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Volumn 42, Issue 9, 2010, Pages 1462-1471

Activation of Erk by sonic hedgehog independent of canonical hedgehog signalling

Author keywords

Erk; Hedgehog; Patched 1; SH3 domain; Signal transduction; Smoothened

Indexed keywords

CYCLOPAMINE; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; HYBRID PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN P85; PROTEIN PATCHED 1; SMOOTHENED PROTEIN; SONIC HEDGEHOG PROTEIN; CELL SURFACE RECEPTOR; PATCHED RECEPTORS; PROTEIN BINDING; SHH PROTEIN, HUMAN;

EID: 77955096244     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2010.04.016     Document Type: Article
Times cited : (51)

References (74)
  • 1
    • 0030602796 scopus 로고    scopus 로고
    • The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal
    • Alcedo J., Ayzenzon M., Von Ohlen T., Noll M., Hooper J.E. The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal. Cell 1996, 86:221-232.
    • (1996) Cell , vol.86 , pp. 221-232
    • Alcedo, J.1    Ayzenzon, M.2    Von Ohlen, T.3    Noll, M.4    Hooper, J.E.5
  • 2
    • 0029858774 scopus 로고    scopus 로고
    • Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins
    • Alexandre C., Jacinto A., Ingham P.W. Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins. Genes Dev 1996, 10:2003-2013.
    • (1996) Genes Dev , vol.10 , pp. 2003-2013
    • Alexandre, C.1    Jacinto, A.2    Ingham, P.W.3
  • 3
    • 0031587830 scopus 로고    scopus 로고
    • Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor
    • Aza-Blanc P., Ramirez-Weber F.A., Laget M.P., Schwartz C., Kornberg T.B. Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. Cell 1997, 89:1043-1053.
    • (1997) Cell , vol.89 , pp. 1043-1053
    • Aza-Blanc, P.1    Ramirez-Weber, F.A.2    Laget, M.P.3    Schwartz, C.4    Kornberg, T.B.5
  • 4
    • 0035341310 scopus 로고    scopus 로고
    • Patched1 interacts with cyclin B1 to regulate cell cycle progression
    • Barnes E.A., Kong M., Ollendorff V., Donoghue D.J. Patched1 interacts with cyclin B1 to regulate cell cycle progression. EMBO J 2001, 20:2214-2223.
    • (2001) EMBO J , vol.20 , pp. 2214-2223
    • Barnes, E.A.1    Kong, M.2    Ollendorff, V.3    Donoghue, D.J.4
  • 5
    • 0031885802 scopus 로고    scopus 로고
    • Control of somite patterning by Sonic hedgehog and its downstream signal response genes
    • Borycki A.G., Mendham L., Emerson C.P. Control of somite patterning by Sonic hedgehog and its downstream signal response genes. Development 1998, 125:777-790.
    • (1998) Development , vol.125 , pp. 777-790
    • Borycki, A.G.1    Mendham, L.2    Emerson, C.P.3
  • 6
    • 0030297553 scopus 로고    scopus 로고
    • Dual roles for patched in sequestering and transducing Hedgehog
    • Chen Y., Struhl G. Dual roles for patched in sequestering and transducing Hedgehog. Cell 1996, 87:553-563.
    • (1996) Cell , vol.87 , pp. 553-563
    • Chen, Y.1    Struhl, G.2
  • 7
    • 0030844141 scopus 로고    scopus 로고
    • Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours
    • Dahmane N., Lee J., Robins P., Heller P., Ruiz i Altaba A. Activation of the transcription factor Gli1 and the Sonic hedgehog signalling pathway in skin tumours. Nature 1997, 389:876-881.
    • (1997) Nature , vol.389 , pp. 876-881
    • Dahmane, N.1    Lee, J.2    Robins, P.3    Heller, P.4    Ruiz i Altaba, A.5
  • 8
    • 0032796826 scopus 로고    scopus 로고
    • Sonic hedgehog regulates the growth and patterning of the cerebellum
    • Dahmane N., Ruiz i Altaba A. Sonic hedgehog regulates the growth and patterning of the cerebellum. Development 1999, 126:3089-3100.
    • (1999) Development , vol.126 , pp. 3089-3100
    • Dahmane, N.1    Ruiz i Altaba, A.2
  • 9
    • 0031855859 scopus 로고    scopus 로고
    • Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice
    • Ding Q., Motoyama J., Gasca S., Mo R., Sasaki H., Rossant J., Hui C.C. Diminished Sonic hedgehog signaling and lack of floor plate differentiation in Gli2 mutant mice. Development 1998, 125:2533-2543.
    • (1998) Development , vol.125 , pp. 2533-2543
    • Ding, Q.1    Motoyama, J.2    Gasca, S.3    Mo, R.4    Sasaki, H.5    Rossant, J.6    Hui, C.C.7
  • 11
    • 0027756145 scopus 로고
    • Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
    • Echelard Y., Epstein D.J., St-Jacques B., Shen L., Mohler J., McMahon J.A., McMahon A.P. Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity. Cell 1993, 75:1417-1430.
    • (1993) Cell , vol.75 , pp. 1417-1430
    • Echelard, Y.1    Epstein, D.J.2    St-Jacques, B.3    Shen, L.4    Mohler, J.5    McMahon, J.A.6    McMahon, A.P.7
  • 12
    • 9144226385 scopus 로고    scopus 로고
    • Depletion of physiological levels of the human TID1 protein renders cancer cell lines resistant to apoptosis mediated by multiple exogenous stimuli
    • Edwards K.M., Munger K. Depletion of physiological levels of the human TID1 protein renders cancer cell lines resistant to apoptosis mediated by multiple exogenous stimuli. Oncogene 2004, 23:8419-8431.
    • (2004) Oncogene , vol.23 , pp. 8419-8431
    • Edwards, K.M.1    Munger, K.2
  • 14
    • 0029589911 scopus 로고
    • Specific interactions outside the proline-rich core of two classes of Src homology 3 ligands
    • Feng S., Kasahara C., Rickles R.J., Schreiber S.L. Specific interactions outside the proline-rich core of two classes of Src homology 3 ligands. Proc Natl Acad Sci USA 1995, 92:12408-12415.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 12408-12415
    • Feng, S.1    Kasahara, C.2    Rickles, R.J.3    Schreiber, S.L.4
  • 15
    • 0029978752 scopus 로고    scopus 로고
    • Hedgehog is required for the proliferation and specification of ovarian somatic cells prior to egg chamber formation in Drosophila
    • Forbes A.J., Lin H., Ingham P.W., Spradling A.C. hedgehog is required for the proliferation and specification of ovarian somatic cells prior to egg chamber formation in Drosophila. Development 1996, 122:1125-1135.
    • (1996) Development , vol.122 , pp. 1125-1135
    • Forbes, A.J.1    Lin, H.2    Ingham, P.W.3    Spradling, A.C.4
  • 16
    • 0027817446 scopus 로고
    • Genetic analysis of hedgehog signalling in the Drosophila embryo
    • Forbes A.J., Nakano Y., Taylor A.M., Ingham P.W. Genetic analysis of hedgehog signalling in the Drosophila embryo. Dev Suppl 1993, 115-124.
    • (1993) Dev Suppl , pp. 115-124
    • Forbes, A.J.1    Nakano, Y.2    Taylor, A.M.3    Ingham, P.W.4
  • 17
    • 4444312892 scopus 로고    scopus 로고
    • Sonic hedgehog regulates the proliferation, differentiation, and migration of enteric neural crest cells in gut
    • Fu M., Lui V.C., Sham M.H., Pachnis V., Tam P.K. Sonic hedgehog regulates the proliferation, differentiation, and migration of enteric neural crest cells in gut. J Cell Biol 2004, 166:673-684.
    • (2004) J Cell Biol , vol.166 , pp. 673-684
    • Fu, M.1    Lui, V.C.2    Sham, M.H.3    Pachnis, V.4    Tam, P.K.5
  • 18
    • 0031040287 scopus 로고    scopus 로고
    • Drosophila cubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes
    • Hepker J., Wang Q.T., Motzny C.K., Holmgren R., Orenic T.V. Drosophila cubitus interruptus forms a negative feedback loop with patched and regulates expression of Hedgehog target genes. Development 1997, 124:549-558.
    • (1997) Development , vol.124 , pp. 549-558
    • Hepker, J.1    Wang, Q.T.2    Motzny, C.K.3    Holmgren, R.4    Orenic, T.V.5
  • 19
    • 0031723219 scopus 로고    scopus 로고
    • The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction
    • Incardona J.P., Gaffield W., Kapur R.P., Roelink H. The teratogenic Veratrum alkaloid cyclopamine inhibits sonic hedgehog signal transduction. Development 1998, 125:3553-3562.
    • (1998) Development , vol.125 , pp. 3553-3562
    • Incardona, J.P.1    Gaffield, W.2    Kapur, R.P.3    Roelink, H.4
  • 21
    • 0037172658 scopus 로고    scopus 로고
    • Sonic hedgehog induces the segregation of patched and smoothened in endosomes
    • Incardona J.P., Gruenberg J., Roelink H. Sonic hedgehog induces the segregation of patched and smoothened in endosomes. Curr Biol 2002, 12:983-995.
    • (2002) Curr Biol , vol.12 , pp. 983-995
    • Incardona, J.P.1    Gruenberg, J.2    Roelink, H.3
  • 24
    • 0034461606 scopus 로고    scopus 로고
    • Sonic hedgehog promotes G(1) cyclin expression and sustained cell cycle progression in mammalian neuronal precursors
    • Kenney A.M., Rowitch D.H. Sonic hedgehog promotes G(1) cyclin expression and sustained cell cycle progression in mammalian neuronal precursors. Mol Cell Biol 2000, 20:9055-9067.
    • (2000) Mol Cell Biol , vol.20 , pp. 9055-9067
    • Kenney, A.M.1    Rowitch, D.H.2
  • 25
    • 7444248522 scopus 로고    scopus 로고
    • Tid1, the human homologue of a Drosophila tumor suppressor, reduces the malignant activity of ErbB-2 in carcinoma cells
    • Kim S.W., Chao T.H., Xiang R., Lo J.F., Campbell M.J., Fearns C., Lee J.D. Tid1, the human homologue of a Drosophila tumor suppressor, reduces the malignant activity of ErbB-2 in carcinoma cells. Cancer Res 2004, 64:7732-7739.
    • (2004) Cancer Res , vol.64 , pp. 7732-7739
    • Kim, S.W.1    Chao, T.H.2    Xiang, R.3    Lo, J.F.4    Campbell, M.J.5    Fearns, C.6    Lee, J.D.7
  • 26
    • 0027749249 scopus 로고
    • A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos
    • Krauss S., Concordet J.P., Ingham P.W. A functionally conserved homolog of the Drosophila segment polarity gene hh is expressed in tissues with polarizing activity in zebrafish embryos. Cell 1993, 75:1431-1444.
    • (1993) Cell , vol.75 , pp. 1431-1444
    • Krauss, S.1    Concordet, J.P.2    Ingham, P.W.3
  • 27
    • 0030805592 scopus 로고    scopus 로고
    • Gli1 is a target of Sonic hedgehog that induces ventral neural tube development
    • Lee J., Platt K.A., Censullo P., Ruiz i Altaba A. Gli1 is a target of Sonic hedgehog that induces ventral neural tube development. Development 1997, 124:2537-2552.
    • (1997) Development , vol.124 , pp. 2537-2552
    • Lee, J.1    Platt, K.A.2    Censullo, P.3    Ruiz i Altaba, A.4
  • 30
    • 10744233219 scopus 로고    scopus 로고
    • Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2
    • Lum L., Zhang C., Oh S., Mann R.K., von Kessler D.P., Taipale J., Weis-Garcia F., Gong R., Wang B., Beachy P.A. Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. Mol Cell 2003, 12:1261-1274.
    • (2003) Mol Cell , vol.12 , pp. 1261-1274
    • Lum, L.1    Zhang, C.2    Oh, S.3    Mann, R.K.4    von Kessler, D.P.5    Taipale, J.6    Weis-Garcia, F.7    Gong, R.8    Wang, B.9    Beachy, P.A.10
  • 31
    • 0029775570 scopus 로고    scopus 로고
    • Structure of the WW domain of a kinase-associated protein complexed with a proline-rich peptide
    • Macias M.J., Hyvonen M., Baraldi E., Schultz J., Sudol M., Saraste M., Oschkinat H. Structure of the WW domain of a kinase-associated protein complexed with a proline-rich peptide. Nature 1996, 382:646-649.
    • (1996) Nature , vol.382 , pp. 646-649
    • Macias, M.J.1    Hyvonen, M.2    Baraldi, E.3    Schultz, J.4    Sudol, M.5    Saraste, M.6    Oschkinat, H.7
  • 32
    • 0035503886 scopus 로고    scopus 로고
    • A spontaneous mouse mutation, mesenchymal dysplasia (mes), is caused by a deletion of the most C-terminal cytoplasmic domain of patched (ptc)
    • Makino S., Masuya H., Ishijima J., Yada Y., Shiroishi T. A spontaneous mouse mutation, mesenchymal dysplasia (mes), is caused by a deletion of the most C-terminal cytoplasmic domain of patched (ptc). Dev Biol 2001, 239:95-106.
    • (2001) Dev Biol , vol.239 , pp. 95-106
    • Makino, S.1    Masuya, H.2    Ishijima, J.3    Yada, Y.4    Shiroishi, T.5
  • 33
    • 0030601955 scopus 로고    scopus 로고
    • Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development
    • Marigo V., Johnson R.L., Vortkamp A., Tabin C.J. Sonic hedgehog differentially regulates expression of GLI and GLI3 during limb development. Dev Biol 1996, 180:273-283.
    • (1996) Dev Biol , vol.180 , pp. 273-283
    • Marigo, V.1    Johnson, R.L.2    Vortkamp, A.3    Tabin, C.J.4
  • 34
    • 0035901616 scopus 로고    scopus 로고
    • The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking
    • Martin V., Carrillo G., Torroja C., Guerrero I. The sterol-sensing domain of Patched protein seems to control Smoothened activity through Patched vesicular trafficking. Curr Biol 2001, 11:601-607.
    • (2001) Curr Biol , vol.11 , pp. 601-607
    • Martin, V.1    Carrillo, G.2    Torroja, C.3    Guerrero, I.4
  • 35
    • 22944485644 scopus 로고    scopus 로고
    • Shh controls epithelial proliferation via independent pathways that converge on N-Myc
    • Mill P., Mo R., Hu M.C., Dagnino L., Rosenblum N.D., Hui C.C. Shh controls epithelial proliferation via independent pathways that converge on N-Myc. Dev Cell 2005, 9:293-303.
    • (2005) Dev Cell , vol.9 , pp. 293-303
    • Mill, P.1    Mo, R.2    Hu, M.C.3    Dagnino, L.4    Rosenblum, N.D.5    Hui, C.C.6
  • 37
    • 0032492995 scopus 로고    scopus 로고
    • Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway
    • Monnier V., Dussillol F., Alves G., Lamour-Isnard C., Plessis A. Suppressor of fused links fused and Cubitus interruptus on the hedgehog signalling pathway. Curr Biol 1998, 8:583-586.
    • (1998) Curr Biol , vol.8 , pp. 583-586
    • Monnier, V.1    Dussillol, F.2    Alves, G.3    Lamour-Isnard, C.4    Plessis, A.5
  • 39
    • 34547807105 scopus 로고    scopus 로고
    • Epidermal hyperplasia and expansion of the interfollicular stem cell compartment in mutant mice with a C-terminal truncation of Patched1
    • Nieuwenhuis E., Barnfield P.C., Makino S., Hui C.C. Epidermal hyperplasia and expansion of the interfollicular stem cell compartment in mutant mice with a C-terminal truncation of Patched1. Dev Biol 2007, 308:547-560.
    • (2007) Dev Biol , vol.308 , pp. 547-560
    • Nieuwenhuis, E.1    Barnfield, P.C.2    Makino, S.3    Hui, C.C.4
  • 41
    • 0032585515 scopus 로고    scopus 로고
    • Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator
    • Ohlmeyer J.T., Kalderon D. Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator. Nature 1998, 396:749-753.
    • (1998) Nature , vol.396 , pp. 749-753
    • Ohlmeyer, J.T.1    Kalderon, D.2
  • 42
    • 0023445561 scopus 로고
    • Cell and cubitus interruptus dominant: two segment polarity genes on the fourth chromosome in Drosophila
    • Orenic T., Chidsey J., Holmgren R. Cell and cubitus interruptus dominant: two segment polarity genes on the fourth chromosome in Drosophila. Dev Biol 1987, 124:50-56.
    • (1987) Dev Biol , vol.124 , pp. 50-56
    • Orenic, T.1    Chidsey, J.2    Holmgren, R.3
  • 43
    • 0025331133 scopus 로고
    • Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila
    • Orenic T.V., Slusarski D.C., Kroll K.L., Holmgren R.A. Cloning and characterization of the segment polarity gene cubitus interruptus Dominant of Drosophila. Genes Dev 1990, 4:1053-1067.
    • (1990) Genes Dev , vol.4 , pp. 1053-1067
    • Orenic, T.V.1    Slusarski, D.C.2    Kroll, K.L.3    Holmgren, R.A.4
  • 44
    • 36849008176 scopus 로고    scopus 로고
    • The primary cilia, a 'Rab-id' transit system for hedgehog signaling
    • Oro A.E. The primary cilia, a 'Rab-id' transit system for hedgehog signaling. Curr Opin Cell Biol 2007, 19:691-696.
    • (2007) Curr Opin Cell Biol , vol.19 , pp. 691-696
    • Oro, A.E.1
  • 48
    • 31544461492 scopus 로고    scopus 로고
    • Protein kinase C-delta and mitogen-activated protein/extracellular signal-regulated kinase-1 control GLI activation in hedgehog signaling
    • Riobo N.A., Haines G.M., Emerson C.P. Protein kinase C-delta and mitogen-activated protein/extracellular signal-regulated kinase-1 control GLI activation in hedgehog signaling. Cancer Res 2006, 66:839-845.
    • (2006) Cancer Res , vol.66 , pp. 839-845
    • Riobo, N.A.1    Haines, G.M.2    Emerson, C.P.3
  • 49
    • 33645220566 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling
    • Riobo N.A., Lu K., Ai X., Haines G.M., Emerson C.P. Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling. Proc Natl Acad Sci USA 2006, 103:4505-4510.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 4505-4510
    • Riobo, N.A.1    Lu, K.2    Ai, X.3    Haines, G.M.4    Emerson, C.P.5
  • 50
    • 33747827890 scopus 로고    scopus 로고
    • Hedgehog signal transduction: signal integration and cross talk in development and cancer
    • Riobo N.A., Lu K., Emerson C.P. Hedgehog signal transduction: signal integration and cross talk in development and cancer. Cell Cycle 2006, 5:1612-1615.
    • (2006) Cell Cycle , vol.5 , pp. 1612-1615
    • Riobo, N.A.1    Lu, K.2    Emerson, C.P.3
  • 51
    • 34247857432 scopus 로고    scopus 로고
    • Pathways of signal transduction employed by vertebrate Hedgehogs
    • Riobo N.A., Manning D.R. Pathways of signal transduction employed by vertebrate Hedgehogs. Biochem J 2007, 403:369-379.
    • (2007) Biochem J , vol.403 , pp. 369-379
    • Riobo, N.A.1    Manning, D.R.2
  • 53
    • 0030838880 scopus 로고    scopus 로고
    • Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2
    • Robbins D.J., Nybakken K.E., Kobayashi R., Sisson J.C., Bishop J.M., Therond P.P. Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2. Cell 1997, 90:225-234.
    • (1997) Cell , vol.90 , pp. 225-234
    • Robbins, D.J.1    Nybakken, K.E.2    Kobayashi, R.3    Sisson, J.C.4    Bishop, J.M.5    Therond, P.P.6
  • 54
    • 0032808138 scopus 로고    scopus 로고
    • Gli proteins encode context-dependent positive and negative functions: implications for development and disease
    • Ruiz i Altaba A. Gli proteins encode context-dependent positive and negative functions: implications for development and disease. Development 1999, 126:3205-3216.
    • (1999) Development , vol.126 , pp. 3205-3216
    • Ruiz i Altaba, A.1
  • 56
    • 0025172883 scopus 로고
    • GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity
    • Ruppert J.M., Vogelstein B., Arheden K., Kinzler K.W. GLI3 encodes a 190-kilodalton protein with multiple regions of GLI similarity. Mol Cell Biol 1990, 10:5408-5415.
    • (1990) Mol Cell Biol , vol.10 , pp. 5408-5415
    • Ruppert, J.M.1    Vogelstein, B.2    Arheden, K.3    Kinzler, K.W.4
  • 57
    • 0030891148 scopus 로고    scopus 로고
    • A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro
    • Sasaki H., Hui C., Nakafuku M., Kondoh H. A binding site for Gli proteins is essential for HNF-3beta floor plate enhancer activity in transgenics and can respond to Shh in vitro. Development 1997, 124:1313-1322.
    • (1997) Development , vol.124 , pp. 1313-1322
    • Sasaki, H.1    Hui, C.2    Nakafuku, M.3    Kondoh, H.4
  • 58
    • 0032848136 scopus 로고    scopus 로고
    • Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling
    • Sasaki H., Nishizaki Y., Hui C., Nakafuku M., Kondoh H. Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development 1999, 126:3915-3924.
    • (1999) Development , vol.126 , pp. 3915-3924
    • Sasaki, H.1    Nishizaki, Y.2    Hui, C.3    Nakafuku, M.4    Kondoh, H.5
  • 59
    • 0030754171 scopus 로고    scopus 로고
    • Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway
    • Sisson J.C., Ho K.S., Suyama K., Scott M.P. Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway. Cell 1997, 90:235-245.
    • (1997) Cell , vol.90 , pp. 235-245
    • Sisson, J.C.1    Ho, K.S.2    Suyama, K.3    Scott, M.P.4
  • 60
    • 0033567213 scopus 로고    scopus 로고
    • Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation
    • St-Jacques B., Hammerschmidt M., McMahon A.P. Indian hedgehog signaling regulates proliferation and differentiation of chondrocytes and is essential for bone formation. Genes Dev 1999, 13:2072-2086.
    • (1999) Genes Dev , vol.13 , pp. 2072-2086
    • St-Jacques, B.1    Hammerschmidt, M.2    McMahon, A.P.3
  • 61
    • 0029146950 scopus 로고
    • Characterization of a novel protein-binding module-the WW domain
    • Sudol M., Chen H.I., Bougeret C., Einbond A., Bork P. Characterization of a novel protein-binding module-the WW domain. FEBS Lett 1995, 369:67-71.
    • (1995) FEBS Lett , vol.369 , pp. 67-71
    • Sudol, M.1    Chen, H.I.2    Bougeret, C.3    Einbond, A.4    Bork, P.5
  • 62
    • 0029936510 scopus 로고    scopus 로고
    • Mesenchymal dysplasia: a recessive mutation on chromosome 13 of the mouse
    • Sweet H.O., Bronson R.T., Donahue L.R., Davisson M.T. Mesenchymal dysplasia: a recessive mutation on chromosome 13 of the mouse. J Hered 1996, 87:87-95.
    • (1996) J Hered , vol.87 , pp. 87-95
    • Sweet, H.O.1    Bronson, R.T.2    Donahue, L.R.3    Davisson, M.T.4
  • 63
    • 0033587716 scopus 로고    scopus 로고
    • TID1, a human homolog of the Drosophila tumor suppressor l(2)tid, encodes two mitochondrial modulators of apoptosis with opposing functions
    • Syken J., De-Medina T., Munger K. TID1, a human homolog of the Drosophila tumor suppressor l(2)tid, encodes two mitochondrial modulators of apoptosis with opposing functions. Proc Natl Acad Sci USA 1999, 96:8499-8504.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 8499-8504
    • Syken, J.1    De-Medina, T.2    Munger, K.3
  • 65
    • 10044278165 scopus 로고    scopus 로고
    • Functional genetic screen for genes involved in senescence: role of Tid1, a homologue of the Drosophila tumor suppressor l(2)tid, in senescence and cell survival
    • Tarunina M., Alger L., Chu G., Munger K., Gudkov A., Jat P.S. Functional genetic screen for genes involved in senescence: role of Tid1, a homologue of the Drosophila tumor suppressor l(2)tid, in senescence and cell survival. Mol Cell Biol 2004, 24:10792-10801.
    • (2004) Mol Cell Biol , vol.24 , pp. 10792-10801
    • Tarunina, M.1    Alger, L.2    Chu, G.3    Munger, K.4    Gudkov, A.5    Jat, P.S.6
  • 66
    • 0029961659 scopus 로고    scopus 로고
    • Phosphorylation of the fused protein kinase in response to signaling from hedgehog
    • Therond P.P., Knight J.D., Kornberg T.B., Bishop J.M. Phosphorylation of the fused protein kinase in response to signaling from hedgehog. Proc Natl Acad Sci USA 1996, 93:4224-4228.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 4224-4228
    • Therond, P.P.1    Knight, J.D.2    Kornberg, T.B.3    Bishop, J.M.4
  • 67
    • 0001133149 scopus 로고
    • Cubitus interruptus, a new genovariation of the fourth chromosome of Drosophila melanogaster
    • Tiniakow G.G., Terentieva E.L. Cubitus interruptus, a new genovariation of the fourth chromosome of Drosophila melanogaster. Genetics 1933, 18:117-120.
    • (1933) Genetics , vol.18 , pp. 117-120
    • Tiniakow, G.G.1    Terentieva, E.L.2
  • 68
    • 30044435438 scopus 로고    scopus 로고
    • Tid1 is a Smad-binding protein that can modulate Smad7 activity in developing embryos
    • Torregroza I., Evans T. Tid1 is a Smad-binding protein that can modulate Smad7 activity in developing embryos. Biochem J 2006, 393:311-320.
    • (2006) Biochem J , vol.393 , pp. 311-320
    • Torregroza, I.1    Evans, T.2
  • 69
    • 0035918219 scopus 로고    scopus 로고
    • A mouse homologue of the Drosophila tumor suppressor l(2)tid gene defines a novel Ras GTPase-activating protein (RasGAP)-binding protein
    • Trentin G.A., Yin X., Tahir S., Lhotak S., Farhang-Fallah J., Li Y., Rozakis-Adcock M. A mouse homologue of the Drosophila tumor suppressor l(2)tid gene defines a novel Ras GTPase-activating protein (RasGAP)-binding protein. J Biol Chem 2001, 276:13087-13095.
    • (2001) J Biol Chem , vol.276 , pp. 13087-13095
    • Trentin, G.A.1    Yin, X.2    Tahir, S.3    Lhotak, S.4    Farhang-Fallah, J.5    Li, Y.6    Rozakis-Adcock, M.7
  • 70
    • 33847138972 scopus 로고    scopus 로고
    • Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice
    • Wakabayashi Y., Mao J.H., Brown K., Girardi M., Balmain A. Promotion of Hras-induced squamous carcinomas by a polymorphic variant of the Patched gene in FVB mice. Nature 2007, 445:761-765.
    • (2007) Nature , vol.445 , pp. 761-765
    • Wakabayashi, Y.1    Mao, J.H.2    Brown, K.3    Girardi, M.4    Balmain, A.5
  • 73
    • 0013484134 scopus 로고
    • Structural basis for the binding of proline-rich peptides to SH3 domains
    • Yu H., Chen J.K., Feng S., Dalgarno D.C., Brauer A.W., Schreiber S.L. Structural basis for the binding of proline-rich peptides to SH3 domains. Cell 1994, 76:933-945.
    • (1994) Cell , vol.76 , pp. 933-945
    • Yu, H.1    Chen, J.K.2    Feng, S.3    Dalgarno, D.C.4    Brauer, A.W.5    Schreiber, S.L.6


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