Nano- and micro-particulate formulations of poorly water-soluble drugs by using a novel optimized technique

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 63, Issue 2, 2006, Pages 173-175

  Douroumis, D ^a   Fahr, A ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Microparticles; Mixer technique; Nanoparticles; Poorly water soluble drugs; Precipitation

Indexed keywords

BETAMETHASONE VALERATE; CARBAMAZEPINE; LIPID; NANOPARTICLE; OXCARBAZEPINE; POLYMER; PROGESTERONE; SURFACTANT; WATER;

AQUEOUS SOLUTION; ARTICLE; DISPERSION; DRUG FORMULATION; DRUG MIXTURE; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; FLOW RATE; FREEZE DRYING; METHODOLOGY; MIXER; PARAMETER; PARTICLE SIZE; PRECIPITATION; SPRAY DRYING; SUSPENSION; TEMPERATURE DEPENDENCE;

CRYOELECTRON MICROSCOPY; MICROSCOPY, ELECTRON, TRANSMISSION; NANOTECHNOLOGY; PARTICLE SIZE; PHARMACEUTICAL PREPARATIONS; SOLUBILITY; WATER;

EID: 33646836468     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2006.02.004     Document Type: Article

References (12)

1. Amidon G.L., and Löbenberg R. Modern bioavailability, bioequivalence and biopharmaceutics classification system. New scientific approaches to international regulatory standards. Eur. J. Pharm. Biopharm. 50 (2000) 3-12
2. Müller B.W., Rasenack N., and Steckel H. Micronization of anti-inflammatory drugs for pulmonary delivery by a controlled crystallization process. J. Pharm. Sci. 92 (2003) 35-44
3. Müller B.W., Rasenack N., and Hartenhauer H. Microcrystals for dissolution rate enhancement of poorly water-soluble drugs. Int. J. Pharm. 254 (2003) 137-145
4. Rogers T.L., Nelsen A.C., Hu J., Brown J.N., Sakrari M., Young T.J., Johnston K.P., and Williams III R.O. A novel particle engineering technology to enhance dissolution of poorly water soluble drugs: spray - freezing into liquid. Eur. J. Pharm. Biopharm. 54 (2002) 271-280
5. Horn D., and Lüddecke E. In: Pelizzetti E. (Ed). Fine Particles Science and Technology - From Micro to Nanoparticles (1996), Kluwer, Dordrecht 761-775
6. Mahajan A.J., and Kirwan D.J. Rapid precipitation of biochemicals. J. Phys. D: Appl. Phys. 26 (1993) B176-B180
7. B. Kühn, Verfahren und Vorrichtung zur In-Situ-Formulierung einer Arzneistofflösung zur parenteralen Applikation. German Patent No. WO 99/32175 A1 (1999).
8. Jürgens K., and Müller B.W. A new formulation concept with drugs with poor water solubility for parenteral application. Pharmazie 60 (2005) 665-670
9. Gassmann P., List M., Schweitzer A., and Sucker H. Hydrosols - alternatives for the parenteral application of poorly water soluble drugs. Eur. J. Pharm. Biopharm. 40 (1994) 64-72
10. Horn D., and Rieger J. Organic nanoparticles in the aqueous phase - theory, experiment, and use. Angew. Chem. Int. Ed. 40 (2001) 4330-4361
11. Baldyga J., and Bourne J.R. Turbulent Mixing and Chemical Reactions (1999), Wiley, Chichester
12. Müller B.J., Leuenberger H., and Kissel T. Albumine nanospheres as carriers for passive drug targeting: an optimized manufacturing technique. Pharm. Res. 13 (1996) 32-37