Microfluidic synthesis of amorphous cefuroxime axetil nanoparticles with size-dependent and enhanced dissolution rate

Chemical Engineering Journal

Volumn 162, Issue 2, 2010, Pages 844-851

  Wang, Jie Xin ^a   Zhang, Qian Xia ^a   Zhou, Yue ^a   Shao, Lei ^a   Chen, Jian Feng ^a  

^a BEIJING UNIVERSITY OF CHEMICAL TECHNOLOGY   (China)

Author keywords

Cefuroxime axetil (CFA); Dissolution; Microfluidics; Nanoparticles; Nanoprecipitation

Indexed keywords

ACETONE SOLUTION; ANTI-SOLVENTS; CEFUROXIME AXETIL (CFA); CONTINUOUS SYNTHESIS; DISSOLUTION RATES; MICRO CHANNEL REACTORS; MICRO-FLUIDIC REACTORS; MICROFLUIDIC SYNTHESIS; NANOPRECIPITATION; OPERATION PARAMETERS; POORLY WATER-SOLUBLE DRUGS; PRECIPITATION TEMPERATURE; SOLUTION CONCENTRATION; SOLUTION FLOW RATE; Y-JUNCTIONS;

ACETONE; MICROFLUIDICS; NANOPARTICLES; PARTICLE SIZE; PRECIPITATION (CHEMICAL);

DISSOLUTION;

EID: 77955272707     PISSN: 13858947     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cej.2010.06.022     Document Type: Article

References (41)

1. Rabinow B.E. Nanosuspensions in drug delivery. Nat. Rev. Drug Discov. 2004, 3:785-796.
2. Müller R.H., Jacobs C., Kayser O. Nanosuspensions as particulate drug formulations in therapy: rationale for development and what we can expect for the future. Adv. Drug Deliv. Rev. 2001, 47:3-19.
3. Pathak P., Meziani M.J., Desai T., Sun Y.P. Nanosizing drug particles in supercritical fluid processing. J. Am. Chem. Soc. 2004, 126:10842-10843.
4. Liversidge G.G., Cundy K.C. Particle size reduction for improvement of oral bioavailability of hydrophobic drugs: absolute oral bioavailability of nanocrystalline danazol in beagle dogs. Int. J. Pharm. 1995, 125:91-97.
5. Mosharraf M., Nystorm C. The effect of particle size and shape on the specific dissolution rate of micronized practically insoluble drugs. Int. J. Pharm. 1995, 122:35-47.
6. Matteucci M.E., Hotze M.A., Johnston K.P., Williams R.O. Drug nanoparticles by antisolvent precipitation: mixing energy versus surfactant stabilization. Langmuir 2006, 22:8951-8959.
7. Chen J.F., Zhang J.Y., Shen Z.G., Zhong J., Yun J. Preparation and characterization of amorphous cefuroxime axetil drug nanoparticles with novel technology: high-gravity antisolvent precipitation. Ind. Eng. Chem. Res. 2006, 45:8723-8727.
8. Dalvi S.V., Dave R.N. Controlling particle size of a poorly water-soluble drug using ultrasound and stabilizers in antisolvent precipitation. Ind. Eng. Chem. Res. 2009, 48:7581-7593.
9. Gradl J., Schwarzer H., Schwertfirm F., Manhart M., Peukert W. Precipitation of nanoparticles in a T-mixer: coupling the particle population with hydrodynamics through direct numerical simulation. Chem. Eng. Process. 2006, 45:908-916.
10. Johnson B.K., Prud'homme R.K. Flash nanoprecipitation of organic actives and block copolymers using a confined impinging jets mixer. Aust. J. Chem. 2003, 56:1021-1024.
11. Zhao H., Wang J.X., Wang Q.A., Chen J.F., Yun J. Controlled liquid antisolvent precipitation of hydrophobic pharmaceutical nanoparticles in a microchannel reactor. Ind. Eng. Chem. Res. 2007, 46:8229-8235.
12. Chen J.F., Wang Y.H., Guo F., Wang X.M., Zheng C. Synthesis of nanoparticles with novel technology: high-gravity reactive precipitation. Ind. Eng. Chem. Res. 2000, 39:948-954.
13. Jähnishch K., Hessel V., Löwe H., Baerns M. Chemistry in microstructured reactors. Angew. Chem. Int. Ed. 2004, 43:406-446.
14. Pennemann H., Hessel V., Löwe H. Chemical microprocess technology-from laboratory-scale to production. Chem. Eng. Sci. 2004, 59:4789-4794.
15. deMello A.J. Control and detection of chemical reactions in microfluidic systems. Nature 2006, 442:394-402.
16. deMello J., deMello A. Microscale reactors: nanoscale products. Lab Chip 2004, 4:11N-15N.
17. Yen B.K.H., Stott N.E., Jensen K.F., Bawendi M.G. A continuous-flow microcapillary reactor for the preparation of a size series of CdSe nanocrystals. Adv. Mater. 2003, 15:1858-1862.
18. Edel J.B., Fortt R., deMello J.C., deMello A.J. Microfluidic routes to the controlled production of nanoparticles. Chem. Commun. 2002, 2:1136-1137.
19. Wagner J., Kirner T., Mayer G., Albert J., Köhler J.M. Generation of metal nanoparticles in a microchannel reactor. Chem. Eng. J. 2004, 101:251-260.
20. Lin X.Z., Terepka A.D., Yang H. Synthesis of silver nanoparticles in a continuous flow tubular microreactor. Nano Lett. 2004, 4:2227-2232.
21. Takagi M., Maki T., Miyahara M., Mae K. Production of titania nanoparticles by using a new microreactor assembled with same axle dual pipe. Chem. Eng. J. 2004, 101:269-276.
22. 3 nanoparticles. Ind. Eng. Chem. Res. 2007, 46:6092-6098.
23. Ying Y., Chen G.W., Zhao Y.C., Li S.L., Yuan Q. A high throughput methodology for continuous preparation of monodispersed nanocrystals in microfluidic reactors. Chem. Eng. J. 2008, 135:209-215.
24. Xu S., Nie Z., Seo M., Lewis P., Kumacheva E., Stone H.A., Garstecki P., Weibel D.B., Gitlin I., Whitesides G.M. Generation of monodisperse particles by using microfluidics: control over size, shape, and composition. Angew. Chem. Int. Ed. 2005, 44:724-728.
25. Zhang S., Shen S., Chen Z., Yun J., Yao K., Chen B., Chen J. Preparation of solid lipid nanoparticles in co-flowing microchannels. Chem. Eng. J. 2008, 144:324-328.
26. Karnik R., Gu F., Basto P., Cannizzaro C., Dean L., Kyei-Manu W., Langer R., Farokhzad O.C. Microfluidic platform for controlled synthesis of polymeric nanoparticles. Nano Lett. 2008, 8:2906-2912.
27. McEvoy G.K. Cephalosporins: cefuroxime sodium and cefuroxime axetil. AHFS Drug Information 2003, American Society of Hospital Pharmacists, Inc., Bethesda, MD, pp. 223-231.
28. McEvoy G.K. Cephalosporins: cefuroxime sodium and cefuroxime axetil. AHFS Drug Information 1994, American Society of Hospital Pharmacists, Inc., Bethesda, MD, pp. 152-159.
29. Oszczapowicz I., Malafiej E., Szelachowska M., Horoszewicz-Malafiej A., Kuklewicz C., Sieranska E., Denys A., Niedworok J. Esters of cephalosporins. Part II. Differences in the properties of various forms of the 1-acetoxyethyl ester of cefuroxime. Acta Polon. Pharm. Drug Res. 1995, 52:397-401.
30. Dhumal R.S., Biradar S.V., Yamamura S., Paradkar A.R., York P. Preparation of amorphous cefuroxime axetil nanoparticles by sonoprecipitation for enhancement of bioavailability. Eur. J. Pharm. Biopharm. 2008, 70:109-115.
31. Varshosaz J., Hassanzadeh F., Mahmoudzadeh M., Sadeghi A. Preparation of cefuroxime axetil nanoparticles by rapid expansion of supercritical fluid technology. Powder Technol. 2009, 189:97-102.
32. Chen J.F., Zheng C., Chen G.T. Interaction of macro- and micromixing on particle size distribution in reactive precipitation. Chem. Eng. Sci. 1996, 51:1957-1966.
33. Brian K.J., Robert K.P. Chemical processing and micromixing in confined impinging jets. AIChE J. 2003, 49:2264-2282.
34. Zhang S., Yun J., Shen S., Chen Z., Yao K. Formation of solid lipid nanoparticles in a microchannel system with a cross-shaped junction. Chem. Eng. Sci. 2008, 63:5600-5605.
35. Zhang J.Y., Shen Z.G., Zhong J., Hu T.T., Chen J.F., Ma Z.Q., Yun J. Preparation of amorphous cefuroxime axetil nanoparticles by controlled nanoprecipitation method without surfactants. Int. J. Pharm. 2006, 323:153-160.
36. Bilati U., Allemann E., Doelker E. Development of a nanoprecipitation method intended for the entrapment of hydrophilic drugs into nanoparticles. Eur. J. Pharm. Sci. 2005, 24:67-75.
37. Kim M.S., Jin S.J., Kim J.S., Park H.J., Song H.S., Neubert R.H.H., Hwang S.J. Preparation, characterization and in vivo evaluation of amorphous atorvastatin calcium nanoparticles using supercritical antisolvent (SAS) process. Eur. J. Pharm. Biopharm. 2008, 69:454-464.
38. Zhang H.X., Wang J.X., Zhang Z.B., Le Y., Shen Z.G., Chen J.F. Micronization of atorvastatin calcium by antisolvent precipitation process. Int. J. Pharm. 2009, 374:106-113.
39. Nelson K.G. The Kelvin equation and solubility of small particles. J. Pharm. Sci. 1972, 61:479-480.
40. Li X.S., Wang J.X., Shen Z.G., Zhang P.Y., Chen J.F., Yun J. Preparation of uniform prednisolone microcrystals by a controlled microprecipitation method. Int. J. Pharm. 2007, 342:26-32.
41. Douroumis D., Fahr A. Nano- and micro-particulate formulations of poorly water-soluble drugs by using a novel optimized technique. Eur. J. Pharm. Biopharm. 2006, 63:173-175.