Controlling drug nanoparticle formation by rapid precipitation

Advanced Drug Delivery Reviews

Volumn 63, Issue 6, 2011, Pages 417-426

  D'Addio, Suzanne M ^a   Prud'homme, Robert K ^a  

^a Princeton University   (United States)

Author keywords

Antisolvent addition; Flash nanoprecipitation; Growth; Nanoparticle; Nucleation; Prodrug; Supersaturation

Indexed keywords

ACTIVE PHARMACEUTICAL INGREDIENTS; ANTI-SOLVENTS; ANTISOLVENT PRECIPITATION; CHEMICAL ROUTES; DRUG NANOPARTICLES; GROWTH; IN-VIVO; MANUFACTURING PROCESS; NANO-SIZED; NANOPRECIPITATION; NUCLEATION AND GROWTH; ORGANIC NANOPARTICLES; PRODRUGS;

DRUG DELIVERY; IONIC DRUGS; NANOPARTICLES; NUCLEATION; PRECIPITATION (CHEMICAL); PROTEINS; STABILIZATION; SUPERSATURATION;

PROCESS CONTROL;

1 METHYL 2 PYRROLIDINONE; 1,4,7,10 TETRAAZACYCLODODECANE 1,4,7,10 TETRAACETIC ACID; ACETONE; ALCOHOL; DIMETHYL SULFOXIDE; DOXORUBICIN; DRUG; INDOMETACIN; METHANOL; MEVINOLIN; N,N DIMETHYLFORMAMIDE; NANOCARRIER; NANOPARTICLE; PACLITAXEL; POLYCAPROLACTONE; POLYPROPYLENE; POLYVINYL ALCOHOL; RADIOISOTOPE; TETRAHYDROFURAN;

ANTISOLVENT ADDITION; CHEMICAL MODIFICATION; CHEMICAL PARAMETERS; CHEMICAL PHENOMENA; CHEMICAL PROCEDURES; COMPLEX FORMATION; CONFINED IMPINGING JET; COOLING; CRITICAL MICELLE CONCENTRATION; CRYSTALLIZATION; DIAGNOSTIC IMAGING; DRUG BIOAVAILABILITY; DRUG CONJUGATION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG FORMULATION; DRUG HALF LIFE; DRUG MANUFACTURE; DRUG RELEASE; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; DRYING TECHNIQUE; FLOW KINETICS; FREEZE DRYING; HEATING; HYDROPHOBICITY; IN VIVO STUDY; ION PAIR FORMATION; KINETICS; MAXIMUM TOLERATED DOSE; MIXER; MULTIPLE INLET VORTEX MIXER; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEATION PROCESS; OPSONIZATION; OSTWALD RIPENING; PARTICLE SIZE; PHASE SEPARATION; PHYSICAL CHEMISTRY; PHYSICAL PHASE; PRECIPITATION; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROCESS TECHNOLOGY; REVIEW; SPRAY DRYING; SUPERSATURATION PROCESS; SURFACE TENSION; TEMPERATURE MEASUREMENT; TEMPERATURE QUENCHING; THERMODYNAMICS; X RAY DIFFRACTION;

CHEMICAL PRECIPITATION; CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; NANOPARTICLES; PARTICLE SIZE; SOLUBILITY;

EID: 79957747768     PISSN: 0169409X     EISSN: 0169409X     Source Type: Journal    
DOI: 10.1016/j.addr.2011.04.005     Document Type: Review

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