Rad51 and DNA-PKcs are involved in the generation of specific telomere aberrations induced by the quadruplex ligand 360A that impair mitotic cell progression and lead to cell death

Cellular and Molecular Life Sciences

Volumn 69, Issue 4, 2012, Pages 629-640

  Gauthier, Laurent R ^a,b,c   Granotier, Christine ^a,b,c   Hoffschir, Françoise ^a,b,c   Etienne, Olivier ^a,b,c   Ayouaz, Ali ^d   Desmaze, Chantal ^a,b,c   Mailliet, Patrick ^e   Biard, Denis S ^d   Boussin, François D ^a,b,c  

^a INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

^b INSERM   (France)

^c Universite Paris Sud   (France)

^d Centre National de la Recherche Scientifique   (France)

^e SANOFI   (France)

Author keywords

DNA PKcs; G quadruplex; Mitosis; Rad51; Telomere

Indexed keywords

DNA DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; PROTEIN KINASE; RAD51 PROTEIN; UNCLASSIFIED DRUG;

ANAPHASE; APOPTOSIS; ARTICLE; CELL CYCLE G1 PHASE; CELL CYCLE PROGRESSION; CHROMOSOME ABERRATION; CONTROLLED STUDY; DNA END JOINING REPAIR; FEMALE; HOMOLOGOUS RECOMBINATION; HUMAN; HUMAN CELL; METAPHASE; MITOSIS INHIBITION; PROTEIN EXPRESSION; PROTEIN FUNCTION; TELOMERE;

ANAPHASE; APOPTOSIS; CELL LINE; DNA END-JOINING REPAIR; DNA-ACTIVATED PROTEIN KINASE; G-QUADRUPLEXES; HOMOLOGOUS RECOMBINATION; HUMANS; LIGANDS; METAPHASE; MITOSIS; NUCLEAR PROTEINS; PYRIDINES; QUINOLINES; RAD51 RECOMBINASE; RNA INTERFERENCE; RNA, SMALL INTERFERING; TELOMERE;

EID: 84856836430     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-011-0767-6     Document Type: Article

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