Discovery of orteronel (TAK-700), a naphthylmethylimidazole derivative, as a highly selective 17,20-lyase inhibitor with potential utility in the treatment of prostate cancer

Bioorganic and Medicinal Chemistry

Volumn 19, Issue 21, 2011, Pages 6383-6399

  Kaku, Tomohiro ^a   Hitaka, Takenori ^a   Ojida, Akio ^a,b   Matsunaga, Nobuyuki ^a   Adachi, Mari ^a   Tanaka, Toshimasa ^a   Hara, Takahito ^a   Yamaoka, Masuo ^a   Kusaka, Masami ^a   Okuda, Teruaki ^a   Asahi, Satoru ^a   Furuya, Shuichi ^a   Tasaka, Akihiro ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

^b KYUSHU UNIVERSITY   (Japan)

Author keywords

17,20 Lyase; Orteronel; Prostate cancer; TAK 700

Indexed keywords

CYTOCHROME P450 3A4; ORTERONEL; PRASTERONE; STEROID 11BETA MONOOXYGENASE; STEROID 17,20 LYASE; TESTOSTERONE;

ANIMAL EXPERIMENT; ARTICLE; ASYMMETRIC SYNTHESIS; CASTRATION RESISTANT PROSTATE CANCER; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG DESIGN; DRUG IDENTIFICATION; DRUG POTENCY; DRUG RESEARCH; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SPECIFICITY; HAPLORHINI; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALE; MOLECULAR DOCKING; NONHUMAN; PHASE 3 CLINICAL TRIAL; PROSTATE CANCER; RACEMIC MIXTURE; RAT; REACTION ANALYSIS; STRUCTURAL HOMOLOGY; STRUCTURE ACTIVITY RELATION; TESTOSTERONE BLOOD LEVEL; X RAY CRYSTALLOGRAPHY;

EID: 84856780403     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.08.066     Document Type: Article

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