-
2
-
-
0038309244
-
Medulloblastoma: present concepts of stratification into risk groups
-
Packer R.J., Rood B.R., MacDonald T.J. Medulloblastoma: present concepts of stratification into risk groups. Pediatr Neurosurg 2003, 39:60-67.
-
(2003)
Pediatr Neurosurg
, vol.39
, pp. 60-67
-
-
Packer, R.J.1
Rood, B.R.2
MacDonald, T.J.3
-
3
-
-
2442681686
-
Histopathological and molecular prognostic markers in medulloblastoma: c-myc, N-myc, TrkC, and anaplasia
-
Eberhart C.G., Kratz J., Wang Y., et al. Histopathological and molecular prognostic markers in medulloblastoma: c-myc, N-myc, TrkC, and anaplasia. J Neuropathol Exp Neurol 2004, 63:441-449.
-
(2004)
J Neuropathol Exp Neurol
, vol.63
, pp. 441-449
-
-
Eberhart, C.G.1
Kratz, J.2
Wang, Y.3
-
4
-
-
1842614251
-
Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma
-
Gajjar A. Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma. J Clin Oncol 2004, 22:984-993.
-
(2004)
J Clin Oncol
, vol.22
, pp. 984-993
-
-
Gajjar, A.1
-
5
-
-
33748660920
-
Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma
-
Packer R.J., Gajjar A., Vezina G., et al. Phase III study of craniospinal radiation therapy followed by adjuvant chemotherapy for newly diagnosed average-risk medulloblastoma. J Clin Oncol 2006, 24:4202-4208.
-
(2006)
J Clin Oncol
, vol.24
, pp. 4202-4208
-
-
Packer, R.J.1
Gajjar, A.2
Vezina, G.3
-
6
-
-
79959568573
-
Disease control and ototoxicity using intensity-modulated radiation therapy tumor-bed boost for medulloblastoma
-
Polkinghorn W.R., Dunkel I.J., Souweidane M.M., et al. Disease control and ototoxicity using intensity-modulated radiation therapy tumor-bed boost for medulloblastoma. Int J Radiat Oncol Biol Phys 2011, 81:e15-e20.
-
(2011)
Int J Radiat Oncol Biol Phys
, vol.81
-
-
Polkinghorn, W.R.1
Dunkel, I.J.2
Souweidane, M.M.3
-
7
-
-
36149000214
-
Medulloblastoma in childhood: new biological advances
-
Crawford J.R., MacDonald T.J., Packer R.J. Medulloblastoma in childhood: new biological advances. Lancet Neurol 2007, 6:1073-1085.
-
(2007)
Lancet Neurol
, vol.6
, pp. 1073-1085
-
-
Crawford, J.R.1
MacDonald, T.J.2
Packer, R.J.3
-
8
-
-
33749044182
-
Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial
-
Gajjar A., Chintagumpala M., Ashley D., et al. Risk-adapted craniospinal radiotherapy followed by high-dose chemotherapy and stem-cell rescue in children with newly diagnosed medulloblastoma (St Jude Medulloblastoma-96): long-term results from a prospective, multicentre trial. Lancet Oncol 2006, 7:813-820.
-
(2006)
Lancet Oncol
, vol.7
, pp. 813-820
-
-
Gajjar, A.1
Chintagumpala, M.2
Ashley, D.3
-
9
-
-
22944436550
-
Treatment of medulloblastoma with postoperative chemotherapy alone: an SFOP prospective trial in young children
-
Grill J., Sainte-Rose C., Jouvet A., et al. Treatment of medulloblastoma with postoperative chemotherapy alone: an SFOP prospective trial in young children. Lancet Oncol 2005, 6:573-580.
-
(2005)
Lancet Oncol
, vol.6
, pp. 573-580
-
-
Grill, J.1
Sainte-Rose, C.2
Jouvet, A.3
-
10
-
-
20044371594
-
Treatment of early childhood medulloblastoma by postoperative chemotherapy alone
-
Rutkowski S., Bode U., Deinlein F., et al. Treatment of early childhood medulloblastoma by postoperative chemotherapy alone. N Engl J Med 2005, 352:978-986.
-
(2005)
N Engl J Med
, vol.352
, pp. 978-986
-
-
Rutkowski, S.1
Bode, U.2
Deinlein, F.3
-
11
-
-
0031983154
-
Intensive chemotherapy and bone marrow rescue for young children with newly diagnosed malignant brain tumors
-
Mason W.P., Grovas A., Halpern S., et al. Intensive chemotherapy and bone marrow rescue for young children with newly diagnosed malignant brain tumors. J Clin Oncol 1998, 16:210-221.
-
(1998)
J Clin Oncol
, vol.16
, pp. 210-221
-
-
Mason, W.P.1
Grovas, A.2
Halpern, S.3
-
13
-
-
79960010294
-
Treatment of young children with localized medulloblastoma by chemotherapy alone: results of the prospective, multicenter trial HIT 2000 confirming the prognostic impact of histology
-
von Bueren A.O., von Hoff K., Pietsch T., et al. Treatment of young children with localized medulloblastoma by chemotherapy alone: results of the prospective, multicenter trial HIT 2000 confirming the prognostic impact of histology. Neuro Oncol 2011, 13:669-679.
-
(2011)
Neuro Oncol
, vol.13
, pp. 669-679
-
-
von Bueren, A.O.1
von Hoff, K.2
Pietsch, T.3
-
14
-
-
55949132115
-
Management of and prognosis with medulloblastoma: therapy at a crossroads
-
Packer R.J., Vezina G. Management of and prognosis with medulloblastoma: therapy at a crossroads. Arch Neurol 2008, 65:1419-1424.
-
(2008)
Arch Neurol
, vol.65
, pp. 1419-1424
-
-
Packer, R.J.1
Vezina, G.2
-
15
-
-
3042777393
-
Late neurocognitive sequelae in survivors of brain tumours in childhood
-
Mulhern R.K., Merchant T.E., Gajjar A., et al. Late neurocognitive sequelae in survivors of brain tumours in childhood. Lancet Oncol 2004, 5:399-408.
-
(2004)
Lancet Oncol
, vol.5
, pp. 399-408
-
-
Mulhern, R.K.1
Merchant, T.E.2
Gajjar, A.3
-
16
-
-
34547122001
-
The 2007 WHO classification of tumours of the central nervous system
-
Louis D.N., Ohgaki H., Wiestler O.D., et al. The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 2007, 114:97-109.
-
(2007)
Acta Neuropathol
, vol.114
, pp. 97-109
-
-
Louis, D.N.1
Ohgaki, H.2
Wiestler, O.D.3
-
17
-
-
79954992066
-
Definition of disease-risk stratification groups in childhood medulloblastoma using combined clinical, pathologic, and molecular variables
-
Ellison D.W., Kocak M., Dalton J., et al. Definition of disease-risk stratification groups in childhood medulloblastoma using combined clinical, pathologic, and molecular variables. J Clin Oncol 2011, 29:1400-1407.
-
(2011)
J Clin Oncol
, vol.29
, pp. 1400-1407
-
-
Ellison, D.W.1
Kocak, M.2
Dalton, J.3
-
18
-
-
9144241696
-
Molecular pathogenesis of childhood brain tumors
-
Pietsch T., Taylor M.D., Rutka J.T. Molecular pathogenesis of childhood brain tumors. J Neurooncol 2004, 70:203-215.
-
(2004)
J Neurooncol
, vol.70
, pp. 203-215
-
-
Pietsch, T.1
Taylor, M.D.2
Rutka, J.T.3
-
19
-
-
0036366824
-
Classifying the medulloblastoma: insights from morphology and molecular genetics
-
Ellison D. Classifying the medulloblastoma: insights from morphology and molecular genetics. Neuropathol Appl Neurobiol 2002, 28:257-282.
-
(2002)
Neuropathol Appl Neurobiol
, vol.28
, pp. 257-282
-
-
Ellison, D.1
-
20
-
-
0036835447
-
Medulloblastoma in adults: treatment results and prognostic factors
-
Abacioglu U., Uzel O., Sengoz M., et al. Medulloblastoma in adults: treatment results and prognostic factors. Int J Radiat Oncol Biol Phys 2002, 54:855-860.
-
(2002)
Int J Radiat Oncol Biol Phys
, vol.54
, pp. 855-860
-
-
Abacioglu, U.1
Uzel, O.2
Sengoz, M.3
-
22
-
-
80053980912
-
FSTL5 is a marker of poor prognosis in non-WNT/Non-SHH medulloblastoma
-
Remke M., Hielscher T., Korshunov A., et al. FSTL5 is a marker of poor prognosis in non-WNT/Non-SHH medulloblastoma. J Clin Oncol 2011, 29:3852-3861.
-
(2011)
J Clin Oncol
, vol.29
, pp. 3852-3861
-
-
Remke, M.1
Hielscher, T.2
Korshunov, A.3
-
23
-
-
79955034739
-
Medulloblastoma comprises four distinct molecular variants
-
Northcott P.A., Korshunov A., Witt H., et al. Medulloblastoma comprises four distinct molecular variants. J Clin Oncol 2011, 29:1408-1414.
-
(2011)
J Clin Oncol
, vol.29
, pp. 1408-1414
-
-
Northcott, P.A.1
Korshunov, A.2
Witt, H.3
-
24
-
-
76549086016
-
Genomics of medulloblastoma: from Giemsa-banding to next-generation sequencing in 20 years
-
Northcott P.A., Rutka J.T., Taylor M.D. Genomics of medulloblastoma: from Giemsa-banding to next-generation sequencing in 20 years. Neurosurg Focus 2010, 28:E6.
-
(2010)
Neurosurg Focus
, vol.28
-
-
Northcott, P.A.1
Rutka, J.T.2
Taylor, M.D.3
-
25
-
-
33646362581
-
Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations
-
Thompson M.C., Fuller C., Hogg T.L., et al. Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. J Clin Oncol 2006, 24:1924-1931.
-
(2006)
J Clin Oncol
, vol.24
, pp. 1924-1931
-
-
Thompson, M.C.1
Fuller, C.2
Hogg, T.L.3
-
26
-
-
20944450853
-
Retrospective family study of childhood medulloblastoma
-
Ng D., Stavrou T., Liu L., et al. Retrospective family study of childhood medulloblastoma. Am J Med Genet A 2005, 134:399-403.
-
(2005)
Am J Med Genet A
, vol.134
, pp. 399-403
-
-
Ng, D.1
Stavrou, T.2
Liu, L.3
-
27
-
-
2442720109
-
Identification of differentially expressed and developmentally regulated genes in medulloblastoma using suppression subtraction hybridization
-
Yokota N., Mainprize T.G., Taylor M.D., et al. Identification of differentially expressed and developmentally regulated genes in medulloblastoma using suppression subtraction hybridization. Oncogene 2004, 23:3444-3453.
-
(2004)
Oncogene
, vol.23
, pp. 3444-3453
-
-
Yokota, N.1
Mainprize, T.G.2
Taylor, M.D.3
-
28
-
-
0041419597
-
Transcriptional profiling of medulloblastoma in children
-
Park P.C., Taylor M.D., Mainprize T.G., et al. Transcriptional profiling of medulloblastoma in children. J Neurosurg 2003, 99:534-541.
-
(2003)
J Neurosurg
, vol.99
, pp. 534-541
-
-
Park, P.C.1
Taylor, M.D.2
Mainprize, T.G.3
-
29
-
-
0034493199
-
Molecular insight into medulloblastoma and central nervous system primitive neuroectodermal tumor biology from hereditary syndromes: a review
-
Taylor M.D., Mainprize T.G., Rutka J.T. Molecular insight into medulloblastoma and central nervous system primitive neuroectodermal tumor biology from hereditary syndromes: a review. Neurosurgery 2000, 47:888-901.
-
(2000)
Neurosurgery
, vol.47
, pp. 888-901
-
-
Taylor, M.D.1
Mainprize, T.G.2
Rutka, J.T.3
-
30
-
-
33750441471
-
Current concepts in the molecular genetics of pediatric brain tumors: implications for emerging therapies
-
Tamber M.S., Bansal K., Liang M.L., et al. Current concepts in the molecular genetics of pediatric brain tumors: implications for emerging therapies. Childs Nerv Syst 2006, 22:1379-1394.
-
(2006)
Childs Nerv Syst
, vol.22
, pp. 1379-1394
-
-
Tamber, M.S.1
Bansal, K.2
Liang, M.L.3
-
31
-
-
78149411577
-
Molecular diagnostics of CNS embryonal tumors
-
Pfister S.M., Korshunov A., Kool M., et al. Molecular diagnostics of CNS embryonal tumors. Acta Neuropathol 2010, 120:553-566.
-
(2010)
Acta Neuropathol
, vol.120
, pp. 553-566
-
-
Pfister, S.M.1
Korshunov, A.2
Kool, M.3
-
33
-
-
0345279586
-
The chromosomal complement of human solid tumors. II. Karyotypes of glial tumors
-
Lubs H.A., Salmon J.H. The chromosomal complement of human solid tumors. II. Karyotypes of glial tumors. J Neurosurg 1965, 22:160-168.
-
(1965)
J Neurosurg
, vol.22
, pp. 160-168
-
-
Lubs, H.A.1
Salmon, J.H.2
-
34
-
-
0002154636
-
Minute chromatin bodies in malignant tumours of childhood
-
Cox D., Yuncken C., Spriggs A.I. Minute chromatin bodies in malignant tumours of childhood. Lancet 1965, 1:55-58.
-
(1965)
Lancet
, vol.1
, pp. 55-58
-
-
Cox, D.1
Yuncken, C.2
Spriggs, A.I.3
-
35
-
-
0020579512
-
A model for human medulloblastoma. Growth, morphology, and chromosomal analysis in vitro and in athymic mice
-
Friedman H.S., Bigner S.H., McComb R.D., et al. A model for human medulloblastoma. Growth, morphology, and chromosomal analysis in vitro and in athymic mice. J Neuropathol Exp Neurol 1983, 42:485-503.
-
(1983)
J Neuropathol Exp Neurol
, vol.42
, pp. 485-503
-
-
Friedman, H.S.1
Bigner, S.H.2
McComb, R.D.3
-
36
-
-
0017647702
-
Establishment of a human medulloblastoma cell line
-
McAllister R.M., Isaacs H., Rongey R., et al. Establishment of a human medulloblastoma cell line. Int J Cancer 1977, 20:206-212.
-
(1977)
Int J Cancer
, vol.20
, pp. 206-212
-
-
McAllister, R.M.1
Isaacs, H.2
Rongey, R.3
-
37
-
-
0021930508
-
Establishment of a human medulloblastoma cell line and its heterotransplantation into nude mice
-
Jacobsen P.F., Jenkyn D.J., Papadimitriou J.M. Establishment of a human medulloblastoma cell line and its heterotransplantation into nude mice. J Neuropathol Exp Neurol 1985, 44:472-485.
-
(1985)
J Neuropathol Exp Neurol
, vol.44
, pp. 472-485
-
-
Jacobsen, P.F.1
Jenkyn, D.J.2
Papadimitriou, J.M.3
-
38
-
-
0023155999
-
Cytogenetic studies of human brain tumors and their clinical significance. 1
-
Latimer F.R., AlSaadi A.A., Robbins T.O. Cytogenetic studies of human brain tumors and their clinical significance. 1. Medulloblastoma. J Neurooncol 1987, 4:287-291.
-
(1987)
Medulloblastoma. J Neurooncol
, vol.4
, pp. 287-291
-
-
Latimer, F.R.1
AlSaadi, A.A.2
Robbins, T.O.3
-
39
-
-
0023831581
-
Chromosome abnormalities in pediatric brain tumors
-
Griffin C.A., Hawkins A.L., Packer R.J., et al. Chromosome abnormalities in pediatric brain tumors. Cancer Res 1988, 48:175-180.
-
(1988)
Cancer Res
, vol.48
, pp. 175-180
-
-
Griffin, C.A.1
Hawkins, A.L.2
Packer, R.J.3
-
40
-
-
0023847681
-
Structural chromosomal abnormalities in human medulloblastoma
-
Bigner S.H., Mark J., Friedman H.S., et al. Structural chromosomal abnormalities in human medulloblastoma. Cancer Genet Cytogenet 1988, 30:91-101.
-
(1988)
Cancer Genet Cytogenet
, vol.30
, pp. 91-101
-
-
Bigner, S.H.1
Mark, J.2
Friedman, H.S.3
-
41
-
-
0024998205
-
Deletion mapping of the medulloblastoma locus on chromosome 17p
-
Cogen P.H., Daneshvar L., Metzger A.K., et al. Deletion mapping of the medulloblastoma locus on chromosome 17p. Genomics 1990, 8:279-285.
-
(1990)
Genomics
, vol.8
, pp. 279-285
-
-
Cogen, P.H.1
Daneshvar, L.2
Metzger, A.K.3
-
42
-
-
0026513426
-
Involvement of multiple chromosome 17p loci in medulloblastoma tumorigenesis: prognostic significance of molecular genetic markers in childhood brain tumors: deletion mapping of the medulloblastoma locus on chromosome 17p
-
Cogen P.H., Daneshvar L., Metzger A.K., et al. Involvement of multiple chromosome 17p loci in medulloblastoma tumorigenesis: prognostic significance of molecular genetic markers in childhood brain tumors: deletion mapping of the medulloblastoma locus on chromosome 17p. Am J Hum Genet 1992, 50:584-589.
-
(1992)
Am J Hum Genet
, vol.50
, pp. 584-589
-
-
Cogen, P.H.1
Daneshvar, L.2
Metzger, A.K.3
-
43
-
-
0026087925
-
Loss of heterozygosity on 6q, 16q, and 17p in human central nervous system primitive neuroectodermal tumors
-
Thomas G.A., Raffel C. Loss of heterozygosity on 6q, 16q, and 17p in human central nervous system primitive neuroectodermal tumors. Cancer Res 1991, 51:639-643.
-
(1991)
Cancer Res
, vol.51
, pp. 639-643
-
-
Thomas, G.A.1
Raffel, C.2
-
44
-
-
0033860991
-
Molecular cytogenetic analysis of medulloblastomas and supratentorial primitive neuroectodermal tumors with conventional banding, comparative genomic hybridization, and spectral karyotyping
-
Bayani J., Zielenska M., Marrano P., et al. Molecular cytogenetic analysis of medulloblastomas and supratentorial primitive neuroectodermal tumors with conventional banding, comparative genomic hybridization, and spectral karyotyping. J Neurosurg 2000, 93:437-448.
-
(2000)
J Neurosurg
, vol.93
, pp. 437-448
-
-
Bayani, J.1
Zielenska, M.2
Marrano, P.3
-
45
-
-
0030223059
-
Correlation of chromosome 17p loss with clinical outcome in medulloblastoma
-
Emadian S.M., McDonald J.D., Gerken S.C., et al. Correlation of chromosome 17p loss with clinical outcome in medulloblastoma. Clin Cancer Res 1996, 2:1559-1564.
-
(1996)
Clin Cancer Res
, vol.2
, pp. 1559-1564
-
-
Emadian, S.M.1
McDonald, J.D.2
Gerken, S.C.3
-
46
-
-
0030988932
-
Prognostic significance of chromosome 17p deletions in childhood primitive neuroectodermal tumors (medulloblastomas) of the central nervous system
-
Biegel J.A., Janss A.J., Raffel C., et al. Prognostic significance of chromosome 17p deletions in childhood primitive neuroectodermal tumors (medulloblastomas) of the central nervous system. Clin Cancer Res 1997, 3:473-478.
-
(1997)
Clin Cancer Res
, vol.3
, pp. 473-478
-
-
Biegel, J.A.1
Janss, A.J.2
Raffel, C.3
-
47
-
-
79955770430
-
Chromosome 17 alterations identify good-risk and poor-risk tumors independently of clinical factors in medulloblastoma
-
McCabe M.G., Backlund L.M., Leong H.S., et al. Chromosome 17 alterations identify good-risk and poor-risk tumors independently of clinical factors in medulloblastoma. Neuro Oncol 2011, 13:376-383.
-
(2011)
Neuro Oncol
, vol.13
, pp. 376-383
-
-
McCabe, M.G.1
Backlund, L.M.2
Leong, H.S.3
-
48
-
-
27644512310
-
Isochromosome 17q is a negative prognostic factor in poor-risk childhood medulloblastoma patients
-
Pan E., Pellarin M., Holmes E., et al. Isochromosome 17q is a negative prognostic factor in poor-risk childhood medulloblastoma patients. Clin Cancer Res 2005, 11:4733-4740.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 4733-4740
-
-
Pan, E.1
Pellarin, M.2
Holmes, E.3
-
49
-
-
79951934386
-
TP53 mutation is frequently associated with ctnnb1 mutation or mycn amplification and is compatible with long-term survival in medulloblastoma
-
Pfaff E., Remke M., Sturm D., et al. TP53 mutation is frequently associated with ctnnb1 mutation or mycn amplification and is compatible with long-term survival in medulloblastoma. J Clin Oncol 2010, 28:5188-5196.
-
(2010)
J Clin Oncol
, vol.28
, pp. 5188-5196
-
-
Pfaff, E.1
Remke, M.2
Sturm, D.3
-
50
-
-
77950497158
-
Universal poor survival in children with medulloblastoma harboring somatic TP53 mutations
-
Tabori U., Baskin B., Shago M., et al. Universal poor survival in children with medulloblastoma harboring somatic TP53 mutations. J Clin Oncol 2010, 28:1345-1350.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1345-1350
-
-
Tabori, U.1
Baskin, B.2
Shago, M.3
-
51
-
-
0028918623
-
Prognostic significance of the c-erbB-2 oncogene product in childhood medulloblastoma
-
Gilbertson R.J., Pearson A.D., Perry R.H., et al. Prognostic significance of the c-erbB-2 oncogene product in childhood medulloblastoma. Br J Cancer 1995, 71:473-477.
-
(1995)
Br J Cancer
, vol.71
, pp. 473-477
-
-
Gilbertson, R.J.1
Pearson, A.D.2
Perry, R.H.3
-
52
-
-
0028040905
-
Physical mapping of chromosome 17p13.3 in the region of a putative tumor suppressor gene important in medulloblastoma
-
McDonald J.D., Daneshvar L., Willert J.R., et al. Physical mapping of chromosome 17p13.3 in the region of a putative tumor suppressor gene important in medulloblastoma. Genomics 1994, 23:229-232.
-
(1994)
Genomics
, vol.23
, pp. 229-232
-
-
McDonald, J.D.1
Daneshvar, L.2
Willert, J.R.3
-
53
-
-
0035445646
-
Clinical and molecular stratification of disease risk in medulloblastoma
-
Gilbertson R., Wickramasinghe C., Hernan R., et al. Clinical and molecular stratification of disease risk in medulloblastoma. Br J Cancer 2001, 85:705-712.
-
(2001)
Br J Cancer
, vol.85
, pp. 705-712
-
-
Gilbertson, R.1
Wickramasinghe, C.2
Hernan, R.3
-
54
-
-
0029031125
-
Prognostic implications of chromosome 17p deletions in human medulloblastomas
-
Batra S.K., McLendon R.E., Koo J.S., et al. Prognostic implications of chromosome 17p deletions in human medulloblastomas. J Neurooncol 1995, 24:39-45.
-
(1995)
J Neurooncol
, vol.24
, pp. 39-45
-
-
Batra, S.K.1
McLendon, R.E.2
Koo, J.S.3
-
55
-
-
0023905242
-
Phenotypic and genotypic analysis of a human medulloblastoma cell line and transplantable xenograft (D341 Med) demonstrating amplification of c-myc
-
Friedman H.S., Burger P.C., Bigner S.H., et al. Phenotypic and genotypic analysis of a human medulloblastoma cell line and transplantable xenograft (D341 Med) demonstrating amplification of c-myc. Am J Pathol 1988, 130:472-484.
-
(1988)
Am J Pathol
, vol.130
, pp. 472-484
-
-
Friedman, H.S.1
Burger, P.C.2
Bigner, S.H.3
-
56
-
-
0025239307
-
Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts
-
Bigner S.H., Friedman H.S., Vogelstein B., et al. Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts. Cancer Res 1990, 50:2347-2350.
-
(1990)
Cancer Res
, vol.50
, pp. 2347-2350
-
-
Bigner, S.H.1
Friedman, H.S.2
Vogelstein, B.3
-
57
-
-
63749118521
-
Outcome prediction in pediatric medulloblastoma based on dna copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci
-
Pfister S., Remke M., Benner A., et al. Outcome prediction in pediatric medulloblastoma based on dna copy-number aberrations of chromosomes 6q and 17q and the MYC and MYCN loci. J Clin Oncol 2009, 27:1627-1636.
-
(2009)
J Clin Oncol
, vol.27
, pp. 1627-1636
-
-
Pfister, S.1
Remke, M.2
Benner, A.3
-
58
-
-
79954991010
-
Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome
-
Cho Y.-J., Tsherniak A., Tamayo P., et al. Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome. J Clin Oncol 2011, 29:1424-1430.
-
(2011)
J Clin Oncol
, vol.29
, pp. 1424-1430
-
-
Cho, Y.-J.1
Tsherniak, A.2
Tamayo, P.3
-
59
-
-
0034890563
-
MYC messenger RNA expression predicts survival outcome in childhood primitive neuroectodermal tumor/medulloblastoma
-
Grotzer M.A., Hogarty M.D., Janss A.J., et al. MYC messenger RNA expression predicts survival outcome in childhood primitive neuroectodermal tumor/medulloblastoma. Clin Cancer Res 2001, 7:2425-2433.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 2425-2433
-
-
Grotzer, M.A.1
Hogarty, M.D.2
Janss, A.J.3
-
60
-
-
0033994659
-
TrkC expression predicts good clinical outcome in primitive neuroectodermal brain tumors
-
Grotzer M.A., Janss A.J., Fung K., et al. TrkC expression predicts good clinical outcome in primitive neuroectodermal brain tumors. J Clin Oncol 2000, 18:1027-1035.
-
(2000)
J Clin Oncol
, vol.18
, pp. 1027-1035
-
-
Grotzer, M.A.1
Janss, A.J.2
Fung, K.3
-
61
-
-
0033843435
-
Neurotrophin receptor TrkC predicts good clinical outcome in medulloblastoma and other primitive neuroectodermal brain tumors
-
Grotzer M.A., Janss A.J., Phillips P.C., et al. Neurotrophin receptor TrkC predicts good clinical outcome in medulloblastoma and other primitive neuroectodermal brain tumors. Klin Padiatr 2000, 212:196-199.
-
(2000)
Klin Padiatr
, vol.212
, pp. 196-199
-
-
Grotzer, M.A.1
Janss, A.J.2
Phillips, P.C.3
-
62
-
-
0028568009
-
Expression of the neurotrophin receptor TrkC is linked to a favorable outcome in medulloblastoma
-
Segal R.A., Goumnerova L.C., Kwon Y.K., et al. Expression of the neurotrophin receptor TrkC is linked to a favorable outcome in medulloblastoma. Proc Natl Acad Sci U S A 1994, 91:12867-12871.
-
(1994)
Proc Natl Acad Sci U S A
, vol.91
, pp. 12867-12871
-
-
Segal, R.A.1
Goumnerova, L.C.2
Kwon, Y.K.3
-
63
-
-
75149189218
-
Neurooncology of familial cancer syndromes
-
Hottinger A.F., Khakoo Y. Neurooncology of familial cancer syndromes. J Child Neurol 2009, 24:1526-1535.
-
(2009)
J Child Neurol
, vol.24
, pp. 1526-1535
-
-
Hottinger, A.F.1
Khakoo, Y.2
-
64
-
-
0028970197
-
The molecular basis of Turcot's syndrome
-
Hamilton S.R., Liu B., Parsons R.E., et al. The molecular basis of Turcot's syndrome. N Engl J Med 1995, 332:839-847.
-
(1995)
N Engl J Med
, vol.332
, pp. 839-847
-
-
Hamilton, S.R.1
Liu, B.2
Parsons, R.E.3
-
65
-
-
33751234205
-
Wnt/Wingless pathway activation and chromosome 6 loss characterize a distinct molecular subgroup of medulloblastomas associated with a favorable prognosis
-
Clifford S.C., Lusher M.E., Lindsey J.C., et al. Wnt/Wingless pathway activation and chromosome 6 loss characterize a distinct molecular subgroup of medulloblastomas associated with a favorable prognosis. Cell Cycle 2006, 5:2666-2670.
-
(2006)
Cell Cycle
, vol.5
, pp. 2666-2670
-
-
Clifford, S.C.1
Lusher, M.E.2
Lindsey, J.C.3
-
66
-
-
79958127479
-
Heterogeneity of familial medulloblastoma and contribution of germline PTCH1 and SUFU mutations to sporadic medulloblastoma
-
Slade I., Murray A., Hanks S., et al. Heterogeneity of familial medulloblastoma and contribution of germline PTCH1 and SUFU mutations to sporadic medulloblastoma. Fam Cancer 2011, 10:337-342.
-
(2011)
Fam Cancer
, vol.10
, pp. 337-342
-
-
Slade, I.1
Murray, A.2
Hanks, S.3
-
67
-
-
77349101119
-
Incomplete penetrance of the predisposition to medulloblastoma associated with germ-line SUFU mutations
-
Brugieres L., Pierron G., Chompret A., et al. Incomplete penetrance of the predisposition to medulloblastoma associated with germ-line SUFU mutations. J Med Genet 2010, 47:142-144.
-
(2010)
J Med Genet
, vol.47
, pp. 142-144
-
-
Brugieres, L.1
Pierron, G.2
Chompret, A.3
-
68
-
-
3042665321
-
Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling
-
Taylor M.D., Zhang X., Liu L., et al. Failure of a medulloblastoma-derived mutant of SUFU to suppress WNT signaling. Oncogene 2004, 23:4577-4583.
-
(2004)
Oncogene
, vol.23
, pp. 4577-4583
-
-
Taylor, M.D.1
Zhang, X.2
Liu, L.3
-
69
-
-
0036648241
-
Mutations in SUFU predispose to medulloblastoma
-
Taylor M.D., Liu L., Raffel C., et al. Mutations in SUFU predispose to medulloblastoma. Nat Genet 2002, 31:306-310.
-
(2002)
Nat Genet
, vol.31
, pp. 306-310
-
-
Taylor, M.D.1
Liu, L.2
Raffel, C.3
-
70
-
-
0030776230
-
Extensive genomic abnormalities in childhood medulloblastoma by comparative genomic hybridization
-
Reardon D.A., Michalkiewicz E., Boyett J.M., et al. Extensive genomic abnormalities in childhood medulloblastoma by comparative genomic hybridization. Cancer Res 1997, 57:4042-4047.
-
(1997)
Cancer Res
, vol.57
, pp. 4042-4047
-
-
Reardon, D.A.1
Michalkiewicz, E.2
Boyett, J.M.3
-
71
-
-
0032694006
-
Genetic alterations in pediatric medulloblastomas detected by comparative genomic hybridization
-
Nishizaki T., Harada K., Kubota H., et al. Genetic alterations in pediatric medulloblastomas detected by comparative genomic hybridization. Pediatric Neurosurg 1999, 31:27-32.
-
(1999)
Pediatric Neurosurg
, vol.31
, pp. 27-32
-
-
Nishizaki, T.1
Harada, K.2
Kubota, H.3
-
72
-
-
0034601455
-
Molecular classification of cutaneous malignant melanoma by gene expression profiling
-
Bittner M., Meltzer P., Chen Y., et al. Molecular classification of cutaneous malignant melanoma by gene expression profiling. Nature 2000, 406:536-540.
-
(2000)
Nature
, vol.406
, pp. 536-540
-
-
Bittner, M.1
Meltzer, P.2
Chen, Y.3
-
73
-
-
0033569406
-
Molecular classification of cancer: class discovery and class prediction by gene expression monitoring
-
Golub T.R., Slonim D.K., Tamayo P., et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 1999, 286:531-537.
-
(1999)
Science
, vol.286
, pp. 531-537
-
-
Golub, T.R.1
Slonim, D.K.2
Tamayo, P.3
-
74
-
-
0034794796
-
Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease
-
MacDonald T.J., Brown K.M., LaFleur B., et al. Expression profiling of medulloblastoma: PDGFRA and the RAS/MAPK pathway as therapeutic targets for metastatic disease. Nat Genet 2001, 29:143-152.
-
(2001)
Nat Genet
, vol.29
, pp. 143-152
-
-
MacDonald, T.J.1
Brown, K.M.2
LaFleur, B.3
-
75
-
-
0242361321
-
PDGFRB is overexpressed in metastatic medulloblastoma
-
Gilbertson R.J., Clifford S.C. PDGFRB is overexpressed in metastatic medulloblastoma. Nat Genet 2003, 35:197-198.
-
(2003)
Nat Genet
, vol.35
, pp. 197-198
-
-
Gilbertson, R.J.1
Clifford, S.C.2
-
76
-
-
0037971940
-
The use of gene expression analysis to gain insights into signaling mechanisms of metastatic medulloblastoma
-
Chopra A., Brown K.M., Rood B.R., et al. The use of gene expression analysis to gain insights into signaling mechanisms of metastatic medulloblastoma. Pediatr Neurosurg 2003, 39:68-74.
-
(2003)
Pediatr Neurosurg
, vol.39
, pp. 68-74
-
-
Chopra, A.1
Brown, K.M.2
Rood, B.R.3
-
77
-
-
0037165140
-
Prediction of central nervous system embryonal tumour outcome based on gene expression
-
Pomeroy S.L., Tamayo P., Gaasenbeek M., et al. Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature 2002, 415:436-442.
-
(2002)
Nature
, vol.415
, pp. 436-442
-
-
Pomeroy, S.L.1
Tamayo, P.2
Gaasenbeek, M.3
-
78
-
-
0032940605
-
Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors
-
Biegel J.A., Zhou J.Y., Rorke L.B., et al. Germ-line and acquired mutations of INI1 in atypical teratoid and rhabdoid tumors. Cancer Res 1999, 59:74-79.
-
(1999)
Cancer Res
, vol.59
, pp. 74-79
-
-
Biegel, J.A.1
Zhou, J.Y.2
Rorke, L.B.3
-
79
-
-
77957284808
-
Focal genomic amplification at 19q13.42 comprises a powerful diagnostic marker for embryonal tumors with ependymoblastic rosettes
-
Korshunov A., Remke M., Gessi M., et al. Focal genomic amplification at 19q13.42 comprises a powerful diagnostic marker for embryonal tumors with ependymoblastic rosettes. Acta Neuropathol 2010, 120:253-260.
-
(2010)
Acta Neuropathol
, vol.120
, pp. 253-260
-
-
Korshunov, A.1
Remke, M.2
Gessi, M.3
-
80
-
-
65649112882
-
Novel genomic amplification targeting the microRNA cluster at 19q13.42 in a pediatric embryonal tumor with abundant neuropil and true rosettes
-
Pfister S., Remke M., Castoldi M., et al. Novel genomic amplification targeting the microRNA cluster at 19q13.42 in a pediatric embryonal tumor with abundant neuropil and true rosettes. Acta Neuropathol 2009, 117:457-464.
-
(2009)
Acta Neuropathol
, vol.117
, pp. 457-464
-
-
Pfister, S.1
Remke, M.2
Castoldi, M.3
-
81
-
-
52449119078
-
Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features
-
Kool M., Koster J., Bunt J., et al. Integrated genomics identifies five medulloblastoma subtypes with distinct genetic profiles, pathway signatures and clinicopathological features. PLoS ONE 2008, 3:e3088.
-
(2008)
PLoS ONE
, vol.3
-
-
Kool, M.1
Koster, J.2
Bunt, J.3
-
82
-
-
32944461274
-
Beta-Catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee
-
Ellison D.W., Onilude O.E., Lindsey J.C., et al. beta-Catenin status predicts a favorable outcome in childhood medulloblastoma: the United Kingdom Children's Cancer Study Group Brain Tumour Committee. J Clin Oncol 2005, 23:7951-7957.
-
(2005)
J Clin Oncol
, vol.23
, pp. 7951-7957
-
-
Ellison, D.W.1
Onilude, O.E.2
Lindsey, J.C.3
-
83
-
-
79953146403
-
Predicting Relapse in Patients With Medulloblastoma by Integrating Evidence From Clinical and Genomic Features
-
Tamayo P., Cho Y.-J., Tsherniak A., et al. Predicting Relapse in Patients With Medulloblastoma by Integrating Evidence From Clinical and Genomic Features. J Clin Oncol 2011, 29:1415-1423.
-
(2011)
J Clin Oncol
, vol.29
, pp. 1415-1423
-
-
Tamayo, P.1
Cho, Y.-J.2
Tsherniak, A.3
-
84
-
-
78650811198
-
Subtypes of medulloblastoma have distinct developmental origins
-
Gibson P., Tong Y., Robinson G., et al. Subtypes of medulloblastoma have distinct developmental origins. Nature 2010, 468:1095-1099.
-
(2010)
Nature
, vol.468
, pp. 1095-1099
-
-
Gibson, P.1
Tong, Y.2
Robinson, G.3
-
85
-
-
79954444747
-
Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups
-
Ellison D.W., Dalton J., Kocak M., et al. Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups. Acta Neuropathol 2011, 121:381-396.
-
(2011)
Acta Neuropathol
, vol.121
, pp. 381-396
-
-
Ellison, D.W.1
Dalton, J.2
Kocak, M.3
-
86
-
-
84870645360
-
Relative survival of childhood and adult medulloblastomas and primitive neuroectodermal tumors (PNETs).
-
Cancer. [Epub ahead of print].
-
Smoll NR. Relative survival of childhood and adult medulloblastomas and primitive neuroectodermal tumors (PNETs). Cancer. [Epub ahead of print].
-
-
-
Smoll, N.R.1
-
87
-
-
34247849227
-
Common strategy for adult and pediatric medulloblastoma: a multicenter series of 253 adults
-
Padovani L., Sunyach M.P., Perol D., et al. Common strategy for adult and pediatric medulloblastoma: a multicenter series of 253 adults. Int J Radiat Oncol Biol Phys 2007, 68:433-440.
-
(2007)
Int J Radiat Oncol Biol Phys
, vol.68
, pp. 433-440
-
-
Padovani, L.1
Sunyach, M.P.2
Perol, D.3
-
88
-
-
52249104363
-
Characteristics and outcomes of medulloblastoma in adults
-
Ang C., Hauerstock D., Guiot M.C., et al. Characteristics and outcomes of medulloblastoma in adults. Pediatr Blood Cancer 2008, 51:603-607.
-
(2008)
Pediatr Blood Cancer
, vol.51
, pp. 603-607
-
-
Ang, C.1
Hauerstock, D.2
Guiot, M.C.3
-
89
-
-
77954602395
-
Adult and pediatric medulloblastomas are genetically distinct and require different algorithms for molecular risk stratification
-
Korshunov A., Remke M., Werft W., et al. Adult and pediatric medulloblastomas are genetically distinct and require different algorithms for molecular risk stratification. J Clin Oncol 2010, 28:3054-3060.
-
(2010)
J Clin Oncol
, vol.28
, pp. 3054-3060
-
-
Korshunov, A.1
Remke, M.2
Werft, W.3
-
90
-
-
79960119129
-
Adult medulloblastoma comprises three major molecular variants
-
Remke M., Hielscher T., Northcott P.A., et al. Adult medulloblastoma comprises three major molecular variants. J Clin Oncol 2011, 29:2717-2723.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2717-2723
-
-
Remke, M.1
Hielscher, T.2
Northcott, P.A.3
-
91
-
-
79960842253
-
Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct
-
Northcott P.A., Hielscher T., Dubuc A., et al. Pediatric and adult sonic hedgehog medulloblastomas are clinically and molecularly distinct. Acta Neuropathol 2011, 122:231-240.
-
(2011)
Acta Neuropathol
, vol.122
, pp. 231-240
-
-
Northcott, P.A.1
Hielscher, T.2
Dubuc, A.3
-
92
-
-
79451469572
-
Preponderance of sonic hedgehog pathway activation characterizes adult medulloblastoma
-
Al-Halabi H., Nantel A., Klekner A., et al. Preponderance of sonic hedgehog pathway activation characterizes adult medulloblastoma. Acta Neuropathol 2011, 121:229-239.
-
(2011)
Acta Neuropathol
, vol.121
, pp. 229-239
-
-
Al-Halabi, H.1
Nantel, A.2
Klekner, A.3
-
93
-
-
77958060845
-
Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma
-
Buonamici S., Williams J., Morrissey M., et al. Interfering with resistance to smoothened antagonists by inhibition of the PI3K pathway in medulloblastoma. Sci Transl Med 2010, 2:51ra70.
-
(2010)
Sci Transl Med
, vol.2
-
-
Buonamici, S.1
Williams, J.2
Morrissey, M.3
-
94
-
-
79954611501
-
Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors
-
LoRusso P.M., Rudin C.M., Reddy J.C., et al. Phase I trial of hedgehog pathway inhibitor vismodegib (GDC-0449) in patients with refractory, locally advanced or metastatic solid tumors. Clin Cancer Res 2011, 17:2502-2511.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 2502-2511
-
-
LoRusso, P.M.1
Rudin, C.M.2
Reddy, J.C.3
-
95
-
-
79960340656
-
Topical treatment of basal cell carcinomas in nevoid basal cell carcinoma syndrome with a smoothened inhibitor
-
Skvara H., Kalthoff F., Meingassner J.G., et al. Topical treatment of basal cell carcinomas in nevoid basal cell carcinoma syndrome with a smoothened inhibitor. J Invest Dermatol 2011, 131:1735-1744.
-
(2011)
J Invest Dermatol
, vol.131
, pp. 1735-1744
-
-
Skvara, H.1
Kalthoff, F.2
Meingassner, J.G.3
-
96
-
-
70349238733
-
Inhibition of the hedgehog pathway in advanced basal-cell carcinoma
-
Von Hoff D.D., LoRusso P.M., Rudin C.M., et al. Inhibition of the hedgehog pathway in advanced basal-cell carcinoma. N Engl J Med 2009, 361:1164-1172.
-
(2009)
N Engl J Med
, vol.361
, pp. 1164-1172
-
-
Von Hoff, D.D.1
LoRusso, P.M.2
Rudin, C.M.3
-
97
-
-
70350496540
-
Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma
-
Yauch R.L., Dijkgraaf G.J., Alicke B., et al. Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma. Science 2009, 326:572-574.
-
(2009)
Science
, vol.326
, pp. 572-574
-
-
Yauch, R.L.1
Dijkgraaf, G.J.2
Alicke, B.3
-
98
-
-
70349244812
-
Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449
-
Rudin C.M., Hann C.L., Laterra J., et al. Treatment of medulloblastoma with hedgehog pathway inhibitor GDC-0449. N Engl J Med 2009, 361:1173-1178.
-
(2009)
N Engl J Med
, vol.361
, pp. 1173-1178
-
-
Rudin, C.M.1
Hann, C.L.2
Laterra, J.3
-
99
-
-
78650355900
-
The notch target Hes1 directly modulates Gli1 expression and hedgehog signaling: a potential mechanism of therapeutic resistance
-
Schreck K.C., Taylor P., Marchionni L., et al. The notch target Hes1 directly modulates Gli1 expression and hedgehog signaling: a potential mechanism of therapeutic resistance. Clin Cancer Res 2010, 16:6060-6070.
-
(2010)
Clin Cancer Res
, vol.16
, pp. 6060-6070
-
-
Schreck, K.C.1
Taylor, P.2
Marchionni, L.3
-
100
-
-
63449115501
-
Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma
-
Northcott P.A., Nakahara Y., Wu X., et al. Multiple recurrent genetic events converge on control of histone lysine methylation in medulloblastoma. Nat Genet 2009, 41:465-472.
-
(2009)
Nat Genet
, vol.41
, pp. 465-472
-
-
Northcott, P.A.1
Nakahara, Y.2
Wu, X.3
-
101
-
-
79251629946
-
The genetic landscape of the childhood cancer medulloblastoma
-
Parsons D.W., Li M., Zhang X., et al. The genetic landscape of the childhood cancer medulloblastoma. Science 2011, 331:435-439.
-
(2011)
Science
, vol.331
, pp. 435-439
-
-
Parsons, D.W.1
Li, M.2
Zhang, X.3
-
102
-
-
80051489586
-
The application of delivery systems for DNA methyltransferase inhibitors
-
Lim S.P., Neilsen P., Kumar R., et al. The application of delivery systems for DNA methyltransferase inhibitors. BioDrugs 2011, 25:227-242.
-
(2011)
BioDrugs
, vol.25
, pp. 227-242
-
-
Lim, S.P.1
Neilsen, P.2
Kumar, R.3
-
103
-
-
80052653226
-
Therapeutic strategies to enhance the anticancer efficacy of histone deacetylase inhibitors
-
Miller C.P., Singh M.M., Rivera-Del Valle N., et al. Therapeutic strategies to enhance the anticancer efficacy of histone deacetylase inhibitors. J Biomed Biotechnol 2011, 2011:514261.
-
(2011)
J Biomed Biotechnol
, vol.2011
, pp. 514261
-
-
Miller, C.P.1
Singh, M.M.2
Rivera-Del Valle, N.3
-
104
-
-
84870629176
-
Targeting epigenetics through histone deacetylase inhibitors in acute lymphoblastic leukemia.
-
Curr Cancer Drug Targets [Epub ahead of print].
-
Mummery A, Narendran A, Lee KY. Targeting epigenetics through histone deacetylase inhibitors in acute lymphoblastic leukemia. Curr Cancer Drug Targets [Epub ahead of print].
-
-
-
Mummery, A.1
Narendran, A.2
Lee, K.Y.3
-
105
-
-
84855178148
-
Histone deacetylase inhibition as an anticancer telomerase-targeting strategy
-
Rahman R., Grundy R. Histone deacetylase inhibition as an anticancer telomerase-targeting strategy. Int J Cancer 2011, 129:2765-2774.
-
(2011)
Int J Cancer
, vol.129
, pp. 2765-2774
-
-
Rahman, R.1
Grundy, R.2
-
106
-
-
0035206170
-
Aberrant hypermethylation of the major breakpoint cluster region in 17p11.2 in medulloblastomas but not supratentorial PNETs
-
Fruhwald M.C., O'Dorisio M.S., Dai Z., et al. Aberrant hypermethylation of the major breakpoint cluster region in 17p11.2 in medulloblastomas but not supratentorial PNETs. Genes Chromosomes Cancer 2001, 30:38-47.
-
(2001)
Genes Chromosomes Cancer
, vol.30
, pp. 38-47
-
-
Fruhwald, M.C.1
O'Dorisio, M.S.2
Dai, Z.3
-
107
-
-
0035899347
-
Aberrant promoter methylation of previously unidentified target genes is a common abnormality in medulloblastomas-implications for tumor biology and potential clinical utility
-
Fruhwald M.C., O'Dorisio M.S., Dai Z., et al. Aberrant promoter methylation of previously unidentified target genes is a common abnormality in medulloblastomas-implications for tumor biology and potential clinical utility. Oncogene 2001, 20:5033-5042.
-
(2001)
Oncogene
, vol.20
, pp. 5033-5042
-
-
Fruhwald, M.C.1
O'Dorisio, M.S.2
Dai, Z.3
-
108
-
-
0034741957
-
[Hypermethylation as a potential prognostic factor and a clue to a better understanding of the molecular pathogenesis of medulloblastoma-results of a genomewide methylation scan]
-
Fruhwald M.C., O'Dorisio M.S., Smith L., et al. [Hypermethylation as a potential prognostic factor and a clue to a better understanding of the molecular pathogenesis of medulloblastoma-results of a genomewide methylation scan]. Klin Padiatr 2001, 213:197-203.
-
(2001)
Klin Padiatr
, vol.213
, pp. 197-203
-
-
Fruhwald, M.C.1
O'Dorisio, M.S.2
Smith, L.3
-
109
-
-
34447307713
-
Epigenetic deregulation of multiple S100 gene family members by differential hypomethylation and hypermethylation events in medulloblastoma
-
Lindsey J.C., Lusher M.E., Anderton J.A., et al. Epigenetic deregulation of multiple S100 gene family members by differential hypomethylation and hypermethylation events in medulloblastoma. Br J Cancer 2007, 97:267-274.
-
(2007)
Br J Cancer
, vol.97
, pp. 267-274
-
-
Lindsey, J.C.1
Lusher, M.E.2
Anderton, J.A.3
-
110
-
-
34247501352
-
Frequent but borderline methylation of p16 (INK4a) and TIMP3 in medulloblastoma and sPNET revealed by quantitative analyses
-
Muhlisch J., Bajanowski T., Rickert C.H., et al. Frequent but borderline methylation of p16 (INK4a) and TIMP3 in medulloblastoma and sPNET revealed by quantitative analyses. J Neurooncol 2007, 83:17-29.
-
(2007)
J Neurooncol
, vol.83
, pp. 17-29
-
-
Muhlisch, J.1
Bajanowski, T.2
Rickert, C.H.3
-
111
-
-
33751223831
-
Identification and analysis of tumor suppressor loci at chromosome 10q23.3-10q25.3 in medulloblastoma
-
Scott D.K., Straughton D., Cole M., et al. Identification and analysis of tumor suppressor loci at chromosome 10q23.3-10q25.3 in medulloblastoma. Cell Cycle 2006, 5:2381-2389.
-
(2006)
Cell Cycle
, vol.5
, pp. 2381-2389
-
-
Scott, D.K.1
Straughton, D.2
Cole, M.3
-
112
-
-
57149120670
-
Global analysis of the medulloblastoma epigenome identifies disease-subgroup-specific inactivation of COL1A2
-
Anderton J.A., Lindsey J.C., Lusher M.E., et al. Global analysis of the medulloblastoma epigenome identifies disease-subgroup-specific inactivation of COL1A2. Neuro-oncology 2008, 10:981-994.
-
(2008)
Neuro-oncology
, vol.10
, pp. 981-994
-
-
Anderton, J.A.1
Lindsey, J.C.2
Lusher, M.E.3
-
113
-
-
77952671657
-
The SFRP family of WNT inhibitors function as novel tumor suppressor genes epigenetically silenced in medulloblastoma
-
Kongkham P.N., Northcott P.A., Croul S.E., et al. The SFRP family of WNT inhibitors function as novel tumor suppressor genes epigenetically silenced in medulloblastoma. Oncogene 2010, 29:3017-3024.
-
(2010)
Oncogene
, vol.29
, pp. 3017-3024
-
-
Kongkham, P.N.1
Northcott, P.A.2
Croul, S.E.3
-
114
-
-
73949114835
-
Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma
-
Nakahara Y., Northcott P.A., Li M., et al. Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma. Neoplasia 2010, 12:20-27.
-
(2010)
Neoplasia
, vol.12
, pp. 20-27
-
-
Nakahara, Y.1
Northcott, P.A.2
Li, M.3
-
115
-
-
57149094865
-
An epigenetic genome-wide screen identifies spint2 as a novel tumor suppressor gene in pediatric medulloblastoma
-
Kongkham P.N., Northcott P.A., Ra Y.S., et al. An epigenetic genome-wide screen identifies spint2 as a novel tumor suppressor gene in pediatric medulloblastoma. Cancer Res 2008, 68:9945-9953.
-
(2008)
Cancer Res
, vol.68
, pp. 9945-9953
-
-
Kongkham, P.N.1
Northcott, P.A.2
Ra, Y.S.3
-
116
-
-
20044372154
-
MGMT gene silencing and benefit from temozolomide in glioblastoma
-
Hegi M.E., Diserens A.C., Gorlia T., et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 2005, 352:997-1003.
-
(2005)
N Engl J Med
, vol.352
, pp. 997-1003
-
-
Hegi, M.E.1
Diserens, A.C.2
Gorlia, T.3
-
117
-
-
51649117107
-
Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity
-
Hegi M.E., Liu L., Herman J.G., et al. Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity. J Clin Oncol 2008, 26:4189-4199.
-
(2008)
J Clin Oncol
, vol.26
, pp. 4189-4199
-
-
Hegi, M.E.1
Liu, L.2
Herman, J.G.3
-
118
-
-
79959954645
-
Expression of O-methylguanine-DNA methyltransferase in childhood medulloblastoma
-
Faoro D., von Bueren A.O., Shalaby T., et al. Expression of O-methylguanine-DNA methyltransferase in childhood medulloblastoma. J Neurooncol 2011, 103:59-69.
-
(2011)
J Neurooncol
, vol.103
, pp. 59-69
-
-
Faoro, D.1
von Bueren, A.O.2
Shalaby, T.3
-
120
-
-
77957873186
-
Translational applications of microRNA genes in medulloblastomas
-
Ajeawung N.F., Li B., Kamnasaran D. Translational applications of microRNA genes in medulloblastomas. Clin Invest Med 2010, 33:E223-E233.
-
(2010)
Clin Invest Med
, vol.33
-
-
Ajeawung, N.F.1
Li, B.2
Kamnasaran, D.3
-
121
-
-
78650139005
-
Survey of microRNA expression in pediatric brain tumors
-
Birks D.K., Barton V.N., Donson A.M., et al. Survey of microRNA expression in pediatric brain tumors. Pediatr Blood Cancer 2011, 56:211-216.
-
(2011)
Pediatr Blood Cancer
, vol.56
, pp. 211-216
-
-
Birks, D.K.1
Barton, V.N.2
Donson, A.M.3
-
122
-
-
53549129980
-
Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells
-
Ferretti E., De Smaele E., Miele E., et al. Concerted microRNA control of Hedgehog signalling in cerebellar neuronal progenitor and tumour cells. EMBO J 2008, 27:2616-2627.
-
(2008)
EMBO J
, vol.27
, pp. 2616-2627
-
-
Ferretti, E.1
De Smaele, E.2
Miele, E.3
-
123
-
-
58149279841
-
MicroRNA profiling in human medulloblastoma
-
Ferretti E., De Smaele E., Po A., et al. MicroRNA profiling in human medulloblastoma. Int J Cancer 2009, 124:568-577.
-
(2009)
Int J Cancer
, vol.124
, pp. 568-577
-
-
Ferretti, E.1
De Smaele, E.2
Po, A.3
-
124
-
-
63449135077
-
MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma
-
Garzia L., Andolfo I., Cusanelli E., et al. MicroRNA-199b-5p impairs cancer stem cells through negative regulation of HES1 in medulloblastoma. PLoS ONE 2009, 4:e4998.
-
(2009)
PLoS ONE
, vol.4
-
-
Garzia, L.1
Andolfo, I.2
Cusanelli, E.3
-
125
-
-
79952430095
-
Distinctive microRNA signature of medulloblastomas associated with the WNT signaling pathway
-
Gokhale A., Kunder R., Goel A., et al. Distinctive microRNA signature of medulloblastomas associated with the WNT signaling pathway. J Cancer Res Ther 2010, 6:521-529.
-
(2010)
J Cancer Res Ther
, vol.6
, pp. 521-529
-
-
Gokhale, A.1
Kunder, R.2
Goel, A.3
-
126
-
-
70350724832
-
Identification of differentially expressed microRNAs by microarray: a possible role for microRNAs gene in medulloblastomas
-
Liu W., Gong Y.H., Chao T.F., et al. Identification of differentially expressed microRNAs by microarray: a possible role for microRNAs gene in medulloblastomas. Chin Med J (Engl) 2009, 122:2405-2411.
-
(2009)
Chin Med J (Engl)
, vol.122
, pp. 2405-2411
-
-
Liu, W.1
Gong, Y.H.2
Chao, T.F.3
-
127
-
-
84870632741
-
Genetic Alterations in Micro-RNAs in Medulloblastomas
-
Brain Pathol. [Epub ahead of print].
-
Lv SQ, Kim YH, Giulio F, et al. Genetic Alterations in Micro-RNAs in Medulloblastomas. Brain Pathol. [Epub ahead of print].
-
-
-
Lv, S.Q.1
Kim, Y.H.2
Giulio, F.3
-
128
-
-
65249186793
-
The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors
-
Northcott P.A., Fernandez L.A., Hagan J.P., et al. The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors. Cancer Res 2009, 69:3249-3255.
-
(2009)
Cancer Res
, vol.69
, pp. 3249-3255
-
-
Northcott, P.A.1
Fernandez, L.A.2
Hagan, J.P.3
-
129
-
-
46349109152
-
Regulation of cyclin dependent kinase 6 by microRNA 124 in medulloblastoma
-
Pierson J., Hostager B., Fan R., et al. Regulation of cyclin dependent kinase 6 by microRNA 124 in medulloblastoma. J Neurooncol 2008, 90:1-7.
-
(2008)
J Neurooncol
, vol.90
, pp. 1-7
-
-
Pierson, J.1
Hostager, B.2
Fan, R.3
-
130
-
-
62449294691
-
The miR-17∼92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma
-
Uziel T., Karginov F.V., Xie S., et al. The miR-17∼92 cluster collaborates with the Sonic Hedgehog pathway in medulloblastoma. Proc Natl Acad Sci USA 2009, 106:2812-2817.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 2812-2817
-
-
Uziel, T.1
Karginov, F.V.2
Xie, S.3
-
131
-
-
74849138386
-
Normal and oncogenic roles for microRNAs in the developing brain
-
Fernandez L.A., Northcott P.A., Taylor M.D., et al. Normal and oncogenic roles for microRNAs in the developing brain. Cell Cycle 2009, 8:4049-4054.
-
(2009)
Cell Cycle
, vol.8
, pp. 4049-4054
-
-
Fernandez, L.A.1
Northcott, P.A.2
Taylor, M.D.3
-
132
-
-
77951115122
-
International network of cancer genome projects
-
Consortium I.C.G. International network of cancer genome projects. Nature 2010, 464:993-998.
-
(2010)
Nature
, vol.464
, pp. 993-998
-
-
Consortium, I.C.G.1
|