Preparation of ultrafine beclomethasone dipropionate drug powder by antisolvent precipitation

Industrial and Engineering Chemistry Research

Volumn 46, Issue 14, 2007, Pages 4839-4845

  Wang, Zhe ^a   Chen, Jian Feng ^a   Le, Yuan ^a   Shen, Zhi Gang ^a   Yun, Jimmy ^b  

^a BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY   (China)

^b NanoMaterials Technology Pte Ltd   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CONCENTRATION (PROCESS); DEIONIZED WATER; FOURIER TRANSFORM INFRARED SPECTROSCOPY; METHANOL; PARTICLE SIZE; SOLVENTS; SUPERSATURATION; X RAY DIFFRACTION;

ANTISOLVENT; MEAN PARTICLE LENGTH; ULTRAFINE BECLOMETHASONE DIPROPIONATE;

SURFACE ACTIVE AGENTS;

CONCENTRATION (PROCESS); DEIONIZED WATER; FOURIER TRANSFORM INFRARED SPECTROSCOPY; METHANOL; PARTICLE SIZE; SOLVENTS; SUPERSATURATION; SURFACE ACTIVE AGENTS; X RAY DIFFRACTION;

EID: 34547150620     PISSN: 08885885     EISSN: None     Source Type: Journal    
DOI: 10.1021/ie0615537     Document Type: Article

References (21)

1. Barnes, P. J. Inhaled glucocorticoids for asthma. New Engl. J. Med. 1995, 332 (13), 868.
2. Ostrander, K. D.; Bosch, H. W.; Bondanza, D. M. An in-vitro assessment of a NanoCrystale beclomethasone dipropionate colloidal dispersion via ultrasonic nebulization. Eur. J. Pharm. Biopharm. 1999, 48, 207.
3. Hansch, C.; Sammes, P. G.; Taylor, J. B. Comprehensive Medicinal Chemistry: The Rational Design, Mechanistic Study & Therapeutic Application of Chemical Compounds; Pergamon Press: New York, 1990; Vol. 5.
4. Mei, X. G. Pharmaceutics of Biotechnologic Drug: Foundation and Application; Chemical Industry Press: Beijing, 2004. (In Chin.)
5. Suarez, S.; Hickey, A. J. Drug properties affecting aerosol behavior. Resp. Care 2000, 45 (6), 652.
6. Rasenack, N.; Steckel, H.; Müller, B. W. Micronization of anti-Inflammatory drugs for pulmonary delivery by a controlled crystallization process. J. Pharm. Sci. 2003, 92 (1), 35.
7. Horn, D.; Rieger, J. Organic nanoparticles in aqueous phase-theory, experiment, and use. Angew. Chem., Int. Ed. 2001, 40, 4330.
8. Steckel, H.; Thies, J.; Müller, B. W. Micronizing of steroids for pulmonary delivery by supercritical carbon dioxide. Int. J. Pharm. 1997, 152, 99.
9. Domingo, C.; Berends, E.; Rosmalen, van G. M. Precipitation of ultrafine organic crystals from the rapid expansion of supercritical solutions over a capillary and a frit nozzle. J. Supercrit. Fluids 1997, 10, 39.
10. 2 antisolvent with enhanced mass transfer. Int. J. Pharm. 2001, 228, 19.
11. Zhong, J.; Shen, Z. G.; Yang, Y.; Chen, J. F. Preparation and characterization of uniform Ultra-fined cephradine by combination of reactive precipitation and liquid anti-solvent precipitation under high gravity environment. Int. J. Pharm. 2005, 301, 286.
12. Ruch, F.; Matijević, E. Preparation of micrometer size budesonide particles by precipitation. J. Colloid Interface Sci. 2000, 229, 207.
13. Ma, J.; Wang, Y. H.; Chen, J. F.; Yun, J. Preparation of ultrafine particles of salbutamol sulfate by anti-solvent precipitation. J. Beijing Univ. Chem. Technol. 2003, 30 (6), 6. (In Chin.)
14. Zhou, M. Y.; Chen, J. F.; Liu, X. L. Preliminary research on recrystallization method to produce micronized ibuprofen particles. Chem. Ind. Eng. Prog. 2003, 22 (5), 524. (In Chin.)
15. Sakagami, M.; Kinoshita, W.; Sakon, K.; Sato, J.; Makino, Y. Mucoadhesive beclomethasone microspheres for powder inhalation: their pharmacokinetics and pharmacodynamics evaluation. J. Controlled Release 2002, 80, 207.
16. Chinese Pharmacopoeia II, Chinese Pharmacopoeia Edition; Chinese Chemical Engineering Press: Beijing, 2005. (In Chin.)
17. Dirksen, J. A.; Ring, T. A. Fundamentals of crystallization: kinetic effects on particles size distributions and morphology. Chem. Eng. Sci. 1991, 46 (10), 2389.
18. Schwarzer, H. C.; Schwertfirm, F.; Manhart, M.; Schmid, H. J.; Peukert, W. Predictive simulation of nanoparticle precipitation based on the population balance equation. Chem. Eng. Sci. 2006, 61, 167.
19. Guo, Z.; Zhang, M.; Li, H.; Wang, J.; Kougoulos, E. Effect of ultrasound on anti-solvent crystallization process. J. Crystal Growth 2005, 273, 555.
20. Chen, J. F.; Zhou, M. Y.; Shao, L.; Wang, Y. Y.; Yun, J.; Chew, N. Y. K.; Chan, H. K. Feasibility of preparing nanodrugs by high-gravity reactive precipitation. Int. J. Pharm. 2004, 269, 267.
21. Torrado, G.; Fraile, S.; Torrado, S.; Torrado, S. Process-induced crystallite size and dissolution changes elucidated by a variety of analytical methods. Int. J. Pharm. 1998, 166, 55.