메뉴 건너뛰기




Volumn 8, Issue 5, 2009, Pages 731-735

Epithelial ovarian cancer: Focus on genetics and animal models

Author keywords

Epithelial ovarian cancer; Genetically modified animal models; Ovarian epithelial cells; Review; Tumorigenesis

Indexed keywords

ABC TRANSPORTER; B RAF KINASE; K RAS PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P53; RETINOBLASTOMA PROTEIN;

EID: 62449340297     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.8.5.7848     Document Type: Review
Times cited : (29)

References (44)
  • 2
    • 0035123775 scopus 로고    scopus 로고
    • Precursor lesions of ovarian epithelial malignancy
    • Feeley KM, Wells M. Precursor lesions of ovarian epithelial malignancy. Histopathology 2001; 38:87-95.
    • (2001) Histopathology , vol.38 , pp. 87-95
    • Feeley, K.M.1    Wells, M.2
  • 4
    • 0020305237 scopus 로고
    • Long-term follow-up and prognostic factors in ovarian carcinoma. The radiumhemmet series 1958 to 1973
    • Bjorkholm E, Pettersson F, Einhorn N, Krebs I, Nilsson B, Tjernberg B. Long-term follow-up and prognostic factors in ovarian carcinoma. The radiumhemmet series 1958 to 1973. Acta Radiol Oncol 1982; 21:413-9.
    • (1982) Acta Radiol Oncol , vol.21 , pp. 413-419
    • Bjorkholm, E.1    Pettersson, F.2    Einhorn, N.3    Krebs, I.4    Nilsson, B.5    Tjernberg, B.6
  • 5
    • 0027473723 scopus 로고
    • Treatment results and prognostic factors in a population-based study of epithelial ovarian cancer
    • Hogberg T, Carstensen J, Simonsen E. Treatment results and prognostic factors in a population-based study of epithelial ovarian cancer. Gynecol Oncol 1993; 48:38-49.
    • (1993) Gynecol Oncol , vol.48 , pp. 38-49
    • Hogberg, T.1    Carstensen, J.2    Simonsen, E.3
  • 6
    • 0020079565 scopus 로고
    • Importance of histologic grading in the prognosis of epithelial ovarian carcinoma
    • Sorbe B, Frankendal B, Veress B. Importance of histologic grading in the prognosis of epithelial ovarian carcinoma. Obstet Gynecol 1982; 59:576-82.
    • (1982) Obstet Gynecol , vol.59 , pp. 576-582
    • Sorbe, B.1    Frankendal, B.2    Veress, B.3
  • 7
    • 0036463478 scopus 로고    scopus 로고
    • Of mice and women
    • Foulkes WD. Of mice and women. Cancer Cell 2002; 1:11-2.
    • (2002) Cancer Cell , vol.1 , pp. 11-12
    • Foulkes, W.D.1
  • 9
    • 0037444396 scopus 로고    scopus 로고
    • Female mice chimeric for expression of the simian virus 40 TAg under control of the MISIIR promoter develop epithelial ovarian cancer
    • Connolly DC, Bao R, Nikitin AY, Stephens KC, Poole TW, Hua X, et al. Female mice chimeric for expression of the simian virus 40 TAg under control of the MISIIR promoter develop epithelial ovarian cancer. Cancer Res 2003; 63:1389-97.
    • (2003) Cancer Res , vol.63 , pp. 1389-1397
    • Connolly, D.C.1    Bao, R.2    Nikitin, A.Y.3    Stephens, K.C.4    Poole, T.W.5    Hua, X.6
  • 10
    • 1942469352 scopus 로고    scopus 로고
    • Ovarian tumorigenesis: A proposed model based on morphological and molecular genetic analysis
    • Shih Ie M, Kurman RJ. Ovarian tumorigenesis: a proposed model based on morphological and molecular genetic analysis. Am J Pathol 2004; 164:1511-8.
    • (2004) Am J Pathol , vol.164 , pp. 1511-1518
    • Shih, I.M.1    Kurman, R.J.2
  • 11
    • 0037454224 scopus 로고    scopus 로고
    • Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma
    • Singer G, Oldt R, 3rd, Cohen Y, Wang BG, Sidransky D, Kurman RJ, et al. Mutations in BRAF and KRAS characterize the development of low-grade ovarian serous carcinoma. J Natl Cancer Inst 2003; 95:484-6.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 484-486
    • Singer, G.1    Oldt 3rd, R.2    Cohen, Y.3    Wang, B.G.4    Sidransky, D.5    Kurman, R.J.6
  • 12
    • 39749171410 scopus 로고    scopus 로고
    • Early events in the pathogenesis of epithelial ovarian cancer
    • Landen CN Jr, Birrer MJ, Sood AK. Early events in the pathogenesis of epithelial ovarian cancer. J Clin Oncol 2008; 26:995-1005.
    • (2008) J Clin Oncol , vol.26 , pp. 995-1005
    • Landen Jr, C.N.1    Birrer, M.J.2    Sood, A.K.3
  • 14
    • 0037342612 scopus 로고    scopus 로고
    • p53 mutations and overexpression affect prognosis of ovarian endometrioid cancer but not clear cell cancer
    • Okuda T, Otsuka J, Sekizawa A, Saito H, Makino R, Kushima M, et al. p53 mutations and overexpression affect prognosis of ovarian endometrioid cancer but not clear cell cancer. Gynecol Oncol 2003; 88:318-25.
    • (2003) Gynecol Oncol , vol.88 , pp. 318-325
    • Okuda, T.1    Otsuka, J.2    Sekizawa, A.3    Saito, H.4    Makino, R.5    Kushima, M.6
  • 15
    • 21644471594 scopus 로고    scopus 로고
    • Clinical and biological characteristics of clear cell carcinomas of the ovary in FIGO stages I-II
    • Skirnisdottir I, Seidal T, Karlsson MG, Sorbe B. Clinical and biological characteristics of clear cell carcinomas of the ovary in FIGO stages I-II. Int J Oncol 2005; 26:177-83.
    • (2005) Int J Oncol , vol.26 , pp. 177-183
    • Skirnisdottir, I.1    Seidal, T.2    Karlsson, M.G.3    Sorbe, B.4
  • 16
    • 0032523808 scopus 로고    scopus 로고
    • Frequent PTEN/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors
    • Obata K, Morland SJ, Watson RH, Hitchcock A, Chenevix-Trench G, Thomas EJ, et al. Frequent PTEN/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors. Cancer Res 1998; 58:2095-7.
    • (1998) Cancer Res , vol.58 , pp. 2095-2097
    • Obata, K.1    Morland, S.J.2    Watson, R.H.3    Hitchcock, A.4    Chenevix-Trench, G.5    Thomas, E.J.6
  • 17
    • 0034671218 scopus 로고    scopus 로고
    • Loss of heterozygosity on 10q23.3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: Possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clear cell carcinoma of the ovary
    • Sato N, Tsunoda H, Nishida M, Morishita Y, Takimoto Y, Kubo T, et al. Loss of heterozygosity on 10q23.3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clear cell carcinoma of the ovary. Cancer Res 2000; 60:7052-6.
    • (2000) Cancer Res , vol.60 , pp. 7052-7056
    • Sato, N.1    Tsunoda, H.2    Nishida, M.3    Morishita, Y.4    Takimoto, Y.5    Kubo, T.6
  • 18
    • 0034993763 scopus 로고    scopus 로고
    • beta-Catenin expression pattern, beta-catenin gene mutations, and microsatellite instability in endometrioid ovarian carcinomas and synchronous endometrial carcinomas
    • Moreno-Bueno G, Gamallo C, Perez-Gallego L, de Mora JC, Suarez A, Palacios J. beta-Catenin expression pattern, beta-catenin gene mutations, and microsatellite instability in endometrioid ovarian carcinomas and synchronous endometrial carcinomas. Diagn Mol Pathol 2001; 10:116-22.
    • (2001) Diagn Mol Pathol , vol.10 , pp. 116-122
    • Moreno-Bueno, G.1    Gamallo, C.2    Perez-Gallego, L.3    de Mora, J.C.4    Suarez, A.5    Palacios, J.6
  • 19
    • 0032998271 scopus 로고    scopus 로고
    • Mutational analysis of beta-catenin gene in Japanese ovarian carcinomas: Frequent mutations in endometrioid carcinomas
    • Sagae S, Kobayashi K, Nishioka Y, Sugimura M, Ishioka S, Nagata M, et al. Mutational analysis of beta-catenin gene in Japanese ovarian carcinomas: frequent mutations in endometrioid carcinomas. Jpn J Cancer Res 1999; 90:510-5.
    • (1999) Jpn J Cancer Res , vol.90 , pp. 510-515
    • Sagae, S.1    Kobayashi, K.2    Nishioka, Y.3    Sugimura, M.4    Ishioka, S.5    Nagata, M.6
  • 20
    • 0033609680 scopus 로고    scopus 로고
    • beta-catenin mutation and expression analysis in ovarian cancer: Exon 3 mutations and nuclear translocation in 16% of endometrioid tumours
    • Wright K, Wilson P, Morland S, Campbell I, Walsh M, Hurst T, et al. beta-catenin mutation and expression analysis in ovarian cancer: exon 3 mutations and nuclear translocation in 16% of endometrioid tumours. Int J Cancer 1999; 82:625-9.
    • (1999) Int J Cancer , vol.82 , pp. 625-629
    • Wright, K.1    Wilson, P.2    Morland, S.3    Campbell, I.4    Walsh, M.5    Hurst, T.6
  • 21
    • 18344373769 scopus 로고    scopus 로고
    • Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract
    • Cheng W, Liu J, Yoshida H, Rosen D, Naora H. Lineage infidelity of epithelial ovarian cancers is controlled by HOX genes that specify regional identity in the reproductive tract. Nat Med 2005; 11:531-7.
    • (2005) Nat Med , vol.11 , pp. 531-537
    • Cheng, W.1    Liu, J.2    Yoshida, H.3    Rosen, D.4    Naora, H.5
  • 22
    • 0032523915 scopus 로고    scopus 로고
    • Abdominal B (AbdB) Hoxa genes: Regulation in adult uterus by estrogen and progesterone and repression in mullerian duct by the synthetic estrogen diethylstilbestrol (DES)
    • Ma L, Benson GV, Lim H, Dey SK, Maas RL. Abdominal B (AbdB) Hoxa genes: regulation in adult uterus by estrogen and progesterone and repression in mullerian duct by the synthetic estrogen diethylstilbestrol (DES). Dev Biol 1998; 197:141-54.
    • (1998) Dev Biol , vol.197 , pp. 141-154
    • Ma, L.1    Benson, G.V.2    Lim, H.3    Dey, S.K.4    Maas, R.L.5
  • 23
    • 0345348899 scopus 로고
    • Ovarian tumorigenesis
    • Jull JW. Ovarian tumorigenesis. Methods Cancer Res 1973; 3:131-86.
    • (1973) Methods Cancer Res , vol.3 , pp. 131-186
    • Jull, J.W.1
  • 25
    • 0019515502 scopus 로고
    • Transformation of cultured rat ovarian surface epithelial cells by Kirsten murine sarcoma virus
    • Adams AT, Auersperg N. Transformation of cultured rat ovarian surface epithelial cells by Kirsten murine sarcoma virus. Cancer Res 1981; 41:2063-72.
    • (1981) Cancer Res , vol.41 , pp. 2063-2072
    • Adams, A.T.1    Auersperg, N.2
  • 26
    • 0026587992 scopus 로고
    • Spontaneous transformation of rat ovarian surface epithelial cells: Association with cytogenetic changes and implications of repeated ovulation in the etiology of ovarian cancer
    • Godwin AK, Testa JR, Handel LM, Liu Z, Vanderveer LA, Tracey PA, et al. Spontaneous transformation of rat ovarian surface epithelial cells: association with cytogenetic changes and implications of repeated ovulation in the etiology of ovarian cancer. J Natl Cancer Inst 1992; 84:592-601.
    • (1992) J Natl Cancer Inst , vol.84 , pp. 592-601
    • Godwin, A.K.1    Testa, J.R.2    Handel, L.M.3    Liu, Z.4    Vanderveer, L.A.5    Tracey, P.A.6
  • 27
    • 0028261059 scopus 로고
    • Spontaneous transformation of rat ovarian surface epithelial cells results in well to poorly differentiated tumors with a parallel range of cytogenetic complexity
    • Testa JR, Getts LA, Salazar H, Liu Z, Handel LM, Godwin AK, et al. Spontaneous transformation of rat ovarian surface epithelial cells results in well to poorly differentiated tumors with a parallel range of cytogenetic complexity. Cancer Res 1994; 54:2778-84.
    • (1994) Cancer Res , vol.54 , pp. 2778-2784
    • Testa, J.R.1    Getts, L.A.2    Salazar, H.3    Liu, Z.4    Handel, L.M.5    Godwin, A.K.6
  • 29
    • 0031786853 scopus 로고    scopus 로고
    • Isolation and characterization of mouse ovarian surface epithelial cell lines
    • Kido M, Shibuya M. Isolation and characterization of mouse ovarian surface epithelial cell lines. Pathol Res Pract 1998; 194:725-30.
    • (1998) Pathol Res Pract , vol.194 , pp. 725-730
    • Kido, M.1    Shibuya, M.2
  • 30
  • 31
    • 0038756581 scopus 로고    scopus 로고
    • Induction of carcinogenesis by concurrent inactivation of p53 and Rb1 in the mouse ovarian surface epithelium
    • Flesken-Nikitin A, Choi KC, Eng JP, Shmidt EN, Nikitin AY. Induction of carcinogenesis by concurrent inactivation of p53 and Rb1 in the mouse ovarian surface epithelium. Cancer Res 2003; 63:3459-63.
    • (2003) Cancer Res , vol.63 , pp. 3459-3463
    • Flesken-Nikitin, A.1    Choi, K.C.2    Eng, J.P.3    Shmidt, E.N.4    Nikitin, A.Y.5
  • 32
    • 0033168562 scopus 로고    scopus 로고
    • The insulin-like growth factor 1 receptor induces transformation and tumorigenicity of ovarian mesothelial cells and downregulates their Fas-receptor expression
    • Coppola D, Saunders B, Fu L, Mao W, Nicosia SV. The insulin-like growth factor 1 receptor induces transformation and tumorigenicity of ovarian mesothelial cells and downregulates their Fas-receptor expression. Cancer Res 1999; 59:3264-70.
    • (1999) Cancer Res , vol.59 , pp. 3264-3270
    • Coppola, D.1    Saunders, B.2    Fu, L.3    Mao, W.4    Nicosia, S.V.5
  • 34
    • 0026808859 scopus 로고
    • Simian virus 40-transformed human ovarian surface epithelial cells escape normal growth controls but retain morphogenetic responses to extracellular matrix
    • Maines-Bandiera SL, Kruk PA, Auersperg N. Simian virus 40-transformed human ovarian surface epithelial cells escape normal growth controls but retain morphogenetic responses to extracellular matrix. Am J Obstet Gynecol 1992; 167:729-35.
    • (1992) Am J Obstet Gynecol , vol.167 , pp. 729-735
    • Maines-Bandiera, S.L.1    Kruk, P.A.2    Auersperg, N.3
  • 36
    • 34548637112 scopus 로고    scopus 로고
    • Disruption of nifA gene influences multiple cellular processes in Sinorhizobium meliloti
    • Gong Z, Zhu J, Yu G, Zou H. Disruption of nifA gene influences multiple cellular processes in Sinorhizobium meliloti. J Genet Genomics 2007; 34:783-9.
    • (2007) J Genet Genomics , vol.34 , pp. 783-789
    • Gong, Z.1    Zhu, J.2    Yu, G.3    Zou, H.4
  • 38
    • 33745686462 scopus 로고    scopus 로고
    • Disabled-2 heterozygous mice are predisposed to endometrial and ovarian tumorigenesis and exhibit sex-biased embryonic lethality in a p53-null background
    • Yang DH, Fazili Z, Smith ER, Cai KQ, Klein-Szanto A, Cohen C, et al. Disabled-2 heterozygous mice are predisposed to endometrial and ovarian tumorigenesis and exhibit sex-biased embryonic lethality in a p53-null background. Am J Pathol 2006; 169:258-67.
    • (2006) Am J Pathol , vol.169 , pp. 258-267
    • Yang, D.H.1    Fazili, Z.2    Smith, E.R.3    Cai, K.Q.4    Klein-Szanto, A.5    Cohen, C.6
  • 39
    • 0033587017 scopus 로고    scopus 로고
    • Disabled-2 inactivation is an early step in ovarian tumorigenicity
    • Fazili Z, Sun W, Mittelstaedt S, Cohen C, Xu XX. Disabled-2 inactivation is an early step in ovarian tumorigenicity. Oncogene 1999; 18:3104-13.
    • (1999) Oncogene , vol.18 , pp. 3104-3113
    • Fazili, Z.1    Sun, W.2    Mittelstaedt, S.3    Cohen, C.4    Xu, X.X.5
  • 40
    • 0032568219 scopus 로고    scopus 로고
    • Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2
    • Xu XX, Yi T, Tang B, Lambeth JD. Disabled-2 (Dab2) is an SH3 domain-binding partner of Grb2. Oncogene 1998; 16:1561-9.
    • (1998) Oncogene , vol.16 , pp. 1561-1569
    • Xu, X.X.1    Yi, T.2    Tang, B.3    Lambeth, J.D.4
  • 41
    • 13444269246 scopus 로고    scopus 로고
    • Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer
    • Dinulescu DM, Ince TA, Quade BJ, Shafer SA, Crowley D, Jacks T. Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer. Nat Med 2005; 11:63-70.
    • (2005) Nat Med , vol.11 , pp. 63-70
    • Dinulescu, D.M.1    Ince, T.A.2    Quade, B.J.3    Shafer, S.A.4    Crowley, D.5    Jacks, T.6
  • 42
    • 34047171574 scopus 로고    scopus 로고
    • Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways
    • Wu R, Hendrix-Lucas N, Kuick R, Zhai Y, Schwartz DR, Akyol A, et al. Mouse model of human ovarian endometrioid adenocarcinoma based on somatic defects in the Wnt/beta-catenin and PI3K/Pten signaling pathways. Cancer Cell 2007; 11:321-33.
    • (2007) Cancer Cell , vol.11 , pp. 321-333
    • Wu, R.1    Hendrix-Lucas, N.2    Kuick, R.3    Zhai, Y.4    Schwartz, D.R.5    Akyol, A.6
  • 44
    • 33645225423 scopus 로고    scopus 로고
    • The tubal fimbria is a preferred site for early adenocarcinoma in women with familial ovarian cancer syndrome
    • Medeiros F, Muto MG, Lee Y, Elvin JA, Callahan MJ, Feltmate C, et al. The tubal fimbria is a preferred site for early adenocarcinoma in women with familial ovarian cancer syndrome. Am J Surg Pathol 2006; 30:230-36.
    • (2006) Am J Surg Pathol , vol.30 , pp. 230-236
    • Medeiros, F.1    Muto, M.G.2    Lee, Y.3    Elvin, J.A.4    Callahan, M.J.5    Feltmate, C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.