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Volumn 19, Issue 11, 2010, Pages 1395-1412

Novel therapeutic strategies targeting vascular endothelium in essential hypertension

Author keywords

angiotensin; blood pressure; endothelium; hypertension; nitric oxide; renin

Indexed keywords

2 [1 (2 FLUOROBENZYL) 1H PYRAZOLO[3,4 B]PYRIDIN 3 YL] 5 MORPHOLINO 4,6 PYRIMIDINEDIAMINE; 4 [[4 CARBOXYBUTYL[2 [(4 PHENETHYLBENZYL)OXY]PHENETHYL]AMINO]METHYL]BENZOIC ACID; 4 AMINO 5 CYCLOPROPYL 2 [1 (2 FLUOROBENZYL) 1H PYRAZOLO[3,4 B]PYRIDIN 3 YL]PYRIMIDINE; ACETYLCYSTEINE; ALISKIREN; ALPHA TOCOPHEROL; AMLODIPINE; ANTIHYPERTENSIVE AGENT; ANTIOXIDANT; ARGININE; ASCORBIC ACID; ATENOLOL; ATORVASTATIN; BENDROFLUMETHIAZIDE; CARVEDILOL; COLECALCIFEROL; GLYCERYL TRINITRATE; HMR 1766; LA 419; NAPROXCINOD; NCX 899; NEBIVOLOL; NITRONAPROXEN; PERINDOPRIL; PLACEBO; POLYPHENOL DERIVATIVE; QUINAPRIL; RAMIPRIL; REACTIVE OXYGEN METABOLITE; SILDENAFIL; TELMISARTAN; TETRAHYDROBIOPTERIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALSARTAN;

EID: 77958466526     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.2010.522989     Document Type: Review
Times cited : (29)

References (169)
  • 2
    • 67649538126 scopus 로고    scopus 로고
    • Disease prevention: The moving target of global cardiovascular health
    • Vedanthan R, Fuster V. Disease prevention: the moving target of global cardiovascular health. Nat Rev Cardiol 2009;6:327-8
    • (2009) Nat Rev Cardiol , vol.6 , pp. 327-8
    • Vedanthan, R.1    Fuster, V.2
  • 3
    • 12344282783 scopus 로고    scopus 로고
    • Global burden of hypertension: Analysis of worldwide data
    • Kearney PM, Whelton M, Reynolds K, et al. Global burden of hypertension: analysis of worldwide data. Lancet 2005;365:217-23
    • (2005) Lancet , vol.365 , pp. 217-23
    • Kearney, P.M.1    Whelton, M.2    Reynolds, K.3
  • 4
    • 2942733214 scopus 로고    scopus 로고
    • Role of endothelial dysfunction in atherosclerosis
    • III
    • Davignon J, Ganz P. Role of endothelial dysfunction in atherosclerosis. Circulation 2004;109(Suppl 1):III 27-32
    • (2004) Circulation , vol.109 , Issue.SUPPL. 1 , pp. 27-32
    • Davignon, J.1    Ganz, P.2
  • 5
    • 0032765471 scopus 로고    scopus 로고
    • Endothelial dysfunction in hypertension
    • Kiowski W. Endothelial dysfunction in hypertension. Clin Exp Hypertens 1999;21:635-46
    • (1999) Clin Exp Hypertens , vol.21 , pp. 635-46
    • Kiowski, W.1
  • 6
    • 0036135630 scopus 로고    scopus 로고
    • Endothelial factors and microvascular hypertensive disease
    • Rizzoni D, Aqabiti-Rosei E. Endothelial factors and microvascular hypertensive disease. J Cardiovasc Pharmacol 2001;38(Suppl 2):S15-18
    • (2001) J Cardiovasc Pharmacol , vol.38 , Issue.SUPPL. 2
    • Rizzoni, D.1    Aqabiti-Rosei, E.2
  • 7
    • 70349934619 scopus 로고    scopus 로고
    • Endothelium-dependent contractions and endothelial dysfunction in human hypertension
    • Versari D, Daghini E, Virdis A, et al. Endothelium-dependent contractions and endothelial dysfunction in human hypertension. Br J Pharmacol 2009;157:527-36
    • (2009) Br J Pharmacol , vol.157 , pp. 527-36
    • Versari, D.1    Daghini, E.2    Virdis, A.3
  • 8
    • 33947497538 scopus 로고    scopus 로고
    • Endothelial dysfunction: Cardiovascular risk factors, therapy, and outcome
    • Hadi HA, Carr CS, Al Suwaidi J. Endothelial dysfunction: cardiovascular risk factors, therapy, and outcome. Vasc Health Risk Manag 2005;1:183-98
    • (2005) Vasc Health Risk Manag , vol.1 , pp. 183-98
    • Hadi, H.A.1    Carr, C.S.2    Al Suwaidi, J.3
  • 10
    • 0023028215 scopus 로고
    • Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries
    • Ludmer PL, Selwyn AP, Shook TL, et al. Paradoxical vasoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N Engl J Med 1986;315:1046-51
    • (1986) N Engl J Med , vol.315 , pp. 1046-51
    • Ludmer, P.L.1    Selwyn, A.P.2    Shook, T.L.3
  • 11
    • 0025015143 scopus 로고
    • Coronary vasomotor response to acetylcholine relate to risk factor for coronary artery disease
    • Seiler C, Hess OM, Buechi M, et al. Coronary vasomotor response to acetylcholine relate to risk factor for coronary artery disease. Circulation 1990;81:491-7
    • (1990) Circulation , vol.81 , pp. 491-7
    • Seiler, C.1    Hess, O.M.2    Buechi, M.3
  • 13
    • 0242607013 scopus 로고    scopus 로고
    • Role of coronary risk factors in blood thrombogenicity and acute coronary syndromes
    • Sambola A, Fuster V, Badimon JJ. Role of coronary risk factors in blood thrombogenicity and acute coronary syndromes. Rev Esp Cardiol 2003;56:1001-9
    • (2003) Rev Esp Cardiol , vol.56 , pp. 1001-9
    • Sambola, A.1    Fuster, V.2    Badimon, J.J.3
  • 14
    • 15944365306 scopus 로고    scopus 로고
    • Acetylcholine and endothelial function
    • Tousoulis D, Davies G, Crake T, et al. Acetylcholine and endothelial function. Circulation 1998;98:1587-90
    • (1998) Circulation , vol.98 , pp. 1587-90
    • Tousoulis, D.1    Davies, G.2    Crake, T.3
  • 15
    • 0029918004 scopus 로고    scopus 로고
    • Variable coronary vasomotor responses to acetylcholine in patients with normal coronary arteriograms: Evidence for localised endothelial dysfunction
    • Tousoulis D, Davies G, Lefroy DC, et al. Variable coronary vasomotor responses to acetylcholine in patients with normal coronary arteriograms: evidence for localised endothelial dysfunction. Heart 1996;75:261-6
    • (1996) Heart , vol.75 , pp. 261-6
    • Tousoulis, D.1    Davies, G.2    Lefroy, D.C.3
  • 16
    • 15844378434 scopus 로고    scopus 로고
    • Evaluating endothelial function in humans: A guide to invasive and non-invasive techniques
    • Tousoulis D, Antoniades C, Stefanadis C. Evaluating endothelial function in humans: a guide to invasive and non-invasive techniques. Heart 2005;91:553-8
    • (2005) Heart , vol.91 , pp. 553-8
    • Tousoulis, D.1    Antoniades, C.2    Stefanadis, C.3
  • 17
    • 0035282036 scopus 로고    scopus 로고
    • Effect of the angiotensin-converting enzyme inhibitor imidapril on reactive hyperemia in patients with essential hypertension: Relationship between treatment periods and resistance artery endothelial function
    • Higashi Y, Sasaki S, Nakagawa K, et al. Effect of the angiotensin-converting enzyme inhibitor imidapril on reactive hyperemia in patients with essential hypertension: relationship between treatment periods and resistance artery endothelial function. J Am Coll Cardiol 2001;37:863-70
    • (2001) J Am Coll Cardiol , vol.37 , pp. 863-70
    • Higashi, Y.1    Sasaki, S.2    Nakagawa, K.3
  • 19
    • 21844470252 scopus 로고    scopus 로고
    • Flow-mediated vasodilation: A diagnostic instrument or an experimental tool?
    • Moens AL, Goovaerts I, Claeys MJ, Vrints CJ. Flow-mediated vasodilation: a diagnostic instrument, or an experimental tool? Chest 2005;127:2254-63
    • (2005) Chest , vol.127 , pp. 2254-63
    • Moens, A.L.1    Goovaerts, I.2    Claeys, M.J.3    Vrints, C.J.4
  • 20
    • 0037116573 scopus 로고    scopus 로고
    • Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: A report of the International Brachial Artery Reactivity Task Force
    • Corretti MC, Anderson TJ, Benjamin EJ, et al. Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force. J Am Coll Cardiol 2002;39:257-65
    • (2002) J Am Coll Cardiol , vol.39 , pp. 257-65
    • Corretti, M.C.1    Anderson, T.J.2    Benjamin, E.J.3
  • 21
    • 61449136198 scopus 로고    scopus 로고
    • Non-invasive diagnostic tools for investigating endothelial dysfunction
    • Ghiadoni L, Versari D, Giannarelli C, et al. Non-invasive diagnostic tools for investigating endothelial dysfunction. Curr Pharm Des 2008;14:3715-22
    • (2008) Curr Pharm des , vol.14 , pp. 3715-22
    • Ghiadoni, L.1    Versari, D.2    Giannarelli, C.3
  • 22
    • 0026478022 scopus 로고
    • Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis
    • Celermajer DS, Sorensen KE, Gooch VM, et al. Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis. Lancet 1992;340:1111-15
    • (1992) Lancet , vol.340 , pp. 1111-15
    • Celermajer, D.S.1    Sorensen, K.E.2    Gooch, V.M.3
  • 23
    • 37349021748 scopus 로고    scopus 로고
    • Altered plasma versus vascular biopterins in human atherosclerosis reveal relationships between endothelial nitric oxide synthase coupling, endothelial function, and inflammation
    • Antoniades C, Shirodaria C, Crabtree M, et al. Altered plasma versus vascular biopterins in human atherosclerosis reveal relationships between endothelial nitric oxide synthase coupling, endothelial function, and inflammation. Circulation 2007;116:2851-9
    • (2007) Circulation , vol.116 , pp. 2851-9
    • Antoniades, C.1    Shirodaria, C.2    Crabtree, M.3
  • 26
    • 41349096436 scopus 로고    scopus 로고
    • Nitric oxide, tetrahydropterin, oxidative stress, and endothelial dysfunction in hypertension
    • Schulz E, Jansen T, Wenzel P, et al. Nitric oxide, tetrahydropterin, oxidative stress, and endothelial dysfunction in hypertension. Antioxid Redox Signal 2008;10:1115-26
    • (2008) Antioxid Redox Signal , vol.10 , pp. 1115-26
    • Schulz, E.1    Jansen, T.2    Wenzel, P.3
  • 27
    • 70349099536 scopus 로고    scopus 로고
    • Essential hypertension: Is there a role for inflammatory mechanisms?
    • Androulakis ES, Tousoulis D, Papageorgiou N, et al. Essential hypertension: is there a role for inflammatory mechanisms? Cardiol Rev 2009;17:216-21
    • (2009) Cardiol Rev , vol.17 , pp. 216-21
    • Androulakis, E.S.1    Tousoulis, D.2    Papageorgiou, N.3
  • 28
    • 34447536457 scopus 로고    scopus 로고
    • Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease
    • Schmidt TS, Alp NJ. Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease. Clin Sci (Lond) 2007;113:47-63
    • (2007) Clin Sci (Lond) , vol.113 , pp. 47-63
    • Schmidt, T.S.1    Alp, N.J.2
  • 29
    • 0026459857 scopus 로고
    • L-Arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans
    • Creager MA, Gallagher SJ, Girerd XJ, et al. L-Arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans. J Clin Invest 1992;90:1248-53
    • (1992) J Clin Invest , vol.90 , pp. 1248-53
    • Creager, M.A.1    Gallagher, S.J.2    Girerd, X.J.3
  • 30
    • 0029021148 scopus 로고
    • Hypertension in mice lacking the gene for endothelial nitric oxide synthase
    • Huang PL, Huang Z, Mashimo H, et al. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature 1995;377:239-42
    • (1995) Nature , vol.377 , pp. 239-42
    • Huang, P.L.1    Huang, Z.2    Mashimo, H.3
  • 31
    • 1642369185 scopus 로고    scopus 로고
    • Reactive oxygen species in vascular biology: Role in arterial hypertension
    • Touyz RM. Reactive oxygen species in vascular biology: role in arterial hypertension. Expert Rev Cardiovasc Ther 2003;1:99-106
    • (2003) Expert Rev Cardiovasc Ther , vol.1 , pp. 99-106
    • Touyz, R.M.1
  • 32
    • 33745532872 scopus 로고    scopus 로고
    • Interaction between nitric oxide and angiotensin II in the endothelium: Role in atherosclerosis and hypertension
    • Schulman IH, Zhou MS, Raij L. Interaction between nitric oxide and angiotensin II in the endothelium: role in atherosclerosis and hypertension. J Hypertens 2006;24:S45-50
    • (2006) J Hypertens , vol.24
    • Schulman, I.H.1    Zhou, M.S.2    Raij, L.3
  • 33
    • 0029843035 scopus 로고    scopus 로고
    • Defective L-arginine-nitric oxide pathway in offspring of essential hypertensive patients
    • Taddei S, Virdis A, Mattei P, et al. Defective L-arginine-nitric oxide pathway in offspring of essential hypertensive patients. Circulation 1996;94:1298-303
    • (1996) Circulation , vol.94 , pp. 1298-303
    • Taddei, S.1    Virdis, A.2    Mattei, P.3
  • 34
    • 10844240824 scopus 로고    scopus 로고
    • Impaired L-arginine transport and endothelial function in hypertensive and genetically predisposed normotensive subjects
    • Schlaich MP, Parnell MM, Ahlers BA, et al. Impaired L-arginine transport and endothelial function in hypertensive and genetically predisposed normotensive subjects. Circulation 2004;110:3680-6
    • (2004) Circulation , vol.110 , pp. 3680-6
    • Schlaich, M.P.1    Parnell, M.M.2    Ahlers, B.A.3
  • 35
    • 33947712377 scopus 로고    scopus 로고
    • Identification of a novel polymorphism in the 3'UTR of the L-arginine transporter gene SLC7A1: Contribution to hypertension and endothelial dysfunction
    • Yang Z, Venardos K, Jones E, et al. Identification of a novel polymorphism in the 3'UTR of the L-arginine transporter gene SLC7A1: contribution to hypertension and endothelial dysfunction. Circulation 2007;115:1269-74
    • (2007) Circulation , vol.115 , pp. 1269-74
    • Yang, Z.1    Venardos, K.2    Jones, E.3
  • 36
    • 0035045172 scopus 로고    scopus 로고
    • Reactive oxygen species mediate endothelium-dependent relaxations in tetrahydrobiopterin-deficient mice
    • Cosentino F, Barker JE, Brand MP, et al. Reactive oxygen species mediate endothelium-dependent relaxations in tetrahydrobiopterin-deficient mice. Arterioscler Thromb Vasc Biol 2001;21:496-502
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 496-502
    • Cosentino, F.1    Barker, J.E.2    Brand, M.P.3
  • 37
    • 70349934619 scopus 로고    scopus 로고
    • Endothelium-dependent contractions and endothelial dysfunction in human hypertension
    • Versari D, Daghini E, Virdis A, et al. Endothelium-dependent contractions and endothelial dysfunction in human hypertension. Br J Pharmacol 2009;157:527-36
    • (2009) Br J Pharmacol , vol.157 , pp. 527-36
    • Versari, D.1    Daghini, E.2    Virdis, A.3
  • 38
    • 2642556244 scopus 로고    scopus 로고
    • Endothelial function: A critical determinant in atherosclerosis?
    • II
    • Landmesser U, Hornig B, Drexler H. Endothelial function: a critical determinant in atherosclerosis? Circulation 2004;109(Suppl 1):II 27-33
    • (2004) Circulation , vol.109 , Issue.SUPPL. 1 , pp. 27-33
    • Landmesser, U.1    Hornig, B.2    Drexler, H.3
  • 39
    • 43249107774 scopus 로고    scopus 로고
    • Endothelial dysfunction, impaired endogenous platelet inhibition and platelet activation in diabetes and atherosclerosis
    • Schafer A, Bauersachs J. Endothelial dysfunction, impaired endogenous platelet inhibition and platelet activation in diabetes and atherosclerosis. Curr Vasc Pharmacol 2008;6:52-60
    • (2008) Curr Vasc Pharmacol , vol.6 , pp. 52-60
    • Schafer, A.1    Bauersachs, J.2
  • 40
    • 0033361836 scopus 로고    scopus 로고
    • Nitric oxide in endothelial dysfunction and vascular remodeling: Clinical correlates and experimental links
    • Rudic RD, Sessa WC. Nitric oxide in endothelial dysfunction and vascular remodeling: clinical correlates and experimental links. Am J Hum Genet 1999;64:673-7
    • (1999) Am J Hum Genet , vol.64 , pp. 673-7
    • Rudic, R.D.1    Sessa, W.C.2
  • 41
    • 34547870941 scopus 로고    scopus 로고
    • Arterial compliance and endothelial function
    • Correia ML, Haynes WG. Arterial compliance and endothelial function. Curr Diab Rep 2007;7:269-75
    • (2007) Curr Diab Rep , vol.7 , pp. 269-75
    • Correia, M.L.1    Haynes, W.G.2
  • 42
    • 0028031563 scopus 로고
    • Direct and sympathetically mediated venoconstriction in essential hypertension. Enhanced responses to endothelin-1
    • Haynes WG, Hand MF, Johnstone HA, et al. Direct and sympathetically mediated venoconstriction in essential hypertension. Enhanced responses to endothelin-1. J Clin Invest 1994;94:1359-64
    • (1994) J Clin Invest , vol.94 , pp. 1359-64
    • Haynes, W.G.1    Hand, M.F.2    Johnstone, H.A.3
  • 43
    • 0033001824 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibition improves venous endothelial dysfunction in chronic smokers
    • Chalon S, Moreno H Jr, Hoffman BB, Blaschke TF. Angiotensin-converting enzyme inhibition improves venous endothelial dysfunction in chronic smokers. Clin Pharmacol Ther 1999;65:295-303
    • (1999) Clin Pharmacol Ther , vol.65 , pp. 295-303
    • Chalon, S.1    Moreno Jr., H.2    Hoffman, B.B.3    Blaschke, T.F.4
  • 44
    • 38449106327 scopus 로고    scopus 로고
    • Venous or arterial endothelium evaluation for early cardiovascular dysfunction in hypertensive patients?
    • Rubira MC, Consolim-Colombo FM, Rabelo ER, et al. Venous or arterial endothelium evaluation for early cardiovascular dysfunction in hypertensive patients? J Clin Hypertens (Greenwich) 2007;9:859-65
    • (2007) J Clin Hypertens (Greenwich) , vol.9 , pp. 859-65
    • Rubira, M.C.1    Consolim-Colombo, F.M.2    Rabelo, E.R.3
  • 45
    • 33847206482 scopus 로고    scopus 로고
    • Vasodilatory action of loop diuretics: A plethysmography study of endothelial function in forearm arteries and dorsal hand veins in hypertensive patients and controls
    • De Berrazueta JR, Gonzalez JP, de Mier I, et al. Vasodilatory action of loop diuretics: a plethysmography study of endothelial function in forearm arteries and dorsal hand veins in hypertensive patients and controls. J Cardiovasc Pharmacol 2007;49:90-5
    • (2007) J Cardiovasc Pharmacol , vol.49 , pp. 90-5
    • De Berrazueta, J.R.1    Gonzalez, J.P.2    De Mier, I.3
  • 46
    • 46449089411 scopus 로고    scopus 로고
    • Endothelial dysfunction: From molecular mechanisms to measurement, clinical implications, and therapeutic opportunities
    • Le Brocq M, Leslie SJ, Milliken P, Megson IL. Endothelial dysfunction: from molecular mechanisms to measurement, clinical implications, and therapeutic opportunities. Antioxid Redox Signal 2008;9:1631-74
    • (2008) Antioxid Redox Signal , vol.9 , pp. 1631-74
    • Le Brocq, M.1    Leslie, S.J.2    Milliken, P.3    Megson, I.L.4
  • 47
    • 41649116606 scopus 로고    scopus 로고
    • Pathophysiology, diagnosis and prognostic implications of endothelial dysfunction
    • Munzel T, Sinning C, Post F, et al. Pathophysiology, diagnosis and prognostic implications of endothelial dysfunction. Ann Med 2009;40:180-96
    • (2009) Ann Med , vol.40 , pp. 180-96
    • Munzel, T.1    Sinning, C.2    Post, F.3
  • 48
    • 67649552969 scopus 로고    scopus 로고
    • Risk prediction in cardiovascular disease: The prognostic significance of endothelial dysfunction
    • Martin BJ, Anderson TJ. Risk prediction in cardiovascular disease: the prognostic significance of endothelial dysfunction. Can J Cardiol 2009;25:15A-20A
    • (2009) Can J Cardiol , vol.25
    • Martin, B.J.1    Anderson, T.J.2
  • 49
    • 34247144576 scopus 로고    scopus 로고
    • The association between endothelial dysfunction and cardiovascular outcomes in a population-based multi-ethnic cohort
    • Shimbo D, Grahame-Clarke C, Miyake Y, et al. The association between endothelial dysfunction and cardiovascular outcomes in a population-based multi-ethnic cohort. Atherosclerosis 2007;192:197-203
    • (2007) Atherosclerosis , vol.192 , pp. 197-203
    • Shimbo, D.1    Grahame-Clarke, C.2    Miyake, Y.3
  • 50
    • 0035838416 scopus 로고    scopus 로고
    • Prognostic significance of endothelial dysfunction in hypertensive patients
    • Perticone F, Ceravolo R, Pujia A, et al. Prognostic significance of endothelial dysfunction in hypertensive patients. Circulation 2001;104:191-6
    • (2001) Circulation , vol.104 , pp. 191-6
    • Perticone, F.1    Ceravolo, R.2    Pujia, A.3
  • 51
    • 3142750573 scopus 로고    scopus 로고
    • Potential mechanisms of impaired endothelial function in arterial hypertension and hypercholesterolemia
    • John S, Schmieder RE. Potential mechanisms of impaired endothelial function in arterial hypertension and hypercholesterolemia. Curr Hypertens Rep 2003;5:199-207
    • (2003) Curr Hypertens Rep , vol.5 , pp. 199-207
    • John, S.1    Schmieder, R.E.2
  • 52
    • 69249205739 scopus 로고    scopus 로고
    • Obesity, inflammation, and atherosclerosis
    • Rocha VZ, Libby P. Obesity, inflammation, and atherosclerosis. Nat Rev Cardiol 2009;6:399-409
    • (2009) Nat Rev Cardiol , vol.6 , pp. 399-409
    • Rocha, V.Z.1    Libby, P.2
  • 53
    • 0041379724 scopus 로고    scopus 로고
    • Emerging importance of HDL cholesterol in developing high-risk coronary plaques in acute coronary syndromes
    • Viles-Gonzalez JF, Fuster V, Corti R, Badimon JJ. Emerging importance of HDL cholesterol in developing high-risk coronary plaques in acute coronary syndromes. Curr Opin Cardiol 2003;18:286-94
    • (2003) Curr Opin Cardiol , vol.18 , pp. 286-94
    • Viles-Gonzalez, J.F.1    Fuster, V.2    Corti, R.3    Badimon, J.J.4
  • 54
    • 8144222977 scopus 로고    scopus 로고
    • Interrelations between brachial endothelial function and carotid intima-media thickness in young adults: The cardiovascular risk in young Finns study
    • Juonala M, Viikari JS, Laitinen T, et al. Interrelations between brachial endothelial function and carotid intima-media thickness in young adults: the cardiovascular risk in young Finns study. Circulation 2004;110:2918-23
    • (2004) Circulation , vol.110 , pp. 2918-23
    • Juonala, M.1    Viikari, J.S.2    Laitinen, T.3
  • 55
    • 33750318148 scopus 로고    scopus 로고
    • European Network for Non-invasive Investigation of Large Arteries. Expert consensus document on arterial stiffness: Methodological issues and clinical applications
    • Laurent S, Cockcroft J, Van Bortel L, et al. European Network for Non-invasive Investigation of Large Arteries. Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J 2006;27:2588-605
    • (2006) Eur Heart J , vol.27 , pp. 2588-605
    • Laurent, S.1    Cockcroft, J.2    Van Bortel, L.3
  • 56
    • 34250819965 scopus 로고    scopus 로고
    • Isolated systolic hypertension is characterized by increased aortic stiffness and endothelial dysfunction
    • Wallace SM, Yasmin, McEniery CM, et al. Isolated systolic hypertension is characterized by increased aortic stiffness and endothelial dysfunction. Hypertension 2007;50:228-33
    • (2007) Hypertension , vol.50 , pp. 228-33
    • Wallace, S.M.1    Yasmin McEniery, C.M.2
  • 57
    • 33750575381 scopus 로고    scopus 로고
    • Endothelial function is associated with pulse pressure, pulse wave velocity, and augmentation index in healthy humans
    • McEniery CM, Wallace S, Mackenzie IS, et al. Endothelial function is associated with pulse pressure, pulse wave velocity, and augmentation index in healthy humans. Hypertension 2006;48:602-8
    • (2006) Hypertension , vol.48 , pp. 602-8
    • McEniery, C.M.1    Wallace, S.2    MacKenzie, I.S.3
  • 58
    • 0023121207 scopus 로고
    • Alterations in the coronary circulation in hypertrophied ventricles
    • Marcus ML, Harrison DG, Chilian WM, et al. Alterations in the coronary circulation in hypertrophied ventricles. Circulation 1987;75:I19-25
    • (1987) Circulation , vol.75
    • Marcus, M.L.1    Harrison, D.G.2    Chilian, W.M.3
  • 59
    • 0024210903 scopus 로고
    • Angina due to coronary microvascular disease in hypertensive patients without left ventricular hypertrophy
    • Brush JE Jr, Cannon RO III, Schenke WH, et al. Angina due to coronary microvascular disease in hypertensive patients without left ventricular hypertrophy. N Engl J Med 1988;319:1302-7
    • (1988) N Engl J Med , vol.319 , pp. 1302-7
    • Brush Jr., J.E.1    Cannon III, R.O.2    Schenke, W.H.3
  • 60
    • 0027475176 scopus 로고
    • Hypertension and left ventricular hypertrophy are associated with impaired endothelium-mediated relaxation in human coronary resistance vessels
    • Treasure CB, Klein JL, Vita JA, et al. Hypertension and left ventricular hypertrophy are associated with impaired endothelium-mediated relaxation in human coronary resistance vessels. Circulation 1993;87:86-93
    • (1993) Circulation , vol.87 , pp. 86-93
    • Treasure, C.B.1    Klein, J.L.2    Vita, J.A.3
  • 61
    • 33847231568 scopus 로고    scopus 로고
    • Coronary microvascular dysfunction
    • Camici PG, Crea F. Coronary microvascular dysfunction. N Engl J Med 2007;356:830-40
    • (2007) N Engl J Med , vol.356 , pp. 830-40
    • Camici, P.G.1    Crea, F.2
  • 62
    • 34247644391 scopus 로고    scopus 로고
    • Increased left ventricular mass and diastolic dysfunction are associated with endothelial dysfunction in normotensive offspring of subjects with essential hypertension
    • Zizek B, Poredos P. Increased left ventricular mass and diastolic dysfunction are associated with endothelial dysfunction in normotensive offspring of subjects with essential hypertension. Blood Press 2007;16:36-44
    • (2007) Blood Press , vol.16 , pp. 36-44
    • Zizek, B.1    Poredos, P.2
  • 64
    • 70350739118 scopus 로고    scopus 로고
    • Cardiovascular risk factors in patients with chronic kidney disease
    • van der Zee S, Baber U, Elmariah S, et al. Cardiovascular risk factors in patients with chronic kidney disease. Nat Rev Cardiol 2009;6:580-9
    • (2009) Nat Rev Cardiol , vol.6 , pp. 580-9
    • Van Der Zee, S.1    Baber, U.2    Elmariah, S.3
  • 65
    • 4143138460 scopus 로고    scopus 로고
    • Endothelial dysfunction and mild renal insufficiency in essential hypertension
    • Perticone F, Maio R, Tripepi G, Zoccali C. Endothelial dysfunction and mild renal insufficiency in essential hypertension. Circulation 2004;110:821-5
    • (2004) Circulation , vol.110 , pp. 821-5
    • Perticone, F.1    Maio, R.2    Tripepi, G.3    Zoccali, C.4
  • 66
    • 38449083655 scopus 로고    scopus 로고
    • Endothelial dysfunction and C-reactive protein are risk factors for diabetes in essential hypertension
    • Perticone F, Maio R, Sciacqua A, et al. Endothelial dysfunction and C-reactive protein are risk factors for diabetes in essential hypertension. Diabetes 2008;57:167-71
    • (2008) Diabetes , vol.57 , pp. 167-71
    • Perticone, F.1    Maio, R.2    Sciacqua, A.3
  • 67
    • 67649662339 scopus 로고    scopus 로고
    • Combination therapy for hypertension
    • Kaplan NM. Combination therapy for hypertension. Nat Rev Cardiol 2009;6:270-1
    • (2009) Nat Rev Cardiol , vol.6 , pp. 270-1
    • Kaplan, N.M.1
  • 68
    • 34250216388 scopus 로고    scopus 로고
    • Endothelial function and hypertension
    • Landmesser U, Drexler H. Endothelial function and hypertension. Curr Opin Cardiol 2007;22:316-20
    • (2007) Curr Opin Cardiol , vol.22 , pp. 316-20
    • Landmesser, U.1    Drexler, H.2
  • 69
    • 67349227865 scopus 로고    scopus 로고
    • The impact of oral L-arginine supplementation on acute smoking-induced endothelial injury and arterial performance
    • Siasos G, Tousoulis D, Vlachopoulos C, et al. The impact of oral L-arginine supplementation on acute smoking-induced endothelial injury and arterial performance. Am J Hypertens 2009;22:586-92
    • (2009) Am J Hypertens , vol.22 , pp. 586-92
    • Siasos, G.1    Tousoulis, D.2    Vlachopoulos, C.3
  • 70
    • 0242499997 scopus 로고    scopus 로고
    • Effects of L-arginine on flow mediated dilatation induced by atrial pacing in diseased epicardial coronary arteries
    • Tousoulis D, Davies GJ, Tentolouris C, et al. Effects of L-arginine on flow mediated dilatation induced by atrial pacing in diseased epicardial coronary arteries. Heart 2003;89:531-4
    • (2003) Heart , vol.89 , pp. 531-4
    • Tousoulis, D.1    Davies, G.J.2    Tentolouris, C.3
  • 71
    • 43049162216 scopus 로고    scopus 로고
    • Short-term treatment with L-arginine prevents the smoking-induced impairment of endothelial function and vascular elastic properties in young individuals
    • Siasos G, Tousoulis D, Vlachopoulos C, et al. Short-term treatment with L-arginine prevents the smoking-induced impairment of endothelial function and vascular elastic properties in young individuals. Int J Cardiol 2008;126:394-9
    • (2008) Int J Cardiol , vol.126 , pp. 394-9
    • Siasos, G.1    Tousoulis, D.2    Vlachopoulos, C.3
  • 72
    • 0036961273 scopus 로고    scopus 로고
    • L-Arginine in cardiovascular disease: Dream or reality?
    • Tousoulis D, Antoniades C, Tentolouris C, et al. L-Arginine in cardiovascular disease: dream or reality? Vasc Med 2002;7:203-11
    • (2002) Vasc Med , vol.7 , pp. 203-11
    • Tousoulis, D.1    Antoniades, C.2    Tentolouris, C.3
  • 73
    • 33847097905 scopus 로고    scopus 로고
    • L-Arginine, the substrate for NO synthesis: An alternative treatment for premature atherosclerosis?
    • Siasos G, Tousoulis D, Antoniades C, et al. L-Arginine, the substrate for NO synthesis: an alternative treatment for premature atherosclerosis? Int J Cardiol 2007;116:300-8
    • (2007) Int J Cardiol , vol.116 , pp. 300-8
    • Siasos, G.1    Tousoulis, D.2    Antoniades, C.3
  • 74
    • 34547631799 scopus 로고    scopus 로고
    • The influence of L-arginine on blood pressure, vascular nitric oxide and renal morphometry in the offspring from diabetic mothers
    • Cavanal Mde F, Gomes GN, Forti AL, et al. The influence of L-arginine on blood pressure, vascular nitric oxide and renal morphometry in the offspring from diabetic mothers. Pediatr Res 2007;62:145-50
    • (2007) Pediatr Res , vol.62 , pp. 145-50
    • Cavanal Mde, F.1    Gomes, G.N.2    Forti, A.L.3
  • 75
    • 0035129814 scopus 로고    scopus 로고
    • L-Arginine improves endothelial function in renal artery of hypertensive Dahl rats
    • Zhou MS, Kosaka H, Tian RX, et al. L-Arginine improves endothelial function in renal artery of hypertensive Dahl rats. J Hypertens 2001;19:421-9
    • (2001) J Hypertens , vol.19 , pp. 421-9
    • Zhou, M.S.1    Kosaka, H.2    Tian, R.X.3
  • 76
    • 38749150313 scopus 로고    scopus 로고
    • Acute administration of L-arginine restores nitric oxide-mediated relaxation in isolated pulmonary arteries from pulmonary hypertensive exercise trained rats
    • Goret L, Tanguy S, Guiraud I, et al. Acute administration of L-arginine restores nitric oxide-mediated relaxation in isolated pulmonary arteries from pulmonary hypertensive exercise trained rats. Eur J Pharmacol 2008;581:148-56
    • (2008) Eur J Pharmacol , vol.581 , pp. 148-56
    • Goret, L.1    Tanguy, S.2    Guiraud, I.3
  • 77
    • 0036888365 scopus 로고    scopus 로고
    • Oral L-arginine improves endothelial dysfunction in patients with essential hypertension
    • Lekakis JP, Papathanassiou S, Papaioannou TG, et al. Oral L-arginine improves endothelial dysfunction in patients with essential hypertension. Int J Cardiol 2002;86:317-23
    • (2002) Int J Cardiol , vol.86 , pp. 317-23
    • Lekakis, J.P.1    Papathanassiou, S.2    Papaioannou, T.G.3
  • 78
    • 33845642067 scopus 로고    scopus 로고
    • Novel therapies targeting vascular endothelium
    • Tousoulis D, Antoniades C, Koumallos N, et al. Novel therapies targeting vascular endothelium. Endothelium 2006;13:411-21
    • (2006) Endothelium , vol.13 , pp. 411-21
    • Tousoulis, D.1    Antoniades, C.2    Koumallos, N.3
  • 79
    • 0037871863 scopus 로고    scopus 로고
    • Effect of tetrahydrobiopterin on blood pressure in rats after subtotal nephrectomy
    • Podjarny E, Benchetrit S, Rathaus M, et al. Effect of tetrahydrobiopterin on blood pressure in rats after subtotal nephrectomy. Nephron Physiol 2003;94:6-9
    • (2003) Nephron Physiol , vol.94 , pp. 6-9
    • Podjarny, E.1    Benchetrit, S.2    Rathaus, M.3
  • 80
    • 0036100972 scopus 로고    scopus 로고
    • Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals
    • Higashi Y, Sasaki S, Nakagawa K, et al. Tetrahydrobiopterin enhances forearm vascular response to acetylcholine in both normotensive and hypertensive individuals. Am J Hypertens 2002;15:326-32
    • (2002) Am J Hypertens , vol.15 , pp. 326-32
    • Higashi, Y.1    Sasaki, S.2    Nakagawa, K.3
  • 81
    • 44049104413 scopus 로고    scopus 로고
    • Tetrahydrobiopterin: A novel antihypertensive therapy
    • Porkert M, Sher S, Reddy U, et al. Tetrahydrobiopterin: a novel antihypertensive therapy. J Hum Hypertens 2008;22:401-7
    • (2008) J Hum Hypertens , vol.22 , pp. 401-7
    • Porkert, M.1    Sher, S.2    Reddy, U.3
  • 82
    • 21644454946 scopus 로고    scopus 로고
    • Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress
    • Kase H, Hashikabe Y, Uchida K, et al. Supplementation with tetrahydrobiopterin prevents the cardiovascular effects of angiotensin II-induced oxidative and nitrosative stress. J Hypertens 2005;23:1375-82
    • (2005) J Hypertens , vol.23 , pp. 1375-82
    • Kase, H.1    Hashikabe, Y.2    Uchida, K.3
  • 83
    • 41149150716 scopus 로고    scopus 로고
    • NADPH oxidases, reactive oxygen species, and hypertension: Clinical implications and therapeutic possibilities
    • Paravicini TM, Touyz RM. NADPH oxidases, reactive oxygen species, and hypertension: clinical implications and therapeutic possibilities. Diabetes Care 2008;31(Suppl 2):S170-80
    • (2008) Diabetes Care , vol.31 , Issue.SUPPL. 2
    • Paravicini, T.M.1    Touyz, R.M.2
  • 84
    • 33947405296 scopus 로고    scopus 로고
    • Supplementation with vitamins C and e improves arterial stiffness and endothelial function in essential hypertensive patients
    • Plantinga Y, Ghiadoni L, Magagna A, et al. Supplementation with vitamins C and E improves arterial stiffness and endothelial function in essential hypertensive patients. Am J Hypertens 2007;20:392-7
    • (2007) Am J Hypertens , vol.20 , pp. 392-7
    • Plantinga, Y.1    Ghiadoni, L.2    Magagna, A.3
  • 85
    • 23744477944 scopus 로고    scopus 로고
    • Superoxide scavenging effects of N-acetylcysteine and vitamin C in subjects with essential hypertension
    • Schneider MP, Delles C, Schmidt BM, et al. Superoxide scavenging effects of N-acetylcysteine and vitamin C in subjects with essential hypertension. Am J Hypertens 2005;18:1111-17
    • (2005) Am J Hypertens , vol.18 , pp. 1111-17
    • Schneider, M.P.1    Delles, C.2    Schmidt, B.M.3
  • 86
    • 33645780634 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase in vascular disease: From marvel to menace
    • Forstermann U, Munzel T. Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation 2006;113:1708-14
    • (2006) Circulation , vol.113 , pp. 1708-14
    • Forstermann, U.1    Munzel, T.2
  • 87
    • 49849085584 scopus 로고    scopus 로고
    • Vitamin D derivatives acutely reduce endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat
    • Wong MS, Delansorne R, Man RY, Vanhoutte PM. Vitamin D derivatives acutely reduce endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol 2008;295:H289-96
    • (2008) Am J Physiol Heart Circ Physiol , vol.295
    • Wong, M.S.1    Delansorne, R.2    Man, R.Y.3    Vanhoutte, P.M.4
  • 88
    • 0242409623 scopus 로고    scopus 로고
    • Effects of combined administration of vitamins C and e on reactive hyperemia and inflammatory process in chronic smokers
    • Tousoulis D, Antoniades C, Tentolouris C, et al. Effects of combined administration of vitamins C and E on reactive hyperemia and inflammatory process in chronic smokers. Atherosclerosis 2003;170:261-7
    • (2003) Atherosclerosis , vol.170 , pp. 261-7
    • Tousoulis, D.1    Antoniades, C.2    Tentolouris, C.3
  • 89
    • 0038489192 scopus 로고    scopus 로고
    • Effects of antioxidant vitamins C and e on endothelial function and thrombosis/fibrinolysis system in smokers
    • Antoniades C, Tousoulis D, Tentolouris C, et al. Effects of antioxidant vitamins C and E on endothelial function and thrombosis/fibrinolysis system in smokers. Thromb Haemost 2003;89:990-5
    • (2003) Thromb Haemost , vol.89 , pp. 990-5
    • Antoniades, C.1    Tousoulis, D.2    Tentolouris, C.3
  • 90
    • 25144481421 scopus 로고    scopus 로고
    • Effects of vitamin C on intracoronary L-arginine dependent coronary vasodilatation in patients with stable angina
    • Tousoulis D, Xenakis C, Tentolouris C, et al. Effects of vitamin C on intracoronary L-arginine dependent coronary vasodilatation in patients with stable angina. Heart 2005;91:1319-23
    • (2005) Heart , vol.91 , pp. 1319-23
    • Tousoulis, D.1    Xenakis, C.2    Tentolouris, C.3
  • 91
    • 77952900968 scopus 로고    scopus 로고
    • The role of cellular micronutrient analysis, nutraceuticals, vitamins, antioxidants and minerals in the prevention and treatment of hypertension and cardiovascular disease
    • Houston MC. The role of cellular micronutrient analysis, nutraceuticals, vitamins, antioxidants and minerals in the prevention and treatment of hypertension and cardiovascular disease. Ther Adv Cardiovasc Dis 2010;4:165-83
    • (2010) Ther Adv Cardiovasc Dis , vol.4 , pp. 165-83
    • Houston, M.C.1
  • 92
    • 70449413936 scopus 로고    scopus 로고
    • The oxidative stress menace to coronary vasculature: Any place for antioxidants?
    • Briasoulis A, Tousoulis D, Antoniades C, Stefanadis C. The oxidative stress menace to coronary vasculature: any place for antioxidants? Curr Pharm Des 2009;15:3078-90
    • (2009) Curr Pharm des , vol.15 , pp. 3078-90
    • Briasoulis, A.1    Tousoulis, D.2    Antoniades, C.3    Stefanadis, C.4
  • 93
    • 0036900193 scopus 로고    scopus 로고
    • Lack of long-term effect of vitamin C supplementation on blood pressure
    • Kim MK, Sasaki S, Sasazuki S, et al. Lack of long-term effect of vitamin C supplementation on blood pressure. Hypertension 2002;40:797-803
    • (2002) Hypertension , vol.40 , pp. 797-803
    • Kim, M.K.1    Sasaki, S.2    Sasazuki, S.3
  • 94
    • 33644983519 scopus 로고    scopus 로고
    • Chronic antioxidant supplementation impairs coronary endothelial function and myocardial perfusion in normal pigs
    • Versari D, Daghini E, Rodriguez-Porcel M, et al. Chronic antioxidant supplementation impairs coronary endothelial function and myocardial perfusion in normal pigs. Hypertension 2006;47:475-81
    • (2006) Hypertension , vol.47 , pp. 475-81
    • Versari, D.1    Daghini, E.2    Rodriguez-Porcel, M.3
  • 95
    • 77951275808 scopus 로고    scopus 로고
    • The activation of endothelin-1 pathway during methionine-induced homocysteinemia mediates endothelial dysfunction in hypertensive individuals
    • Tousoulis D, Bouras G, Antoniades C, et al. The activation of endothelin-1 pathway during methionine-induced homocysteinemia mediates endothelial dysfunction in hypertensive individuals. J Hypertens 2010;28:925-30
    • (2010) J Hypertens , vol.28 , pp. 925-30
    • Tousoulis, D.1    Bouras, G.2    Antoniades, C.3
  • 96
    • 33846604213 scopus 로고    scopus 로고
    • Effects of atorvastatin and vitamin C on forearm hyperaemic blood flow, asymmentrical dimethylarginine levels and the inflammatory process in patients with type 2 diabetes mellitus
    • Tousoulis D, Antoniades C, Vasiliadou C, et al. Effects of atorvastatin and vitamin C on forearm hyperaemic blood flow, asymmentrical dimethylarginine levels and the inflammatory process in patients with type 2 diabetes mellitus. Heart 2007;93:244-6
    • (2007) Heart , vol.93 , pp. 244-6
    • Tousoulis, D.1    Antoniades, C.2    Vasiliadou, C.3
  • 97
    • 28344457465 scopus 로고    scopus 로고
    • Effects of combined administration of low dose atorvastatin and vitamin e on inflammatory markers and endothelial function in patients with heart failure
    • Tousoulis D, Antoniades C, Vassiliadou C, et al. Effects of combined administration of low dose atorvastatin and vitamin E on inflammatory markers and endothelial function in patients with heart failure. Eur J Heart Fail 2005;7:1126-32
    • (2005) Eur J Heart Fail , vol.7 , pp. 1126-32
    • Tousoulis, D.1    Antoniades, C.2    Vassiliadou, C.3
  • 98
    • 40849116500 scopus 로고    scopus 로고
    • Wine polyphenols improve endothelial function in large vessels of female spontaneously hypertensive rats
    • Lopez-Sepulveda R, Jimenez R, Romero M, et al. Wine polyphenols improve endothelial function in large vessels of female spontaneously hypertensive rats. Hypertension 2008;51:1088-95
    • (2008) Hypertension , vol.51 , pp. 1088-95
    • Lopez-Sepulveda, R.1    Jimenez, R.2    Romero, M.3
  • 99
    • 33845197949 scopus 로고    scopus 로고
    • Red wine polyphenols prevent angiotensin II-induced hypertension and endothelial dysfunction in rats: Role of NADPH oxidase
    • Sarr M, Chataigneau M, Martins S, et al. Red wine polyphenols prevent angiotensin II-induced hypertension and endothelial dysfunction in rats: role of NADPH oxidase. Cardiovasc Res 2006;71:794-802
    • (2006) Cardiovasc Res , vol.71 , pp. 794-802
    • Sarr, M.1    Chataigneau, M.2    Martins, S.3
  • 100
    • 34948894467 scopus 로고    scopus 로고
    • Mechanisms and effects of green tea on cardiovascular health
    • Basu A, Lucas EA. Mechanisms and effects of green tea on cardiovascular health. Nutr Rev 2007;65:361-75
    • (2007) Nutr Rev , vol.65 , pp. 361-75
    • Basu, A.1    Lucas, E.A.2
  • 101
    • 56149099037 scopus 로고    scopus 로고
    • The acute effect of green tea consumption on endothelial function in healthy individuals
    • Alexopoulos N, Vlachopoulos C, Aznaouridis K, et al. The acute effect of green tea consumption on endothelial function in healthy individuals. Eur J Cardiovasc Prev Rehabil 2008;15:300-5
    • (2008) Eur J Cardiovasc Prev Rehabil , vol.15 , pp. 300-5
    • Alexopoulos, N.1    Vlachopoulos, C.2    Aznaouridis, K.3
  • 102
    • 36348974617 scopus 로고    scopus 로고
    • Prevention of hypertension, cardiovascular damage and endothelial dysfunction with green tea extracts
    • Antonello M, Montemurro D, Bolognesi M, et al. Prevention of hypertension, cardiovascular damage and endothelial dysfunction with green tea extracts. Am J Hypertens 2007;20:1321-8
    • (2007) Am J Hypertens , vol.20 , pp. 1321-8
    • Antonello, M.1    Montemurro, D.2    Bolognesi, M.3
  • 103
    • 0031718279 scopus 로고    scopus 로고
    • Long-term administration of L-arginine did not influence blood pressure, heart rate, cardiac hypertrophy or arterial wall thickness of spontaneously hypertensive rats
    • Kristek F. Long-term administration of L-arginine did not influence blood pressure, heart rate, cardiac hypertrophy or arterial wall thickness of spontaneously hypertensive rats. Exp Physiol 1998;83:595-603
    • (1998) Exp Physiol , vol.83 , pp. 595-603
    • Kristek, F.1
  • 104
    • 77950847452 scopus 로고    scopus 로고
    • Vitamins C and e to prevent complications of pregnancy-associated hypertension
    • Roberts JM, Myatt L, Spong CY, et al. Vitamins C and E to prevent complications of pregnancy-associated hypertension. N Engl J Med 2001;362:1282-91
    • (2001) N Engl J Med , vol.362 , pp. 1282-91
    • Roberts, J.M.1    Myatt, L.2    Spong, C.Y.3
  • 105
    • 68349104172 scopus 로고    scopus 로고
    • Nitric oxide mechanisms of nebivolol
    • Maffei A, Lembo G. Nitric oxide mechanisms of nebivolol. Ther Adv Cardiovasc Dis 2009;3:317-27
    • (2009) Ther Adv Cardiovasc Dis , vol.3 , pp. 317-27
    • Maffei, A.1    Lembo, G.2
  • 106
    • 70350445237 scopus 로고    scopus 로고
    • Nebivolol: The somewhat-different beta-adrenergic receptor blocker
    • Munzel T, Gori T. Nebivolol: the somewhat-different beta-adrenergic receptor blocker. J Am Coll Cardiol 2009;54:1491-9
    • (2009) J Am Coll Cardiol , vol.54 , pp. 1491-9
    • Munzel, T.1    Gori, T.2
  • 107
    • 70849120726 scopus 로고    scopus 로고
    • Nebivolol in high-risk, obese African Americans with stage 1 hypertension: Effects on blood pressure, vascular compliance, and endothelial function
    • Merchant N, Searles CD, Pandian A, et al. Nebivolol in high-risk, obese African Americans with stage 1 hypertension: effects on blood pressure, vascular compliance, and endothelial function. J Clin Hypertens (Greenwich) 2009;11:720-5
    • (2009) J Clin Hypertens (Greenwich) , vol.11 , pp. 720-5
    • Merchant, N.1    Searles, C.D.2    Pandian, A.3
  • 108
    • 54249107160 scopus 로고    scopus 로고
    • Nebivolol treatment reduces serum levels of asymmetric dimethylarginine and improves endothelial dysfunction in essential hypertensive patients
    • Pasini AF, Garbin U, Stranieri C, et al. Nebivolol treatment reduces serum levels of asymmetric dimethylarginine and improves endothelial dysfunction in essential hypertensive patients. Am J Hypertens 2008;21:1251-7
    • (2008) Am J Hypertens , vol.21 , pp. 1251-7
    • Pasini, A.F.1    Garbin, U.2    Stranieri, C.3
  • 109
    • 45949084608 scopus 로고    scopus 로고
    • Early effects of treatment with nebivolol and quinapril on endothelial function in patients with hypertension
    • Korkmaz H, Karaca I, Koc M, et al. Early effects of treatment with nebivolol and quinapril on endothelial function in patients with hypertension. Endothelium 2008;15:149-55
    • (2008) Endothelium , vol.15 , pp. 149-55
    • Korkmaz, H.1    Karaca, I.2    Koc, M.3
  • 110
    • 0035979349 scopus 로고    scopus 로고
    • Nebivolol reverses endothelial dysfunction in essential hypertension: A randomized, double-blind, crossover study
    • Tzemos N, Lim PO, MacDonald TM. Nebivolol reverses endothelial dysfunction in essential hypertension: a randomized, double-blind, crossover study. Circulation 2001;104:511-4
    • (2001) Circulation , vol.104 , pp. 511-4
    • Tzemos, N.1    Lim, P.O.2    MacDonald, T.M.3
  • 111
    • 44249083511 scopus 로고    scopus 로고
    • Impact of nebivolol on levels of serum nitric oxide plasma von Willebrand factor and exercise stress testing parameters in hypertensive and ischemic heart disease patients
    • Kobusiak-Prokopowicz M, Jolda-Mydlowska B, Zubkiewicz A, et al. Impact of nebivolol on levels of serum nitric oxide, plasma von Willebrand factor and exercise stress testing parameters in hypertensive and ischemic heart disease patients. Cardiol J 2008;15:162-8
    • (2008) Cardiol J , vol.15 , pp. 162-8
    • Kobusiak-Prokopowicz, M.1    Jolda-Mydlowska, B.2    Zubkiewicz, A.3
  • 112
    • 67449104782 scopus 로고    scopus 로고
    • Arterial stiffness, hypertension, and rational use of nebivolol
    • Aqabiti-Rosei E, Porteri E, Rizzoni D. Arterial stiffness, hypertension, and rational use of nebivolol. Vasc Health Risk Manag 2009;5:353-60
    • (2009) Vasc Health Risk Manag , vol.5 , pp. 353-60
    • Aqabiti-Rosei, E.1    Porteri, E.2    Rizzoni, D.3
  • 113
    • 33846977745 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of a nitric oxide-releasing derivative of enalapril in male beagles
    • Okuyama CE, Mendes GD, Faro R, et al. Pharmacokinetics and pharmacodynamics of a nitric oxide-releasing derivative of enalapril in male beagles. Clin Exp Pharmacol Physiol 2007;34:290-5
    • (2007) Clin Exp Pharmacol Physiol , vol.34 , pp. 290-5
    • Okuyama, C.E.1    Mendes, G.D.2    Faro, R.3
  • 114
    • 2442640601 scopus 로고    scopus 로고
    • A nitric oxide-releasing derivative of enalapril, NCX 899, prevents progressive cardiac dysfunction and remodeling in hamsters with heart failure
    • Iwanaga Y, Gu Y, Dieterle T, et al. A nitric oxide-releasing derivative of enalapril, NCX 899, prevents progressive cardiac dysfunction and remodeling in hamsters with heart failure. FASEB J 2004;18:587-8
    • (2004) FASEB J , vol.18 , pp. 587-8
    • Iwanaga, Y.1    Gu, Y.2    Dieterle, T.3
  • 115
    • 69449105980 scopus 로고    scopus 로고
    • Effects of the cyclooxygenase inhibiting nitric oxide donator naproxcinod versus naproxen on systemic blood pressure in patients with osteoarthritis
    • White WB, Schnitzer TJ, Fleming R, et al. Effects of the cyclooxygenase inhibiting nitric oxide donator naproxcinod versus naproxen on systemic blood pressure in patients with osteoarthritis. Am J Cardiol 2009;104:840-5
    • (2009) Am J Cardiol , vol.104 , pp. 840-5
    • White, W.B.1    Schnitzer, T.J.2    Fleming, R.3
  • 116
    • 77958449728 scopus 로고    scopus 로고
    • The nitric oxide donator naproxcinod has blood pressure effects similar to placebo in patients on renin-angiotensin system blockers
    • White W, Schnitzer T, Dijian J, et al. The nitric oxide donator naproxcinod has blood pressure effects similar to placebo in patients on renin-angiotensin system blockers. J Hypertens 2010;28:e441
    • (2010) J Hypertens , vol.28
    • White, W.1    Schnitzer, T.2    Dijian, J.3
  • 117
    • 77958449032 scopus 로고    scopus 로고
    • Naproxcinod counterbalances vasoconstriction due to Cox inhibition in human arteries with endothelial dysfunction
    • Miglietta D, Poggi A, Vergani B, et al. Naproxcinod counterbalances vasoconstriction due to Cox inhibition in human arteries with endothelial dysfunction. J Hypertens 2010;28:e125
    • (2010) J Hypertens , vol.28
    • Miglietta, D.1    Poggi, A.2    Vergani, B.3
  • 118
    • 36448954982 scopus 로고    scopus 로고
    • LA419, a novel nitric oxide donor, prevents pathological cardiac remodeling in pressure-overloaded rats via endothelial nitric oxide synthase pathway regulation
    • Ruiz-Hurtado G, Fernandez-Velasco M, Mourelle M, Delgado C. LA419, a novel nitric oxide donor, prevents pathological cardiac remodeling in pressure-overloaded rats via endothelial nitric oxide synthase pathway regulation. Hypertension 2007;50:1049-56
    • (2007) Hypertension , vol.50 , pp. 1049-56
    • Ruiz-Hurtado, G.1    Fernandez-Velasco, M.2    Mourelle, M.3    Delgado, C.4
  • 119
    • 67349152760 scopus 로고    scopus 로고
    • Oxidative stress impairs vasorelaxation induced by the soluble guanylyl cyclase activator BAY 41-2272 in spontaneously hypertensive rats
    • Priviero FB, Zemse SM, Teixeira CE, Webb RC. Oxidative stress impairs vasorelaxation induced by the soluble guanylyl cyclase activator BAY 41-2272 in spontaneously hypertensive rats. Am J Hypertens 2009;22:493-9
    • (2009) Am J Hypertens , vol.22 , pp. 493-9
    • Priviero, F.B.1    Zemse, S.M.2    Teixeira, C.E.3    Webb, R.C.4
  • 120
    • 58849112709 scopus 로고    scopus 로고
    • Activation of BKCa channels by nitric oxide prevents coronary artery endothelial dysfunction in ouabain-induced hypertensive rats
    • Briones AM, Padilha AS, Cogolludo AL, et al. Activation of BKCa channels by nitric oxide prevents coronary artery endothelial dysfunction in ouabain-induced hypertensive rats. J Hypertens 2009;27:83-91
    • (2009) J Hypertens , vol.27 , pp. 83-91
    • Briones, A.M.1    Padilha, A.S.2    Cogolludo, A.L.3
  • 121
    • 33644981623 scopus 로고    scopus 로고
    • Vasorelaxing effect of BAY 41-2272 in rat basilar artery: Involvement of cGMP-dependent and independent mechanisms
    • Teixeira CE, Priviero FB, Todd J Jr, Webb RC. Vasorelaxing effect of BAY 41-2272 in rat basilar artery: involvement of cGMP-dependent and independent mechanisms. Hypertension 2006;47:596-602
    • (2006) Hypertension , vol.47 , pp. 596-602
    • Teixeira, C.E.1    Priviero, F.B.2    Todd Jr., J.3    Webb, R.C.4
  • 122
    • 33644999416 scopus 로고    scopus 로고
    • Activation of soluble guanylate cyclase reverses experimental pulmonary hypertension and vascular remodeling
    • Dumitrascu R, Weissmann N, Ghofrani HA, et al. Activation of soluble guanylate cyclase reverses experimental pulmonary hypertension and vascular remodeling. Circulation 2006;113:286-95
    • (2006) Circulation , vol.113 , pp. 286-95
    • Dumitrascu, R.1    Weissmann, N.2    Ghofrani, H.A.3
  • 123
    • 0036177297 scopus 로고    scopus 로고
    • Pharmacological actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: In vitro studies
    • Stasch JP, Alonso-Alija C, Apeler H, et al. Pharmacological actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vitro studies. Br J Pharmacol 2002;135:333-43
    • (2002) Br J Pharmacol , vol.135 , pp. 333-43
    • Stasch, J.P.1    Alonso-Alija, C.2    Apeler, H.3
  • 124
    • 0036178227 scopus 로고    scopus 로고
    • Cardiovascular actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: In vivo studies
    • Stasch JP, Dembowsky K, Perzborn E, Stahl E. Cardiovascular actions of a novel NO-independent guanylyl cyclase stimulator, BAY 41-8543: in vivo studies. Br J Pharmacol 2002;135:344-55
    • (2002) Br J Pharmacol , vol.135 , pp. 344-55
    • Stasch, J.P.1    Dembowsky, K.2    Perzborn, E.3    Stahl, E.4
  • 125
    • 36849026670 scopus 로고    scopus 로고
    • Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation
    • Evgenov OV, Kohane DS, Bloch KD, et al. Inhaled agonists of soluble guanylate cyclase induce selective pulmonary vasodilation. Am J Respir Crit Care Med 2007;176:1138-45
    • (2007) Am J Respir Crit Care Med , vol.176 , pp. 1138-45
    • Evgenov, O.V.1    Kohane, D.S.2    Bloch, K.D.3
  • 126
    • 77958511631 scopus 로고    scopus 로고
    • Pre-conditioning with the soluble guanylate cyclase activator Cinaciguat reduces ischaemia-reperfusion injury after cardiopulmonary bypass
    • published online 29 June 2010 doi:10.1016/j.ejcts.2010.05.025
    • Radovits T, Korkmaz S, Miesel-Groschel C, et al. Pre-conditioning with the soluble guanylate cyclase activator Cinaciguat reduces ischaemia-reperfusion injury after cardiopulmonary bypass. Eur J Cardiothorac Surg 2010: published online 29 June 2010, doi:10.1016/j.ejcts.2010.05.025
    • (2010) Eur J Cardiothorac Surg
    • Radovits, T.1    Korkmaz, S.2    Miesel-Groschel, C.3
  • 127
    • 33748302123 scopus 로고    scopus 로고
    • Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels
    • Stasch JP, Schmidt PM, Nedvetsky PI, et al. Targeting the heme-oxidized nitric oxide receptor for selective vasodilatation of diseased blood vessels. J Clin Invest 2006;116:2552-61
    • (2006) J Clin Invest , vol.116 , pp. 2552-61
    • Stasch, J.P.1    Schmidt, P.M.2    Nedvetsky, P.I.3
  • 128
    • 67651211549 scopus 로고    scopus 로고
    • Cinaciguat, a soluble guanylate cyclase activator, causes potent and sustained pulmonary vasodilation in the ovine fetus
    • Chester M, Tourneux P, Seedorf G, et al. Cinaciguat, a soluble guanylate cyclase activator, causes potent and sustained pulmonary vasodilation in the ovine fetus. Am J Physiol Lung Cell Mol Physiol 2009;297:L318-25
    • (2009) Am J Physiol Lung Cell Mol Physiol , vol.297
    • Chester, M.1    Tourneux, P.2    Seedorf, G.3
  • 129
    • 77956895152 scopus 로고    scopus 로고
    • Guanylyl cyclase activator ataciguat improves vascular function and reduces platelet activation in heart failure
    • published online 22 June 2010 doi:10.1016/j.phrs.2010.06.008
    • Schafer A, Fraccarollo D, Werner L, Bauersachs J. Guanylyl cyclase activator ataciguat improves vascular function and reduces platelet activation in heart failure. Pharmacol Res 2010: published online 22 June 2010, doi:10.1016/j.phrs.2010.06.008
    • (2010) Pharmacol Res
    • Schafer, A.1    Fraccarollo, D.2    Werner, L.3    Bauersachs, J.4
  • 130
    • 67650227315 scopus 로고    scopus 로고
    • Stimulation of cGMP signalling protects coronary endothelium against reperfusion-induced intercellular gap formation
    • Kasseckert SA, Schafer C, Kluger A, et al. Stimulation of cGMP signalling protects coronary endothelium against reperfusion-induced intercellular gap formation. Cardiovasc Res 2009;83:381-7
    • (2009) Cardiovasc Res , vol.83 , pp. 381-7
    • Kasseckert, S.A.1    Schafer, C.2    Kluger, A.3
  • 131
    • 57049114424 scopus 로고    scopus 로고
    • Soluble guanylyl cyclase activation by HMR-1766 (ataciguat) in cells exposed to oxidative stress
    • Zhou Z, Pyriochou A, Kotanidou A, et al. Soluble guanylyl cyclase activation by HMR-1766 (ataciguat) in cells exposed to oxidative stress. Am J Physiol Heart Circ Physiol 2008;295:H1763-71
    • (2008) Am J Physiol Heart Circ Physiol , vol.295
    • Zhou, Z.1    Pyriochou, A.2    Kotanidou, A.3
  • 132
    • 76749132472 scopus 로고    scopus 로고
    • Phosphodiesterase type 5 inhibitors in pulmonary arterial hypertension
    • Montani D, Chaumais MC, Savale L, et al. Phosphodiesterase type 5 inhibitors in pulmonary arterial hypertension. Adv Ther 2009;26:813-25
    • (2009) Adv Ther , vol.26 , pp. 813-25
    • Montani, D.1    Chaumais, M.C.2    Savale, L.3
  • 133
    • 34047141131 scopus 로고    scopus 로고
    • Cyclic guanosine monophosphate phosphodiesterase-5 inhibitor promotes an endothelium NO-dependent-like vasodilation in patients with refractory hypertension
    • Yugar-Toledo JC, Ferreira-Melo SE, Consolim-Colombo FM, et al. Cyclic guanosine monophosphate phosphodiesterase-5 inhibitor promotes an endothelium NO-dependent-like vasodilation in patients with refractory hypertension. Nitric Oxide 2007;16:315-21
    • (2007) Nitric Oxide , vol.16 , pp. 315-21
    • Yugar-Toledo, J.C.1    Ferreira-Melo, S.E.2    Consolim-Colombo, F.M.3
  • 134
    • 75149146799 scopus 로고    scopus 로고
    • Chronic sildenafil treatment corrects endothelial dysfunction and improves hypertension
    • Yaguas K, Bautista R, Quiroz Y, et al. Chronic sildenafil treatment corrects endothelial dysfunction and improves hypertension. Am J Nephrol 2010;31:283-91
    • (2010) Am J Nephrol , vol.31 , pp. 283-91
    • Yaguas, K.1    Bautista, R.2    Quiroz, Y.3
  • 135
    • 39849090160 scopus 로고    scopus 로고
    • Phosphodiesterase type 5 inhibition reverses impaired forearm exercise-induced vasodilatation in hypertensive patients
    • Attina TM, Malatino LS, Maxwell SR, et al. Phosphodiesterase type 5 inhibition reverses impaired forearm exercise-induced vasodilatation in hypertensive patients. J Hypertens 2008;26:501-7
    • (2008) J Hypertens , vol.26 , pp. 501-7
    • Attina, T.M.1    Malatino, L.S.2    Maxwell, S.R.3
  • 136
    • 33847686720 scopus 로고    scopus 로고
    • Sildenafil reduces L-NAME-induced severe hypertension and worsening of myocardial ischaemia-reperfusion damage in the rat
    • Rossoni G, Manfredi B, De Gennaro Colonna V, et al. Sildenafil reduces L-NAME-induced severe hypertension and worsening of myocardial ischaemia-reperfusion damage in the rat. Br J Pharmacol 2007;150:567-76
    • (2007) Br J Pharmacol , vol.150 , pp. 567-76
    • Rossoni, G.1    Manfredi, B.2    De Gennaro Colonna, V.3
  • 137
    • 33746029051 scopus 로고    scopus 로고
    • Sildenafil reduces cardiovascular remodeling associated with hypertensive cardiomyopathy in NOS inhibitor-treated rats
    • Ferreira-Melo SE, Yugar-Toledo JC, Coelho OR, et al. Sildenafil reduces cardiovascular remodeling associated with hypertensive cardiomyopathy in NOS inhibitor-treated rats. Eur J Pharmacol 2006;542:141-7
    • (2006) Eur J Pharmacol , vol.542 , pp. 141-7
    • Ferreira-Melo, S.E.1    Yugar-Toledo, J.C.2    Coelho, O.R.3
  • 138
    • 77953807828 scopus 로고    scopus 로고
    • Clinical potential of combined organic nitrate and phosphodiesterase type 5 inhibitor in treatment-resistant hypertension
    • Oliver JJ, Dear JW, Webb DJ. Clinical potential of combined organic nitrate and phosphodiesterase type 5 inhibitor in treatment-resistant hypertension. Hypertension 2010;56:62-7
    • (2010) Hypertension , vol.56 , pp. 62-7
    • Oliver, J.J.1    Dear, J.W.2    Webb, D.J.3
  • 139
    • 70449713762 scopus 로고    scopus 로고
    • Sildenafil increases endothelial progenitor cell function and improves ischemia-induced neovascularization in hypercholesterolemic apolipoprotein E-deficient mice
    • Dussault S, Maingrette F, Menard C, et al. Sildenafil increases endothelial progenitor cell function and improves ischemia-induced neovascularization in hypercholesterolemic apolipoprotein E-deficient mice. Hypertension 2009;54:1043-9
    • (2009) Hypertension , vol.54 , pp. 1043-9
    • Dussault, S.1    Maingrette, F.2    Menard, C.3
  • 140
    • 77953211239 scopus 로고    scopus 로고
    • Chronic inhibition of nitric-oxide synthase induces hypertension and erectile dysfunction in the rat that is not reversed by sildenafil
    • Gur S, Kadowitz PJ, Gurkan L, et al. Chronic inhibition of nitric-oxide synthase induces hypertension and erectile dysfunction in the rat that is not reversed by sildenafil. BJU Int 2010;106:78-83
    • (2010) BJU Int , vol.106 , pp. 78-83
    • Gur, S.1    Kadowitz, P.J.2    Gurkan, L.3
  • 141
    • 77955886101 scopus 로고    scopus 로고
    • The emergence of oral tadalafil as a once-daily treatment for pulmonary arterial hypertension
    • FalkJA, Philip KJ, Schwarz ER. The emergence of oral tadalafil as a once-daily treatment for pulmonary arterial hypertension. Vasc Health Risk Manag 2010;6:273-80
    • (2010) Vasc Health Risk Manag , vol.6 , pp. 273-80
    • Falkja Philip, K.J.1    Schwarz, E.R.2
  • 142
    • 73349135641 scopus 로고    scopus 로고
    • Tadalafil, a long-acting inhibitor of PDE5, improves pulmonary hemodynamics and survival rate of monocrotaline-induced pulmonary artery hypertension in rats
    • Sawamura F, Kato M, Fujita K, et al. Tadalafil, a long-acting inhibitor of PDE5, improves pulmonary hemodynamics and survival rate of monocrotaline-induced pulmonary artery hypertension in rats. J Pharmacol Sci 2009;111:235-43
    • (2009) J Pharmacol Sci , vol.111 , pp. 235-43
    • Sawamura, F.1    Kato, M.2    Fujita, K.3
  • 143
    • 33847362727 scopus 로고    scopus 로고
    • Relationship between chronic tadalafil administration and improvement of endothelial function in men with erectile dysfunction: A pilot study
    • Aversa A, Greco E, Bruzziches R, et al. Relationship between chronic tadalafil administration and improvement of endothelial function in men with erectile dysfunction: a pilot study. Int J Impot Res 2007;19:200-7
    • (2007) Int J Impot Res , vol.19 , pp. 200-7
    • Aversa, A.1    Greco, E.2    Bruzziches, R.3
  • 144
    • 34547105106 scopus 로고    scopus 로고
    • Angiotensin receptor blockers versus angiotensin-converting enzyme inhibitors: Where do we stand now?
    • Bohm M. Angiotensin receptor blockers versus angiotensin-converting enzyme inhibitors: where do we stand now? Am J Cardiol 2007;100:38J-44J
    • (2007) Am J Cardiol , vol.100
    • Bohm, M.1
  • 145
    • 77954723350 scopus 로고    scopus 로고
    • Inflammatory markers in essential hypertension: Potential clinical implications
    • Stefanadi E, Tousoulis D, Androulakis ES, et al. Inflammatory markers in essential hypertension: potential clinical implications. Curr Vasc Pharmacol 2010;8:509-16
    • (2010) Curr Vasc Pharmacol , vol.8 , pp. 509-16
    • Stefanadi, E.1    Tousoulis, D.2    Androulakis, E.S.3
  • 146
    • 38149104528 scopus 로고    scopus 로고
    • Effects of irbesartan and perindopril on forearm reactive hyperemia and inflammatory process, in normotensive patients with coronary artery disease
    • Tousoulis D, Kourtellaris P, Antoniades C, et al. Effects of irbesartan and perindopril on forearm reactive hyperemia and inflammatory process, in normotensive patients with coronary artery disease. Int J Cardiol 2008;124:127-9
    • (2008) Int J Cardiol , vol.124 , pp. 127-9
    • Tousoulis, D.1    Kourtellaris, P.2    Antoniades, C.3
  • 147
    • 38949118304 scopus 로고    scopus 로고
    • Effects of ramipril on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young normotensive subjects with successfully repaired coarctation of aorta: A randomized cross-over study
    • Brili S, Tousoulis D, Antoniades C, et al. Effects of ramipril on endothelial function and the expression of proinflammatory cytokines and adhesion molecules in young normotensive subjects with successfully repaired coarctation of aorta: a randomized cross-over study. J Am Coll Cardiol 2008;51:742-9
    • (2008) J Am Coll Cardiol , vol.51 , pp. 742-9
    • Brili, S.1    Tousoulis, D.2    Antoniades, C.3
  • 148
    • 34249889636 scopus 로고    scopus 로고
    • Cardiovascular risk reduction by reversing endothelial dysfunction: ARBs, ACE inhibitors, or both? Expectations from the ONTARGET Trial Programme
    • Ruilope LM, Redon J, Schmieder ER Cardiovascular risk reduction by reversing endothelial dysfunction: ARBs, ACE inhibitors, or both? Expectations from the ONTARGET Trial Programme. Vasc Health Risk Manag 2007;3:1-9
    • (2007) Vasc Health Risk Manag , vol.3 , pp. 1-9
    • Ruilope, L.M.1    Redon, J.2    Schmieder, E.R.3
  • 149
    • 34548181979 scopus 로고    scopus 로고
    • C. Alpha-1 microglobulin as a new inflammatory marker in newly diagnosed hypertensive patients
    • Vyssoulis GP, Tousoulis D, Antoniades C, et al. C. Alpha-1 Microglobulin as a new inflammatory marker in newly diagnosed hypertensive patients. Am J Hypertens 2007;20:1016-21
    • (2007) Am J Hypertens , vol.20 , pp. 1016-21
    • Vyssoulis, G.P.1    Tousoulis, D.2    Antoniades, C.3
  • 150
    • 58249108732 scopus 로고    scopus 로고
    • Renal vascular endothelial function in hypertensive patients with type 2 diabetes mellitus
    • Ritt M, Ott C, Raff U, et al. Renal vascular endothelial function in hypertensive patients with type 2 diabetes mellitus. Am J Kidney Dis 2009;53:281-9
    • (2009) Am J Kidney Dis , vol.53 , pp. 281-9
    • Ritt, M.1    Ott, C.2    Raff, U.3
  • 151
    • 47549101296 scopus 로고    scopus 로고
    • Cardioprotective effects of telmisartan in uncomplicated and complicated hypertension
    • Grassi G, Quarti-Trevano F, Mancia G. Cardioprotective effects of telmisartan in uncomplicated and complicated hypertension. J Renin Angiotensin Aldosterone Syst 2008;9:66-74
    • (2008) J Renin Angiotensin Aldosterone Syst , vol.9 , pp. 66-74
    • Grassi, G.1    Quarti-Trevano, F.2    Mancia, G.3
  • 152
    • 0031922168 scopus 로고    scopus 로고
    • Effects of perindopril and carvedilol on endothelium-dependent vascular functions in patients with diabetes and hypertension
    • Giugliano D, Marfella R, Acampora R, et al. Effects of perindopril and carvedilol on endothelium-dependent vascular functions in patients with diabetes and hypertension. Diabetes Care 1998;21:631-6
    • (1998) Diabetes Care , vol.21 , pp. 631-6
    • Giugliano, D.1    Marfella, R.2    Acampora, R.3
  • 153
    • 68849129003 scopus 로고    scopus 로고
    • Valsartan improves endothelial dysfunction in hypertension: A randomized, double-blind study
    • Tzemos N, Lim PO, Macdonald TM. Valsartan improves endothelial dysfunction in hypertension: a randomized, double-blind study. Cardiovasc Ther 2009;27:151-8
    • (2009) Cardiovasc Ther , vol.27 , pp. 151-8
    • Tzemos, N.1    Lim, P.O.2    MacDonald, T.M.3
  • 154
    • 34047231332 scopus 로고    scopus 로고
    • Angiotensin II reactivation and aldosterone escape phenomena in renin-angiotensin-aldosterone system blockade: Is oral renin inhibition the solution?
    • Athyros VG, Mikhailidis DP, Kakafika AI, et al. Angiotensin II reactivation and aldosterone escape phenomena in renin-angiotensin-aldosterone system blockade: is oral renin inhibition the solution? Expert Opin Pharmacother 2007;8:529-35
    • (2007) Expert Opin Pharmacother , vol.8 , pp. 529-35
    • Athyros, V.G.1    Mikhailidis, D.P.2    Kakafika, A.I.3
  • 155
    • 77649314549 scopus 로고    scopus 로고
    • Success and failure of vaccines against renin-angiotensin system components
    • Brown MJ. Success and failure of vaccines against renin-angiotensin system components. Nat Rev Cardiol 2009;6:639-47
    • (2009) Nat Rev Cardiol , vol.6 , pp. 639-47
    • Brown, M.J.1
  • 156
    • 0033786342 scopus 로고    scopus 로고
    • Statins and cardiovascular diseases: The multiple effects of lipid-lowering therapy by statins
    • Rauch U, Osende JI, Chesebro JH, et al. Statins and cardiovascular diseases: the multiple effects of lipid-lowering therapy by statins. Atherosclerosis 2000;153:181-9
    • (2000) Atherosclerosis , vol.153 , pp. 181-9
    • Rauch, U.1    Osende, J.I.2    Chesebro, J.H.3
  • 157
    • 67651027580 scopus 로고    scopus 로고
    • Role and significance of statins in the treatment of hypertensive patients
    • Stepien M, Banach M, Mikhailidis DP, et al. Role and significance of statins in the treatment of hypertensive patients. Curr Med Res Opin 2009;25:1995-2005
    • (2009) Curr Med Res Opin , vol.25 , pp. 1995-2005
    • Stepien, M.1    Banach, M.2    Mikhailidis, D.P.3
  • 159
    • 33748163009 scopus 로고    scopus 로고
    • The role of statins in endothelial dysfunction in hypertension
    • Sarkar K, Sihna AK, Mehta JL. The role of statins in endothelial dysfunction in hypertension. Curr Opin Cardiol 2006;21:316-21
    • (2006) Curr Opin Cardiol , vol.21 , pp. 316-21
    • Sarkar, K.1    Sihna, A.K.2    Mehta, J.L.3
  • 160
    • 34547587360 scopus 로고    scopus 로고
    • Beneficial effects of statins on endothelial dysfunction and vascular stiffness
    • Dilaveris P, Giannopoulos G, Riga M, et al. Beneficial effects of statins on endothelial dysfunction and vascular stiffness. Curr Vasc Pharmacol 2007;5:227-37
    • (2007) Curr Vasc Pharmacol , vol.5 , pp. 227-37
    • Dilaveris, P.1    Giannopoulos, G.2    Riga, M.3
  • 161
    • 44349111370 scopus 로고    scopus 로고
    • Statin treatment improves cerebral more than systemic endothelial dysfunction in patients with arterial hypertension
    • Pretnar-Oblak J, Sebestjen M, Sabovic M. Statin treatment improves cerebral more than systemic endothelial dysfunction in patients with arterial hypertension. Am J Hypertens 2008;21:674-8
    • (2008) Am J Hypertens , vol.21 , pp. 674-8
    • Pretnar-Oblak, J.1    Sebestjen, M.2    Sabovic, M.3
  • 162
    • 67049099141 scopus 로고    scopus 로고
    • Atorvastatin prevents endothelial dysfunction in mesenteric arteries from spontaneously hypertensive rats: Role of cyclooxygenase 2-derived contracting prostanoids
    • Virdis A, Colucci R, Versari D, et al. Atorvastatin prevents endothelial dysfunction in mesenteric arteries from spontaneously hypertensive rats: role of cyclooxygenase 2-derived contracting prostanoids. Hypertension 2009;53:1008-16
    • (2009) Hypertension , vol.53 , pp. 1008-16
    • Virdis, A.1    Colucci, R.2    Versari, D.3
  • 163
    • 68949144593 scopus 로고    scopus 로고
    • Vascular endothelial function predicts mortality risk in patients with advanced ischaemic chronic heart failure
    • Shechter M, Matetzky S, Arad M, et al. Vascular endothelial function predicts mortality risk in patients with advanced ischaemic chronic heart failure. Eur J Heart Fail 2009;11:588-93
    • (2009) Eur J Heart Fail , vol.11 , pp. 588-93
    • Shechter, M.1    Matetzky, S.2    Arad, M.3
  • 164
    • 65449175653 scopus 로고    scopus 로고
    • Brachial arterial flow mediated dilation in acute ischemic stroke
    • Santos-Garcia D, Blanco M, Serena J, et al. Brachial arterial flow mediated dilation in acute ischemic stroke. Eur J Neurol 2009;16:684-90
    • (2009) Eur J Neurol , vol.16 , pp. 684-90
    • Santos-Garcia, D.1    Blanco, M.2    Serena, J.3
  • 165
    • 33751192267 scopus 로고    scopus 로고
    • Long-term prognostic role of flow-mediated dilatation of the brachial artery after acute coronary syndromes without ST elevation
    • Karatzis EN, Ikonomidis I, Vamvakou GD, et al. Long-term prognostic role of flow-mediated dilatation of the brachial artery after acute coronary syndromes without ST elevation. Am J Cardiol 2006;98:1424-8
    • (2006) Am J Cardiol , vol.98 , pp. 1424-8
    • Karatzis, E.N.1    Ikonomidis, I.2    Vamvakou, G.D.3
  • 166
    • 11244356892 scopus 로고    scopus 로고
    • Impaired flow-mediated dilation and risk of restenosis in patients undergoing coronary stent implantation
    • Patti G, Pasceri V, Melfi R, et al. Impaired flow-mediated dilation and risk of restenosis in patients undergoing coronary stent implantation. Circulation 2005;111:70-5
    • (2005) Circulation , vol.111 , pp. 70-5
    • Patti, G.1    Pasceri, V.2    Melfi, R.3
  • 167
    • 69449105430 scopus 로고    scopus 로고
    • Predictive value of brachial flow-mediated dilation for incident cardiovascular events in a population-based study: The multi-ethnic study of atherosclerosis
    • Yeboah J, Folsom AR, Burke GL, et al. Predictive value of brachial flow-mediated dilation for incident cardiovascular events in a population-based study: the multi-ethnic study of atherosclerosis. Circulation 2009;120:502-9
    • (2009) Circulation , vol.120 , pp. 502-9
    • Yeboah, J.1    Folsom, A.R.2    Burke, G.L.3
  • 168
    • 64149106514 scopus 로고    scopus 로고
    • Long-term association of brachial artery flow-mediated vasodilation and cardiovascular events in middle-aged subjects with no apparent heart disease
    • Shechter M, Issachar A, Marai I, et al. Long-term association of brachial artery flow-mediated vasodilation and cardiovascular events in middle-aged subjects with no apparent heart disease. Int J Cardiol 2009;134:52-8
    • (2009) Int J Cardiol , vol.134 , pp. 52-8
    • Shechter, M.1    Issachar, A.2    Marai, I.3
  • 169
    • 33947511609 scopus 로고    scopus 로고
    • Association of improvement of brachial artery flow-mediated vasodilation with cardiovascular events
    • Suessenbacher A, Frick M, Alber HF, et al. Association of improvement of brachial artery flow-mediated vasodilation with cardiovascular events. Vasc Med 2006;11:239-44
    • (2006) Vasc Med , vol.11 , pp. 239-44
    • Suessenbacher, A.1    Frick, M.2    Alber, H.F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.