Liquid antisolvent precipitation and stabilization of nanoparticles of poorly water soluble drugs in aqueous suspensions: Recent developments and future perspective

Chemical Engineering Journal

Volumn 181-182, Issue , 2012, Pages 1-34

  Thorat, Alpana A ^a   Dalvi, Sameer V ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY GANDHINAGAR   (India)

Author keywords

Antisolvent; Growth; Mixing; Nanoparticles; Nucleation; Poorly water soluble drugs; Precipitation; Stabilization; Supersaturation; Ultrasound

Indexed keywords

ANTI-SOLVENTS; AQUEOUS SUSPENSIONS; FUTURE PERSPECTIVES; LIQUID ANTISOLVENT; NON-SOLVENTS; PHARMACEUTICAL INGREDIENTS; POORLY WATER-SOLUBLE DRUGS; PRECIPITATION PROCESS; PROCESS INTENSIFICATION; RAPID MIXING; SOLVENT POWER; ULTRAFINE PARTICLE;

GROWTH (MATERIALS); INORGANIC COMPOUNDS; LIQUIDS; MIXING; NANOPARTICLES; NUCLEATION; POLYMERS; STABILIZATION; SUPERSATURATION; SURFACE ACTIVE AGENTS; SUSPENSIONS (FLUIDS); ULTRASONICS;

PRECIPITATION (CHEMICAL);

EID: 84856355692     PISSN: 13858947     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cej.2011.12.044     Document Type: Review

References (237)

1. Amidon G., Lennernas H., Shah V., Crison J. A theoretical basis for a biopharmaceutical drug classification: the correlation of in vitro drug product dissolution and in vivo bioavailability. Pharmceutical Research 1995, 12:413-420.
2. Lipper R.A. E pluribus product. Modern Drug Discovery 1999, 55-60.
3. Lipinski C.A. Drug-like properties and the causes of poor solubility and poor permeability. Journal of Pharmacological and Toxicological Methods 2000, 44:235-249.
4. Liversidge E., Liversidge G. Drug nanoparticles: formulating poorly water-soluble compounds. Toxicologic Pathology 2008, 36:43-48.
5. C.M.Keck, R.H.Muller Drug nanocrystals of poorly soluble drugs produced by high pressure homogenization. European Journal of Pharmaceutics and Biopharmaceutics 2006, 62:3-16.
6. Muller R.H., Akkar A. Drug nanocrystals of poorly soluble drugs. Encyclopedia of Nanoscience and Nanotechnology 2004, 627-638. American Scientific Valencia, CA. H.S.E. Nalwa (Ed.).
7. Patravale V.B., Date A.A., Kulkarni R.M. Nanosuspensions: a promising drug delivery strategy. Journal of Pharmacy and Pharmacology 2004, 56:827-840.
8. Shah P. Use of nanotechnologies for drug delivery. MRS Bulletin 2006, 31:894-899.
9. Wiedmann T.S., DeCastro L., Wood R.W. Nebulization of NanoCrystals™: production of a respirable solid-in-liquid-in-air colloidal dispersion. Pharmaceutical Research 1997, 14:112-116.
10. Ostrander K.D., Bosch H.W., Bondanza D.M. An in vitro assessment of a NanoCrystal™ beclomethasone dipropionate colloidal dispersion via ultrasonic nebulization. European Journal of Pharmaceutics and Biopharmaceutics 1999, 48:207-215.
11. Ali H.S.M., York P., Blagden N. Preparation of hydrocortisone nanosuspension through a bottom-up nanoprecipitation technique using microfluidic reactors. International Journal of Pharmaceutics 2009, 375:107-113.
12. Yang W., Johnston K.P., Williams Iii R.O. Comparison of bioavailability of amorphous versus crystalline itraconazole nanoparticles via pulmonary administration in rats. European Journal of Pharmaceutics and Biopharmaceutics 2010, 75:33-41.
13. Tam J.M., Engstrom J.D., Ferrer D., Williams R.O., Johnston K.P. Templated open flocs of anisotropic particles for pulmonary delivery with pressurized metered dose inhalers. Journal of Pharmaceutical Sciences 2010, 99:3150-3165.
14. Rabinow B.E. Nanosuspensions in drug delivery. Nature Reviews Drug Discovery 2004, 3:785-796.
15. Rasenack N., Müller B.W. Micron-size drug particles: common and novel micronization techniques. Pharmaceutical Development and Technology 2004, 9:1-13.
16. Chow A., Tong H., Chattopadhyay P., Shekunov B. Particle engineering for pulmonary drug delivery. Pharmaceutical Research 2007, 24:411-437.
17. Müller R.H., Jacobs C., Kayser O. Nanosuspensions as particulate drug formulations in therapy: rationale for development and what we can expect for the future. Advanced Drug Delivery Reviews 2001, 47:3-19.
18. Weers J.G., Tarara T.E., Clark A.R. Design of fine particles for pulmonary drug delivery. Expert Opinion on Drug Delivery 2007, 4:297-313.
19. Vehring R. Pharmaceutical particle engineering via spray drying. Pharmaceutical Research 2008, 25:999-1022.
20. Dickinson P.A., Howells S.W., Kellaway I.W. Novel nanoparticles for pulmonary drug administration. Journal of Drug Targeting 2001, 9:295-302.
21. Chen X., Young T.J., Sarkari M., Williams R.O., Johnston K.P. Preparation of cyclosporine A nanoparticles by evaporative precipitation into aqueous solution. International Journal of Pharmaceutics 2002, 242:3-14.
22. Foster T.P., Leatherman M.W. Powder characteristics of proteins spray-dried from different spray-dryers. Drug Development and Industrial Pharmacy 1995, 21:1705-1723.
23. Rogers T.L., Nelsen A.C., Hu J., Brown J.N., Sarkari M., Young T.J., Johnston K.P., Williams R.O. A novel particle engineering technology to enhance dissolution of poorly water soluble drugs: spray-freezing into liquid. European Journal of Pharmaceutics and Biopharmaceutics 2002, 54:271-280.
24. Kompella U.B. Drug delivery applications of supercritical fluid technology. IDrugs 1999, 2:33-34.
25. Kawashima Y., York P. Drug delivery applications of supercritical fluid technology. Advanced Drug Delivery Reviews 2008, 60:297-298.
26. Mullin J.W., Nývlt J. Programmed cooling of batch crystallizers. Chemical Engineering Science 1971, 26:369-377.
27. Jones A.G., Mullin J.W. Programmed cooling crystallization of potassium sulphate solutions. Chemical Engineering Science 1974, 29:105-118.
28. Dirksen J.A., Ring T.A. Fundamentals of crystallization: kinetic effects on particle size distributions and morphology. Chemical Engineering Science 1991, 46:2389-2427.
29. Sugimoto T. Formation of monodispersed nano- and micro-particles controlled in size, shape, and internal structure. Chemical Engineering & Technology 2003, 26:313-321.
30. Cushing B.L., Kolesnichenko V.L., O'Connor C.J. Recent advances in the liquid-phase syntheses of inorganic nanoparticles. Chemical Reviews 2004, 104:3893-3946.
31. Söhnel O., Garside J. Precipitation: Basic Principles and Industrial Applications 1992, Butterworth-Heinemann.
32. Johnson B.K. Flash Nanoprecipitation of Organic Actives via Confined Micromixing and Block Copolymer Stabilization 2003, Princeton University.
33. LaMer V.K., Dinegar R.H. Theory, production and mechanism of formation of monodispersed hydrosols. Journal of the American Chemical Society 1950, 72:4847-4854.
34. Guo Z., Zhang M., Li H., Wang J., Kougoulos E. Effect of ultrasound on anti-solvent crystallization process. Journal of Crystal Growth 2005, 273:555-563.
35. Matteucci M.E., Hotze M.A., Johnston K.P., Williams R.O. Drug nanoparticles by antisolvent precipitation: mixing energy versus surfactant stabilization. Langmuir 2006, 22:8951-8959.
36. Dalvi S.V., Dave R.N. Analysis of nucleation kinetics of poorly water-soluble drugs in presence of ultrasound and hydroxypropyl methyl cellulose during antisolvent precipitation. International Journal of Pharmaceutics 2010, 387:172-179.
37. Granberg R.A., Ducreux C., Gracin S., Rasmuson å.C. Primary nucleation of paracetamol in acetone-water mixtures. Chemical Engineering Science 2001, 56:2305-2313.
38. Dixit N.M., Zukoski C.F. Nucleation rates and induction times during colloidal crystallization: links between models and experiments. Physical Review E 2002, 66:051602.
39. Lyczko N., Espitalier F., Louisnard O., Schwartzentruber J. Effect of ultrasound on the induction time and the metastable zone widths of potassium sulphate. Chemical Engineering Journal 2002, 86:233-241.
40. Barrett P., Glennon B. Characterizing the metastable zone width and solubility curve using Lasentec FBRM and PVM. Chemical Engineering Research and Design 2002, 80:799-805.
41. Omar W., Mohnicke M., Ulrich J. Determination of the solid liquid interfacial energy and thereby the critical nucleus size of paracetamol in different solvents. Crystal Research and Technology 2006, 41:337-343.
42. Schöll J., Lindenberg C., Vicum L., Mazzotti M., Brozio J. Antisolvent precipitation of PDI 747: kinetics of particle formation and growth. Crystal Growth & Design 2007, 7:1653-1661.
43. Lindenberg C., Mazzotti M. Effect of temperature on the nucleation kinetics of [alpha] l-glutamic acid. Journal of Crystal Growth 2009, 311:1178-1184.
44. Kelly R.C., Rodrίguez-Hornedo N. Solvent effects on the crystallization and preferential nucleation of carbamazepine anhydrous polymorphs: a molecular recognition perspective. Organic Process Research & Development 2009, 13:1291-1300.
45. Mahajan A., Kirwan D. Rapid precipitation of biochemicals. Journal of Physics D: Applied Physics 1993, 26:176-180.
46. Kim K.-J., Mersmann A. Estimation of metastable zone width in different nucleation processes. Chemical Engineering Science 2001, 56:2315-2324.
47. Chen J.-F., Wang Y.-H., Guo F., Wang X.-M., Zheng C. Synthesis of nanoparticles with novel technology: high-gravity reactive precipitation. Industrial & Engineering Chemistry Research 2000, 39:948-954.
48. Dalvi S.V., Dave R.N. Controlling particle size of a poorly water-soluble drug using ultrasound and stabilizers in antisolvent precipitation. Industrial & Engineering Chemistry Research 2009, 48:7581-7593.
49. Thybo P., Hovgaard L., Lindeløv J., Brask A., Andersen S. Scaling up the spray drying process from pilot to production scale using an atomized droplet size criterion. Pharmaceutical Research 2008, 25:1610-1620.
50. Sun Y.P. Supercritical Fluid Technology in Materials Science and Engineering: Syntheses, Properties, and Applications 2002, Marcel Dekker.
51. Jones A.G. Crystallization Process Systems 2002, Butterworth-Heinemann, Oxford, Boston.
52. Lince F., Marchisio D.L., Barresi A.A. Strategies to control the particle size distribution of poly-[epsilon]-caprolactone nanoparticles for pharmaceutical applications. Journal of Colloid and Interface Science 2008, 322:505-515.
53. Johnson B.K., Prud'homme R.K. Chemical processing and micromixing in confined impinging jets. AIChE Journal 2003, 49:2264-2282.
54. Johnson B.K., Prud'homme R.K. Flash nanoprecipitation of organic actives and block copolymers using a confined impinging jets mixer. Australian Journal of Chemistry 2003, 56:1021-1024.
55. Gradl J., Schwarzer H.-C., Schwertfirm F., Manhart M., Peukert W. Precipitation of nanoparticles in a T-mixer: coupling the particle population dynamics with hydrodynamics through direct numerical simulation. Chemical Engineering and Processing 2006, 45:908-916.
56. Yu Shekunov B., Baldyga J., York P. Particle formation by mixing with supercritical antisolvent at high Reynolds numbers. Chemical Engineering Science 2001, 56:2421-2433.
57. Baldyga J., Bourne J.R., Hearn S.J. Interaction between chemical reactions and mixing on various scales. Chemical Engineering Science 1997, 52:457-466.
58. Muntó M., Sala S., Cano M., Gimeno M., Ventosa N., Veciana J. New technologies for the preparation of micro- and nanostructured materials with potential applications in drug delivery and clinical diagnostics. Contributions to Science 2005, 3:11-18.
59. Zhao H., Wang J.-X., Wang Q.-A., Chen J.-F., Yun J. Controlled liquid antisolvent precipitation of hydrophobic pharmaceutical nanoparticles in a microchannel reactor. Industrial & Engineering Chemistry Research 2007, 46:8229-8235.
60. Beck C., Dalvi S.V., Dave R.N. Controlled liquid antisolvent precipitation using a rapid mixing device. Chemical Engineering Science 2010, 65:5669-5675.
61. Gassmann P., List M., Schweitzer A., Sucker H. Hydrosols: alternatives for the parenteral application of poorly water soluble drugs. European Journal of Pharmaceutics and Biopharmaceutics 1994, 40:64-72.
62. Douroumis D., Fahr A. Nano- and micro-particulate formulations of poorly water-soluble drugs by using a novel optimized technique. European Journal of Pharmaceutics and Biopharmaceutics 2006, 63:173-175.
63. Douroumis D., Scheler S., Fahr A. Using a modified shepards method for optimization of a nanoparticulate cyclosporine a formulation prepared by a static mixer technique. Journal of Pharmaceutical Sciences 2008, 97:919-930.
64. Dong Y., Ng W.K., Hu J., Shen S., Tan R.B.H. A continuous and highly effective static mixing process for antisolvent precipitation of nanoparticles of poorly water-soluble drugs. International Journal of Pharmaceutics 2010, 386:256-261.
65. Hu J., Ng W.K., Dong Y., Shen S., Tan R.B.H. Continuous and scalable process for water-redispersible nanoformulation of poorly aqueous soluble APIs by antisolvent precipitation and spray-drying. International Journal of Pharmaceutics 2011, 404:198-204.
66. Hu T., Chiou H., Chan H.-K., Chen J.-F., Yun J. Preparation of inhalable salbutamol sulphate using reactive high gravity controlled precipitation. Journal of Pharmaceutical Sciences 2008, 97:944-949.
67. Zhao H., Wang J., Zhang H., Shen Z., Yun J., Chen J. Facile preparation of danazol nanoparticles by high-gravity anti-solvent precipitation (HGAP) method. Chinese Journal of Chemical Engineering 2009, 17:318-323.
68. Chiou H., Li L., Hu T., Chan H.-K., Chen J.-F., Yun J. Production of salbutamol sulfate for inhalation by high-gravity controlled antisolvent precipitation. International Journal of Pharmaceutics 2007, 331:93-98.
69. Zhong J., Shen Z., Yang Y., Chen J. Preparation and characterization of uniform nanosized cephradine by combination of reactive precipitation and liquid anti-solvent precipitation under high gravity environment. International Journal of Pharmaceutics 2005, 301:286-293.
70. Chen J.-F., Zhang J.-Y., Shen Z.-G., Zhong J., Yun J. Preparation and characterization of amorphous cefuroxime axetil drug nanoparticles with novel technology: high-gravity antisolvent precipitation. Industrial & Engineering Chemistry Research 2006, 45:8723-8727.
71. Mahajan A.J., Kirwan D.J. Micromixing effects in a two-impinging-jets precipitator. AIChE Journal 1996, 42:1801-1814.
72. Chiou H., Chan H.-K., Heng D., Prud'homme R.K., Raper J.A. A novel production method for inhalable cyclosporine A powders by confined liquid impinging jet precipitation. Journal of Aerosol Science 2008, 39:500-509.
73. Liu Y., Kathan K., Saad W., Prud'homme R.K. Ostwald ripening of beta-carotene nanoparticles. Physical Review Letters 2007, 98:036102.
74. Liu Y., Cheng C., Prud'homme R.K., Fox R.O. Mixing in a multi-inlet vortex mixer (MIVM) for flash nano-precipitation. Chemical Engineering Science 2008, 63:2829-2842.
75. Gindy M.E., Ji S., Hoye T.R., Panagiotopoulos A.Z., Prud'homme R.K. Preparation of poly(ethylene glycol) protected nanoparticles with variable bioconjugate ligand density. Biomacromolecules 2008, 9:2705-2711.
76. Gindy M.E., Panagiotopoulos A.Z., Prud'homme R.K. Composite block copolymer stabilized nanoparticles: simultaneous encapsulation of organic actives and inorganic nanostructures. Langmuir 2008, 24:83-90.
77. Kumar V., Hong S.Y., Maciag A.E., Saavedra J.E., Adamson D.H., Prud'homme R.K., Keefer L.K., Chakrapani H. Stabilization of the nitric oxide (NO) prodrugs and anticancer leads, PABA/NO and double JS-K, through incorporation into PEG-protected nanoparticles. Molecular Pharmaceutics 2009, 7:291-298.
78. Zhu Z., Margulis-Goshen K., Magdassi S., Talmon Y., Macosko C.W. Polyelectrolyte stabilized drug nanoparticles via flash nanoprecipitation: a model study with β-carotene. Journal of Pharmaceutical Sciences 2010, 99:4295-4306.
79. Cheng J.C., Olsen M.G., Fox R.O. A microscale multi-inlet vortex nanoprecipitation reactor: turbulence measurement and simulation. Applied Physics Letters 2009, 94:204104.
80. Ehrfeld W., Golbig K., Hessel V., Löwe H., Richter T. Characterization of mixing in micromixers by a test reaction: single mixing units and mixer arrays. Industrial & Engineering Chemistry Research 1999, 38:1075-1082.
81. Panagiotou T., Mesite S.V., Fisher R.J. Production of norfloxacin nanosuspensions using microfluidics reaction technology through solvent/antisolvent crystallization. Industrial & Engineering Chemistry Research 2009, 48:1761-1771.
82. Wang J.-X., Zhang Q.-X., Zhou Y., Shao L., Chen J.-F. Microfluidic synthesis of amorphous cefuroxime axetil nanoparticles with size-dependent and enhanced dissolution rate. Chemical Engineering Journal 2010, 162:844-851.
83. Zhang H.-X., Wang J.-X., Shao L., Chen J.-F. Microfluidic fabrication of monodispersed pharmaceutical colloidal spheres of atorvastatin calcium with tunable sizes. Industrial & Engineering Chemistry Research 2010, 49:4156-4161.
84. Wong S.H., Ward M.C.L., Wharton C.W. Micro T-mixer as a rapid mixing micromixer. Sensors and Actuators B: Chemical 2004, 100:359-379.
85. Wang Q.-A., Wang J.-X., Yu W., Shao L., Chen G.-Z., Chen J.-F. Investigation of micromixing efficiency in a novel high-throughput microporous tube-in-tube microchannel reactor. Industrial & Engineering Chemistry Research 2009, 48:5004-5009.
86. Zhu W.-Z., Wang J.-X., Shao L., Zhang H.-x., Zhang Q.-x., Chen J.-F. Liquid antisolvent preparation of amorphous cefuroxime axetil nanoparticles in a tube-in-tube microchannel reactor. International Journal of Pharmaceutics 2010, 395:260-265.
87. Ruecroft G., Hipkiss D., Ly T., Maxted N., Cains P.W. Sonocrystallization: the use of ultrasound for improved industrial crystallization. Organic Process Research & Development 2005, 9:923-932.
88. Luque de Castro M.D., Priego-Capote F. Ultrasound-assisted crystallization (sonocrystallization). Ultrasonics Sonochemistry 2007, 14:717-724.
89. Kipp J.E., Wong T., Chung J., Doty M.J., Werling J., Rebbeck C.L., Brynjelsen S. Method for Preparing Submicron Particle Suspensions 2005, Baxter International Inc., United States of America.
90. Werling J., Doty M.J., Rebbeck C.L., Wong J.C.T., Kipp J.E. Polymorphic Form of Itraconazole 2007, Baxter International Inc., United States of America.
91. Dhumal R.S., Biradar S.V., Yamamura S., Paradkar A.R., York P. Preparation of amorphous cefuroxime axetil nanoparticles by sonoprecipitation for enhancement of bioavailability. European Journal of Pharmaceutics and Biopharmaceutics 2008, 70:109-115.
92. Dhumal R.S., Biradar S.V., Paradkar A.R., York P. Particle engineering using sonocrystallization: salbutamol sulphate for pulmonary delivery. International Journal of Pharmaceutics 2009, 368:129-137.
93. Verma S., Gokhale R., Burgess D.J. A comparative study of top-down and bottom-up approaches for the preparation of micro/nanosuspensions. International Journal of Pharmaceutics 2009, 380:216-222.
94. Zheng Z., Zhang X., Carbo D., Clark C., Nathan C.-A., Lvov Y. Sonication-assisted synthesis of polyelectrolyte-coated curcumin nanoparticles. Langmuir 2010, 26:7679-7681.
95. Xia D., Quan P., Piao H., Piao H., Sun S., Yin Y., Cui F. Preparation of stable nitrendipine nanosuspensions using the precipitation-ultrasonication method for enhancement of dissolution and oral bioavailability. European Journal of Pharmaceutical Sciences 2010, 40:325-334.
96. El-Gendy N., Aillon K.L., Berkland C. Dry powdered aerosols of diatrizoic acid nanoparticle agglomerates as a lung contrast agent. International Journal of Pharmaceutics 2010, 391:305-312.
97. Gandhi P.J., Murthy Z.V.P. Solubility and crystal size of sirolimus in different organic solvents. Journal of Chemical & Engineering Data 2010, 55:5050-5054.
98. Torbacke M., Rasmuson å.C. Influence of different scales of mixing in reaction crystallization. Chemical Engineering Science 2001, 56:2459-2473.
99. Kim Y.H., Lee K., Koo K.K., Shul Y.G., Haam S. Comparison study of mixing effect on batch cooling crystallization of 3-nitro-1,2,4-triazol-5-one (NTO) using mechanical stirrer and ultrasound irradiation. Crystal Research and Technology 2002, 37:928-944.
100. Dodds J., Espitalier F., Louisnard O., Grossier R., David R., Hassoun M., Baillon F., Gatumel C., Lyczko N. The effect of ultrasound on crystallisation-precipitation processes: some examples and a new segregation model. Particle & Particle Systems Characterization 2007, 24:18-28.
101. Virone C., Kramer H.J.M., van Rosmalen G.M., Stoop A.H., Bakker T.W. Primary nucleation induced by ultrasonic cavitation. Journal of Crystal Growth 2006, 294:9-15.
102. McCausland L.J., Cains P.W., Martin P.D. Use the power of sonocrystallization for improved properties. Chemical Engineering Progress 2001, 97:56-63.
103. Li H., Li H., Guo Z., Liu Y. The application of power ultrasound to reaction crystallization. Ultrasonics Sonochemistry 2006, 13:359-363.
104. 2O melt being used as a heat storage material. Ultrasonics Sonochemistry 2006, 13:308-312.
105. Chan H.-K., Kwok P.C.L. Production methods for nanodrug particles using the bottom-up approach. Advanced Drug Delivery Reviews 2011, 63:406-416.
106. Yeo S.-D., Lee J.-C. Crystallization of sulfamethizole using the supercritical and liquid antisolvent processes. Journal of Supercritical Fluids 2004, 30:315-323.
107. Dennehy R.D. Particle engineering using power ultrasound. Organic Process Research & Development 2003, 7:1002-1006.
108. Narducci O., Jones A.G., Kougoulos E. An assessment of the use of ultrasound in the particle engineering of micrometer-scale adipic acid crystals. Crystal Growth & Design 2011, 11:1742-1749.
109. Patel S.R., Murthy Z.V.P. Effect of process parameters on crystal size and morphology of lactose in ultrasound-assisted crystallization. Crystal Research and Technology 2011, 46:243-248.
110. Gracin S., Uusi-Penttilä M., Rasmuson å.C. Influence of ultrasound on the nucleation of polymorphs of p-Aminobenzoic acid. Crystal Growth & Design 2005, 5:1787-1794.
111. Siddiqui S.W., Zhao Y., Kukukova A., Kresta S.M. Characteristics of a confined impinging jet reactor: energy dissipation, homogeneous and heterogeneous reaction products, and effect of unequal flow. Industrial & Engineering Chemistry Research 2009, 48:7945-7958.
112. Kougoulos E., Marziano I., Miller P.R. Lactose particle engineering: influence of ultrasound and anti-solvent on crystal habit and particle size. Journal of Crystal Growth 2010, 312:3509-3520.
113. Ross S., Morrison I.D. Colloidal Systems and Interfaces 1988, Wiley.
114. Adamson A.W., Gast A.P. Physical Chemistry of Surfaces 1997, Wiley.
115. Hill T.L. A different approach to nanothermodynamics. Nano Letters 2001, 1:273-275.
116. Lee J., Lee S.-J., Choi J.-Y., Yoo J.Y., Ahn C.-H. Amphiphilic amino acid copolymers as stabilizers for the preparation of nanocrystal dispersion. European Journal of Pharmaceutical Sciences 2005, 24:441-449.
117. Kind M. Colloidal aspects of precipitation processes. Chemical Engineering Science 2002, 57:4287-4293.
118. Lee R.W., McShane J., Shaw J.M., Wood R.W., Shenoy D.B. Particle size reduction. Water-Insoluble Drug Formulation 2000, 467-498. Interpharm Press. R. Liu (Ed.).
119. Maity D., Agrawal D.C. Synthesis of iron oxide nanoparticles under oxidizing environment and their stabilization in aqueous and non-aqueous media. Journal of Magnetism and Magnetic Materials 2007, 308:46-55.
120. Rasenack N., Müller B.W. Dissolution rate enhancement by in situ micronization of poorly water-soluble drugs. Pharmaceutical Research 2002, 19:1894-1900.
121. Li X.-S., Wang J.-X., Shen Z.-G., Zhang P.-Y., Chen J.-F., Yun J. Preparation of uniform prednisolone microcrystals by a controlled microprecipitation method. International Journal of Pharmaceutics 2007, 342:26-32.
122. Matteucci M., Paguio J., Miller M., Williams Iii R., Johnston K. Flocculated amorphous nanoparticles for highly supersaturated solutions. Pharmaceutical Research 2008, 25:2477-2487.
123. Kumar V., Wang L., Riebe M., Tung H.-H., Prud'homme R.K. Formulation and stability of itraconazole and odanacatib nanoparticles: governing physical parameters. Molecular Pharmaceutics 2009, 6:1118-1124.
124. Dong Y., Ng W.K., Shen S., Kim S., Tan R.B.H. Preparation and characterization of spironolactone nanoparticles by antisolvent precipitation. International Journal of Pharmaceutics 2009, 375:84-88.
125. Duro R., Souto C., Gómez-Amoza J.L., Martínez-Pacheco R., Concheiro A. Interfacial adsorption of polymers and surfactants: implications for the properties of disperse systems of pharmaceutical interest. Drug Development and Industrial Pharmacy 1999, 25:817-829.
126. Kim C.-J. Surface chemistry and colloids. Advanced Pharmaceutics: Physicochemical Principles 2004, 193-256. CRC Press. C.-J. Kim (Ed.).
127. Nutan M.T.H., Reddy I.K. General principles of suspensions. Pharmaceutical Suspensions: from Formulation Development to Manufacturing 2009, 39-66. Springer. A.K. Kulshreshtha, O.N. Singh, G.M. Wall (Eds.).
128. Wu L., Zhang J., Watanabe W. Physical and chemical stability of drug nanoparticles. Advanced Drug Delivery Reviews 2011, 63:456-469.
129. Duro R., Gómez-Amoza J.L., Martínez-Pacheco R., Souto C., Concheiro A. Adsorption of polysorbate 80 on pyrantel pamoate: effects on suspension stability. International Journal of Pharmaceutics 1998, 165:211-216.
130. Kayes J.B., Rawlins D.A. Adsorption characteristics of certain polyoxyethylene-polyoxypropylene block co-polymers on polystyrene latex. Colloid & Polymer Science 1979, 257:622-629.
131. Steinby K., Silveston R., Kronberg B. The effect of temperature on the adsorption of a nonionic surfactant on a PMMA latex. Journal of Colloid and Interface Science 1993, 155:70-78.
132. Duro R., Alvarez C., Martínez-Pacheco R., Gómez-Amoza J.L., Concheiro A., Souto C. The adsorption of cellulose ethers in aqueous suspensions of pyrantel pamoate: effects on zeta potential and stability. European Journal of Pharmaceutics and Biopharmaceutics 1998, 45:181-188.
133. Rozenberg B.A., Tenne R. Polymer-assisted fabrication of nanoparticles and nanocomposites. Progress in Polymer Science 2008, 33:40-112.
134. Scheutjens J.M.H.M., Fleer G.J. Statistical theory of the adsorption of interacting chain molecules. 2. Train, loop, and tail size distribution. Journal of Physical Chemistry 1980, 84:178-190.
135. Heller W., Pugh T.L. Steric stabilization of colloidal solutions by adsorption of flexible macromolecules. Journal of Polymer Science 1960, 47:203-217.
136. Napper D.H. Polymeric Stabilization of Colloidal Dispersions 1983, Academic Press.
137. Stuart M.A.C. Adsorbed polymers in colloidal systems: from statics to dynamics. Polymer Journal 1991, 23:669-682.
138. Kiratzis N., Faers M., Luckham P.F. Depletion flocculation of particulate systems induced by hydroxyethylcellulose. Colloids and Surfaces A: Physicochemical and Engineering Aspects 1999, 151:461-471.
139. Jongen N., Bowen P., Lemaître J., Valmalette J.-C., Hofmann H. Precipitation of self-organized copper oxalate polycrystalline particles in the presence of hydroxypropylmethylcellulose (HPMC): control of morphology. Journal of Colloid and Interface Science 2000, 226:189-198.
140. Terayama H., Inada K., Nakayama H., Yasueda S., Esumi K. Preparation of stable aqueous suspension of a hydrophobic drug with polymers. Colloids and Surfaces B: Biointerfaces 2004, 39:159-164.
141. Verma S., Kumar S., Gokhale R., Burgess D.J. Physical stability of nanosuspensions: investigation of the role of stabilizers on Ostwald ripening. International Journal of Pharmaceutics 2011, 406:145-152.
142. Raghavan S.L., Trividic A., Davis A.F., Hadgraft J. Crystallization of hydrocortisone acetate: influence of polymers. International Journal of Pharmaceutics 2001, 212:213-221.
143. Raghavan S.L., Schuessel K., Davis A., Hadgraft J. Formation and stabilisation of triclosan colloidal suspensions using supersaturated systems. International Journal of Pharmaceutics 2003, 261:153-158.
144. Douroumis D., Fahr A. Stable carbamazepine colloidal systems using the cosolvent technique. European Journal of Pharmaceutical Sciences 2007, 30:367-374.
145. Zhang Z.-B., Shen Z.-G., Wang J.-X., Zhao H., Chen J.-F., Yun J. Nanonization of megestrol acetate by liquid precipitation. Industrial & Engineering Chemistry Research 2009, 48:8493-8499.
146. Ziller K.H., Rupprecht H. Conteol of crystal growth in drug suspensions: (1) design of a conteol unit and application to acetaminophen suspensions). Drug Development and Industrial Pharmacy 1988, 14:2341-2370.
147. Simonelli A.P., Mehta S.C., Higuchi W.I. Inhibition of sulfathiazole crystal growth by polyvinylpyrrolidone. Journal of Pharmaceutical Sciences 1970, 59:633-638.
148. Choi J.-Y., Yoo J.Y., Kwak H.-S., Uk Nam B., Lee J. Role of polymeric stabilizers for drug nanocrystal dispersions. Current Applied Physics 2005, 5:472-474.
149. Savage A.B. Ethers. Cellulose and Cellulose Derivatives 1971, Wiley-Interscience, New York. N.M. Bikales, L. Segal (Eds.).
150. Budijono S.J., Russ B., Saad W., Adamson D.H., Prud'homme R.K. Block copolymer surface coverage on nanoparticles. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2010, 360:105-110.
151. Zhu Z., Anacker J.L., Ji S., Hoye T.R., Macosko C.W., Prud'homme R.K. Formation of block copolymer-protected nanoparticles via reactive impingement mixing. Langmuir 2007, 23:10499-10504.
152. D'Addio S.M., Kafka C., Akbulut M., Beattie P., Saad W., Herrera M., Kennedy M.T., Prud'homme R.K. Novel method for concentrating and drying polymeric nanoparticles: hydrogen bonding coacervate precipitation. Molecular Pharmaceutics 2010, 7:557-564.
153. D'Addio S.M., Prud'homme R.K. Controlling drug nanoparticle formation by rapid precipitation. Advanced Drug Delivery Reviews 2011, 63:417-426.
154. Choi S.-W., Kwon H.-Y., Kim W.-S., Kim J.-H. Thermodynamic parameters on poly(d,l-lactide-co-glycolide) particle size in emulsification-diffusion process. Colloids and Surfaces A: Physicochemical and Engineering Aspects 2002, 201:283-289.
155. Slavtchev S., Mendes M.A. Marangoni instability in binary liquid-liquid systems. International Journal of Heat and Mass Transfer 2004, 47:3269-3278.
156. Hillgren A., Lindgren J., Aldén M. Protection mechanism of Tween 80 during freeze-thawing of a model protein, LDH. International Journal of Pharmaceutics 2002, 237:57-69.
157. Pattekari P., Zheng Z., Zhang X., Levchenko T., Torchilin V., Lvov Y. Top-down and bottom-up approaches in production of aqueous nanocolloids of low solubility drug paclitaxel. Physical Chemistry Chemical Physics 2011, 13:9014-9019.
158. Derjaguin B.V., Landau L. Theory of the stability of strongly charged lyophobic sols and of the adhesion of strongly charged particles in solutions of electrolytes. Acta Physochimica URSS 1941, 14:633-662.
159. Verwey E.J.W. Theory of the stability of lyophobic colloids. Journal of Physical and Colloid Chemistry 1947, 51:631-636.
160. Grahame D.C. The electrical double layer and the theory of electrocapillarity. Chemical Reviews 1947, 41:441-501.
161. Lifshitz I.M., Slyozov V.V. The kinetics of precipitation from supersaturated solid solutions. Jounal of Physics and Chemistry of Solids 1961, 19:35-50.
162. Lindfors L., Skantze P., Skantze U., Rasmusson M., Zackrisson A., Olsson U. Amorphous drug nanosuspensions. 1. Inhibition of Ostwald ripening. Langmuir 2006, 22:906-910.
163. Mullin J.W. Crystallization 1993, Butterworth Heinemann, Oxford, UK. Third ed.
164. Davis S.S., Round H.P., Purewal T.S. Ostwald ripening and the stability of emulsion systems: an explanation for the effect of an added third component. Journal of Colloid and Interface Science 1981, 80:508-511.
165. Hoang T.K.N., Deriemaeker L., La V.B., Finsy R. Monitoring the simultaneous Ostwald ripening and solubilization of emulsions. Langmuir 2004, 20:8966-8969.
166. Kumar V., Prud'homme R.K. Nanoparticle stability: processing pathways for solvent removal. Chemical Engineering Science 2009, 64:1358-1361.
167. He Y., Huang Y., Wang W., Cheng Y. Integrating micromixer precipitation and electrospray drying toward continuous production of drug nanoparticles. Chemical Engineering Journal 2011, 168:931-937.
168. Pathak P., Meziani M.J., Desai T., Sun Y.-P. Nanosizing drug particles in supercritical fluid processing. Journal of the American Chemical Society 2004, 126:10842-10843.
169. Won D.-H., Kim M.-S., Lee S., Park J.-S., Hwang S.-J. Improved physicochemical characteristics of felodipine solid dispersion particles by supercritical anti-solvent precipitation process. International Journal of Pharmaceutics 2005, 301:199-208.
170. Ali R., Jain G.K., Iqbal Z., Talegaonkar S., Pandit P., Sule S., Malhotra G., Khar R.K., Bhatnagar A., Ahmad F.J. Development and clinical trial of nano-atropine sulfate dry powder inhaler as a novel organophosphorous poisoning antidote. Nanomedicine: Nanotechnology, Biology, and Medicine 2009, 5:55-63.
171. Sultana S., Talegaonkar S., Ali R., Mittal G., Bhatnagar A., Ahmad F.J. Formulation development and optimization of alpha ketoglutarate nanoparticles for cyanide poisoning. Powder Technology 2011, 211:1-9.
172. Yen F.-L., Wu T.-H., Tzeng C.-W., Lin L.-T., Lin C.-C. Curcumin nanoparticles improve the physicochemical properties of curcumin and effectively enhance its antioxidant and antihepatoma activities. Journal of Agricultural and Food Chemistry 2010, 58:7376-7382.
173. Dong Y., Ng W.K., Shen S., Kim S., Tan R.B.H. Controlled antisolvent precipitation of spironolactone nanoparticles by impingement mixing. International Journal of Pharmaceutics 2011, 410:175-179.
174. Bhavna, Ahmad F.J., Mittal G., Jain G.K., Malhotra G., Khar R.K., Bhatnagar A. Nano-salbutamol dry powder inhalation: a new approach for treating broncho-constrictive conditions. European Journal of Pharmaceutics and Biopharmaceutics 2009, 71:282-291.
175. Beckmann W. Nucleation phenomena during the crystallisation and precipitation of Abecarnil. Journal of Crystal Growth 1999, 198-199:1307-1314.
176. Zhang H.-X., Wang J.-X., Zhang Z.-B., Le Y., Shen Z.-G., Chen J.-F. Micronization of atorvastatin calcium by antisolvent precipitation process. International Journal of Pharmaceutics 2009, 374:106-113.
177. Sigfridsson K., Forssén S., Holländer P., Skantze U., de Verdier J. A formulation comparison, using a solution and different nanosuspensions of a poorly soluble compound. European Journal of Pharmaceutics and Biopharmaceutics 2007, 67:540-547.
178. Wang Z., Chen J.-F., Le Y., Shen Z.-G., Yun J. Preparation of ultrafine beclomethasone dipropionate drug powder by antisolvent precipitation. Industrial & Engineering Chemistry Research 2007, 46:4839-4845.
179. Le Y., Ji H., Chen J.-F., Shen Z., Yun J., Pu M. Nanosized bicalutamide and its molecular structure in solvents. International Journal of Pharmaceutics 2009, 370:175-180.
180. Lindfors L., Forssén S., Westergren J., Olsson U. Nucleation and crystal growth in supersaturated solutions of a model drug. Journal of Colloid and Interface Science 2008, 325:404-413.
181. Li C., Li C., Le Y., Chen J.-F. Formation of bicalutamide nanodispersion for dissolution rate enhancement. International Journal of Pharmaceutics 2011, 404:257-263.
182. Hu T.-T., Zhao H., Jiang L.-C., Le Y., Chen J.-F.t, Yun J. Engineering pharmaceutical fine particles of budesonide for dry powder inhalation (DPI). Industrial & Engineering Chemistry Research 2008, 47:9623-9627.
183. Zhang J.-Y., Shen Z.-G., Zhong J., Hu T.-T., Chen J.-F., Ma Z.-Q., Yun J. Preparation of amorphous cefuroxime axetil nanoparticles by controlled nanoprecipitation method without surfactants. International Journal of Pharmaceutics 2006, 323:153-160.
184. Zhao H., Le Y., Liu H., Hu T., Shen Z., Yun J., Chen J.-F. Preparation of microsized spherical aggregates of ultrafine ciprofloxacin particles for dry powder inhalation (DPI). Powder Technology 2009, 194:81-86.
185. Anand P., Nair H.B., Sung B., Kunnumakkara A.B., Yadav V.R., Tekmal R.R., Aggarwal B.B. Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo. Biochemical Pharmacology 2010, 79:330-338.
186. He Y., Huang Y., Cheng Y. Structure evolution of curcumin nanoprecipitation from a micromixer. Crystal Growth & Design 2010, 10:1021-1024.
187. Liu Z., Huang Y., Jin Y., Cheng Y. Mixing intensification by chaotic advection inside droplets for controlled nanoparticle preparation. Microfluidics and Nanofluidics 2010, 9:773-786.
188. Yadav K., Sawant K. Modified nanoprecipitation method for preparation of cytarabine-loaded PLGA nanoparticles. AAPS PharmSciTech 2010, 11:1456-1465.
189. Cheng J., Teply B.A., Sherifi I., Sung J., Luther G., Gu F.X., Levy-Nissenbaum E., Radovic-Moreno A.F., Langer R., Farokhzad O.C. Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery. Biomaterials 2007, 28:869-876.
190. Lindfors L., Skantze P., Skantze U., Westergren J., Olsson U. Amorphous drug nanosuspensions. 3. Particle dissolution and crystal growth. Langmuir 2007, 23:9866-9874.
191. Meng X., Chen Y., Chowdhury S.R., Yang D., Mitra S. Stabilizing dispersions of hydrophobic drug molecules using cellulose ethers during anti-solvent synthesis of micro-particulates. Colloids and Surfaces B: Biointerfaces 2009, 70:7-14.
192. Desai C., Meng X., Yang D., Wang X., Akkunuru V., Mitra S. Effect of solvents on stabilization of micro drug particles. Journal of Crystal Growth 2011, 314:353-358.
193. Ali H.S.M., York P., Ali A.M.A., Blagden N. Hydrocortisone nanosuspensions for ophthalmic delivery: a comparative study between microfluidic nanoprecipitation and wet milling. Journal of Controlled Release 2011, 149:175-181.
194. Klingler C., Müller B.W., Steckel H. Insulin-micro- and nanoparticles for pulmonary delivery. International Journal of Pharmaceutics 2009, 377:173-179.
195. Wang C., Hickey A. Isoxyl aerosols for tuberculosis treatment: preparation and characterization of particles. AAPS PharmSciTech 2010, 11:538-549.
196. Matteucci M.E., Paguio J.C., Miller M.A., Williams Iii R.O., Johnston K.P. Highly supersaturated solutions from dissolution of amorphous itraconazole microparticles at pH 6.8. Molecular Pharmaceutics 2009, 6:375-385.
197. Cho E., Cho W., Cha K.-H., Park J., Kim M.-S., Kim J.-S., Park H.J., Hwang S.-J. Enhanced dissolution of megestrol acetate microcrystals prepared by antisolvent precipitation process using hydrophilic additives. International Journal of Pharmaceutics 2010, 396:91-98.
198. El-Gendy N., Berkland C. Combination chemotherapeutic dry powder aerosols via controlled nanoparticle agglomeration. Pharmaceutical Research 2009, 26:1752-1763.
199. Bilati U., Allémann E., Doelker E. Development of a nanoprecipitation method intended for the entrapment of hydrophilic drugs into nanoparticles. European Journal of Pharmaceutical Sciences 2005, 24:67-75.
200. Valencia P.M., Basto P.A., Zhang L., Rhee M., Langer R., Farokhzad O.C., Karnik R. Single-step assembly of homogenous lipid-polymeric and lipid-quantum dot nanoparticles enabled by microfluidic rapid mixing. ACS Nano 2010, 4:1671-1679.
201. Salem H.F. Sustained-release progesterone nanosuspension following intramuscular injection in ovariectomized rats. International Journal of Nanomedicine 2010, 5:943-954.
202. Murnane D., Marriott C., Martin G.P. Developing an environmentally benign process for the production of microparticles: amphiphilic crystallization. European Journal of Pharmaceutics and Biopharmaceutics 2008, 69:72-82.
203. Salem H.F., Abdelrahim M.E., Eid K.A., Sharaf M.A. Nanosized rods agglomerates as a new approach for formulation of a dry powder inhaler. International Journal of Nanomedicine 2011, 6:311-320.
204. Hameri K., Kulmala M. Homogeneous nucleation in a laminar flow diffusion chamber: the effect of temperature and carrier gas on dibutyl phthalate vapor nucleation rate at high supersaturations. Journal of Chemical Physics 1996, 105:7696-7704.
205. Cornel J., Mazzotti M. Estimating crystal growth rates using in situ ATR-FTIR and Raman spectroscopy in a calibration-free manner. Industrial & Engineering Chemistry Research 2009, 48:10740-10745.
206. Jiang S., ter Horst J.H., Jansens P.J. Concomitant polymorphism of o-Aminobenzoic acid in antisolvent crystallization. Crystal Growth & Design 2007, 8:37-43.
207. Srinivasan K., Meera K., Ramasamy P. A contemporary method to enhance the metastable zone width for crystal growth from solution. Materials Science and Engineering B 2001, 84:233-236.
208. Zhi M., Wang Y., Wang J. Determining the primary nucleation and growth mechanism of cloxacillin sodium in methanol-butyl acetate system. Journal of Crystal Growth 2011, 314:213-219.
209. Teychene' S., Biscans B. Nucleation kinetics of polymorphs: induction period and interfacial energy measurements. Crystal Growth & Design 2008, 8:1133-1139.
210. Chen J.-F., Zhou M.-Y., Shao L., Wang Y.-Y., Yun J., Chew N.Y.K., Chan H.-K. Feasibility of preparing nanodrugs by high-gravity reactive precipitation. International Journal of Pharmaceutics 2004, 269:267-274.
211. Yang H.-J., Chu G.-W., Zhang J.-W., Shen Z.-G., Chen J.-F. Micromixing efficiency in a rotating packed bed: experiments and simulation. Industrial & Engineering Chemistry Research 2005, 44:7730-7737.
212. Lince F., Marchisio D.L., Barresi A.A. A comparative study for nanoparticle production with passive mixers via solvent-displacement: use of CFD models for optimization and design. Chemical Engineering and Processing: Process Intensification 2011, 50:356-368.
213. Chen W., Gu B., Wang H., Pan J., Lu W., Hou H. Development and evaluation of novel itraconazole-loaded intravenous nanoparticles. International Journal of Pharmaceutics 2008, 362:133-140.
214. Erdemir D., Lee A.Y., Myerson A.S. Nucleation of crystals from solution: classical and two-step models. Accounts of Chemical Research 2009, 42:621-629.
215. Teeranachaideekul V., Junyaprasert V.B., Souto E.B., Müller R.H. Development of ascorbyl palmitate nanocrystals applying the nanosuspension technology. International Journal of Pharmaceutics 2008, 354:227-234.
216. Teeranachaideekul V., Souto E.B., Müller R.H., Junyaprasert V.B. Physicochemical characterization and in vitro release studies of ascorbyl palmitate-loaded semi-solid nanostructured lipid carriers (NLC gels). Journal of Microencapsulation 2008, 25:111-120.
217. Kim M.-S., Jin S.-J., Kim J.-S., Park H.J., Song H.-S., Neubert R.H.H., Hwang S.-J. Preparation, characterization and in vivo evaluation of amorphous atorvastatin calcium nanoparticles using supercritical antisolvent (SAS) process. European Journal of Pharmaceutics and Biopharmaceutics 2008, 69:454-465.
218. Kim J.-S., Kim M.-S., Park H.J., Jin S.-J., Lee S., Hwang S.-J. Physicochemical properties and oral bioavailability of amorphous atorvastatin hemi-calcium using spray-drying and SAS process. International Journal of Pharmaceutics 2008, 359:211-219.
219. Eerikäinen H., Kauppinen E.I. Preparation of polymeric nanoparticles containing corticosteroid by a novel aerosol flow reactor method. International Journal of Pharmaceutics 2003, 263:69-83.
220. Oh Y.J., Lee J., Seo J.Y., Rhim T., Kim S.-H., Yoon H.J., Lee K.Y. Preparation of budesonide-loaded porous PLGA microparticles and their therapeutic efficacy in a murine asthma model. Journal of Controlled Release 2011, 150:56-62.
221. Uzun I.N., Sipahigil O., Dinçer S. Coprecipitation of Cefuroxime Axetil-PVP composite microparticles by batch supercritical antisolvent process. Journal of Supercritical Fluids 2011, 55:1059-1069.
222. Bhawana, Basniwal R.K., Buttar H.S., Jain V.K., Jain N. Curcumin nanoparticles: preparation, characterization, and antimicrobial study. Journal of Agricultural and Food Chemistry 2011, 59:2056-2061.
223. Das R.K., Kasoju N., Bora U. Encapsulation of curcumin in alginate-chitosan-pluronic composite nanoparticles for delivery to cancer cells. Nanomedicine: Nanotechnology, Biology and Medicine 2010, 6:153-160.
224. Gupta V., Aseh A., Ríos C.N., Aggarwal B.B. Fabrication and characterization of silk fibroin-derived curcumin nanoparticles for cancer therapy. International Journal of Nanomedicine 2009, 4:115-122.
225. Mukerjee A., Vishwanatha J.K. Formulation, characterization and evaluation of curcumin-loaded PLGA nanospheres for cancer therapy. Anticancer Research 2009, 29:3867-3875.
226. Donsí F., Wang Y., Li J., Huang Q. Preparation of curcumin sub-micrometer dispersions by high-pressure homogenization. Journal of Agricultural and Food Chemistry 2010, 58:2848-2853.
227. Vogt M., Kunath K., Dressman J.B. Dissolution improvement of four poorly water soluble drugs by cogrinding with commonly used excipients. European Journal of Pharmaceutics and Biopharmaceutics 2008, 68:330-337.
228. Bikiaris D., Papageorgiou G.Z., Stergiou A., Pavlidou E., Karavas E., Kanaze F., Georgarakis M. Physicochemical studies on solid dispersions of poorly water-soluble drugs: evaluation of capabilities and limitations of thermal analysis techniques. Thermochimica Acta 2005, 439:58-67.
229. Karavas E., Ktistis G., Xenakis A., Georgarakis E. Effect of hydrogen bonding interactions on the release mechanism of felodipine from nanodispersions with polyvinylpyrrolidone. European Journal of Pharmaceutics and Biopharmaceutics 2006, 63:103-114.
230. Sant V.P., Smith D., Leroux J.-C. Enhancement of oral bioavailability of poorly water-soluble drugs by poly(ethylene glycol)-block-poly(alkyl acrylate-co-methacrylic acid) self-assemblies. Journal of Controlled Release 2005, 104:289-300.
231. Huang Q.-P., Wang J.-X., Zhang Z.-B., Shen Z.-G., Chen J.-F., Yun J. Preparation of ultrafine fenofibrate powder by solidification process from emulsion. International Journal of Pharmaceutics 2009, 368:160-164.
232. Chen Y., Lu Y., Chen J., Lai J., Sun J., Hu F., Wu W. Enhanced bioavailability of the poorly water-soluble drug fenofibrate by using liposomes containing a bile salt. International Journal of Pharmaceutics 2009, 376:153-160.
233. Wong S.M., Kellaway I.W., Murdan S. Enhancement of the dissolution rate and oral absorption of a poorly water soluble drug by formation of surfactant-containing microparticles. International Journal of Pharmaceutics 2006, 317:61-68.
234. Carr A.G., Mammucari R., Foster N.R., Solubility Micronization of griseofulvin in subcritical water. Industrial & Engineering Chemistry Research 2010, 49:3403-3410.
235. Lee M.K., Kim S., Ahn C.H., Lee J., Hydrophilic hydrophobic amino acid copolymers for nano-comminution of poorly soluble drugs. International Journal of Pharmaceutics 2010, 384:173-180.
236. Mohammed A.R., Weston N., Coombes A.G.A., Fitzgerald M., Perrie Y. Liposome formulation of poorly water soluble drugs: optimisation of drug loading and ESEM analysis of stability. International Journal of Pharmaceutics 2004, 285:23-34.
237. Owen H., Graham S., Werling J.O., Carter P.W. Anion effects on electrostatic charging of sterically stabilized, water insoluble drug particles. International Journal of Pharmaceutics 2009, 368:154-159.