Using a modified shepards method for optimization of a nanoparticulate cyclosporine A formulation prepared by a static mixer technique

Journal of Pharmaceutical Sciences

Volumn 97, Issue 2, 2008, Pages 919-930

  Douroumis, Dionysios ^a   Scheler, Stefan ^a   Fahr, Alfred ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Liposomes; Mathematical model; Mixing; Nanoparticles; Polymeric drug delivery systems

Indexed keywords

CYCLOSPORIN A; GELATIN; NANOPARTICLE;

AQUEOUS SOLUTION; ARTICLE; CRYOELECTRON MICROSCOPY; DATA ANALYSIS; DRUG DETERMINATION; DRUG FORMULATION; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; DRUG SYNTHESIS; IN VITRO STUDY; NANOTECHNOLOGY; PARTICLE SIZE; PRECIPITATION; TRANSMISSION ELECTRON MICROSCOPY;

EID: 39749176446     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21001     Document Type: Article

References (29)

1. Gassmann P, List M, Schweitzer A, Sucke H. 1994. Hydrosols - Alternatives for the parenteral application of poorly water soluble drugs. Eur J Pharm Biopharm 40:64-72.
2. Sucker H. 1998. In: Pharmazeutische technologie: Moderne arzneisformen. Müller RH, Hildebrand GE, editors. Stuttgart: WVG, pp 383-391.
3. Horn D, Rieger.2001. J. Organic nanoparticles in the aqueous phase - Theory, experiment, and use. Angew Chem Int Ed 40:4330-4361.
4. Schote U, Ganz P, Fahr A, Seelig J. 2002. Interactions of cyclosporines with lipid membranes as studied by solid state nuclear magnetic resonance spectroscopy and high-sensitivity titration calorimetry. J Pharm Sci 91:856-867.
5. O'Leary TJ, Ross PD, Lieber MR, Lewin IW. 1986. Effects of cyclosporine A on biomembranes. Vibrational spectroscopic, calorimetric, and hemolysis studies. Biophys J 49:795-801.
6. Wiedmann TS, Trouard T, Shekar SC, Polikandritou M, Rahman YE. 1990. Interaction of cyclosporine A with dipalmitoylphosphatidylcholine. Biochim Biophys Acta 1023:12-18.
7. Söderlund T, Lehtonen JY, Kinnunen PK. 1990. Interaction of cyclosporine A with phospholipid membranes. Effect of cholesterol. Mol Pharmacol 55:32-38.
8. Fahr A, Holz M, Flicker G. 1995. Liposomal formulations of cyclosporine A: Effect of lipid type and dose on pharmacokinetics. Pharm Res 12:1189-1198.
9. Zsigmondy R. 1901. Die hochrothe goldlösung als reagens auf colloide. Z Analytische Chem 40:697.
10. Box GEP, Hunter WG, Hunter JS. 1978. Statistics for experimenters. New York: Wiley.
11. Fonner DE, Jr, Buck JR, Banker GS. 1970. Mathematical optimization techniques in drug product and process analysis. J Pharm Sci 59:1587-1596.
12. Takayama K, Nagai T. 1991. Simultaneous optimization for several characteristics concerning percutaneous absorption and skin damage of ketoprofen hydrogels containing d-limonene. Int J Pharm 74:115-126.
13. Levison KK, Takayama K, Isowa K, Okabe K, Nagai T. 1994. Formulation optimization of indomethacin gels containing a combination of three kinds of cyclic monoterpenes as percutaneous absorption enhancers. J Pharm Sci 83:1367-1372.
14. Yang CS, Kao SP, Lee FB, Hung PS. 2004. Twelve Different Interpolation Methods: A Case Study of Surfer 8.0, Proc. of the 20th Congress of ISPRS, Vol 35, Part B, Istanbul, 12-23 July, pp 778-785.
15. Nielson GM, Sung J. 1997. Interval Volume Tetrahedrization, Proceedings: 8th IEEE Visualization Conference, Phoenix, AZ.
16. Douroumis D, Fahr A. 2006. Nano- and microparticulate formulations of poorly soluble drugs by using a novel optimized technique. Eur J Pharm Biopharm.
17. Box GEP, Behnken DW. 1960. Some New Three Level Designs for the Study of Quantitative Variables. Technometrics 2. pp 455-475.
18. Box GEP, Draper NR. 1987. Empirical model-building and response surfaces. New York: John Wiley & Sons. p 249.
19. Khuri AI, Cornell JA. 1987. Response surfaces: Designs and analyses. New York: Marcel Dekker, Inc.
20. Montgomery DC. 2001. Design and analysis of experiments. 5th edn. New York: John Wiley & Sons.
21. Renka RJ. 1988. Multivariate Interpolation of Large Sets of Scattered Data. ACM Trans Math Softw 14:139-148.
22. Corvari SJ, Hollenbeck RG, Leslie J, Plaisance KI, Young D. 1991. Absorption and disposition of colloidal drug delivery systems. I. High-performance liquid chromatography analysis of a cyclosporine emulsion. Pharm Res 8:40-42.
23. Jaiswal J, Gupta SK, Kreuter J. 2004. Preparation of biodegradable cyclosporine nanoparticles by high-pressure emulsification-solvent evaporation process. J Control Release 96:169-178.
24. Molpeceres J, Aberturas MR, Guzman M. 2000. Biodegradable nanoparticles as a delivery system of cyclosporine: Preparation and characterization. J Micro Encapsul 17:599-614.
25. Young TJ, Johnston KP, Pace GW, Mishra AK. 2003. Phospolipid-stabilised nanoparticles of cyclosporine A by rapid expansion from supercritical to aqueous solution. AAPS Pharmscitech 5:1-16.
26. Rasenack N, Müller BW. 2002. Dissolution rate enhancement by in situ micronization of poorly water-soluble drugs. Pharm Res 19:1894-1900.
27. Passerini N, Craig DQM. 2002. Characterization of ciclosporin A loaded poly (D,L lactide-co-glycolide) microspheres using modulated temperature differential scanning calorimetry. J Pharm Pharmacol 54:913-919.
28. Bertacche V, Pini E, Stradi R, Stratta F. 2005. Quantitative determination of amorphous cyclosporine in crystalline cyclosporine samples by Fourier transform infrared spectroscopy. J Pharm Sci 95:159-166.
29. Noyes AS, Whitney WR. 1897. The rate of solution of solid substances in their own solutions. J Amer Chem Soc 19:930-934.