메뉴 건너뛰기




Volumn 21, Issue 4, 2000, Pages 136-142

G-quadruplex DNA: A potential target for anti-cancer drug design

Author keywords

[No Author keywords available]

Indexed keywords

ANTHRAQUINONE DERIVATIVE; ANTINEOPLASTIC AGENT; CHAPERONE; DOUBLE STRANDED DNA; PERYLENE; PORPHYRIN; PORPHYRIN DERIVATIVE; TELOMERASE;

EID: 0034176194     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-6147(00)01457-7     Document Type: Review
Times cited : (473)

References (76)
  • 1
    • 0024787884 scopus 로고
    • Monovalent cation-induced structure of telomeric DNA: The G-quartet model
    • Williamson J.R.et al. Monovalent cation-induced structure of telomeric DNA: the G-quartet model. Cell. 59:1989;871-880.
    • (1989) Cell , vol.59 , pp. 871-880
    • Williamson, J.R.1
  • 2
    • 0023788886 scopus 로고
    • Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis
    • Sen D., Gilbert W. Formation of parallel four-stranded complexes by guanine-rich motifs in DNA and its implications for meiosis. Nature. 334:1988;364-366.
    • (1988) Nature , vol.334 , pp. 364-366
    • Sen, D.1    Gilbert, W.2
  • 3
    • 0027750779 scopus 로고
    • Solution structure of a parallel-stranded G-quadruplex DNA
    • Wang Y., Patel D.J. Solution structure of a parallel-stranded G-quadruplex DNA. J. Mol. Biol. 234:1993;1171-1183.
    • (1993) J. Mol. Biol. , vol.234 , pp. 1171-1183
    • Wang, Y.1    Patel, D.J.2
  • 4
    • 0026591751 scopus 로고
    • Crystal structure of four-stranded Oxytricha telomeric DNA
    • Kang C.et al. Crystal structure of four-stranded Oxytricha telomeric DNA. Nature. 356:1992;126-131.
    • (1992) Nature , vol.356 , pp. 126-131
    • Kang, C.1
  • 5
    • 0026554887 scopus 로고
    • Quadruplex structure of Oxytricha telomeric DNA oligonucleotides
    • Smith F.W., Feigon J. Quadruplex structure of Oxytricha telomeric DNA oligonucleotides. Nature. 356:1992;164-168.
    • (1992) Nature , vol.356 , pp. 164-168
    • Smith, F.W.1    Feigon, J.2
  • 6
    • 0029645583 scopus 로고
    • Solution structures of unimolecular quadruplexes formed by oligonucleotides containing Oxytricha telomere repeats
    • Smith F.W.et al. Solution structures of unimolecular quadruplexes formed by oligonucleotides containing Oxytricha telomere repeats. Structure. 3:1995;997-1008.
    • (1995) Structure , vol.3 , pp. 997-1008
    • Smith, F.W.1
  • 8
    • 85042639894 scopus 로고
    • Helix formation by guanylic acid
    • Gellert M.et al. Helix formation by guanylic acid. Proc. Natl. Acad. Sci. U. S. A. 48:1962;2013-2018.
    • (1962) Proc. Natl. Acad. Sci. U. S. A. , vol.48 , pp. 2013-2018
    • Gellert, M.1
  • 9
    • 0025649498 scopus 로고
    • Four-stranded nucleic acid structures 25 years later: From guanosine gels to telomer DNA
    • Guschlbauer W.et al. Four-stranded nucleic acid structures 25 years later: from guanosine gels to telomer DNA. J. Biomol. Struct. Dynamics. 8:1990;491-511.
    • (1990) J. Biomol. Struct. Dynamics , vol.8 , pp. 491-511
    • Guschlbauer, W.1
  • 10
    • 0021761296 scopus 로고
    • S1-hypersensitive sites in eukaryotic promoter regions
    • Evans T.et al. S1-hypersensitive sites in eukaryotic promoter regions. Nucleic Acids Res. 12:1984;8043-8058.
    • (1984) Nucleic Acids Res. , vol.12 , pp. 8043-8058
    • Evans, T.1
  • 11
    • 0023002908 scopus 로고
    • Unusual DNA structures in the adenovirus genome
    • Kilpatrick M.W.et al. Unusual DNA structures in the adenovirus genome. J. Biol. Chem. 261:1986;11350-11354.
    • (1986) J. Biol. Chem. , vol.261 , pp. 11350-11354
    • Kilpatrick, M.W.1
  • 12
    • 0031727943 scopus 로고    scopus 로고
    • G-quadruplex DNA: A target for drug design
    • Mergny J.L., Helene C. G-quadruplex DNA: a target for drug design. Nat. Med. 4:1998;1366-1367.
    • (1998) Nat. Med. , vol.4 , pp. 1366-1367
    • Mergny, J.L.1    Helene, C.2
  • 14
    • 0030978765 scopus 로고    scopus 로고
    • The DNA structures at the ends of eukaryotic chromosomes
    • Wellinger R.J., Sen D. The DNA structures at the ends of eukaryotic chromosomes. Eur. J. Cancer. 33:1997;735-749.
    • (1997) Eur. J. Cancer , vol.33 , pp. 735-749
    • Wellinger, R.J.1    Sen, D.2
  • 15
    • 0026657080 scopus 로고
    • Guanine quartet structures
    • Sen D., Gilbert W. Guanine quartet structures. Methods Enzymol. 211:1992;191-199.
    • (1992) Methods Enzymol. , vol.211 , pp. 191-199
    • Sen, D.1    Gilbert, W.2
  • 16
    • 0028146763 scopus 로고
    • Promotion of parallel DNA quadruplexes by a yeast telomere binding protein: A circular dichroism study
    • Giraldo R.et al. Promotion of parallel DNA quadruplexes by a yeast telomere binding protein: a circular dichroism study. Proc. Natl. Acad. Sci. U. S. A. 91:1994;7658-7662.
    • (1994) Proc. Natl. Acad. Sci. U. S. A. , vol.91 , pp. 7658-7662
    • Giraldo, R.1
  • 17
    • 0027220845 scopus 로고
    • The β-subunit of Oxytricha telomere-binding protein promotes G-quartet formation by telomeric DNA
    • Fang G., Cech T.R. The β-subunit of Oxytricha telomere-binding protein promotes G-quartet formation by telomeric DNA. Cell. 74:1993;875-885.
    • (1993) Cell , vol.74 , pp. 875-885
    • Fang, G.1    Cech, T.R.2
  • 18
    • 0030904750 scopus 로고    scopus 로고
    • Sequence-specific binding protein of single-stranded and unimolecular quadruplex telomeric DNA from rat hepatocytes
    • Erlitzki R., Fry M. Sequence-specific binding protein of single-stranded and unimolecular quadruplex telomeric DNA from rat hepatocytes. J. Biol. Chem. 272:1997;15881-15890.
    • (1997) J. Biol. Chem. , vol.272 , pp. 15881-15890
    • Erlitzki, R.1    Fry, M.2
  • 19
    • 0027412191 scopus 로고
    • QUAD, a protein from hepatocyte chromatin that binds selectively to guanine-rich quadruplex DNA
    • Weisman-Shomer P., Fry M. QUAD, a protein from hepatocyte chromatin that binds selectively to guanine-rich quadruplex DNA. J. Biol. Chem. 268:1993;3306-3312.
    • (1993) J. Biol. Chem. , vol.268 , pp. 3306-3312
    • Weisman-Shomer, P.1    Fry, M.2
  • 20
    • 0031047969 scopus 로고    scopus 로고
    • Purification and characterization of qTBP42, a new single-stranded and quadruplex telomeric DNA-binding protein from rat hepatocytes
    • Sarig G.et al. Purification and characterization of qTBP42, a new single-stranded and quadruplex telomeric DNA-binding protein from rat hepatocytes. J. Biol. Chem. 272:1997;4474-4482.
    • (1997) J. Biol. Chem. , vol.272 , pp. 4474-4482
    • Sarig, G.1
  • 21
    • 0033534467 scopus 로고    scopus 로고
    • G4 DNA binding by LR1 and its subunits, nucleolin and hnRNP D: A role for G-G pairing in immunoglobulin switch recombination
    • Dempsey L.A.et al. G4 DNA binding by LR1 and its subunits, nucleolin and hnRNP D: a role for G-G pairing in immunoglobulin switch recombination. J. Biol. Chem. 274:1999;1066-1071.
    • (1999) J. Biol. Chem. , vol.274 , pp. 1066-1071
    • Dempsey, L.A.1
  • 22
    • 0027520196 scopus 로고
    • Characterization of a G-quartet formation reaction promoted by the β-subunit of the Oxytricha telomere-binding protein
    • Fang G., Cech T.R. Characterization of a G-quartet formation reaction promoted by the β-subunit of the Oxytricha telomere-binding protein. Biochemistry. 32:1993;11646-11657.
    • (1993) Biochemistry , vol.32 , pp. 11646-11657
    • Fang, G.1    Cech, T.R.2
  • 23
    • 0029074362 scopus 로고
    • Duplex to quadruplex equilibrium of the self-complementary oligonucleotide d(GGGGCCCC)
    • Deng H., Braunlin W.H. Duplex to quadruplex equilibrium of the self-complementary oligonucleotide d(GGGGCCCC). Biopolymers. 35:1995;677-681.
    • (1995) Biopolymers , vol.35 , pp. 677-681
    • Deng, H.1    Braunlin, W.H.2
  • 24
    • 0028275836 scopus 로고
    • Structural polymorphism of telomere DNA: Interquadruplex and duplex-quadruplex conversions probed by Raman spectroscopy
    • Miura T., Thomas G.J. Jr. Structural polymorphism of telomere DNA: interquadruplex and duplex-quadruplex conversions probed by Raman spectroscopy. Biochemistry. 33:1994;7848-7856.
    • (1994) Biochemistry , vol.33 , pp. 7848-7856
    • Miura, T.1    Thomas G.J., Jr.2
  • 25
    • 0030765180 scopus 로고    scopus 로고
    • The SV40 large T-antigen helicase can unwind four-stranded DNA structures linked by G-quartets
    • Baran N.et al. The SV40 large T-antigen helicase can unwind four-stranded DNA structures linked by G-quartets. Nucleic Acids Res. 25:1997;297-303.
    • (1997) Nucleic Acids Res. , vol.25 , pp. 297-303
    • Baran, N.1
  • 26
    • 0032538453 scopus 로고    scopus 로고
    • The Bloom's syndrome helicase unwinds G4 DNA
    • Sun H.et al. The Bloom's syndrome helicase unwinds G4 DNA. J. Biol. Chem. 273:1998;27587-27592.
    • (1998) J. Biol. Chem. , vol.273 , pp. 27587-27592
    • Sun, H.1
  • 27
    • 0033135161 scopus 로고    scopus 로고
    • The Saccharomyces cerevisiae Sgs1 helicase efficiently unwinds G-G paired DNAs
    • Sun H.et al. The Saccharomyces cerevisiae Sgs1 helicase efficiently unwinds G-G paired DNAs. Nucleic Acids Res. 27:1999;1978-1984.
    • (1999) Nucleic Acids Res. , vol.27 , pp. 1978-1984
    • Sun, H.1
  • 29
    • 0033569847 scopus 로고    scopus 로고
    • G-strand overhangs on telomeres in telomerase-deficient mouse cells
    • Hemann M.T., Greider C.W. G-strand overhangs on telomeres in telomerase-deficient mouse cells. Nucleic Acids Res. 27:1999;3964-3969.
    • (1999) Nucleic Acids Res. , vol.27 , pp. 3964-3969
    • Hemann, M.T.1    Greider, C.W.2
  • 30
    • 0003893137 scopus 로고
    • E.H. Blackburn, & C.W. Greider. Cold Spring Harbor Press
    • Blackburn E.H., Greider C.W. Telomere. 1995;Cold Spring Harbor Press.
    • (1995) Telomere
  • 31
    • 0029563009 scopus 로고
    • Telomeres: Beginning to understand the end
    • Zakian V.A. Telomeres: beginning to understand the end. Science. 270:1995;1601-1607.
    • (1995) Science , vol.270 , pp. 1601-1607
    • Zakian, V.A.1
  • 32
    • 0027421043 scopus 로고
    • Loss of a yeast telomere: Arrest, recovery, and chromosome loss
    • Sandell L.L., Zakian V.A. Loss of a yeast telomere: arrest, recovery, and chromosome loss. Cell. 75:1993;729-739.
    • (1993) Cell , vol.75 , pp. 729-739
    • Sandell, L.L.1    Zakian, V.A.2
  • 33
    • 0023663911 scopus 로고
    • Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine-guanine base pairs
    • Henderson E.et al. Telomeric DNA oligonucleotides form novel intramolecular structures containing guanine-guanine base pairs. Cell. 51:1987;899-908.
    • (1987) Cell , vol.51 , pp. 899-908
    • Henderson, E.1
  • 34
    • 0027264711 scopus 로고
    • Triplex model of chromosome ends
    • Veselkov A.G.et al. Triplex model of chromosome ends. Nature. 364:1993;496.
    • (1993) Nature , vol.364 , pp. 496
    • Veselkov, A.G.1
  • 35
    • 0024843757 scopus 로고
    • Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loops
    • Sundquist W.I., Klug A. Telomeric DNA dimerizes by formation of guanine tetrads between hairpin loops. Nature. 342:1989;825-829.
    • (1989) Nature , vol.342 , pp. 825-829
    • Sundquist, W.I.1    Klug, A.2
  • 36
    • 0027509950 scopus 로고
    • Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase
    • Wellinger R.J.et al. Saccharomyces telomeres acquire single-strand TG1-3 tails late in S phase. Cell. 72:1993;51-60.
    • (1993) Cell , vol.72 , pp. 51-60
    • Wellinger, R.J.1
  • 37
    • 0029845892 scopus 로고    scopus 로고
    • Cdc13p: A single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance
    • Nugent C.I.et al. Cdc13p: a single-strand telomeric DNA-binding protein with a dual role in yeast telomere maintenance. Science. 274:1996;249-252.
    • (1996) Science , vol.274 , pp. 249-252
    • Nugent, C.I.1
  • 38
    • 0031800617 scopus 로고    scopus 로고
    • Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase
    • LaBranche H.et al. Telomere elongation by hnRNP A1 and a derivative that interacts with telomeric repeats and telomerase. Nat. Genet. 19:1998;199-202.
    • (1998) Nat. Genet. , vol.19 , pp. 199-202
    • Labranche, H.1
  • 39
    • 0033553536 scopus 로고    scopus 로고
    • Mammalian telomeres end in a large duplex loop
    • Griffith J.D.et al. Mammalian telomeres end in a large duplex loop. Cell. 97:1999;503-514.
    • (1999) Cell , vol.97 , pp. 503-514
    • Griffith, J.D.1
  • 40
    • 0030468992 scopus 로고    scopus 로고
    • Thermally induced DNA-RNA hybrid to G-quadruplex transitions: Possible implications for telomere synthesis by telomerase
    • Salazar M.et al. Thermally induced DNA-RNA hybrid to G-quadruplex transitions: possible implications for telomere synthesis by telomerase. Biochemistry. 35:1996;16110-16115.
    • (1996) Biochemistry , vol.35 , pp. 16110-16115
    • Salazar, M.1
  • 41
    • 0025877846 scopus 로고
    • Inhibition of telomerase by G-quartet DNA structures
    • Zahler A.M.et al. Inhibition of telomerase by G-quartet DNA structures. Nature. 350:1991;718-720.
    • (1991) Nature , vol.350 , pp. 718-720
    • Zahler, A.M.1
  • 42
    • 0030786928 scopus 로고    scopus 로고
    • Inhibition of human telomerase by a G-quadruplex-interactive compound
    • Sun D.et al. Inhibition of human telomerase by a G-quadruplex-interactive compound. J. Med. Chem. 40:1997;2113-2116.
    • (1997) J. Med. Chem. , vol.40 , pp. 2113-2116
    • Sun, D.1
  • 44
    • 0029670040 scopus 로고    scopus 로고
    • The chicken β-globin gene promoter forms a novel 'cinched' tetrahelical structure
    • Howell R.M.et al. The chicken β-globin gene promoter forms a novel 'cinched' tetrahelical structure. J. Biol. Chem. 271:1996;5208-5214.
    • (1996) J. Biol. Chem. , vol.271 , pp. 5208-5214
    • Howell, R.M.1
  • 45
    • 0026541582 scopus 로고
    • Retinoblastoma susceptibility genes contain 5′ sequences with a high propensity to form guanine-tetrad structures
    • Murchie A.I., Lilley D.M. Retinoblastoma susceptibility genes contain 5′ sequences with a high propensity to form guanine-tetrad structures. Nucleic Acids Res. 20:1992;49-53.
    • (1992) Nucleic Acids Res. , vol.20 , pp. 49-53
    • Murchie, A.I.1    Lilley, D.M.2
  • 46
    • 0032030327 scopus 로고    scopus 로고
    • DNA tetraplex formation in the control region of c-myc
    • Simonsson T.et al. DNA tetraplex formation in the control region of c-myc. Nucleic Acids Res. 26:1998;1167-1172.
    • (1998) Nucleic Acids Res. , vol.26 , pp. 1167-1172
    • Simonsson, T.1
  • 47
    • 0033556134 scopus 로고    scopus 로고
    • A DNA polymerase stop assay for G-quadruplex-interactive compounds
    • Han H.et al. A DNA polymerase stop assay for G-quadruplex-interactive compounds. Nucleic Acids Res. 27:1999;537-542.
    • (1999) Nucleic Acids Res. , vol.27 , pp. 537-542
    • Han, H.1
  • 48
    • 0032504020 scopus 로고    scopus 로고
    • Cation-regulated self-association of 'synapsable' DNA duplexes
    • Fahlman R.P., Sen D. Cation-regulated self-association of 'synapsable' DNA duplexes. J. Mol. Biol. 280:1998;237-244.
    • (1998) J. Mol. Biol. , vol.280 , pp. 237-244
    • Fahlman, R.P.1    Sen, D.2
  • 49
    • 0026599251 scopus 로고
    • Interstitial telomeres are hotspots for illegitimate recombination with DNA molecules injected into the macronucleus of Paramecium primaurelia
    • Katinka M.D., Bourgain F.M. Interstitial telomeres are hotspots for illegitimate recombination with DNA molecules injected into the macronucleus of Paramecium primaurelia. EMBO J. 11:1992;725-732.
    • (1992) EMBO J. , vol.11 , pp. 725-732
    • Katinka, M.D.1    Bourgain, F.M.2
  • 50
    • 0027407146 scopus 로고
    • A 'hot spot' of recombination coincides with an interstitial telomeric sequence in the Armenian hamster
    • Ashley T., Ward D.C. A 'hot spot' of recombination coincides with an interstitial telomeric sequence in the Armenian hamster. Cytogenet. Cell Genet. 62:1993;169-171.
    • (1993) Cytogenet. Cell Genet. , vol.62 , pp. 169-171
    • Ashley, T.1    Ward, D.C.2
  • 51
    • 0029584496 scopus 로고
    • Trinucleotide repeat expansion and human disease
    • Ashley C.T. Jr., Warren S.T Trinucleotide repeat expansion and human disease. Annu. Rev. Genet. 29:1995;703-728.
    • (1995) Annu. Rev. Genet. , vol.29 , pp. 703-728
    • Ashley C.T., Jr.1    Warren, S.T.2
  • 52
    • 0030671246 scopus 로고    scopus 로고
    • Preclinical and clinical strategies for development of telomerase and telomere inhibitors
    • Sharma S.et al. Preclinical and clinical strategies for development of telomerase and telomere inhibitors. Ann. Oncol. 8:1997;1063-1074.
    • (1997) Ann. Oncol. , vol.8 , pp. 1063-1074
    • Sharma, S.1
  • 53
    • 0031760366 scopus 로고    scopus 로고
    • Telomeres and telomerase: Targets for cancer chemotherapy?
    • Perry P.J., Kelland L.R. Telomeres and telomerase: targets for cancer chemotherapy? Exp. Opin. Ther. Patents. 8:1998;1567-1586.
    • (1998) Exp. Opin. Ther. Patents , vol.8 , pp. 1567-1586
    • Perry, P.J.1    Kelland, L.R.2
  • 54
    • 0026776299 scopus 로고
    • Anthracene-9,10-diones as potential anticancer agents. Synthesis, DNA-binding, and biological studies on a series of 2,6-disubstituted derivatives
    • Agbandje M.et al. Anthracene-9,10-diones as potential anticancer agents. Synthesis, DNA-binding, and biological studies on a series of 2,6-disubstituted derivatives. J. Med. Chem. 35:1992;1418-1429.
    • (1992) J. Med. Chem. , vol.35 , pp. 1418-1429
    • Agbandje, M.1
  • 55
    • 0029821295 scopus 로고    scopus 로고
    • Molecular anchoring of duplex and triplex DNA by disubstituted anthracene-9,10-diones: Calorimetric, UV melting, and competition dialysis studies
    • Haq I.et al. Molecular anchoring of duplex and triplex DNA by disubstituted anthracene-9,10-diones: calorimetric, UV melting, and competition dialysis studies. J. Am. Chem. Soc. 118:1996;10693-10701.
    • (1996) J. Am. Chem. Soc. , vol.118 , pp. 10693-10701
    • Haq, I.1
  • 56
    • 0026465344 scopus 로고
    • Substituent position dictates the intercalative DNA-binding mode for anthracene-9,10-dione antitumor drugs
    • Tanious F.A.et al. Substituent position dictates the intercalative DNA-binding mode for anthracene-9,10-dione antitumor drugs. Biochemistry. 31:1992;11632-11640.
    • (1992) Biochemistry , vol.31 , pp. 11632-11640
    • Tanious, F.A.1
  • 57
    • 0030174907 scopus 로고    scopus 로고
    • Photodynamic therapy: A promising new modality for the treatment of cancer
    • Schuitmaker J.J.et al. Photodynamic therapy: a promising new modality for the treatment of cancer. J. Photochem. Photobiol. B. 34:1996;3-12.
    • (1996) J. Photochem. Photobiol. B. , vol.34 , pp. 3-12
    • Schuitmaker, J.J.1
  • 59
    • 0032495774 scopus 로고    scopus 로고
    • Cationic porphyrins as telomerase inhibitors: The interaction of tetra-(N-methyl-4-pyridyl)porphine with quadruplex DNA
    • Wheelhouse R.T.et al. Cationic porphyrins as telomerase inhibitors: the interaction of tetra-(N-methyl-4-pyridyl)porphine with quadruplex DNA. J. Am. Chem. Soc. 120:1998;3261-3262.
    • (1998) J. Am. Chem. Soc. , vol.120 , pp. 3261-3262
    • Wheelhouse, R.T.1
  • 60
    • 0033594341 scopus 로고    scopus 로고
    • Interaction of TMPyP4 and TMPyP2 with quadruplex DNA. Structural basis for the differential effects on telomerase inhibition
    • Han F.X.et al. Interaction of TMPyP4 and TMPyP2 with quadruplex DNA. Structural basis for the differential effects on telomerase inhibition. J. Am. Chem. Soc. 121:1999;3561-3570.
    • (1999) J. Am. Chem. Soc. , vol.121 , pp. 3561-3570
    • Han, F.X.1
  • 61
    • 0033541133 scopus 로고    scopus 로고
    • Intercalative G-tetraplex stabilization of telomeric DNA by a cationic porphyrin
    • Haq I.et al. Intercalative G-tetraplex stabilization of telomeric DNA by a cationic porphyrin. J. Am. Chem. Soc. 121:1999;1768-1779.
    • (1999) J. Am. Chem. Soc. , vol.121 , pp. 1768-1779
    • Haq, I.1
  • 62
    • 0033083378 scopus 로고    scopus 로고
    • Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells
    • Izbicka E.et al. Effects of cationic porphyrins as G-quadruplex interactive agents in human tumor cells. Cancer Res. 59:1999;639-644.
    • (1999) Cancer Res. , vol.59 , pp. 639-644
    • Izbicka, E.1
  • 63
    • 0032742766 scopus 로고    scopus 로고
    • Telomere-interactive agents affect proliferation rates and induce chromosomal destabilization in sea urchin embryos
    • Izbicka E.et al. Telomere-interactive agents affect proliferation rates and induce chromosomal destabilization in sea urchin embryos. Anti-Cancer Drug Des. 14:1999;355-365.
    • (1999) Anti-Cancer Drug Des. , vol.14 , pp. 355-365
    • Izbicka, E.1
  • 64
    • 0032529641 scopus 로고    scopus 로고
    • Fluorescent dyes specific for quadruplex DNA
    • Arthanari H.et al. Fluorescent dyes specific for quadruplex DNA. Nucleic Acids Res. 26:1998;3724-3728.
    • (1998) Nucleic Acids Res. , vol.26 , pp. 3724-3728
    • Arthanari, H.1
  • 65
    • 0029945146 scopus 로고    scopus 로고
    • Recognition of anionic porphyrins by DNA aptamers
    • Li Y.et al. Recognition of anionic porphyrins by DNA aptamers. Biochemistry. 35:1996;6911-6922.
    • (1996) Biochemistry , vol.35 , pp. 6911-6922
    • Li, Y.1
  • 66
    • 0029744121 scopus 로고    scopus 로고
    • Molecular similarity based on DOCK-generated fingerprints
    • Briem H., Kuntz I.D. Molecular similarity based on DOCK-generated fingerprints. J. Med. Chem. 39:1996;3401-3408.
    • (1996) J. Med. Chem. , vol.39 , pp. 3401-3408
    • Briem, H.1    Kuntz, I.D.2
  • 67
    • 0032497405 scopus 로고    scopus 로고
    • NMR-based model of a telomerase-inhibiting compound bound to G-quadruplex DNA
    • Fedoroff O.et al. NMR-based model of a telomerase-inhibiting compound bound to G-quadruplex DNA. Biochemistry. 37:1998;12367-12374.
    • (1998) Biochemistry , vol.37 , pp. 12367-12374
    • Fedoroff, O.1
  • 68
    • 0039129145 scopus 로고    scopus 로고
    • Accelerated assembly of G-quadruplex structures by a small molecule
    • Han H.et al. Accelerated assembly of G-quadruplex structures by a small molecule. Biochemistry. 38:1999;6981-6986.
    • (1999) Biochemistry , vol.38 , pp. 6981-6986
    • Han, H.1
  • 69
    • 0033548147 scopus 로고    scopus 로고
    • DNA molecules can drive the assembly of other DNA molecules into specific four-stranded structures
    • Marco-Haviv Y.et al. DNA molecules can drive the assembly of other DNA molecules into specific four-stranded structures. J. Mol. Biol. 286:1999;45-56.
    • (1999) J. Mol. Biol. , vol.286 , pp. 45-56
    • Marco-Haviv, Y.1
  • 70
    • 0026608237 scopus 로고
    • Interaction of the dye ethidium bromide with DNA containing guanine repeats
    • Guo Q.et al. Interaction of the dye ethidium bromide with DNA containing guanine repeats. Biochemistry. 31:1992;2451-2455.
    • (1992) Biochemistry , vol.31 , pp. 2451-2455
    • Guo, Q.1
  • 71
    • 0033566092 scopus 로고    scopus 로고
    • 2,7-Disubstituted amidofluorenone derivatives as inhibitors of human telomerase
    • Perry P.J.et al. 2,7-Disubstituted amidofluorenone derivatives as inhibitors of human telomerase. J. Med. Chem. 42:1999;2679-2684.
    • (1999) J. Med. Chem. , vol.42 , pp. 2679-2684
    • Perry, P.J.1
  • 72
    • 0033530113 scopus 로고    scopus 로고
    • Human telomerase inhibition by substituted acridine derivatives
    • Harrison R.J.et al. Human telomerase inhibition by substituted acridine derivatives. Bioorg. Med. Chem. Lett. 9:1999;2463-2468.
    • (1999) Bioorg. Med. Chem. Lett. , vol.9 , pp. 2463-2468
    • Harrison, R.J.1
  • 73
    • 0029978893 scopus 로고    scopus 로고
    • Spectroscopic recognition of guanine dimeric hairpin quadruplexes by a carbocyanine dye
    • Chen Q.et al. Spectroscopic recognition of guanine dimeric hairpin quadruplexes by a carbocyanine dye. Proc. Natl. Acad. Sci. U. S. A. 93:1996;2635-2639.
    • (1996) Proc. Natl. Acad. Sci. U. S. A. , vol.93 , pp. 2635-2639
    • Chen, Q.1
  • 74
    • 0031605324 scopus 로고    scopus 로고
    • Stability and structure of model DNA triplexes and quadruplexes and their interactions with small ligands
    • Shafer R.H. Stability and structure of model DNA triplexes and quadruplexes and their interactions with small ligands. Prog. Nucleic Acid Res. Mol. Biol. 59:1998;55-94.
    • (1998) Prog. Nucleic Acid Res. Mol. Biol. , vol.59 , pp. 55-94
    • Shafer, R.H.1
  • 75
    • 0033566150 scopus 로고    scopus 로고
    • Ecteinascidin 743: A minor groove alkylator that bends DNA toward the major groove
    • Zewail-Foote M., Hurley L.H. Ecteinascidin 743: a minor groove alkylator that bends DNA toward the major groove. J. Med. Chem. 42:1999;2493-2497.
    • (1999) J. Med. Chem. , vol.42 , pp. 2493-2497
    • Zewail-Foote, M.1    Hurley, L.H.2
  • 76
    • 0024463685 scopus 로고
    • DNA and associated targets for drug design
    • Hurley L.H. DNA and associated targets for drug design. J. Med. Chem. 32:1989;2027-2033.
    • (1989) J. Med. Chem. , vol.32 , pp. 2027-2033
    • Hurley, L.H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.