaris P, Antoniades C, et al. Effects of irbesartan and perindopril on forearm reactive hyperemia and inflammatory process, in normotensive patients with coronary artery disease. Int J Cardiol 2008; 124: 127-9.
37. Brili S, Tousoulis D, Antoniades C, et al. Effects of ramipril on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young normotensive subjects with successfully repaired coarctation of aorta: a randomized cross-over study. J Am Coll Cardiol 2008; 51: 742-9.
38. Ruilope LM, Redón J, Schmieder ER. Cardiovascular risk reduction by reversing endothelial dysfunction: ARBs, ACE inhibitors, or both? Expectations from the ONTARGET Trial Programme. Vasc Health Risk Manag 2007; 3: 1-9.
39. Tzemos N, Lim PO, Macdonald TM. Valsartan improves endothelial dysfunction in hypertension: A randomized, double-blind study. Cardiovasc Ther 2009; 27: 151-8.
40. Dilaveris P, Giannopoulos G, Riga M, Synetos A, Stefanadis C. Beneficial effects of statins on endothelial dysfunction and vascular stiffness. Curr Vasc Pharmacol 2007; 5: 227-37.
41. Siasos G, Tousoulis D, Vlachopoulos C, et al. Short-term treatment with L-arginine prevents the smoking-induced impairment of endothelial function and vascular elastic properties in young individuals. Int J Cardiol 2008; 126: 394-9.
42. Porkert M, Sher S, Reddy U, et al. Tetrahydrobiopterin: a novel antihypertensive therapy. J Hum Hypertens 2008; 22: 401-7.
43. Münzel T, Gori T. Nebivolol: the somewhat-different beta-adrenergic receptor blocker. J Am Coll Cardiol 2009; 54: 1491-9.
44. Schäfer A, Fraccarollo D, Werner L, Bauersachs J. Guanylyl cyclase activator ataciguat improves vascular function and reduces platelet activation in heart failure. Pharmacol Res 2010; 62: 432-8.
45. Attinà TM, Malatino LS, Maxwell SR, Padfield PL, Webb DJ. Phosphodiesterase type 5 inhibition reverses impaired forearm exercise-induced vasodilatation in hypertensive patients. J Hypertens 2008; 26: 501-7.
46. Dussault S, Maingrette F, Ménard C, et al. Sildenafil increases endothelial progenitor cell function and improves ischemia-induced neovascularization in hypercholesterolemic apolipoprotein Edeficient mice. Hypertension 2009; 54: 1043-9.
47. Ludmer PL, Selwyn AP, Shook TL, et al. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Eng J Med 1986; 315: 1046-51.
48. Vita JA, Treasure CB, Nabel EG, et al. Coronary vasomotor response to acetylcholine relate to risk factor for coronary artery disease. Circulation 1990; 81: 491-7.
49. Tousoulis D, Davies G, Crake T, Lerman A, Hasdai D, Holmes D. Acetylcholine and endothelial function. Circulation 1998; 98: 1587A-90.
50. Tousoulis D, Davies G, Lefroy DC, Haider AW, Crake T. Variable coronary vasomotor responses to acetylcholine in patients with normal coronary arteriograms: evidence for localised endothelial dysfunction. Heart 1996; 75: 261-6.
51. Tousoulis D, Antoniades C, Stefanadis C. Evaluating endothelial function in humans: A guide to invasive and non-invasive techniques. Heart 2005; 91: 553-8.
52. Deanfield J, Donald A, Ferri C, et al. Endothelial function and dysfunction. Part I: methodological issues for assessment in the different vascular beds: a statement by the Working Group on Endothelin and Endothelial Factors of the European Society of Hypertension. J Hypertens 2005; 23: 7-17.
53. Moens AL, Goovaerts I, Claeys MJ, Vrints CJ. Flow-mediated vasodilation: a diagnostic instrument, or an experimental tool? Chest 2005; 127: 2254-63.
54. Corretti MC, Anderson TJ, Benjamin EJ, et al. International Brachial Artery Reactivity Task Force. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 2002; 39: 257-65.
55. Ghiadoni L, Versari D, Giannarelli C, Faita F, Taddei S. Noninvasive diagnostic tools for investigating endothelial dysfunction. Curr Pharm Des 2008; 14: 3715-22.
56. Celermajer DS. Brachial artery FMD with 5-minute distal cuff occlusion-a useful pathophysiological test after all! J Appl Physiol 2005; 99: 1619.
57. Celermajer DS. Testing endothelial function using ultrasound. J Cardiovasc Pharmacol 1998; 32(Suppl 3): S29-32.
58. Dengel DR, Kelly AS, Steinberger J, Sinaikos AR. Effect of oral glucose loading on endothelial function in normal-weight and overweight children. Clin Sci 2007; 112: 493-8.
59. Qureshi E, Diamond GA, Chouraqui P, et al. Usefulness of finger blood flow during exercise as a marker of functionally signicficant coronary heart disease. Am J Cardiol 2002; 90: 756-9.
60. Haller MJ, Stein J, Shuster J, et al. Peripheral artery tonometry demonstrates altered endothelial function in children with type 1 diabetes. Pediatr Diab. 2007; 8: 193-8.
61. Haller MJ, Silverstein JH, Shuster JJ. Correlation between radial artery tonometryand fingertip tonometry-derived augmentation index in children with type 1 diabetes. Diabetes Vasc Dis Research 2007; 4: 66.
62. Gul K, Ahmadi N, Wang Z, et al. Digital thermal monitoring of vascular function: a novel tool to improve cardiovascular risk assessment. Vasc Med 2009; 14: 143-8.
63. Dhindsa M, Sommerlad SM, DeVan AE, et al. Interrelationships among non-invasive measures of postischemic macroand microvascular reactivity. J Appl Physiol 2008; 105: 427-32.
64. Khot UN, Khot MB, Bajzer CT, et al. Prevalence of conventional risk factors in patients with coronary heart disease. JAMA 2003; 290: 898-904.
65. Greenland P, Knoll MD, Stamler J, et al. Major risk factors as antecedents of fatal and non-fatal coronary heart disease events. JAMA 2003; 290: 891-7.
66. Topol EJ. The genetics of heart attack. Heart 2006; 92: 855-61.
67. Moller DE, Kaufman KD. Metabolic syndrome: a clinical and molecular perspective. Annu Rev Med 2005; 56: 45-62.
68. MacDougald OA, Burant CF. The rapidly expanding family of adipokines. Cell Metab 2007; 6: 159-61.
69. Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, Hotamisligil GS. Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell 2008; 134: 933-44.
70. Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 2004; 89: 2548-56.
71. Cirillo P, Angri V, De Rosa S, et al. Pro-atherothrombotic effects of leptin in human coronary endothelial cells. Thromb Haemost 2010; 103: 1065-75.
72. Zhang H, Cui J, Zhang C. Emerging role of adipokines as mediators in atherosclerosis. World J Cardiol 2010; 2: 370-6.
73. Achike FI, To NH, Wang H, Kwan CY. Obesity, metabolic syndrome, adipocytes and vascular function: A holistic viewpoint. Clin Exp Pharmacol Physiol 2011; 38: 1-10.
74. Ziccardi P, Nappo F, Giugliano G, et al. Reduction of inflammatory cytokine concentrations and improvement of endothelial functions in obese women after weight loss over one year. Circulation 2002; 105: 804-9.
75. Pulerwitz T, Grahame-Clarke C, Rodriguez CJ, et al. Association of increased body mass index and impaired endothelial function among Hispanic women. Am J Cardiol 2006; 97: 68-70.
76. Brook RD, Bard RL, Rubenfire M, Ridker PM, Rajagopalan S. Usefulness of visceral obesity (waist/hip ratio) in predicting vascular endothelial function in healthy overweight adults. Am J Cardiol 2001; 88: 1264-9.
77. Barton M. Obesity and aging: determinants of endothelial cell dysfunction and atherosclerosis. Pflugers Arch 2010; 460: 825-37.
78. Perseghin G. The role of non-alcoholic fatty liver disease in cardiovascular disease. Dig Dis 2010; 28: 210-3.
79. Skilton MR, Celermajer DS. Endothelial dysfunction and arterial abnormalities in childhood obesity. Int J Obes (Lond) 2006; 30: 1041-9.
80. Short KR, Blackett PR, Gardner AW, Copeland KC. Vascular health in children and adolescents: effects of obesity and diabetes. Vasc Health Risk Manag 2009; 5: 973-90.
81. Aggoun Y, Farpour-Lambert NJ, Marchand LM, Golay E, Maggio AB, Beghetti M. Impaired endothelial and smooth muscle functions and arterial stiffness appear before puberty in obese children and are associated with elevated ambulatory blood pressure. Eur Heart J 2008; 29: 792-9.
82. Peña AS, Wiltshire E, MacKenzie K, et al. Vascular endothelial and smooth muscle function relates to body mass index and glucose in obese and non-obese children. J Clin Endocrinol Metab 2006; 91: 4467-71.
83. Meyer AA, Kundt G, Steiner M, Schuff-Werner P, Kienast W. Impaired flow-mediated vasodilation, carotid artery intima-media thickening, and elevated endothelial plasma markers in obese children: the impact of cardiovascular risk factors. Pediatrics 2006; 117: 1560-7.
84. McGill HC Jr, McMahan CA, Herderick EE, et al. Pathobiological Determinants of Atherosclerosis in Youth (PDAY) Research Group. Obesity accelerates the progression of coronary atherosclerosis in young men. Circulation 2002; 105: 2712-8.
85. Ambrose JA, Barua RS. The pathophysiology of cigarette smoking and cardiovascular disease: an update. J Am Coll Cardiol 2004; 43: 1731-7.
86. Aird WC. Endothelial biomedicine. New York, Cambridge University Press, 2007.
87. Armani C, Landini L Jr, Leone A. Molecular and biochemical changes of the cardiovascular system due to smoking exposure. Curr Pharm Des 2009; 15: 1038-53.
88. Naya M, Morita K, Yoshinaga K, et al. Long-term smoking causes more advanced coronary endothelial dysfunction in middle-aged smokers compared to young smokers. Eur J Nucl Med Mol Imaging 2011; 38: 491-8.
89. Ozaki K, Hori T, Ishibashi T, Nishio M, Aizawa Y. Effects of chronic cigarette smoking on endothelial function in young men. J Cardiol 2010; 56: 307-13.
90. Yue WS, Wang M, Yan GH, et al. Smoking is associated with depletion of circulating endothelial progenitor cells and elevated pulmonary artery systolic pressure in patients with coronary artery disease. Am J Cardiol 2010; 106: 1248-54.
91. Leone A. Smoking and hypertension: independent or additive effects to determining vascular damage? Curr Vasc Pharmacol 2011; 9: 585-93.
92. Talukder MA, Johnson WM, Varadharaj S, et al. Chronic cigarette smoking causes hypertension, increased oxidative stress, impaired NO bioavailability, endothelial dysfunction, and cardiac remodeling in mice. Am J Physiol Heart Circ Physiol 2011; 300: H388-96.
93. Tsiamis E, Toutouzas K, Synetos A, et al. Prognostic clinical and angiographic characteristics for the development of a new significant lesion in remote segments after successful percutaneous coronary intervention. Int J Cardiol 2010; 143: 29-34.
94. Toda N, Toda H. Nitric oxide-mediated blood flow regulation as affected by smoking and nicotine. Eur J Pharmacol 2010; 649: 1-13.
95. Jefferis BJ, Lowe GD, Welsh P, et al. Secondhand smoke (SHS) exposure is associated with circulating markers of inflammation and endothelial function in adult men and women. Atherosclerosis 2010; 208: 550-6.
96. Bonetti PO, Lardi E, Geissmann C, Kuhn MU, Brüesch H, Reinhart WH. Effect of brief secondhand smoke exposure on endothelial function and circulating markers of inflammation. Atherosclerosis 2011; 215: 218-22.
97. Heiss C, Amabile N, Lee AC, et al. Brief secondhand smoke exposure depresses endothelial progenitor cells activity and endothelial function: sustained vascular injury and blunted nitric oxide production. J Am Coll Cardiol 2008; 51: 1760-71.
98. Skodova Z, Nagyova I, van Dijk JP, et al. Socioeconomic differences in psychosocial factors contributing to coronary heart disease: a review. J Clin Psychol Med Settings 2008; 15: 204-13.
99. Cooper DC, Milic MS, Tafur JR, et al. Adverse impact of mood on flow-mediated dilation. Psychosom Med 2010; 72: 122-7.
100. Chida Y, Steptoe A. The association of anger and hostility with future coronary heart disease: a meta-analytic review of prospective evidence. J Am Coll Cardiol 2009; 53: 936-46
101. Schott LL, Kamarck TW, Matthews KA, Brockwell SE, SuttonTyrrell K. Is brachial artery flow-mediated dilation associated with negative affect? Int J Behav Med 2009; 16: 241-7.
102. Osika W, Montgomery SM, Dangardt F, et al. Anger, depression and anxiety associated with endothelial function in childhood and adolescence. Arch Dis Child 2011; 96: 38-43.
103. d'Audiffret AC, Frisbee SJ, Stapleton PA, Goodwill AG, Isingrini E, Frisbee JC. Depressive behavior and vascular dysfunction: a link between clinical depression and vascular disease? J Appl Physiol 2010; 108: 1041-51.
104. Ohno Y, Hashiguchi T, Maenosono R, et al. The diagnostic value of endothelial function as a potential sensor of fatigue in health. Vasc Health Risk Manag 2010; 6: 135-44.
105. Harris KF, Matthews KA. Interactions between autonomic nervous system activity and endothelial function: a model for the development of cardiovascular disease. Psychosom Med 2004; 66: 153-64.
106. Alexeeff SE, Coull BA, Gryparis A, et al. Medium-term exposure to traffic-related air pollution and markers of inflammation and endothelial function. Environ Health Perspect 2011; 119: 481-6.
107. Jones LR, Wilson CI, Wadden TA. Lifestyle modification in the treatment of obesity: an educational challenge and opportunity. Clin Pharmacol Ther 2007; 81: 776-9.
108. Leung FP, Yung LM, Laher I, Yao X, Chen ZY, Huang Y. Exercise, vascular wall and cardiovascular diseases: an update (Part 1). Sports Med 2008; 38: 1009-24.
109. Hamdy O, Ledbury S, Mullooly C, et al. Lifestyle modification improves endothelial function in obese subjects with the insulin resistance syndrome. Diabetes Care 2003; 26: 2119-25.
110. Rector RS, Turk JR, Sun GY, et al. Short-term lifestyle modification alters circulating biomarkers of endothelial health in sedentary, overweight adults. Appl Physiol Nutr Metab 2006; 31: 512-7.
111. Kelishadi R, Hashemi M, Mohammadifard N, Asgary S, Khavarian N. Association of changes in oxidative and proinflammatory states with changes in vascular function after a lifestyle modification trial among obese children. Clin Chem 2008; 54: 147-53.
112. Martos R, Valle M, Morales RM, Cañete R, Gascón F, Urbano MM. Changes in body mass index are associated with changes in inflammatory and endothelial dysfunction biomarkers in obese prepubertal children after 9 months of body mass index SD score loss. Metabolism 2009; 58: 1153-60.
113. DeSouza CA, Shapiro LF, Clevenger CM, et al. Regular aerobic exercise prevents and restores age-related declines in endotheliumdependent vasodilation in healthy men. Circulation 2000; 102: 1351-7.
114. Hambrecht R, Fiehn E, Weigl C, et al. Regular physical exercise corrects endothelial dysfunction and improves exercise capacity in patients with chronic heart failure. Circulation 1998; 98: 2709-15.
115. Hambrecht R, Wolf A, Gielen S, et al. Effect of exercise on coronary endothelial function in patients with coronary artery disease. N Engl J Med 2000; 342: 454-60.
116. Gokce N, Vita JA, Bader DS, et al. Effect of exercise on upper and lower extremity endothelial function in patients with coronary artery disease. Am J Cardiol 2002; 90: 124-7.
117. Goto C, Higashi Y, Kimura M, et al. Effect of different intensities of exercise on endothelium-dependent vasodilation in humans: role of endothelium-dependent nitric oxide and oxidative stress. Circulation 2003; 108: 530-5.
118. Celermajer DS, Sorensen KE, Georgakopoulos D, et al. Cigarette smoking is associated with dose related and potentially reversible impairment of endothelium dependent dilation in healthy young adults. Circulation 1993; 88: 2149-55.
119. Morita K, Tsukamoto T, Naya M, et al. Smoking cessation normalizes coronary endothelial vasomotor response assessed with 15Owater and PET in healthy young smokers. J Nucl Med 2006; 47: 1914-20.
120. Puls M, Schroeter MR, Steier J, et al. Effect of smoking cessation on the number and adhesive properties of early outgrowth endothelial progenitor cells. Int J Cardiol 2011; 152: 61-9.
121. Song GY, Gao Y, Di YW, Pan LL, Zhou Y, Ye JM. High-fat feeding reduces endothelium-dependent vasodilation in rats: differential mechanisms for saturated and unsaturated fatty acids? Clin Exp Pharmacol Physiol 2006; 33: 708-13.
122. Hall WL. Dietary saturated and unsaturated fats as determinants of blood pressure and vascular function. Nutr Res Rev 2009; 22: 18-38.
123. Vogel RA, Corretti MC, Plotnick GD. Effect of a single high-fat meal on endothelial function in healthy subjects. Am J Cardiol 1997; 79: 350-4.
124. Lichtenstein AH, Appel LJ, Brands M, et al. Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee. Circulation 2006; 114: 82-96.
125. Kay CD, Kris-Etherton PM, West SG. Effects of antioxidant-rich foods on vascular reactivity: review of the clinical evidence. Curr Atheroscler Rep 2006; 8: 510-22.
126. Esposito K, Marfella R, Ciotola M, et al. Effect of a mediterraneanstyle diet on endothelial dysfunction and markers of vascular inflammation in the metabolic syndrome: a randomized trial. JAMA 2004; 292: 1440-6.
127. Rallidis LS, Lekakis J, Kolomvotsou A, et al. Close adherence to a Mediterranean diet improves endothelial function in subjects with abdominal obesity. Am J Clin Nutr 2009; 90: 263-8.
128. Papageorgiou N, Tousoulis D, Psaltopoulou T, et al. Divergent anti-inflammatory effects of different oil acute consumption on healthy individuals. Eur J Clin Nutr 2011; 65: 514-9.
129. Tousoulis D, Papageorgiou N, Antoniades C, et al. Acute effects of different types of oil consumption on endothelial function, oxidative stress status and vascular inflammation in healthy volunteers. Br J Nutr 2010; 103: 43-9.
130. López-Miranda J, Pérez-Jiménez F, Ros E, et al. Olive oil and health: summary of the II international conference on olive oil and health consensus report, Jaén and Córdoba (Spain) 2008. Nutr Metab Cardiovasc Dis 2010; 20: 284-94.
131. Calder PC. n-3 Fatty acids and cardiovascular disease: evidence explained and mechanisms explored. Clin Sci (Lond) 2004; 107: 1-11.
132. Egert S, Stehle P. Impact of n-3 fatty acids on endothelial function: results from human interventions studies. Curr Opin Clin Nutr Metab Care 2011; 14: 121-31.
133. Renaud S, de Lorgeril M. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet 1992; 339: 1523-6.
134. Kozararevic D, McGee D, Vojvodic N, et al. Frequency of alcohol consumption and morbidity and mortality. Lancet 1980; 1: 613-6.
135. Marmot MG, Rose G, Shipley MJ, Thomas BJ. Alcohol and mortality: explaining the U-shaped curve. Lancet 1981; 1: 580-3.
136. Shaper AG, Wattamethee G, Walker M. Alcohol and mortality in British men: explaining the U-shaped curve. Lancet 1988; 1: 1267-73.
137. Wannamethee SG, Shaper AG. Lifelong teetotallers, ex-drinkers and drinkers: mortality and the incidence of major coronary heart disease events in middle-aged British men. Int J Epidemiol 1997; 26: 523-31.
138. Klatsky AL, Friedman GD, Armstrong MA, Kipp H. Wine, liquor, beer, and mortality. AmJ Epidemiol 2003; 158: 585-95.
139. Suzuki K, Elkind MS, Boden-Albala B, et al. Moderate alcohol consumption is associated with better endothelial function: a cross sectional study. BMC Cardiovasc Disord 2009; 9: 8.
140. Schaller G, Kretschmer S, Gouya G, et al. Alcohol acutely increases vascular reactivity together with insulin sensitivity in type 2 diabetic men. Exp Clin Endocrinol Diabetes 2010; 118: 57-60.
141. Tousoulis D, Ntarladimas I, Antoniades C, et al. Acute effects of different alcoholic beverages on vascular endothelium, inflammatory markers and thrombosis fibrinolysis system. Clin Nutr 2008; 27: 594-600.
142. Schini-Kerth VB, Etienne-Selloum N, Chataigneau T, Auger C. Vascular protection by natural product-derived polyphenols: in vitro and in vivo evidence. Planta Med 2011; 77: 1161-7.
143. Stoclet JC, Chataigneau T, Ndiaye M, et al. Vascular protection by dietary polyphenols. Eur J Pharmacol 2004; 500: 299-313.
144. Lippi G, Franchini M, Favaloro EJ, Targher G.Moderate red wine consumption and cardiovascular disease risk: beyond the "French paradox". Semin Thromb Hemost 2010; 36: 59-70.
145. Frankel E, Kanner J, German J, Parks E, Kinsella JE. Inhibition of oxidation of human low-density lipoprotein by phenolic substances in red wine. Lancet 1993; 341: 454-7.
146. Freedman JE, Parker C 3rd, Li L, et al. Select flavonoids and whole juice from purple grapes inhibit platelet function and enhance nitric oxide release. Circulation 2001; 103: 2792-8.
147. Pendurthi U, Williams T, Vijaya M. Resveratrol, a polyphenolic compound found in wine, inhibits tissue factor expression in vascular cells. Arterioscler Thromb Vasc Biol 1999; 19: 419-26.
148. Wollny T, Aiello L, Di Tommaso D, et al. Modulation of haemostatic function and prevention of experimental thrombosis by red wine in rats: a role for increased nitric oxide production. Br J Pharmacol 1999; 127: 747-55.
149. Andrade AC, Cesena FH, Consolim-Colombo FM, et al. Shortterm red wine consumption promotes differential effects on plasma levels of high-density lipoprotein cholesterol, sympathetic activity, and endothelial function in hypercholesterolemic, hypertensive, and healthy subjects. Clinics (Sao Paulo) 2009; 64: 435-42.
150. Micallef M, Lexis L, Lewandowski P. Red wine consumption increases antioxidant status and decreases oxidative stress in the circulation of both young and old humans. Nutrition Journal 2007; 6: 27.
151. Agewall S, Wright S, Doughty RN, Whalley GA, Duxbury M, Sharpe N. Does a glass of red wine improve endothelial function? Eur Heart J 2000; 21: 74-8.
152. Porteri E, Rizzoni D, De Ciuceis C, et al. Vasodilator effects of red wines in subcutaneous small resistance artery of patients with essential hypertension. Am J Hypertens 2010; 23: 373-8.
153. López-Sepúlveda R, Jiménez R, Romero M, et al. Wine polyphenols improve endothelial function in large vessels of female spontaneously hypertensive rats. Hypertension 2008; 51: 1088-95.
154. Chan SL, Capdeville-Atkinson C, Atkinson J. Red wine polyphenols improve endothelium-dependent dilation in rat cerebral arterioles. J Cardiovasc Pharmacol 2008; 51: 553-8.
155. Pignatelli P, Ghiselli A, Buchetti B, et al. Polyphenols synergistically inhibit oxidative stress in subjects given red and white wine. Atherosclerosis 2006; 188: 77-83.
156. Botden IP, Langendonk JG, Meima ME, et al. Daily red wine consumption improves vascular function by a soluble guanylyl cyclase-dependent pathway. Am J Hypertens 2011; 24: 162-8.
157. Nicholson SK, Tucker GA, Brameld JM. Physiological concentrations of dietary polyphenols regulate vascular endothelial cell expression of genes important in cardiovascular health. Br J Nutr 2010; 103: 1398-403.
158. Figueroa A, Sanchez-Gonzalez MA, Perkins-Veazie PM, Arjmandi BH. Effects of watermelon supplementation on aortic blood pressure and wave reflection in individuals with prehypertension: a pilot study. Am J Hypertens 2011; 24: 40-4.
159. Auclair S, Chironi G, Milenkovic D, et al. The regular consumption of a polyphenol-rich apple does not influence endothelial function: a randomised double-blind trial in hypercholesterolemic adults. Eur J Clin Nutr 2010; 64: 1158-65.
160. Gollücke AP. Recent applications of grape polyphenols in foods, beverages and supplements. Recent Pat Food Nutr Agric 2010; 2: 105-9.
161. Pérez-Jiménez J, Saura-Calixto F. Grape products and cardiovascular disease risk factors. Nutr Res Rev 2008; 21: 158-73.
162. Vislocky LM, Fernandez ML. Biomedical effects of grape products. Nutr Rev 2010; 68: 656-70.
163. Riemersma RA, Rice-Evans CA, Tyrrell RM, Clifford MN, Lean ME. Tea flavonoids and cardiovascular health. Q J Med 2001; 94: 277-82.
164. Stangl V, Dreger H, Stangl K, Lorenz M. Molecular targets of tea polyphenols in the cardiovascular system. Cardiovasc Res 2007; 73: 348-58.
165. Ras RT, Zock PL, Draijer R. Tea consumption enhances endothelial-dependent vasodilation; a meta-analysis. PLoS One 2011; 6: e16974.
166. Jochmann N, Lorenz M, Krosigk A, et al. The efficacy of black tea in ameliorating endothelial function is equivalent to that of green tea. Br J Nutr 2008; 99: 863-8.
167. Lorenz M, Urban J, Engelhardt U, Baumann G, Stangl K, Stangl V. Green and black tea are equally potent stimuli of NO production and vasodilation: new insights into tea ingredients involved. Basic Res Cardiol 2009; 104: 100-10.
168. Rimbach G, Egert S, de Pascual-Teresa S. Chocolate: (un)healthy source of polyphenols? Genes Nutr 2011; 6: 1-3.
169. Vlachopoulos C, Aznaouridis K, Alexopoulos N, Economou E, Andreadou I, Stefanadis C. Effect of dark chocolate on arterial function in healthy individuals. Am J Hypertens 2005; 18: 785-91.
170. Ried K, Sullivan T, Fakler P, Frank OR, Stocks NP. Does chocolate reduce blood pressure? A meta-analysis. BMC Med 2010; 8: 39.
171. Faridi Z, Njike VY, Dutta S, Ali A, Katz DL. Acute dark chocolate and cocoa ingestion and endothelial function: a randomized controlled crossover trial. Am J Clin Nutr 2008; 88: 58-63.
172. Shiina Y, Funabashi N, Lee K, et al. Acute effect of oral flavonoidrich dark chocolate intake on coronary circulation, as compared with non-flavonoid white chocolate, by transthoracic Doppler echocardiography in healthy adults. Int J Cardiol 2009; 131: 424-9.
173. Hooper L, Kroon PA, Rimm EB, et al. Flavonoids, flavonoid-rich foods, and cardiovascular risk: a meta-analysis of randomized controlled trials. Am J Clin Nutr 2008; 88: 38-50.
174. Steptoe A, Brydon L. Emotional triggering of cardiac events. Neurosci Biobehav Rev 2009; 33: 63-70.
175. Strike PC, Steptoe A. Behavioral and emotional triggers of acute coronary syndromes: a systematic review and critique. Psychosom Med 2005; 67: 179-86.
176. Burg MM, Graeber B, Vashist A, et al. Non-invasive detection of risk for emotion-provoked myocardial ischemia. Psychosom Med 2009; 71: 14-20.
177. Miller M, Mangano C, Park Y, Goel R, Plotnick GD, Vogel RA. Impact of cinematic viewing on endothelial function. Heart 2006; 92: 261-2.
178. Wang JS, Lan C, Chen SY, Wong MK. Tai Chi Chuan training is associated with enhanced endothelium-dependent dilation in skin vasculature of healthy older men. J Am Geriatr Soc 2002; 50: 1024-30.
179. Sivasankaran S, Pollard-Quintner S, Sachdeva R, Pugeda J, Hoq SM, Zarich SW. The effect of a six-week program of yoga and meditation on brachial artery reactivity: do psychosocial interventions affect vascular tone? Clin Cardiol 2006; 29: 393-8.
180. Chida Y, Steptoe A. Positive psychological well-being and mortality: a quantitative review of prospective observational studies. Psychosom Med 2008; 70: 741-56.
181. Imamura M, Biro S, Kihara T, et al. Repeated thermal therapy improves impaired vascular endothelial function in patients with coronary risk factors. J Am Coll Cardiol 2001; 38: 1083-8.
182. Dod HS, Bhardwaj R, Sajja V, et al. Effect of intensive lifestyle changes on endothelial function and on inflammatory markers of atherosclerosis. Am J Cardiol 2010; 105: 362-7.
183. Leeson CP, Hingorani AD, Mullen MJ, et al. Glu298Asp endothelial nitric oxide synthase gene polymorphism interacts with environmental and dietary factors to influence endothelial function. Circ Res 2002; 90: 1153-8.
184. Erbs S, Baither Y, Linke A, et al. Promoter but not exon 7 polymorphism of endothelial nitric oxide synthase affects traininginduced correction of endothelial dysfunction. Arterioscler Thromb Vasc Biol 2003; 23: 1814-9.