Effect of oral glucose loading on endothelial function in normal-weight and overweight children

Clinical Science

Volumn 112, Issue 9-10, 2007, Pages 493-498

  Dengel, Donald R ^a,b   Kelly, Aaron S ^c,d   Steinberger, Julia ^d   Sinaiko, Alan R ^d  

^a UNIVERSITY OF MINNESOTA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c St Paul Heart Clinic   (United States)

^d UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Echocardiography; Endothelium derived dilation; Glucose tolerance; Hyperglycaemia; Insulin; Overweight children

Indexed keywords

GLUCOSE; GLYCERYL TRINITRATE; INSULIN;

ARTICLE; BODY MASS; CELL FUNCTION; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; HUMAN; HYPERGLYCEMIA; MALE; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; SCHOOL CHILD; BLOOD PRESSURE; BRACHIAL ARTERY; CHILD; CLINICAL TRIAL; COMPARATIVE STUDY; GLUCOSE BLOOD LEVEL; METABOLISM; MULTICENTER STUDY; PATHOPHYSIOLOGY; PHYSIOLOGY; VASCULAR ENDOTHELIUM; VASODILATATION;

BLOOD GLUCOSE; BLOOD PRESSURE; BRACHIAL ARTERY; CHILD; ENDOTHELIUM, VASCULAR; FEMALE; GLUCOSE; HUMANS; HYPERGLYCEMIA; INSULIN; MALE; OVERWEIGHT; VASODILATION;

EID: 34248551194     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20060305     Document Type: Article

References (30)

1. Stamler, J., Loh, E., Roddy, M., Currie, K. and Creager, M. (1994) Nitric oxide regulates basal systemic and pulmonary vascular resistance in healthy humans. Circulation 89, 2035-2040
2. Vallance, P., Collier, J. and Moncada, S. (1989) Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet 2, 997-1000
3. Kubes, P., Suzuki, M. and Granger, D. (1991) Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc. Natl. Acad. Sci. U.S.A. 88, 4651-4655
4. Kuvin, J. T. and Karas, R. H. (2003) Clinical utility of endothelial function testing: ready for prime time? Circulation 107, 3243-3247
5. Widlansky, M. E., Gocke, N., Keaney, J. F. and Vita, J. A. (2003) The clinical implications of endothelial dysfunction. J. Am. Coll. Cardiol. 42, 1149-1160
6. Akbari, C. M., Saouaf, R., Barnhill, D. F., Newman, P. A., LoGerfo, F. W. and Veves, A. (1988) Endothelium-dependent vasodilation is impaired in both microcirculation and macrocirculation during acute hyperglycemia. J. Vasc. Surg. 28, 687-694
7. Kawano, H., Motoyama, T., Hirashima, O. et al. (1999) Hyperglycemia rapidly suppresses flow-mediated endothelium-dependent vasodilation of brachial artery. J. Am. Coll. Cardiol. 34, 146-154
8. Reed, A. S., Charkoudian, N., Vella, A., Shah, P., Rizza, R. A. and Joyner, M. J. (2004) Forearm vascular control during acute hyperglycemia in healthy humans. Am. J. Physiol. Endocrinol. Metab. 286, E472-E480
9. Siafarikas, A., Watts, K., Beye, P., Jones, T. W., Davis, E. A. and Green, D. J. (2004) Lack of effect of oral glucose loading on conduit vessel endothelial function in healthy subjects. Clin. Sci. 107, 191-196
10. Title, L. M., Cummings, P. M., Giddens, K. and Nassar, B. A. (2000) Oral glucose loading acutely attenuates endothelium-dependent vasodilation in healthy adults without diabetes: an effect prevented by vitamins C and E. J. Am. Coll. Cardiol. 36, 2185-2191
11. Williams, S. B., Goldfine, A. B., Timimi, F. K. et al. (1998) Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivo. Circulation 97, 1695-1701
12. Cook, S., Weitzman, M., Auinger, P., Nguyen, M. and Dietz, W. H. (2003) Prevalence of a metabolic syndrome phenotype in adolescents: findings from the third National Health and Nutrition Examination Survey, 1988-1994. Arch. Pediatr. Adolesc. Med. 157, 821-827
13. Freedman, D., Dietz, W. H., Srinivasan, S. R. and Berenson, G. S. (1999) The relation of overweight to cardiovascular frisk factors among children and adolescents: the Bogalusa Heart Study. Pediatrics 103, 1175-1182
14. Rosner, B., Prineas, R., Loggie, J. and Daniels, S. R. (1998) Percentiles for body mass index in US children 5 to 17 years of age. J. Pediatr. 32, 211-222
15. Celermajer, D. S., Sorensen, K. E., Gooch, V. M. et al. (1992) Non-invasive detection of endothelial dysfunction in children and adults at risk for atherosclerosis. Lancet 340, 1111-1115
16. Kelly, A. S., Wetzsteon, R. J., Kaiser, D. R., Steinberger, J., Bank, A. J. and Dengel, D. R. (2004) Inflammation, insulin, and endothelial function in overweight children and adolescents: the role of exercise. J. Pediatr. 145, 731-736
17. Kelly, A. S., Kaiser, D. R., Dengel, D. R. and Bank, A. J. (2004) Comparison of B-mode and echo-tracking methods of assessing flow-mediated dilation. Ultrasound Med. Biol. 30, 1447-1449
18. Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F. and Turner, R. C. (1985) Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28, 412-419
19. Calles-Escandon, J. and Cipolla, M. (2001) Diabetes and endothelial dysfunction: a clinical perspective. Endocr. Rev. 22, 36-52
20. Cosentino, F. and Luscher, T. F. (1998) Endothelial dysfunction in diabetes mellitus. J. Cardiovasc. Pharmacol. 32 (Suppl. 3), S54-S61
21. Linder, L., Kiowski, W., Buhler, F. R. and Luscher, T. F. (1990) Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo: blunted response in essential hypertension. Circulation 81, 1762-1767
22. Panza, J. A., Casino, P. R., Kilcoyne, C. M. and Quyyumi, A. A. (1994) Impaired endothelium-dependent vasodilation in patients with essential hypertension: evidence that the abnormality is not at the muscarinic receptor level. J. Am. Coll. Cardiol. 23, 1610-1616
23. Fichtlscherer, S., Rosenberger, G., Walter, D. H., Breuer, S., Dimmeler, S. and Zeiher, A. M. (2000) Elevated C-reactive protein levels and impaired endothelial vasoreactivity in patients with coronary artery disease. Circulation 102, 1000-1006
24. Yudkin, J. S., Stehouwer, C. D. A., Emeis, J. J. and Coppack, S. W. (1999) C-reactive protein in healthy subjects: associations with obesity, insulin resistance, and endothelial dysfunction. A potential role for cytokines originating from adipose tissue? Arterioscler. Thromb. Vasc. Biol. 19, 972-978
25. Bodary, P. F., Gu, S., Shen, Y., Hasty, A. H., Buckler, J. M. and Eitzman, D. T. (2005) Recombinant leptin promotes atherosclerosis and thrombosis in apolipoprotein E-deficient mice. Arterioscler. Thromb. Vasc. Biol. 25, e119-e122
26. Maahs, D. M., Ogden, L. G., Kinney, G. L. et al. (2005) Low plasma adiponectin levels predict progression of coronary artery calcification. Circulation 111, 747-753
27. Dohi, Y., Thiel, M. A., Buhler, F. R. and Luscher, T. F. (1990) Activation of endothelial L-arginine pathway in resistance arteries: effects of age and hypertension. Hypertension 15, 170-179
28. Tounian, P., Aggoun, Y., Dubern, B. et al. (2001) Presence of increased stiffness of the common carotid artery and endothelial dysfunction in severely obese children: a prospective study. Lancet 358, 1400-1404
29. Watts, K., Beye, P., Siafarikas, A. et al. (2004) Effects of exercise training on vascular function in obese children. J. Pediatr. 144, 620-625
30. Adams, M. R., Robinson, J., McCredie, R. et al. (1998) Smooth muscle dysfunction occurs independently of impaired of impaired endothelium-dependent dilation in adults at risk of atherosclerosis. J. Am. Coll. Cardiol. 32, 123-127