Hypermethylation as a potential prognostic factor and a clue to a better understanding of the molecular pathogenesis of medulloblastoma - Results of a genomewide methylation scan

Klinische Padiatrie

Volumn 213, Issue 4, 2001, Pages 197-203

  Fruhwald M C ^a,b,c   O'Dorisio, M S ^c,d   Smith, L ^b   Dai, Z ^b   Wright, F A ^b   Paulus, W ^a   Jurgens H ^a   Plass, C ^b  

^a UNIVERSITY OF MÜNSTER   (Germany)

^b OHIO STATE UNIVERSITY   (United States)

^c NATIONWIDE CHILDREN S HOSPITAL   (United States)

^d UNIVERSITY OF IOWA   (United States)

Author keywords

Hypermethylation; Medulloblastoma; Primitive neuroectodermal tumor; Prognosis

Indexed keywords

DNA; PROTEIN P15; PROTEIN P16; UVOMORULIN; TUMOR MARKER;

ADOLESCENT; ADULT; ARTICLE; CANCER DIAGNOSIS; CANCER RISK; CARCINOGENESIS; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; DNA METHYLATION; FEMALE; GENE LOCUS; HUMAN; HUMAN TISSUE; MALE; MEDULLOBLASTOMA; NEUROECTODERM TUMOR; POLYMERASE CHAIN REACTION; PROGNOSIS; PROMOTER REGION; RISK ASSESSMENT; TUMOR SUPPRESSOR GENE; BRAIN TUMOR; CELL CULTURE; GENE LIBRARY; GENETICS; INFANT; PRESCHOOL CHILD; SURVIVAL;

ADOLESCENT; ADULT; BRAIN NEOPLASMS; CHILD; CHILD, PRESCHOOL; DNA METHYLATION; FEMALE; GENOMIC LIBRARY; HUMANS; INFANT; MALE; MEDULLOBLASTOMA; NEUROECTODERMAL TUMORS, PRIMITIVE; POLYMERASE CHAIN REACTION; PROGNOSIS; SURVIVAL ANALYSIS; TUMOR CELLS, CULTURED; TUMOR MARKERS, BIOLOGICAL;

EID: 0034741957     PISSN: 03008630     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2001-16851     Document Type: Article

References (22)

1. Neurocognitive deficits in medulloblastoma survivors and white matter loss
2. Metastasis stage, adjuvant treatment, and residual tumor are prognostic factors for medulloblastoma in children: Conclusions from the Children's Cancer Group 921 randomized phase III study
3. Molecular analysis of childhood primitive neuroectodermal tumors defines markers associated with poor outcome
4. TrkC expression predicts good clinical outcome in primitive neuroectodermal brain tumors
5. Cytogenetics and molecular genetics of childhood brain tumors
6. DNA hypermethylation in tumorigenesis: Epigenetics joins genetics
7. Gene amplification in PNETs/medulloblastomas: Mapping of a novel amplified gene within the MYCN amplicon
8. Characterization of five new cell lines derived from human primitive neuroectodermal tumors of the central nervous system
9. Aberrant hypermethylation of the major breakpoint cluster region in 17p11.2 in medulloblastomas but not supratentorial PNETs
10. A new tool for the rapid cloning of amplified and hypermethylated human DNA sequences from RLGS gels
11. Methylation-specific PCR: A novel PCR assay for methylation status of CpG islands
12. Aberrant promoter methylation of novel rather than known methylation targets is a common abnormality in medulloblastomas - Implications for tumor biology and potential clinical utility
13. Aberrant CpG-island methylation has non-random and tumour-type-specific patterns
14. Mapping of the breakpoints on the short arm of chromosome 17 in neoplasms with an i(17q)
15. Alterations in DNA methylation: A fundamental aspect of neoplasia
16. Inactivation of the DNA-Repair Gene MGMT and the clinical response of gliomas to alkylating agents
17. A new predictive factor for hepatocellular carcinoma based on two-dimensional electrophoresis of genomic DNA
18. Predicting lung cancer by detecting aberrant promoter methylation in sputum
19. E-Cadherin in human brain tumours: Loss of immunoreactivity in malignant meningiomas
20. Infrequent alterations of the p15, p16, CDK4 and cyclin D1 genes in non-astrocytic human brain tumors
21. Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum